Article
Chemistry, Multidisciplinary
Lingpu Zhang, Kun Shang, Xiaomin Li, Meifang Shen, Sheng Lu, Dongsheng Tang, Hongbin Han, Yingjie Yu
Summary: A reduction-sensitive polymer is designed to encapsulate a cationic phenanthriplatin drug into nanoparticles, which can release the drug in cancer cells and induce DNA damage and activate immune responses, improving the efficacy of chemo-immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Cell Biology
Qiang Guo, Ximiao Chen, Jiaoxiang Chen, Gang Zheng, Chenglong Xie, Hongqiang Wu, Zhimin Miao, Yan Lin, Xiangyang Wang, Weiyang Gao, Xiangtao Zheng, Zongyou Pan, Yifei Zhou, Yaosen Wu, Xiaolei Zhang
Summary: The study investigated the role of STING in osteoarthritis progression, revealing its involvement in ECM metabolism, apoptosis, and senescence in chondrocytes. STING activation of NF-kappa B signaling cascade was found to contribute to OA development, with suppression of STING showing potential as a therapeutic approach.
CELL DEATH & DISEASE
(2021)
Article
Engineering, Biomedical
Lei Cao, Huixiang Tian, Man Fang, Zhe Xu, Dongsheng Tang, Juan Chen, Jiye Yin, Haihua Xiao, Kun Shang, Hongbin Han, Xiangping Li
Summary: This study developed a new nano delivery system to activate the cGAS-STING pathway and enhance the effect of chemotherapy and immunotherapy by releasing chemotherapeutic drugs cisplatin and camptothecin. It provides a new strategy for clinical antitumor therapy.
Article
Biochemistry & Molecular Biology
Wei Wan, Chuying Qian, Qian Wang, Jin Li, Hongtao Zhang, Lei Wang, Maomao Pu, Yewei Huang, Zhengfu He, Tianhua Zhou, Han-Ming Shen, Wei Liu
Summary: The cGAS-STING pathway plays a crucial role in host defense by sensing pathogen DNA and inducing immune responses. In this study, it was discovered that STING directly interacts with WIPI2, a key protein involved in autophagy. This interaction is necessary for the formation of autophagosomes induced by STING, but does not affect the activation and trafficking of STING. Furthermore, the specific interaction between STING and WIPI2 leads to competition with PI3P binding, resulting in mutual inhibition between STING-induced autophagy and canonical PI3P-dependent autophagy.
Review
Cell Biology
Hiroshi Ebata, Tze Mun Loo, Akiko Takahashi
Summary: This review summarizes the unique characteristics of cancer cells, such as high proliferation and aberrant DNA damage response, and the role of telomerase and ALT in cancer regulation. It focuses on their noncanonical functions beyond telomere maintenance, as well as intercellular communication in the tumor microenvironment (TME) through the cGAS-STING pathway. Understanding the functional connection between telomere-related molecules and TME regulation is crucial for developing cancer therapeutics targeting specific pathways.
Review
Cell Biology
Rong Shen, Disheng Liu, Xiaoning Wang, Zhao Guo, Haonan Sun, Yanfeng Song, Degui Wang
Summary: DNA damage plays a crucial role in tumorigenesis and development, and the cGAS/STING pathway is a key player in immune response. Recent studies have highlighted its significance in tumor immunotherapy and initiation/metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Rong Shen, Disheng Liu, Xiaoning Wang, Zhao Guo, Haonan Sun, Yanfeng Song, Degui Wang
Summary: DNA damage in tumorigenesis triggers strong inflammatory responses due to its immunogenicity, with the cGAS/STING pathway playing a crucial role in this process. Activation of the cGAS/STING pathway is essential for anti-tumor immunity, but may also be involved in tumor initiation and metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Zi-Jie Long, Jun-Dan Wang, Jue-Qiong Xu, Xin-Xing Lei, Quentin Liu
Summary: The accurate duplication and transfer of genetic material is crucial for cell division. The interaction between cell cycle regulation and cGAS/STING signaling plays a significant role in cancer initiation, development, and treatment.
Article
Cell Biology
Lu Zhou, Yi-Fei Zhang, Fu-Hua Yang, Han-Qing Mao, Zhi Chen, Lu Zhang
Summary: This study identified the role of mtDNA as an inflammatory driver in odontoblasts, which defended against bacterial invasion through the cGAS-STING pathway. The findings suggest that targeting the mtDNA-cGAS-STING axis could be a potential therapeutic strategy for preventing severe bacterial inflammation in pulpitis.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Virology
Meng Lou, Dingbo Huang, Zhenbang Zhou, Xinyu Shi, Miaowei Wu, Yajuan Rui, Jiaming Su, Wenwen Zheng, Xiao-Fang Yu
Summary: Cellular infections by DNA viruses trigger innate immune responses mediated by DNA sensors. HPV18 E7 selectively antagonizes STING-triggered NF-kappa B activation, but not IRF3 activation. Multiple viral proteins antagonize host innate immunity by inhibiting STING-triggered NF-kappa B or IRF3 activation, suggesting convergent evolution.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Na-Lee Ka, Mi Kyung Park, Seung-Su Kim, Yoon Jeon, Sewon Hwang, Sun Mi Kim, Ga Young Lim, Ho Lee, Mi-Ock Lee
Summary: NR1D1 enhances antitumor immunity and suppresses breast cancer progression and lung metastasis by activating the cGAS-STING pathway, suggesting potential immunotherapeutic strategies for breast cancer.
Review
Immunology
Xinrui Wang, Meijia Lin, Liping Zhu, Zhoujie Ye
Summary: The cGAS-STING pathway plays a crucial role in recognizing and activating DNA molecules, and it promotes innate immunity and T-cell antitumor immunity through the production of type I interferons. This pathway is important in both traditional tumor therapy and immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Guanghou Fu, Yunfei Wu, Guanan Zhao, Xiaoyi Chen, Zhijie Xu, Junjie Sun, Junjie Tian, Zhengjun Cheng, Yue Shi, Baiye Jin
Summary: This study demonstrates the immune effects of cisplatin in bladder cancer through the activation of the cGAS-STING signaling pathway. Cisplatin inhibits bladder cancer cell proliferation and increases immune cell infiltration. Combination therapy of cisplatin and immunotherapy may have a synergistic effect for bladder cancer treatment.
Article
Virology
Huifang Zhu, Rongzhao Zhang, Li Yi, Yan-Dong Tang, Chunfu Zheng
Summary: This study demonstrates that UNC93B1 acts as a crucial regulator of STING, attenuating its signaling pathway through autophagy-lysosome degradation, and provides novel insights into UNC93B1's function in antiviral innate immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Luhao Zhang, Xin Zhang, Jiaming Liao, Linting Xu, Shaozhu Kang, Hong Chen, Mengshi Sun, Siting Wu, Zhuqing Xu, Shina Wei, Qiwei Qin, Jingguang Wei
Summary: This study cloned and identified a cGAS homolog, EccGAS, from orange-spotted grouper. EccGAS was found to be abundantly expressed in the blood, skin, and gills, and it inhibited the production of type I interferon and interacted with other signaling molecules, suggesting it may serve as a negative regulator of the cGAS-STING signaling pathway in fish.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Peripheral Vascular Disease
Nicolas Renna, Daniel Piskorz, Diego Stisman, Diego Martinez, Ludmila Lescano, Sergio Vissani, Walter Espeche, Diego Marquez, Roberto Parodi, Diego Naninni, Marcos Baroni, Daniel Llanos, Rocio Martinez, Jessica Barochinner, Gustavo Staffieri, Fernando Lanas, Monica Velasquez, Marcos Marin, Bryan Williams, Irene Ennis
Summary: This document provides a comprehensive review of the scientific evidence on the use of single pill combinations (SPCs) in the treatment of hypertension. It highlights the importance of using multiple drugs to achieve blood pressure goals and the inverse relationship between treatment adherence and the number of drugs taken. The document also discusses the effectiveness and adverse effects of SPCs, their use in special populations, and their impact on hypertensive-mediated organ damage.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Norm R. C. Campbell, Paul K. Whelton, Marcelo Orias, Richard D. Wainford, Francesco P. Cappuccio, Nicole Ide, Bruce Neal, Jennifer Cohn, Laura K. Cobb, Jacqui Webster, Kathy Trieu, Feng J. He, Rachael M. McLean, Adriana Blanco-Metzler, Mark Woodward, Nadia Khan, Yoshihiro Kokubo, Leo Nederveen, JoAnne Arcand, Graham A. MacGregor, Mayowa O. Owolabi, Liu Lisheng, Gianfranco Parati, Daniel T. Lackland, Fadi J. Charchar, Bryan Williams, Maciej Tomaszewski, Cesar A. Romero, Beatriz Champagne, Mary R. L'Abbe, Michael A. Weber, Markus P. Schlaich, Agnes Fogo, Valery L. Feigin, Rufus Akinyemi, Felipe Inserra, Bindu Menon, Marcia Simas, Mario Fritsch Neves, Krassimira Hristova, Carolyn Pullen, Sanjay Pandeya, Junbo Ge, Jorge E. Jalil, Ji-Guang Wang, Jiri Wideimsky, Reinhold Kreutz, Ulrich Wenzel, Michael Stowasser, Manuel Arango, Athanasios Protogerou, Eugenia Gkaliagkousi, Flavio Danni Fuchs, Mansi Patil, Andy Wai-Kwong Chan, Janos Nemcsik, Ross T. Tsuyuki, Sanjeevi Nathamuni Narasingan, Nizal Sarrafzadegan, Maria Eugenia Ramos, Natalie Yeo, Hiromi Rakugi, Agustin J. Ramirez, Guillermo Alvarez, Adel Berbari, Cho-il Kim, Sang-Hyun Ihm, Yook-Chin Chia, Tsolmon Unurjargal, Hye Kyung Park, Kolawole Wahab, Helen McGuire, Naranjargal J. Dashdorj, Mohammed Ishaq, Deborah Ignacia D. Ona, Leilani B. Mercado-Asis, Aleksander Prejbisz, Marianne Leenaerts, Carla Simao, Fernando Pinto, Bader Ali Almustafa, Jonas Spaak, Stefan Farsky, Dragan Lovic, Xin-Hua Zhang
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Dean S. Picone, Elif Stoneman, Antoine Cremer, Martin G. Schultz, Petr Otahal, Alun D. Hughes, J. Andrew Black, Willem Jan Bos, Chen-Huan Chen, Hao-Min Cheng, Nathan Dwyer, Peter Lacy, Esben Laugesen, Fuyou Liang, Hack-Lyoung Kim, Nobuyuki Ohte, Sho Okada, Stefano Omboni, Christian Ott, Telmo Pereira, Giacomo Pucci, Ronak Rajani, Roland Schmieder, Manish D. Sinha, Ralph Stewart, George A. Stouffer, Kenji Takazawa, Jiguang Wang, Thomas Weber, Berend E. Westerhof, Bryan Williams, Hirotsugu Yamada, James E. Sharman
Summary: Accurate blood pressure measurement is crucial for cardiovascular risk management. A study found that for the same cuff systolic blood pressure, women had higher invasive aortic systolic blood pressure than men. Cuff measurements may underestimate cardiovascular risk in women.
Review
Cardiac & Cardiovascular Systems
Aletta E. Schutte, Tazeen H. Jafar, Neil R. Poulter, Albertino Damasceno, Nadia A. Khan, Peter M. Nilsson, Jafar Alsaid, Dinesh Neupane, Kazuomi Kario, Hind Beheiry, Sofie Brouwers, Dylan Burger, Fadi J. Charchar, Myeong Chan Cho, Tomasz J. Guzik, Ghazi F. Haji Al-Saedi, Muhammad Ishaq, Hiroshi Itoh, Erika S. W. Jones, Taskeen Khan, Yoshihiro Kokubo, Praew Kotruchin, Elizabeth Muxfeldt, Augustine Odili, Mansi Patil, Udaya Ralapanawa, Cesar A. Romero, Markus P. Schlaich, Abdulla Shehab, Ching Siew Mooi, U. Muscha Steckelings, George Stergiou, Rhian M. Touyz, Thomas Unger, Richard D. Wainford, Ji-Guang Wang, Bryan Williams, Brandi M. Wynne, Maciej Tomaszewski
Summary: Hypertension is the leading cause of preventable death globally, but there are significant challenges in its detection, treatment, and control, particularly in low-resource settings. Disparities based on resources, sociodemographic environment, and race contribute to the disproportionate burden of hypertension-related outcomes. Immediate action is needed to address these challenges and reduce inequities in hypertension care.
CARDIOVASCULAR RESEARCH
(2023)
Article
Medicine, General & Internal
Alfred K. Cheung, Paul K. Whelton, Paul Muntner, Aletta E. Schutte, Andrew E. Moran, Bryan Williams, Pantelis Sarafidis, Tara I. Chang, Stella S. Daskalopoulou, John M. Flack, Garry Jennings, Stephen P. Juraschek, Reinhold Kreutz, Giuseppe Mancia, Shawna Nesbitt, Pedro Ordunez, Raj Padwal, Alexandre Persu, Doreen Rabi, Markus P. Schlaich, George S. Stergiou, Sheldon W. Tobe, Maciej Tomaszewski, Kim A. Williams Sr, Johannes F. E. Mann
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Nicola Riccardo Pugliese, Nicolo De Biase, Lavinia Del Punta, Alessio Balletti, Silvia Armenia, Simona Buralli, Alessandro Mengozzi, Stefano Taddei, Marco Metra, Matteo Pagnesi, Barry A. Borlaug, Bryan Williams, Stefano Masi
Summary: This study evaluated the role of hypertensive response to exercise (HRE) in heart failure and investigated the hemodynamic and prognostic factors associated with HRE. The results showed that systolic blood pressure and workload slope were significantly different in heart failure patients, and HRE was associated with adverse outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Peripheral Vascular Disease
Peter S. Lacy, Dawid Jedrzejewski, Ewan McFarlane, Bryan Williams
Summary: This study compared the effectiveness of different blood pressure measurement modalities in predicting hypertension-mediated cardiac damage. The results showed that under strict measurement conditions, clinic blood pressure and noninvasive central aortic systolic pressure were as effective as 24-hour ambulatory blood pressure monitoring in predicting left ventricular mass index. Previous observations of inferiority of clinic blood pressure in predicting cardiac damage may be due to poor measurement technique or failure to exclude white-coat hypertension.
JOURNAL OF HYPERTENSION
(2023)
Letter
Peripheral Vascular Disease
George Stergiou, Thomas MacDonald, Robin Young, Konstantinos G. Kyriakoulis, Anastasios Kollias, Bryan Williams, Maciej Tomaszewski
JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O'Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Summary: The small molecule idronoxil inhibits the signalling of TBK1/IKK epsilon, a key signalling component involved in antiviral activities and pro-inflammatory responses. This finding highlights the critical role of TBK1/IKK epsilon signalling in SARS-CoV-2 hyper-inflammation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Marion C. Bichet, Jack Adderley, Laura Avellaneda-Franco, Isabelle Magnin-Bougma, Natasha Torriero-Smith, Linden J. Gearing, Celine Deffrasnes, Cassandra David, Genevieve Pepin, Michael P. Gantier, Ruby C. Y. Lin, Ruzeen Patwa, Gregory W. Moseley, Christian Doerig, Jeremy J. Barr
Summary: It has been found that bacteriophage T4 does not activate DNA-mediated inflammatory pathways, but triggers protein phosphorylation cascades that promote cellular growth and survival. This finding suggests that mammalian cells internalize bacteriophages as a resource to enhance cellular growth and metabolism.
Meeting Abstract
Peripheral Vascular Disease
Dawid Jedrzejewski, Ewan McFarlane, Peter Lacy, Bryan Williams
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Thomas MacLennal MacDonald, Isla Shelah Mackenzie, Amy Rogers, Neil R. Poulter, Bryan Williams, Morris J. Brown, David J. Webb, Ian Ford, David Rorie, Kerr Grieve, Fillippo Pigazzani, Peter M. Rothwell, Robin Young, Alex McConnachie, Chim C. Lang
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Nicola Riccardo Pugliese, Francesco Faita, Frank Ruschitzka, Stefano Taddei, Bryan Williams, Francesco Antonini Canterin, Stefano Masi
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Nicola Riccardo Pugliese, Alessio Balletti, Silvia Armenia, Nicolo De Biase, Francesco Faita, Alessandro Mengozzi, Francesco Paneni, Frank Ruschitzka, Agostino Virdis, Lorenzo Ghiadoni, Stefano Taddei, Bryan Williams, Francesco Antonini-Canterin, Stefano Masi
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Frank L. J. Visseren, Francois Mach, Yvo M. Smulders, David Carballo, Konstantinos C. Koskinas, Maria Back, Athanase Benetos, Alessandro Biffi, Jose-Manuel Boavida, Davide Capodanno, Bernard Cosyns, Carolyn Crawford, Constantinos H. Davos, Ileana Desormais, Emanuele Di Angelantonio, Oscar H. Franco, Sigrun Halvorsen, F. D. Richard Hobbs, Monika Hollander, Ewa A. Jankowska, Matthias Michal, Simona Sacco, Naveed Sattar, Lale Tokgozoglu, Serena Tonstad, Konstantinos P. Tsioufis, Ineke van Dis, Isabelle C. van Gelder, Christoph Wanner, Bryan Williams
GIORNALE ITALIANO DI CARDIOLOGIA
(2022)