Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

(2016) Clémence Cheignon et al.   DALTON TRANSACTIONS

Distinct oxidative cleavage and modification of bovine [Cu– Zn]-SOD by an ascorbic acid/Cu(II) system: Identification of novel copper binding site on SOD molecule

(2016) Hiroshi Uehara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Free Superoxide is an Intermediate in the Production of H2 O2 by Copper(I)-Aβ Peptide and O2

(2015) Karine Reybier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An integrated study of the affinities of the Aβ16 peptide for Cu(i) and Cu(ii): implications for the catalytic production of reactive oxygen species

(2014) Tessa R. Young et al.   Metallomics

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production

(2013) Laure-Estelle Cassagnes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

(2013) Bruno Alies et al.   CHEMICAL COMMUNICATIONS

Hydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition

(2013) Randi H. Gottfredsen et al.   Redox Biology

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

(2012) Christelle Hureau   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 2: Dependence of Cu(II) binding sites with Aβ sequences

(2012) Christelle Hureau et al.   COORDINATION CHEMISTRY REVIEWS

Copper Coordination to Native N-Terminally Modified versus Full-Length Amyloid-β: Second-Sphere Effects Determine the Species Present at Physiological pH

(2012) Bruno Alies et al.   INORGANIC CHEMISTRY

A new water-soluble Cu(II) chelator that retrieves Cu from Cu(amyloid-β) species, stops associated ROS production and prevents Cu(II)‐induced Aβ aggregation

(2012) Sabrina Noël et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Reevaluation of Copper(I) Affinity for Amyloid-β Peptides by Competition with Ferrozine-An Unusual Copper(I) Indicator

(2011) Bruno Alies et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural characterization of Cu2+, Ni2+ and Zn2+ binding sites of model peptides associated with neurodegenerative diseases

(2011) Caterina Migliorini et al.   COORDINATION CHEMISTRY REVIEWS

Affinity of Cu+for the Copper-Binding Domain of the Amyloid-β Peptide of Alzheimer’s Disease

(2011) Heather A. Feaga et al.   INORGANIC CHEMISTRY

Quantification of the Binding Properties of Cu2+to the Amyloid Beta Peptide: Coordination Spheres for Human and Rat Peptides and Implication on Cu2+-Induced Aggregation†

(2010) Lian Hong et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-  copper complex follow a preorganization mechanism

(2010) V. Balland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening Assay for Metal-Catalyzed Oxidation Inhibitors Using Liquid Chromatography−Mass Spectrometry with an N-Terminal β-Amyloid Peptide

(2009) Koichi Inoue et al.   ANALYTICAL CHEMISTRY

Deprotonation of the Asp1Ala2 Peptide Bond Induces Modification of the Dynamic Copper(II) Environment in the Amyloid-β Peptide near Physiological pH

(2009) Christelle Hureau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aβ-mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease

(2009) Christelle Hureau et al.   BIOCHIMIE

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-β complexes

(2009) Christelle Hureau et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease

(2009) Andreana C. Leskovjan et al.   NEUROIMAGE

Structural Studies of Copper(I) Complexes of Amyloid-β Peptide Fragments: Formation of Two-Coordinate Bis(histidine) Complexes

(2008) Richard A. Himes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid β−Cu2+Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2Catalytically but Quench Hydroxyl Radicals†

(2008) Rebecca C. Nadal et al.   BIOCHEMISTRY

Identifying the Minimal Copper- and Zinc-binding Site Sequence in Amyloid-β Peptides

(2008) Velia Minicozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amyloid-β Peptide of Alzheimer’s Disease Binds CuIin a Linear Bis-His Coordination Environment: Insight into a Possible Neuroprotective Mechanism for the Amyloid-β Peptide

(2008) Jason Shearer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Stress and Neurotoxicity

(2007) Lawrence M. Sayre et al.   CHEMICAL RESEARCH IN TOXICOLOGY