Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints

The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism

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Measuring epistasis in fitness landscapes: The correlation of fitness effects of mutations

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Biophysical principles predict fitness landscapes of drug resistance

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Evolvability as a Function of Purifying Selection in TEM-1 β-Lactamase

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(2015) Derek N Woolfson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

(2015) Lea M. Starita et al.   GENETICS

Site-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs

(2015) Michael B. Doud et al.   MOLECULAR BIOLOGY AND EVOLUTION

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(2015) Po-Ssu Huang et al.   Nature Chemical Biology

Clusters of isoleucine, leucine, and valine side chains define cores of stability in high-energy states of globular proteins: Sequence determinants of structure and stability

(2015) Sagar V. Kathuria et al.   PROTEIN SCIENCE

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Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

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A Comprehensive Biophysical Description of Pairwise Epistasis throughout an Entire Protein Domain

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An Experimentally Informed Evolutionary Model Improves Phylogenetic Fit to Divergent Lactamase Homologs

(2014) Jesse D. Bloom   MOLECULAR BIOLOGY AND EVOLUTION

Mutational Studies on Resurrected Ancestral Proteins Reveal Conservation of Site-Specific Amino Acid Preferences throughout Evolutionary History

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A Systematic Survey of an Intragenic Epistatic Landscape

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An Experimentally Determined Evolutionary Model Dramatically Improves Phylogenetic Fit

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Clusters of Branched Aliphatic Side Chains Serve As Cores of Stability in the Native State of the HisF TIM Barrel Protein

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Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate

(2013) Benjamin P. Roscoe et al.   JOURNAL OF MOLECULAR BIOLOGY

Cross-species comparison of site-specific evolutionary-rate variation in influenza haemagglutinin

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Mutational effects on stability are largely conserved during protein evolution

(2013) O. Ashenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein

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Fitness analyses of all possible point mutations for regions of genes in yeast

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(2012) I. Rivalta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

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A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

(2011) Trevor Hinkley et al.   NATURE GENETICS

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(2011) R. T. Hietpas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A biophysical protein folding model accounts for most mutational fitness effects in viruses

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High-resolution mapping of protein sequence-function relationships

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Correction: Pervasive Cryptic Epistasis in Molecular Evolution

(2010) Mark Lunzer et al.   PLoS Genetics

Protein Sectors: Evolutionary Units of Three-Dimensional Structure

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(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein Design through Systematic Catalytic Loop Exchange in the (β/α)8 Fold

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Fundamental Link between Folding States and Functional States of Proteins

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