Mimicking Cardiac Fibrosis in a Dish: Fibroblast Density Rather than Collagen Density Weakens Cardiomyocyte Function

Role of tissue transglutaminase in age-associated ventricular stiffness

(2016) Young Jun Oh et al.   AMINO ACIDS

Engineering approaches to study fibrosis in 3-D in vitro systems

(2016) Ana M Porras et al.   CURRENT OPINION IN BIOTECHNOLOGY

Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy

(2016) Timothy J. Cashman et al.   PLoS One

Cardiac extracellular matrix–fibrin hybrid scaffolds with tunable properties for cardiovascular tissue engineering

(2015) Corin Williams et al.   Acta Biomaterialia

The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects

(2015) Megan V. Cannon et al.   EUROPEAN JOURNAL OF HEART FAILURE

Collagen content does not alter the passive mechanical properties of fibrotic skeletal muscle in mdx mice

(2014) Lucas R. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells

(2014) Lu Han et al.   CARDIOVASCULAR RESEARCH

Dynamic Changes in Myocardial Matrix and Relevance to Disease

(2014) Ai-Hsien Li et al.   CIRCULATION RESEARCH

T 1 Mapping Detects Pharmacological Retardation of Diffuse Cardiac Fibrosis in Mouse Pressure-Overload Hypertrophy

(2014) Daniel J. Stuckey et al.   Circulation-Cardiovascular Imaging

Injection of mesenchymal stromal cells into a mechanically stimulated in vitro model of cardiac fibrosis has paracrine effects on resident fibroblasts

(2014) Peter A. Galie et al.   CYTOTHERAPY

The influence of matrix (an)isotropy on cardiomyocyte contraction in engineered cardiac microtissues

(2014) A. C. C. van Spreeuwel et al.   Integrative Biology

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Low dystrophin levels in heart can delay heart failure in mdx mice

(2014) Maaike van Putten et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

(2014) Daniel Cabrera et al.   Skeletal Muscle

Pressure Overload Induces Early Morphological Changes in the Heart

(2012) Colby A. Souders et al.   AMERICAN JOURNAL OF PATHOLOGY

Collagen Cross-Linking But Not Collagen Amount Associates With Elevated Filling Pressures in Hypertensive Patients With Stage C Heart Failure

(2012) Begoña López et al.   HYPERTENSION

Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy

(2012) Justin M Percival et al.   JOURNAL OF PATHOLOGY

2D and 3D-Organized Cardiac Cells Shows Differences in Cellular Morphology, Adhesion Junctions, Presence of Myofibrils and Protein Expression

(2012) Carolina Pontes Soares et al.   PLoS One

Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization

(2011) Saïd F.A. Askar et al.   CARDIOVASCULAR RESEARCH

In vitro–in vivo correlation: Perspectives on model development

(2011) Ying Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis

(2011) Elza D. van Deel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Assessment of Myocardial Fibrosis With Cardiovascular Magnetic Resonance

(2011) Nathan Mewton et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging

(2011) Ingrid E.C. Verhaart et al.   NEUROMUSCULAR DISORDERS

A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues

(2011) Thomas Boudou et al.   TISSUE ENGINEERING PART A

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

The origin of fibroblasts and mechanism of cardiac fibrosis

(2010) Guido Krenning et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epicardium-derived cells enhance proliferation, cellular maturation and alignment of cardiomyocytes

(2010) Alida Weeke-Klimp et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting Fibrosis in Duchenne Muscular Dystrophy

(2010) Lan Zhou et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Spiral Waves and Reentry Dynamics in an In Vitro Model of the Healed Infarct Border Zone

(2009) Marvin G. Chang et al.   CIRCULATION RESEARCH

Cardiac Fibroblast

(2009) Colby A. Souders et al.   CIRCULATION RESEARCH

Downregulation of survival signalling pathways and increased apoptosis in the transition of pressure overload-induced cardiac hypertrophy to heart failure

(2009) Xiao-Mei Li et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Myofibroblasts in diseased hearts: New players in cardiac arrhythmias?

(2009) Stephan Rohr   HEART RHYTHM

Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues

(2009) W. R. Legant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone

(2008) Kyla D. Huebner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload

(2008) Ying Xia et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Gene-mediated Restoration of Normal Myofiber Elasticity in Dystrophic Muscles

(2008) Stefania Puttini et al.   MOLECULAR THERAPY

Dystrophin-deficient cardiomyopathy in mouse: Expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart

(2008) Christopher F. Spurney et al.   NEUROMUSCULAR DISORDERS