Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease

Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP+)-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling pathway

(2016) Song Yu et al.   CELL STRESS & CHAPERONES

Astroglia dynamics in ageing and Alzheimer's disease

(2016) Alexei Verkhratsky et al.   CURRENT OPINION IN PHARMACOLOGY

Protection of cultured dopamine neurons from MPP+requires a combination of neurotrophic factors

(2016) Juliann D. Jaumotte et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Astrocytic GAP43 Induced by the TLR4/NF- B/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity

(2016) C.-C. Hung et al.   JOURNAL OF NEUROSCIENCE

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

(2016) Ming Lei et al.   NEUROBIOLOGY OF DISEASE

Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders

(2016) Alexei Verkhratsky et al.   NEUROBIOLOGY OF DISEASE

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP+ and Rotenone Toxicity

(2016) Kirsten Bayer Andersen et al.   Frontiers in Cellular Neuroscience

Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice

(2016) Richard Jay Smeyne et al.   PLoS One

Donepezil Regulates 1-Methyl-4-phenylpyridinium-Induced Microglial Polarization in Parkinson’s Disease

(2015) Teng Chen et al.   ACS Chemical Neuroscience

Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson’s Disease

(2015) Beatrice Macchi et al.   CNS & Neurological Disorders-Drug Targets

Targeting glutamatergic synapses in Parkinson's disease

(2015) Fabrizio Gardoni et al.   CURRENT OPINION IN PHARMACOLOGY

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

(2015) Charles Finsterwald et al.   CURRENT PHARMACEUTICAL DESIGN

FGF2 alleviates PTSD symptoms in rats by restoring GLAST function in astrocytes via the JAK/STAT pathway

(2015) Dayun Feng et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Chronic and progressive Parkinson's disease MPTP model in adult and aged mice

(2015) Ana B. Muñoz-Manchado et al.   JOURNAL OF NEUROCHEMISTRY

Neuropathology of α-synuclein propagation and braak hypothesis

(2015) Heather McCann et al.   MOVEMENT DISORDERS

Role of Immunity and Inflammation in the Pathophysiology of Neurodegenerative Diseases

(2015) Marc Fakhoury   Neurodegenerative Diseases

The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia

(2015) Rowan A. Radford et al.   Frontiers in Cellular Neuroscience

Ceftriaxone Protects Astrocytes from MPP+ via Suppression of NF-κB/JNK/c-Jun Signaling

(2014) Yunlong Zhang et al.   MOLECULAR NEUROBIOLOGY

Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra

(2014) Maxime Assous et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice

(2014) Sachin P. Patil et al.   NEUROPHARMACOLOGY

The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease

(2014) Ilona Joniec-Maciejak et al.   Pharmacological Reports

Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivation

(2013) Yi-Fei Ji et al.   GLIA

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

(2013) Giulia Ambrosi et al.   JOURNAL OF NEURAL TRANSMISSION

Activation of microglia induces symptoms of Parkinson’s disease in wild-type, but not in IL-1 knockout mice

(2013) Sachiko Tanaka et al.   Journal of Neuroinflammation

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation

(2012) Noemí García-Tardón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MPTP modulates hippocampal synaptic transmission and activity-dependent synaptic plasticity via dopamine receptors

(2012) GuoQi Zhu et al.   JOURNAL OF NEUROCHEMISTRY

Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP

(2012) J. D. Pita-Almenar et al.   LEARNING & MEMORY

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

(2012) Kangyong Liu et al.   NEUROCHEMICAL RESEARCH

IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP+-Induced Neurodegeneration

(2012) Björn Spittau et al.   NEUROMOLECULAR MEDICINE

Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease

(2012) Karlijn J. Doorn et al.   PROGRESS IN NEUROBIOLOGY

Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice

(2011) Shigeki Moriguchi et al.   JOURNAL OF NEUROCHEMISTRY

Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability

(2011) Syama Sundar Boyalla et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification

(2011) Paramita Chakrabarty et al.   NATURE NEUROSCIENCE

Dopaminergic and behavioral correlates of progressive lesioning of the nigrostriatal pathway with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

(2011) N.R.S. Goldberg et al.   NEUROSCIENCE

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

(2011) C Barcia et al.   Cell Death & Disease

Short communication Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease

(2010) T. Müller et al.   ACTA NEUROLOGICA SCANDINAVICA

PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes

(2010) Xiaofeng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Manganese-induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin-mediated proteolytic system

(2010) Marta Sidoryk-Wȩgrzynowicz et al.   GLIA

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

MPTP-Induced Neuroinflammation Increases the Expression of Pro-Inflammatory Cytokines and Their Receptors in Mouse Brain

(2010) Dario Domenico Lofrumento et al.   NEUROIMMUNOMODULATION

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation

(2009) Xue-zhong Li et al.   NEUROSCIENCE RESEARCH

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

(2008) Rebecca Banerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats

(2008) E.K.Y. Chung et al.   JOURNAL OF COMPARATIVE NEUROLOGY