Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

Regulation of actin nucleation and autophagosome formation

(2016) Amanda S. Coutts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Diffusion Barriers, Mechanical Forces, and the Biophysics of Phagocytosis

(2016) Philip P. Ostrowski et al.   DEVELOPMENTAL CELL

Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse

(2016) Sricharan Murugesan et al.   JOURNAL OF CELL BIOLOGY

Lamellipodia are crucial for haptotactic sensing and response

(2016) Samantha J. King et al.   JOURNAL OF CELL SCIENCE

WASP, Tregs, and food allergies — rare disease provides insight into a common problem

(2016) Yun Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy

(2016) Willem S. Lexmond et al.   JOURNAL OF CLINICAL INVESTIGATION

The FAK–Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin

(2016) Vinay Swaminathan et al.   MOLECULAR BIOLOGY OF THE CELL

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects

(2016) Tamara J. Laskowski et al.   Stem Cell Reports

Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC)

(2015) Lukman Bin Md Auzair et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Cytoskeletal regulation of platelet formation: Coordination of F-actin and microtubules

(2015) Natalie S. Poulter et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts

(2015) Dessislava Malinova et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine

(2015) Kang Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

Isoform diversity in the Arp2/3 complex determines actin filament dynamics

(2015) Jasmine V. G. Abella et al.   NATURE CELL BIOLOGY

Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex

(2015) Natalie S. Poulter et al.   Nature Communications

Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo

(2015) Duy T. Tran et al.   Nature Communications

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells

(2014) Sou Nakamura et al.   Cell Stem Cell

Actin cytoskeletal defects in immunodeficiency

(2014) Dale A. Moulding et al.   IMMUNOLOGICAL REVIEWS

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

Space–time wiring specificity supports direction selectivity in the retina

(2014) Jinseop S. Kim et al.   NATURE

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Regulation of focal adhesion formation by a vinculin-Arp2/3 hybrid complex

(2014) Dror S. Chorev et al.   Nature Communications

Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs

(2014) Malgorzata Boczkowska et al.   Nature Communications

Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott–Aldrich syndrome-like platelet defect

(2014) Markus Bender et al.   Nature Communications

Wiskott-Aldrich syndrome: a comprehensive review

(2013) Michel J. Massaad et al.   Annals of the New York Academy of Sciences

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

(2013) H. Schachtner et al.   BLOOD

The incredible journey: From megakaryocyte development to platelet formation

(2013) Kellie R. Machlus et al.   JOURNAL OF CELL BIOLOGY

Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation

(2013) K. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Does size matter in platelet production?

(2012) J. N. Thon et al.   BLOOD

The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet  -granule biogenesis

(2012) D. Urban et al.   BLOOD

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

(2012) Praveen Suraneni et al.   JOURNAL OF CELL BIOLOGY

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP

(2012) Gaetana Lanzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Arp2/3 complex is bound and activated by two WASP proteins

(2011) S. B. Padrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets

(2010) I. Pleines et al.   BLOOD

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A

(2010) Poonam R. Molli et al.   JOURNAL OF CELL BIOLOGY

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome

(2009) M. Bosticardo et al.   BLOOD

Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer

(2009) Eeva Laurila et al.   GENES CHROMOSOMES & CANCER

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Primary immune deficiencies with aberrant IgE production

(2008) Esra Ozcan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY