Targeting the Tumor Stroma: the Biology and Clinical Development of Pegylated Recombinant Human Hyaluronidase (PEGPH20)
出版年份 2017 全文链接
标题
Targeting the Tumor Stroma: the Biology and Clinical Development of Pegylated Recombinant Human Hyaluronidase (PEGPH20)
作者
关键词
Pegylated recombinant human hyaluronidase, PEGPH20, Hyaluronic acid, Hyaluronan, Glycosaminoglycan, Pancreatic ductal adenocarcinoma, Interstitial fluid pressure, Stromal resistance, Tumor stroma, Tumor microenvironment, Extracellular matrix, Diffusion, Convection, Tumor perfusion, Gemcitabine, Nab-paclitaxel, Immunotherapy, Thromboembolic events, KPC mice, CD44, RHAMM
出版物
Current Oncology Reports
Volume 19, Issue 7, Pages -
出版商
Springer Nature
发表日期
2017-06-06
DOI
10.1007/s11912-017-0608-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy
- (2016) J. M. Pitt et al. ANNALS OF ONCOLOGY
- Cancer statistics, 2016
- (2016) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer
- (2016) S. R. Hingorani et al. CLINICAL CANCER RESEARCH
- Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma
- (2016) Christopher C. DuFort et al. GASTROENTEROLOGY
- Assessment of hyaluronic acid in tumor microenvironment (TME) of intrahepatic cholangiocarcinoma (CCA).
- (2016) Leslie Jane Padrnos et al. JOURNAL OF CLINICAL ONCOLOGY
- Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer
- (2015) C. J. Whatcott et al. CLINICAL CANCER RESEARCH
- Exploratory biomarker results from early investigation of PEGPH20 in combination with gemcitabine (Gem) in patients with pancreatic cancer (PDA).
- (2015) Sunil R. Hingorani et al. JOURNAL OF CLINICAL ONCOLOGY
- Efficacy of Prophylactic Low–Molecular Weight Heparin for Ambulatory Patients With Advanced Pancreatic Cancer: Outcomes From the CONKO-004 Trial
- (2015) Uwe Pelzer et al. JOURNAL OF CLINICAL ONCOLOGY
- Receptor for Hyaluronic Acid-Mediated Motility is Associated with Poor Survival in Pancreatic Ductal Adenocarcinoma
- (2015) Xiao-Bo Cheng et al. Journal of Cancer
- Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy
- (2014) N. C. Singha et al. MOLECULAR CANCER THERAPEUTICS
- Hyaluronan, fluid pressure and stromal resistance in pancreas cancer
- (2013) P P Provenzano et al. BRITISH JOURNAL OF CANCER
- Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
- (2013) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Venous Thromboembolism Risk in Patients With Cancer Receiving Chemotherapy: A Real-World Analysis
- (2013) G. H. Lyman et al. ONCOLOGIST
- Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis
- (2013) L. Bian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Abstract LB-307: Hyaluronan deposition correlates with poor survival in pancreatic cancer
- (2012) C. J. Whatcott et al. CANCER RESEARCH
- Abstract 2672: Phase 1 pharmacokinetics (PK) & pharmacodynamics (PD) of PEGylated hyaluronidase PH20 (PEGPH20) in patients with solid tumors
- (2012) Daniel C. Maneval et al. CANCER RESEARCH
- Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
- (2012) Michael A Jacobetz et al. GUT
- Therapeutic Targeting of Hyaluronan in the Tumor Stroma
- (2012) Anne Kultti et al. Cancers
- ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors
- (2011) P. L. Bollyky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD44, a therapeutic target for metastasising tumours
- (2010) Véronique Orian-Rousseau EUROPEAN JOURNAL OF CANCER
- Hyaluronan in human malignancies
- (2010) R.K. Sironen et al. EXPERIMENTAL CELL RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started