Article
Biology
Alicia Tapias, David Lazaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Summary: The study reveals the importance of TRRAP for neuroprotection and the network connecting TRRAP, HAT, and SP1 in regulating microtubule dynamics.
Article
Medicine, Research & Experimental
Noritaka Saeki, Kazuki Inoue, Maky Ideta-Otsuka, Kunihiko Watamori, Shinichi Mizuki, Katsuto Takenaka, Katsuhide Igarashi, Hiromasa Miura, Shu Takeda, Yuuki Imai
Summary: The study reveals that UHRF1 is a central epigenetic regulator in rheumatoid arthritis (RA) pathogenesis, playing a suppressive role in multiple disease processes. Stabilizing UHRF1 through Ryuvidine administration ameliorates the pathogenic events in arthritis, suggesting that targeting UHRF1 could be a therapeutic strategy for RA.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Jingwen Song, Syed Nabeel-Shah, Shuye Pu, Hyunmin Lee, Ulrich Braunschweig, Zuyao Ni, Nujhat Ahmed, Edyta Marcon, Guoqing Zhong, Debashish Ray, Kevin C. H. Ha, Xinghua Guo, Zhaolei Zhang, Timothy R. Hughes, Benjamin J. Blencowe, Jack F. Greenblatt
Summary: Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the diversity of mRNA transcripts. A study found that the transcription factor Sp1 binds RNA and is a common repressor of distal poly(A) site usage. Sp1 inhibits cleavage at distal sites by interacting with the subunits of the core cleavage and polyadenylation (CPA) machinery.
Review
Immunology
Miaoran Xia, Bingbing Wang, Zihan Wang, Xulong Zhang, Xi Wang
Summary: NK cells are a heterogeneous and plastic population that can directly kill target cells without prior immunization, with their activation controlled by the balance of multiple germline-encoded activating and inhibitory receptors. Epigenetic regulation plays an important role in NK cell-mediated antitumor immunity, and NK cell-based immunotherapy is considered a promising strategy for cancer treatment. By targeting intrinsic epigenetic regulators alone or in combination with other strategies, there is potential to enhance NK cell-mediated antitumor cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Hyeonwoo La, Hyunjin Yoo, Young Bin Park, Nguyen Xuan Thang, Chanhyeok Park, Seonho Yoo, Hyeonji Lee, Youngsok Choi, Hyuk Song, Jeong Tae Do, Kwonho Hong
Summary: The lymphatic system is crucial for maintaining lipid and interstitial fluid homeostasis, as well as regulating immune cell development and functions. Recent studies have shown that epigenetic regulation plays a critical role in embryonic lymphatic endothelial cell (LEC) development and function. Understanding the epigenetic mechanisms involved in lymphatic development and function is important for managing lymphatic disorders.
Article
Cell Biology
Kelly E. Leon, Raquel Buj, Elizabeth Lesko, Erika S. Dahl, Chi-Wei Chen, Naveen Kumar Tangudu, Yuka Imamura-Kawasawa, Andrew Kossenkov, Ryan P. Hobbs, Katherine M. Aird
Summary: Oncogene-induced senescence (OIS) is a stable cell cycle arrest that occurs in normal cells upon oncogene activation. The expression of DOT1L has been identified as an epigenetic regulator of the SASP, providing a potential strategy to inhibit the negative side effects of senescence while maintaining the beneficial inhibition of proliferation.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
B. He, V. Kram, T. Furusawa, O. Duverger, E. Y. Chu, R. Nanduri, M. Ishikawa, P. Zhang, B. A. Amendt, J. S. Lee, M. Bustin
Summary: The study suggests that HMGN proteins play a role in regulating ameloblast differentiation and enamel mineralization by modulating lineage-specific chromatin accessibility and transcription factor binding to ameloblast regulatory sites. The absence of HMGN proteins in mice leads to faster ameloblast differentiation and increased enamel deposition rate in molars and incisors.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Emilie Bourdonnay, Thomas Henry
Summary: Gasdermins (GSDM) are a family of proteins that play important roles in cell death, immune response, disease susceptibility, and treatment response. The expression of GSDM genes is influenced by various factors and has been associated with diseases such as asthma, inflammatory bowel disease, and cancer.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiyoung Lee, Sunmi Lee, Seongchun Min, Sang Won Kang
Summary: This study provides the first evidence that mitochondrial superoxide accumulation is a consequence of necroptosis.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Harish K. Datta, Marianne K. Kringen, Stephen P. Tuck, Georgia Salpingidou, Ole K. Olstad, Kaare M. Gautvik, Simon J. Cockell, Vigdis T. Gautvik, Michael Prediger, Jun Jie Wu, Mark A. Birch, Sjur Reppe
Summary: Mechanical loading plays a significant role in bone density and architecture. The study demonstrates that the transcriptional factor ZIC1 is strongly associated with genes characteristically associated with bone cells. The findings also suggest a link between mechanical stress and epigenetic control of gene expression, with implications for bone pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Reilly A. Sample, Marina F. Nogueira, Robi D. Mitra, Sidharth V. Puram
Summary: Epithelial-to-mesenchymal transition (EMT) is a process in cancer where cells lose their epithelial characteristics and gain mesenchymal phenotypes, driving tumor invasion and metastasis. Recent studies have identified intermediate hybrid E/M states along an epithelial-mesenchymal continuum during EMT. This summary focuses on the involvement of epigenetic regulators, chromatin remodelers, and DNA methylation in hybrid E/M states, while also addressing the challenges of pharmacologically targeting EMT and proposing future research directions.
Article
Physiology
Lingling Liu, Jin Wang, Shenghua Wang, Mudi Wang, Yuanhua Chen, Liming Zheng
Summary: This study found that TET1 overexpression affects the self-renewal state of spermatogonia and maintains the continuous production of sperm by regulating the expression of genes such as SP1 and DAXX.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Plant Sciences
Yuming Dong, Sen Li, Haoying Wu, Yiming Gao, Zhongxuan Feng, Xi Zhao, Li Shan, Zhongren Zhang, Huazhong Ren, Xingwang Liu
Summary: Plant growth and development are regulated by complex gene regulatory networks, with epigenetic factors playing a crucial role. Trichomes, specialized appendages arising from epidermal cells, are significant for plant growth and development. Recent studies have implicated epigenetic regulation in trichome development, particularly through microRNA-mediated post-transcriptional regulation.
HORTICULTURE RESEARCH
(2023)
Article
Plant Sciences
Peng Feng, Xiaohuan Sun, Xiaodong Liu, Yuqiu Li, Qi Sun, Haoran Lu, Minglong Li, Xiaodong Ding, Yingshan Dong
Summary: The study found that the interaction between GsMYST1 and GsSnRK1 can regulate the expression of the COR15B gene through acetylation. Additionally, it was demonstrated that salt stress can activate GsSnRK1, which subsequently phosphorylates GsMYST1 to enhance its acetyltransferase activity, potentially promoting target gene expression through epigenetics.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Weifen Sun, Gangcai Xie, Xi Jiang, Philipp Khaitovich, Dingding Han, Xiling Liu
Summary: By characterizing the genome-wide profiles of histone modifications in the prefrontal cortex of humans, chimpanzees, and rhesus macaques, this study reveals the important regulatory role of histone modifications, especially the HP-H3K27ac mark, in gene expression. Additionally, it shows that histone-modifying enzymes partially contribute to an epigenetic disturbance among primates, specifically for the H3K27ac epigenomic marker. The findings comprehensively elucidate the species-specific gene-histone-enzyme landscape in the prefrontal cortex.
Article
Chemistry, Medicinal
Haikuo Ma, Qin Chen, Fang Zhu, Jiyue Zheng, Jiajun Li, Hongjian Zhang, Shuaishuai Chen, Haimei Xing, Lusong Luo, Long Tai Zheng, Sudan He, Xiaohu Zhang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Review
Immunology
Sudan He, Xiaodong Wang
Review
Biochemistry & Molecular Biology
Fang Zhu, Wei Zhang, Tao Yang, Su-dan He
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2019)
Article
Cell Biology
Jue Hou, Jie Ju, Zili Zhang, Cong Zhao, Zhanhui Li, Jiyue Zheng, Tian Sheng, Hongjian Zhang, Linkun Hu, Xiaoliang Yu, Wei Zhang, Yangxin Li, Meng Wu, Haikuo Ma, Xiaohu Zhang, Sudan He
CELL DEATH & DISEASE
(2019)
Article
Chemistry, Medicinal
Fang Zhu, Yujie Wang, Qian Du, Wenxiang Ge, Zhanhui Li, Xu Wang, Chunyan Fu, Lusong Luo, Sheng Tian, Haikuo Ma, Jiyue Zheng, Yi Zhang, Xiaotian Sun, Sudan He, Xiaohu Zhang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Microbiology
Qiang Huang, Jue Hou, Peng Yang, Jun Yan, Xiaoliang Yu, Ying Zhuo, Sudan He, Feng Xu
Article
Biochemistry & Molecular Biology
Chengkui Yang, Qiao Ran, Yifei Zhou, Shan Liu, Cong Zhao, Xiaoliang Yu, Fang Zhu, Yuting Ji, Qian Du, Tao Yang, Wei Zhang, Sudan He
Article
Chemistry, Medicinal
Yu Lin, Zhanhui Li, Haikuo Ma, Yujie Wang, Xu Wang, Shiwei Song, Li Zhao, Shuwei Wu, Sheng Tian, Chunyan Fu, Lusong Luo, Fang Zhu, Sudan He, Jiyue Zheng, Xiaohu Zhang
Article
Cell Biology
Cong Zhao, Yifei Zhou, Qiao Ran, Ying Yao, Haoran Zhang, Jie Ju, Tao Yang, Wei Zhang, Xiaoliang Yu, Sudan He
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yu Lin, Zhanhui Li, Chen Xu, Kaijiang Xia, Shuwei Wu, Yongjin Hao, Qing Yang, Haikuo Ma, Jiyue Zheng, Lusong Luo, Fang Zhu, Sudan He, Xiaohu Zhang
BIOORGANIC CHEMISTRY
(2020)
Article
Cell Biology
Kaijiang Xia, Fang Zhu, Chengkui Yang, Shuwei Wu, Yu Lin, Haikuo, Xiaoliang Yu, Cong Zhao, Yuting Ji, Wenxiang Ge, Jingrui Wang, Yayun Du, Wei Zhang, Tao Yang, Xiaohu Zhang, Sudan He
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Chemistry, Medicinal
Shuwei Wu, Chen Xu, Kaijiang Xia, Yu Lin, Sheng Tian, Haikuo Ma, Yuting Ji, Fang Zhu, Sudan He, Xiaohu Zhang
Summary: Novel RIPK3 inhibitors were designed, synthesized, and evaluated, with lead compound 38 showing potent activity and good selectivity and safety profiles. Compound 38 efficiently blocked cell death and demonstrated promising therapeutic effects in a mouse model.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Zhanhui Li, Yongjin Hao, Chengkui Yang, Qing Yang, Shuwei Wu, Haikuo Ma, Sheng Tian, Haohao Lu, Jingrui Wang, Tao Yang, Sudan He, Xiaohu Zhang
Summary: This study reports a series of potent RIPK1 inhibitors, with compound 70 being highly active and stable in blocking necroptosis in inflammatory signaling and cell death. Compound 70 exhibits excellent properties and activity in both in vitro and in vivo experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyan Dou, Xiaoliang Yu, Shujing Du, Yu Han, Liang Li, Haoran Zhang, Ying Yao, Yayun Du, Xinhui Wang, Jingjing Li, Tao Yang, Wei Zhang, Chengkui Yang, Feng Ma, Sudan He
Summary: MiR-324-5p negatively regulates necroptosis by targeting MLKL expression, and its downregulation by interferons facilitates the activation of necroptosis for host antiviral defense.
Article
Hematology
Xiaoliang Yu, Haikuo Ma, Bohan Li, Yuting Ji, Yayun Du, Siying Liu, Zhanhui Li, Yongjin Hao, Sheng Tian, Cong Zhao, Qian Du, Zhongqin Jin, Xueming Zhu, Yuanyuan Tian, Xin Chen, Xue Sun, Chengkui Yang, Fang Zhu, Jie Ju, Yunjing Zheng, Wei Zhang, Jingrui Wang, Tao Yang, Xinhui Wang, Jingjing Li, Xiangping Xu, Shujing Du, Haohao Lu, Feng Ma, Haibing Zhang, Yi Zhang, Xiaohu Zhang, Shaoyan Hu, Sudan He
Summary: Intestinal epithelial cells (IECs) require receptor-interacting protein kinase-3 (RIPK3) to drive gastrointestinal (GI) tract and systemic graft-versus-host disease (GVHD) after stem cell transplantation. The RIPK1/RIPK3 cascade in IECs triggers the production of T-cell-recruiting chemokines and MHC class II molecules, leading to a feed-forward inflammatory cascade. Targeting RIPK1/RIPK3 in IECs presents a potential strategy for treating GVHD and GI tract inflammation.