Article
Medicine, Research & Experimental
Hongxing Liao, Zhihui Zhang, Zhanliang Liu, Weiming Lin, Jian Huang, Yingmei Huang
Summary: The miR-218-5p inhibitor can attenuate synovial inflammation and cartilage injury in KOA rats by promoting SOST.
Review
Cell Biology
Jingliang Gu, Wu Rao, Shaochuan Huo, Tianyou Fan, Minlei Qiu, Haixia Zhu, Deta Chen, Xiaoping Sheng
Summary: Osteoarthritis (OA) is a common musculoskeletal disease that is characterized by progressive loss of articular cartilage and other pathological changes. Non-coding RNAs (ncRNAs), especially miRNAs and lncRNAs, play vital roles in regulating cartilage homeostasis and the progression of OA. Changes in ncRNA expression levels can promote or decelerate OA progression through distinct molecular mechanisms. The potential of ncRNAs as diagnostic biomarkers, prognostic indicators, and therapeutic targets for OA has been emphasized.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Zhuoxuan Jia, Bijun Kang, Yizuo Cai, Chingyu Chen, Zheyuan Yu, Wei Li, Wenjie Zhang
Summary: The study found that CEFFE (a cell-free fat extract containing multiple cytokines) inhibits the progression of osteoarthritis by promoting cartilage regeneration and limiting joint inflammation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Orthopedics
Eugenie Macfarlane, Lauryn Cavanagh, Colette Fong-Yee, Jan Tuckermann, Di Chen, Christopher B. Little, Markus J. Seibel, Hong Zhou
Summary: Disrupting endogenous glucocorticoid signaling in bone cells attenuates osteoarthritis in aged mice, but the role of glucocorticoids in chondrocytes is unknown. This study found that glucocorticoid signaling in chondrocytes promotes synovial activation, chondrocyte senescence, and cartilage degradation through upregulation of catabolic signaling via HIF-2 alpha. Therefore, inhibiting glucocorticoid signaling early after injury may be a promising way to slow osteoarthritic cartilage degeneration.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Chemistry, Medicinal
Jhi Biau Foo, Qi Hao Looi, Chee Wun How, Sau Har Lee, Maimonah Eissa Al-Masawa, Pei Pei Chong, Jia Xian Law
Summary: Exosomes are small extracellular vesicles secreted by cells for intercellular communication, with miRNAs being a promising therapeutic factor for cartilage regeneration. They can promote chondrocyte proliferation and matrix secretion, reduce scar tissue formation, and decrease inflammation, but the optimization of exosome therapy for cartilage injuries is still lacking.
Article
Chemistry, Multidisciplinary
Sirong Shi, Tianyu Chen, Weitong Lu, Yang Chen, Dexuan Xiao, Yunfeng Lin
Summary: This study presents a novel therapeutic strategy for osteoarthritis (OA) treatment by synthesizing tetrahedral framework nucleic acids (tFNAs) carrying miR-124 (T-miR3). T-miR3 efficiently prevents OA progression by inhibiting chondrocyte apoptosis, smoothing cartilage surfaces, suppressing extracellular matrix degradation, and increasing synovial thickness.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Plant Sciences
Priyanka Kothari, Ashish Kumar Tripathi, Aboli Girme, Divya Rai, Ruchi Singh, Shradha Sinha, Dharmendra Choudhary, Geet Kumar Nagar, Rakesh Maurya, Lal Hingorani, Ritu Trivedi
Summary: DS extract showed protective effects on joint cartilage and subchondral bone deterioration in vivo, while CAFG inhibited the effects induced by IL-1 beta and could be a potential therapeutic for treating osteoarthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Engineering, Environmental
Yibo Zhang, Liu He, Yiqi Yang, Jieqiong Cao, Zijian Su, Bihui Zhang, Huiying Guo, Zhenyu Wang, Peiguang Zhang, Junye Xie, Jieruo Li, Jinshao Ye, Zhengang Zha, Hengyi Yu, An Hong, Xiaojia Chen
Summary: Triclocarban (TCC), a widely used EDC, has been found to cause osteoarthritis (OA) in zebrafish by stimulating the expression of DNMT1 and initiating DNA hypermethylation. This leads to the suppression of type II collagen and other extracellular matrices, resulting in decreased cartilage tissue and narrowing of the intraarticular space, characteristic of OA pathogenesis. The regulation of OA occurrence by TCC is conserved in both zebrafish cartilage tissue and human chondrocytes. DNMT1 is highlighted as a potential therapeutic target for TCC-induced OA.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Xue Hao, Jing Zhao, Liyuan Jia, Ting He, Huanbo Wang, Jing Fan, Yating Yang, Fei Su, Qingda Lu, Chao Zheng, Liu Yang, Qiang Jie
Summary: This study found that XMU-MP-1 has a therapeutic effect on osteoarthritis (OA) by inhibiting inflammation, reducing chondrocyte apoptosis, and promoting cell proliferation. These findings provide a new potential option for the treatment of OA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Zhen Li, Zhenyue Chen, Jiayi Chen, Zhutong Liu, Zehui Li, He Sun, Xiaochao Wang, Jinqiang Wei, Xuewei Cao, Decai Zheng
Summary: This study found that monotropein (MON), the main active ingredient of Morinda officinalis F.C. How, has therapeutic effects on chondrocytes and a mouse model of OA. It alleviates OA progression by inhibiting cartilage matrix degradation, apoptosis, and pyroptosis of chondrocytes through NF-kappa B pathway inactivation. MON shows promise as an alternative treatment for OA.
Article
Immunology
Jianxin Qiu, Xiaohang Zheng, Guoping Cai, Jiajing Ye, Ting Jiang, Lihua Chen, Ze Li, Yuhang Gong, Zhenghua Hong, Haixiao Chen
Summary: This study provides evidence supporting the potential role of AZD8330 in the management of osteoarthritis by attenuating inflammation and regulating the NF-kappa B/P65 signaling pathway to alleviate chondrocyte degradation. The findings from animal experiments and in vitro cell experiments support this conclusion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ting Jiang, Yuhang Gong, Wekang Zhang, Jianxin Qiu, Xiaohang Zheng, Ze Li, Guangyong Yang, Zhenghua Hong
Summary: In this study, PD0325901, a specific inhibitor of ERK, was found to have potential as a therapeutic agent for osteoarthritis. The study showed that PD0325901 inhibited osteoclast differentiation in bone marrow monocytes/macrophages and had protective effects on ATDC5 cells. It also reduced osteochondral pathological changes in post-OA subchondral bone destruction. Overall, PD0325901 may serve as a new generation alternative therapy for osteoarthritis.
BIOORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Huan Yu, Sai Yao, Chengchong Zhou, Fangda Fu, Huan Luo, Weibin Du, Hongting Jin, Peijian Tong, Di Chen, Chengliang Wu, Hongfeng Ruan
Summary: The study demonstrated that morroniside can attenuate the progression of osteoarthritis in mice by promoting cartilage matrix synthesis, inhibiting chondrocyte pyroptosis, reducing osteophyte formation, and subchondral sclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Hyun Sik Na, Ji Ye Kwon, Seon-Yeong Lee, Seung Hoon Lee, A. Ram Lee, Jin Seok Woo, KyungAh Jung, Keun-Hyung Cho, Jeong-Won Choi, Dong Hwan Lee, Hong-Ki Min, Sung-Hwan Park, Seok Jung Kim, Mi-La Cho
Summary: The study found that metformin can slow down the progression of experimental osteoarthritis, showing both analgesic and cartilage-protecting effects. The combined administration of metformin and celecoxib was more effective in controlling cartilage damage. In chondrocytes, metformin reduced inflammatory factor expression and promoted autophagy.
Article
Multidisciplinary Sciences
Ming-Liang Ji, Hua Jiang, Zhuang Li, Rui Geng, Jun Zheng Hu, Yu Cheng Lin, Jun Lu
Summary: Sirt6 acts as a regulator of chondrocyte senescence and osteoarthritis by interacting with STAT5 and inhibiting IL-15/JAK3/STAT5 signaling.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xiaolin Xu, Chenglong Wang, Peipei Zhang, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Jia Yuan, Hongjing Dou, Guoxiong Xu
Summary: This study reveals that chemoresistant cancer cells show decreased ROS levels and increased oxidative phosphorylation. Chemoresistant cells generate more energy through oxidative phosphorylation and enhance ROS scavenging systems to resist the effects of chemotherapy. Furthermore, increased ROS production efficiently inhibits chemoresistance and promotes cell death in chemoresistant cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Orthopedics
Chenglong Wang, Liqiang Cui, Qinwen Gu, Sheng Guo, Bin Zhu, Xueli Liu, Yujie Li, Xinyue Liu, Dingxuan Wang, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a common cause of low back pain, and its pathological mechanism involves complex genetic, developmental, biochemical, and biomechanical factors. Non-coding RNA, especially miRNA, has been found to play a crucial role in the development of IDD through various cellular and molecular processes. However, there is still a lack of effective non-surgical treatment options for IDD.
ORTHOPAEDIC SURGERY
(2022)
Article
Integrative & Complementary Medicine
Joon-Ho Lee, Yuan-Ji Wei, Zhong-Yan Zhou, Yu-Ming Hou, Cheng-Long Wang, Li-Bo Wang, Hong-Jin Wu, Yu Zhang, Wei-Wei Dai
Summary: The herbal pair of Radix Achyranthis Bidentatae and Eucommiae Cortex can ameliorate the effects of glucocorticoid-induced osteoporosis in zebrafish, with a 1:1 dosage ratio being the most effective.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Developmental Biology
Yanshu Wang, Arjun Venkatesh, Jiajia Xu, Mingxin Xu, John Williams, Philip M. Smallwood, Aaron James, Jeremy Nathans
Summary: In vascular endothelial cells of the central nervous system, signaling involving ligands WNT7A and WNT7B and co-activator proteins GPR124 and RECK is crucial for limb development. Reductions in the function of these ligands and/or co-activators result in decreased and abnormal limb bone growth, as well as other limb phenotypes. These findings demonstrate that the WNT7A/WNT7B-FRIZZLED-LRP5/LRP6-GPR124-RECK signaling system functions as a unified unit in limb development.
Review
Physiology
Sheng Guo, Chenglong Wang, Changming Xiao, Qinwen Gu, Longhai Long, Xiaoqiang Wang, Houping Xu, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a complex skeletal disease involving multiple factors. The piezo1 ion channel has been identified as a critical factor in the pathogenesis of IDD. Inactivating or interfering with the piezo1 channel can effectively prevent the progression of IDD.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Article
Cell Biology
Yuhang Liu, Xudong Zhang, Xiaodong Chen, Bingjun Zhang, Liming Dai, Chenglong Wang, Yang Li, Xiaoling Zhang
Summary: MicroRNAs are crucial in the chondrogenesis of bone marrow mesenchymal stem cells (MSCs) and regulate joint regeneration in osteoarthritis. This study aimed to determine the role of miR146a in the chondrogenic differentiation of MSCs and its underlying mechanisms. The results showed that miR146a inhibits chondrogenesis in MSCs by directly targeting Lsm11.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Geriatrics & Gerontology
Hongyu Pan, Hongtao Li, Sheng Guo, Chenglong Wang, Xiaoqiang Wang, Houyin Shi, Kaiquan Zhang, Hui Chen, Sen Li
Summary: Low back pain (LBP) is a common health problem caused by intervertebral disc degeneration (IDD), which is mainly attributed to aging, mechanical stress, and lack of nutrition. The pathological mechanism of IDD is complex, involving inflammatory response and cell metabolism disorder. Tumor necrosis factor-alpha (TNF-alpha) plays a crucial role in IDD by promoting extracellular matrix degradation and inflammatory responses. Anti-TNF-alpha therapy is an effective treatment for alleviating IDD.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Geriatrics & Gerontology
Hongtao Li, Xiaoqiang Wang, Hongyu Pan, Changming Xiao, Chenglong Wang, Sheng Guo, Longhai Long, Houyin Shi, Hui Chen, Sen Li
Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP) and disability in the elderly, resulting in a significant global public health and economic burden. The mechanisms of IDD are complex and the specific targets for reversing IDD remain unclear. Interleukin-1 beta (IL-1 beta), a key mediator of IDD, has been found to regulate IVD cell death through various mechanisms, including apoptosis, pyroptosis, and ferroptosis. Inhibition of IL-1 beta has shown promise as a biological therapy for IDD by inhibiting inflammatory processes and regulating ECM degradation. This article reviews the mechanisms and functions of IL-1 beta in IDD and explores advances in IL-1 beta inhibition as a potential biotherapeutic approach for disc degeneration.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Acoustics
Yujie Li, Wei Li, Xinyue Liu, Xueli Liu, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li, Zhongfa Zhang
Summary: Tendon injuries are common soft tissue injuries caused by overuse and degeneration. Tendon repair is slow and inefficient due to the lack of cellular structure and blood vessels. Low-intensity pulsed ultrasound (LIPUS) is a promising non-invasive method for promoting tendon healing. This review examines studies on LIPUS and summarizes its effects on tendon injury, with 87.5% of studies showing improvement. Further research on the application of LIPUS in tendon diseases is warranted.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ginny Ching-Yun Hsu, Yiyun Wang, Amy Z. Lu, Mario A. Gomez-Salazar, Jiajia Xu, Dongqing Li, Carolyn Meyers, Stefano Negri, Sintawat Wangsiricharoen, Kristen Broderick, Bruno Peault, Carol Morris, Aaron W. James
Summary: By comparing microarrays of pericytes derived from human adipose tissue and periosteum, this study identified TIAM1 as a key regulator of cell morphology and differentiation decisions. TIAM1 acts as a tissue-specific determinant, promoting adipocytic differentiation in adipose tissue-derived pericytes and osteoblastic differentiation in periosteum-derived pericytes. These findings were confirmed in an animal model, where TIAM1 misexpression altered bone or adipose tissue generation. Small molecule inhibitors of Rac1 or RhoA/ROCK signaling reversed TIAM1-induced changes in pericyte differentiation potential.
Review
Orthopedics
Shanjun Huang, Yujiao Liu, Chenglong Wang, Wei Xiang, Nianwu Wang, Li Peng, Xuanang Jiang, Xiaomin Zhang, Zhijiang Fu
Summary: Osteoarthritis (OA) is a debilitating disease with significant economic and social burden. Cartilage injury, characterized by excessive chondrocyte death, inflammation, abnormal bone metabolism, and imbalance of extracellular matrix, presents a major pathological feature of OA. Mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) have shown promise as both early diagnostic biomarkers and therapeutic strategies for OA, due to their important role in intercellular communication. This paper comprehensively reviews the functions and mechanisms of MSCs-EVs in cartilage repair, highlighting their potential in protecting chondrocyte death, regulating bone metabolism, balancing extracellular matrix metabolism, alleviating inflammation, and regulating angiogenesis.
ORTHOPAEDIC SURGERY
(2023)
Article
Geochemistry & Geophysics
Jie Nie, Chengyu Zheng, Chenglong Wang, Zijie Zuo, Xiaowei Lv, Shusong Yu, Zhiqiang Wei
Summary: In this paper, a scale-relation joint decoupling network (SRJDN) is proposed for the semantic segmentation of remote sensing (RS) images, which considers decoupling scales and decoupling relationships to explore more complete relationships of multiscale RS objects. The SRJDN consists of three steps: scale decoupling (SD), relation decoupling (RD), and fine-granularity guided fusion (FGF). Experimental results on two large-scale fine-resolution RS image datasets demonstrate the effectiveness and robustness of the proposed joint decoupling strategy and the FGF module in RS image semantic segmentation tasks.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Article
Computer Science, Information Systems
Jingyu Wang, Chenglong Wang, Qicheng Yang, Chengyu Zheng, Jie Nie, Mingxing Jiang
Summary: In this paper, a Bidirectional Macro-Micro Adaptive Enhancement (BMMAEnet) framework is proposed for the re-colorization of remote sensing images. The framework consists of three modules: the Downward Micro Enhancement (DME) module, the Upward Adaptive Macro Enhancement (UAME) module, and the Macro-Micro Balance (MMB) module. Experimental results show that the proposed method outperforms other methods in terms of pixel color value restoration performance and human perceptive understanding.
Article
Multidisciplinary Sciences
Jiajia Xu, Zhao Li, Robert J. Tower, Stefano Negri, Yiyun Wang, Carolyn A. Meyers, Takashi Sono, Qizhi Qin, Amy Lu, Xin Xing, Edward F. McCarthy, Thomas L. Clemens, Aaron W. James
Summary: Bone regeneration following injury is coordinated by inflammatory signals and sensory nerve infiltration. This study demonstrates that nerve growth factor (NGF) signals through p75 to affect migration of mesenchymal osteogenic precursors, thereby impacting bone healing. Lack of NGF or p75 results in delayed bone repair.
Article
Cell & Tissue Engineering
Jiajia Xu, Yiyun Wang, Zhu Li, Ye Tian, Zhao Li, Amy Lu, Ching-Yun Hsu, Stefano Negri, Cammy Tang, Robert J. Tower, Carol Morris, Aaron W. James
Summary: Cells within the periosteum act as a stem cell reservoir for bone formation and repair. Activating PDGFR alpha reporter genes allows tracking and manipulation of these cells.