Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions

(2017) Vinay Swaminathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin extension enables ultrasensitive regulation by cytoskeletal force

(2017) Jing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Molecule Force Measurements in Living Cells Reveal a Minimally Tensioned Integrin State

(2016) Alice C. Chang et al.   ACS Nano

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Leukocyte integrin αLβ2headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops

(2016) Mehmet Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissection of molecular assembly dynamics by tracking orientation and position of single molecules in live cells

(2016) Shalin B. Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative nanoscale imaging of orientational order in biological filaments by polarized superresolution microscopy

(2016) Cesar Augusto Valades Cruz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinated integrin activation by actin-dependent force during T-cell migration

(2016) Pontus Nordenfelt et al.   Nature Communications

Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse

(2016) William A. Comrie et al.   Frontiers in Immunology

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

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The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Talin determines the nanoscale architecture of focal adhesions

(2015) Jaron Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A palette of fluorescent proteins optimized for diverse cellular environments

(2015) Lindsey M. Costantini et al.   Nature Communications

An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2

(2014) Mehmet Sen et al.   JOURNAL OF CELL BIOLOGY

Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions

(2014) Rosario Recacha et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

(2013) Ingo Thievessen et al.   JOURNAL OF CELL BIOLOGY

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of integrin affinity on cell surfaces

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Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy

(2011) Martin Kampmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

(2011) Po-Ssu Huang et al.   PLoS One

Integrin Structure, Activation, and Interactions

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Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

(2009) Jieqing Zhu et al.   MOLECULAR CELL

Adaptive force transmission in amoeboid cell migration

(2009) Jörg Renkawitz et al.   NATURE CELL BIOLOGY

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS