期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-00658-6
关键词
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资金
- Wellcome Trust UK Project [094763]
- Wellcome Trust PhD Studentships [089892, 096988]
- Medical Research Council UK
- Netherlands Organization for Scientific Research (NWO) [VIDI 917-76-365]
- Horizon Marie Curie Intra-European Fellowship (IEF)
- German Research Foundation (DFG)
- Research Centre for Immunotherapy (FZI) Mainz
- MRC [MR/L008289/1] Funding Source: UKRI
- Medical Research Council [MR/L008289/1] Funding Source: researchfish
CD103(+)CD11b(+) dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGF beta beta R1) has an indispensable, cell intrinsic role in the development of these cells. Deletion of Tgfbr1 results in markedly fewer intestinal CD103(+)CD11b(+) DCs and a reciprocal increase in the CD103(-)CD11b(+) dendritic cell subset. Transcriptional profiling identifies markers that define the CD103(+)CD11b(+) DC lineage, including CD101, TREM1 and Siglec-F, and shows that the absence of CD103(+)CD11b(+) DCs in CD11c-Cre. Tgfbr1(fl/fl) mice reflects defective differentiation from CD103(-)CD11b(+) intermediaries, rather than an isolated loss of CD103 expression. The defect in CD103(+)CD11b(+) DCs is accompanied by reduced generation of antigen-specific, inducible FoxP3(+) regulatory T cells in vitro and in vivo, and by reduced numbers of endogenous Th17 cells in the intestinal mucosa. Thus, TGF beta R1-mediated signalling may explain the tissue-specific development of these unique DCs.
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