A Metabolic Therapy for Malignant Glioma Requires a Clinical Measure

Hyperpolarized13C-lactate to13C-bicarbonate ratio as a biomarker for monitoring the acute response of anti-vascular endothelial growth factor (anti-VEGF) treatment

(2016) Jae Mo Park et al.   NMR IN BIOMEDICINE

Metabolic reprogramming & inflammation: Fuelling the host response to pathogens

(2016) Laura E. Gleeson et al.   SEMINARS IN IMMUNOLOGY

On-target Inhibition of Tumor Fermentative Glycolysis as Visualized by Hyperpolarized Pyruvate

(2015) Pankaj Seth et al.   NEOPLASIA

Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

(2015) John Kurhanewicz et al.   NEOPLASIA

Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging

(2013) J. M. Park et al.   NEURO-ONCOLOGY

Measuring mitochondrial metabolism in rat brainin vivousing MR Spectroscopy of hyperpolarized [2-13C]pyruvate

(2013) Jae Mo Park et al.   NMR IN BIOMEDICINE

Metabolic effects of anti-angiogenic therapy in tumors

(2012) Elisabetta Zulato et al.   BIOCHIMIE

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization

(2011) G. Nardo et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression

(2011) Simon Hu et al.   Cell Metabolism

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

Enzymatic features of the glucose metabolism in tumor cells

(2011) Anique Herling et al.   FEBS Journal

Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging

(2011) Ilwoo Park et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors

(2011) I. Park et al.   NEURO-ONCOLOGY

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism

(2010) Prashanth Ak et al.   FASEB JOURNAL

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC

(2010) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate

(2010) Ralph E. Hurd et al.   MAGNETIC RESONANCE IN MEDICINE

Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report

(2010) Giulio Zuccoli et al.   Nutrition & Metabolism

The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

(2010) Phillip Stafford et al.   Nutrition & Metabolism

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

(2010) Mark Stein et al.   PROSTATE

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

(2009) Ramon C. Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Akt and c-Myc Differentially Activate Cellular Metabolic Programs and Prime Cells to Bioenergetic Inhibition

(2009) Yongjun Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice

(2009) Matthew L. Zierhut et al.   JOURNAL OF MAGNETIC RESONANCE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3

(2008) Muthusamy Thangaraju et al.   BIOCHEMICAL JOURNAL

Serum and Tissue LDH Levels in Patients with Breast/Gynaecological Cancer and Benign Diseases

(2008) Michael I. Koukourakis et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Advances in MR Spectroscopy of the Prostate

(2008) John Kurhanewicz et al.   Magnetic Resonance Imaging Clinics of North America

13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized13C-labeled glutamine

(2008) Ferdia A. Gallagher et al.   MAGNETIC RESONANCE IN MEDICINE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite quantification and high-field MRS in breast cancer

(2007) Ihab S. Haddadin et al.   NMR IN BIOMEDICINE