Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

(2015) Thomas C. Eadsforth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced annotations and features for comparing thousands ofPseudomonasgenomes in the Pseudomonas genome database

(2015) Geoffrey L. Winsor et al.   NUCLEIC ACIDS RESEARCH

Long-term social dynamics drive loss of function in pathogenic bacteria

(2015) Sandra Breum Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential genome ofPseudomonas aeruginosain cystic fibrosis sputum

(2015) Keith H. Turner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

General and condition-specific essential functions ofPseudomonas aeruginosa

(2015) Samuel A. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MetDraw: automated visualization of genome-scale metabolic network reconstructions and high-throughput data

(2014) Paul A. Jensen et al.   BIOINFORMATICS

Functional analysis of pyochelin-/enantiopyochelin-related genes from a pathogenicity island of Pseudomonas aeruginosa strain PA14

(2014) Alessandro Maspoli et al.   BIOMETALS

Pseudomonas aeruginosa:the making of a pathogen

(2014) Víctor de Lorenzo   ENVIRONMENTAL MICROBIOLOGY

Interclonal gradient of virulence in thePseudomonas aeruginosapangenome from disease and environment

(2014) Rolf Hilker et al.   ENVIRONMENTAL MICROBIOLOGY

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

(2014) Seungsoo Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection

(2014) Keith H. Turner et al.   PLoS Genetics

Small molecule screen yields inhibitors of pseudomonas homoserine lactone-induced host responses

(2013) Cathleen D. Valentine et al.   CELLULAR MICROBIOLOGY

Pseudomonas aeruginosa Uses Multiple Pathways To Acquire Iron during Chronic Infection in Cystic Fibrosis Lungs

(2013) Anna F. Konings et al.   INFECTION AND IMMUNITY

Pouring Salt on a Wound: Pseudomonas aeruginosa Virulence Factors Alter Na+ and Cl- Flux in the Lung

(2013) A. E. Ballok et al.   JOURNAL OF BACTERIOLOGY

Comparative Metabolic Systems Analysis of Pathogenic Burkholderia

(2013) J. A. Bartell et al.   JOURNAL OF BACTERIOLOGY

Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms

(2013) Tim van Opijnen et al.   NATURE REVIEWS MICROBIOLOGY

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases

(2013) Ron Caspi et al.   NUCLEIC ACIDS RESEARCH

Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development

(2013) L. Imamovic et al.   Science Translational Medicine

A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries

(2013) David Skurnik et al.   PLoS Pathogens

Phenazine Content in the Cystic Fibrosis Respiratory Tract Negatively Correlates with Lung Function and Microbial Complexity

(2012) Ryan C. Hunter et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MetRxn: a knowledgebase of metabolites and reactions spanning metabolic models and databases

(2012) Akhil Kumar et al.   BMC BIOINFORMATICS

Drugs that target pathogen public goods are robust against evolved drug resistance

(2012) John W. Pepper   Evolutionary Applications

Acinetobacter baumanniiFolD ligand complexes - potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571

(2012) Thomas C. Eadsforth et al.   FEBS Journal

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

Assessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target

(2012) Thomas C. Eadsforth et al.   PLoS One

A metabolic network approach for the identification and prioritization of antimicrobial drug targets

(2012) Arvind K. Chavali et al.   TRENDS IN MICROBIOLOGY

Genome-Wide Identification of Pseudomonas aeruginosa Virulence-Related Genes Using a Caenorhabditis elegans Infection Model

(2012) Rhonda L. Feinbaum et al.   PLoS Pathogens

Direct Evaluation of Pseudomonas aeruginosa Biofilm Mediators in a Chronic Infection Model

(2011) Matthew S. Byrd et al.   INFECTION AND IMMUNITY

Cooperation and cheating in Pseudomonas aeruginosa: the roles of the las, rhl and pqs quorum-sensing systems

(2011) Cara N Wilder et al.   ISME Journal

Intrinsic and Environmental Mutagenesis Drive Diversification and Persistence of Pseudomonas aeruginosa in Chronic Lung Infections

(2011) Alexandro Rodríguez-Rojas et al.   JOURNAL OF INFECTIOUS DISEASES

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

(2011) Linda Ejim et al.   Nature Chemical Biology

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0

(2011) Jan Schellenberger et al.   Nature Protocols

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Competitive and cooperative metabolic interactions in bacterial communities

(2011) Shiri Freilich et al.   Nature Communications

Reconciliation of Genome-Scale Metabolic Reconstructions for Comparative Systems Analysis

(2011) Matthew A. Oberhardt et al.   PLoS Computational Biology

Characterization of Pseudomonas aeruginosa fatty acid profiles in biofilms and batch planktonic cultures

(2010) Jerry Chao et al.   CANADIAN JOURNAL OF MICROBIOLOGY

High-throughput generation, optimization and analysis of genome-scale metabolic models

(2010) Christopher S Henry et al.   NATURE BIOTECHNOLOGY

In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

(2010) Thomas Bjarnsholt et al.   Nature Protocols

A protocol for generating a high-quality genome-scale metabolic reconstruction

(2010) Ines Thiele et al.   Nature Protocols

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Optimal Drug Synergy in Antimicrobial Treatments

(2010) Joseph Peter Torella et al.   PLoS Computational Biology

Synthesis of the siderophore pyoverdine in Pseudomonas aeruginosa involves a periplasmic maturation

(2009) Emilie Yeterian et al.   AMINO ACIDS

Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules

(2009) Paul Williams et al.   CURRENT OPINION IN MICROBIOLOGY

Identification of Specific and Universal Virulence Factors in Burkholderia cenocepacia Strains by Using Multiple Infection Hosts

(2009) S. Uehlinger et al.   INFECTION AND IMMUNITY

Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation

(2009) Liang Yang et al.   MOLECULAR MICROBIOLOGY

Molecular basis of pyoverdine siderophore recycling in Pseudomonas aeruginosa

(2009) F. Imperi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

iBsu1103: a new genome-scale metabolic model of Bacillus subtilis based on SEED annotations

(2009) Christopher S Henry et al.   GENOME BIOLOGY

The Burkholderia Genome Database: facilitating flexible queries and comparative analyses

(2008) G. L. Winsor et al.   BIOINFORMATICS

DEFEATING PATHOGEN DRUG RESISTANCE: GUIDANCE FROM EVOLUTIONARY THEORY

(2008) John W. Pepper   EVOLUTION

Genome-Scale Metabolic Network Analysis of the Opportunistic Pathogen Pseudomonas aeruginosa PAO1

(2008) M. A. Oberhardt et al.   JOURNAL OF BACTERIOLOGY