Article
Environmental Sciences
Wanzhen Wang, Jiafu Guan, Yueying Feng, Shanji Liu, Yu Zhao, Yuanyuan Xu, Hengyi Xu, Fen Fu
Summary: This study investigated the effects of microplastics exposure on ovarian apoptosis in juveniles, revealing that microplastics exposure led to oxidative and endoplasmic reticulum stresses and damage to ovarian function. These findings provide new insights into the potential health risks of children exposed to microplastics.
Article
Cell Biology
Lin Chen, Ling Pan, Yuexi Zeng, Xiaonan Zhu, Li You
Summary: This study identifies CPNE1 as an important modifier in sarcopenia, which regulates myogenic cell proliferation and differentiation through the PERK-eIF2 alpha pathway. Overexpression of CPNE1 leads to increased muscle atrophy characteristics and reduced muscle fibrosis regeneration and exercise capacity. These findings provide a novel target for the treatment of age-related sarcopenia.
CELL AND TISSUE RESEARCH
(2023)
Article
Engineering, Environmental
Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin Li
Summary: Arsenic is the primary toxicant among hazardous environmental chemicals, implicated in neurotoxicity such as cognitive dysfunction, neurodevelopmental changes, and neurodegenerative diseases. It is believed that sustained pro-inflammatory response may trigger arsenic-induced neurotoxicity, potentially involving microglia activation and release of pro-inflammatory cytokines. Further research is needed to clarify the role of these cytokines in arsenic-induced neurotoxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiaojing Liu, Ruizhe Huang, Yuguang Gao, Meili Gao, Jianping Ruan, Jianghong Gao
Summary: The study demonstrated that Ca2+ treatment can reverse fluoride-induced apoptosis and inhibition of KLK4 in ameloblast-lineage cells. This suggests the potential preventive effects of Ca2+ supplementation on fluorosis.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Environmental Sciences
Wensi Ni, Haoxuan Gao, Bing Wu, Ji Zhao, Jian Sun, Yanan Song, Yiping Sun, Huifang Yang
Summary: This study evaluated the effect of cyfluthrin exposure during pregnancy on placenta development and found that exposure to cyfluthrin leads to placental developmental disorder, which might be associated with ER stress-mediated PERK signaling pathway.
Article
Environmental Sciences
Xiaoyu Wang, Yu Zhuang, Yukun Fang, Huabin Cao, Caiying Zhang, Chenghong Xing, Xiaoquan Guo, Guyue Li, Ping Liu, Guoliang Hu, Fan Yang
Summary: Excessive copper can trigger ER stress and apoptosis in duck renal tubular epithelial cells via the PERK/ATF4/CHOP signaling pathway. Treatment with PERK inhibitor can ameliorate the adverse effects caused by copper exposure.
ENVIRONMENTAL POLLUTION
(2021)
Article
Neurosciences
Cancan You, Zilong Zhang, Huiya Ying, Zijing Yang, Yixuan Ma, Jingyi Hong, Mingjie Xue, Xuan Li, Huimin Li, Chengrui Zhang, Wei Wang, Xiaohong Cai, Xiucui Li
Summary: This study investigated the role of CaSR in cognitive impairment induced by obstructive sleep apnea-hypopnea syndrome (OSAHS), and revealed that it promoted hippocampal neuronal apoptosis through the PERK-ATF4-CHOP pathway. The results indicated that inhibition of CaSR could alleviate cognitive impairment caused by OSAHS.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Lu Liu, Lei Tang, Jia-ming Luo, Si-yu Chen, Chun-yan Yi, Xue-mei Liu, Chang-hua Hu
Summary: In this study, the activation of ER stress and its role in lipid metabolism dysfunction induced by OLZ treatment were investigated. ER stress inhibitors attenuated OLZ-induced dyslipidemia, suggesting that targeting ER stress could be a potentially effective intervention for this metabolic side effect.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Environmental Sciences
Yan Zhao, Kechen Fan, Yan Zhu, Yongbo Zhao, Jing Cai, Liping Jin
Summary: This study investigated the adverse effects of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on placental development and function. The results showed that gestational exposure to BDE-209 significantly reduced placental weight, impaired placental vascular development, and induced placental cell apoptosis. Furthermore, BDE-209 exposure also affected placental transport and endocrine function. Mechanistically, BDE-209 activated the endoplasmic reticulum stress-mediated PERK/ATF4/CHOP signaling pathway in mouse placentas, leading to placental injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Yan-Jun Cui, Le-Yi Chen, Xu Zhou, Zhi-Ning Tang, Chong Wang, Hai-Feng Wang
Summary: Heat stress induces apoptosis of intestinal epithelial cells, downregulates tight junction proteins, and triggers endoplasmic reticulum stress response, ultimately compromising intestinal barrier integrity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shijie Guo, Weiwei Huang, Qingqing Cao, Qingbin Guo, Jianzhong Han, Yumei Qin
Summary: This study used intestinal organoids as an in vitro model to analyze the effects of four (epi)catechins on the development of the intestinal epithelial structure. The results showed that (epi)catechins promoted intestinal epithelial apoptosis and stress response, leading to intestinal damage and increased risk of intestinal injury.
Article
Pharmacology & Pharmacy
Yurong Song, Linlin Liu, Bin Liu, Rui Liu, Youwen Chen, Chenxi Li, Guangzhi Liu, Zhiqian Song, Cheng Lu, Aiping Lu, Yuanyan Liu
Summary: The study indicates that nobiletin protects renal function from MTX-induced nephrotoxicity by reducing the accumulation of 7-OH MTX and modulating the ER stress-related PERK/CHOP pathway.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Changqin Song, Jiaxi Chen, Xiaotian Li, Runyu Yang, Xiaomei Cao, Lvqi Zhou, Yanfen Zhou, Hanjie Ying, Qi Zhang, Yang Sun
Summary: Limonin mitigates DSS-induced chronic colitis by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-kappa B signaling, showing potential as an effective drug for IBD in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaobo Hu, Cong Hu, Jun Liu, Zhuan Wu, Tingting Duan, Zhaohui Cao
Summary: The study showed that 1,25-(OH)(2)D-3 prevents MIN6 cells from ER stress-induced apoptosis by inhibiting the PERK-ATF4-CHOP pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Environmental Sciences
Hong-qiang Chen, Dong-jiao Chen, Yan Li, Wen-bo Yuan, Jun Fan, Zhe Zhang, Fei Han, Xiao Jiang, Jian-ping Chen, Dan-dan Wang, Jia Cao, Jin-yi Liu, Wen-bin Liu
Summary: TET1, an important regulator for DNA methylation and hydroxymethylation balance, is down-regulated in chemical carcinogenesis and lung cancer. TET1 expression is regulated by DNA methylation, which in turn regulates the base excision repair (BER) pathway to inhibit lung cancer progression. Targeting TET1 and the BER pathway may be a potential therapeutic strategy for lung cancer.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Hong-qiang Chen, Dong-jiao Chen, Yan Li, Fei Han, Xiao Jiang, Jia Cao, Jin-yi Liu, Wen-bin Liu
Summary: The study successfully established a model of 3-MCA-induced malignant transformation of HBE cells, revealing key genes involved in lung carcinogenesis through processes such as cell growth, migration, and invasion. Gene expression and DNA methylation and hydroxymethylation play important roles in environmental 3-MCA-induced lung carcinogenesis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Na Sun, Pingping Gao, Yanling Li, Zexuan Yan, Zaihui Peng, Yi Zhang, Fei Han, Xiaowei Qi
Summary: This study analyzed gene expression profiles of breast cancer patients, identifying key common and specific differentially expressed genes (DEGs) and conducting functional enrichment and signaling pathway analyses, laying the foundation for more refined molecular typing of breast cancer and new therapeutic targets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Fei Han, Li Yin, Xiao Jiang, Xi Zhang, Ning Zhang, Jun-tang Yang, Wei-ming Ouyang, Xiang-lin Hao, Wen-bin Liu, Yong-sheng Huang, Hong-qiang Chen, Fei Gao, Zhong-tai Li, Qiao-nan Guo, Jia Cao, Jin-yi Liu
Summary: Sox30 is an age-related and essential regulator of meiosis in the postnatal testis, playing a critical role in germ-cell differentiation by directly regulating key regulators. Its re-expression in Sox30-null mice successfully restores germ-cell meiosis, differentiation and Leydig cell proliferation, improving fertility over time.
Article
Oncology
Yang Wang, Bo He, Yan Dong, Gong-Jing He, Xiao-Wei Qi, Yan Li, Yi-Fei Yang, Yu Rao, Zhong-Shun Cen, Fei Han, Jun Ding, Jian-Jun Li
Summary: HOXA13, an upregulated gene in lung cancer, is associated with patient age and has different prognostic implications in ADC and SCC. It serves as a prognostic factor related to sex and smoking in ADC. HOXA13 can act as a diagnostic biomarker for lung cancer, promoting tumor growth and metastasis by regulating P53 and Wnt/beta-catenin signaling pathways.
Article
Endocrinology & Metabolism
Fuquan Shi, Zhonghao Zhang, Jiankang Wang, Yimeng Wang, Jiuyang Deng, Yingfei Zeng, Peng Zou, Xi Ling, Fei Han, Jinyi Liu, Lin Ao, Jia Cao
Summary: This study investigated the mechanisms of PM2.5-induced male reproductive toxicity through in vitro and in vivo experiments. The results showed that PM2.5 exposure damaged spermatocytes and disrupted energy metabolism. Activation of the aryl hydrocarbon receptor pathway and increased reactive oxygen species were also observed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Fuquan Shi, Zhonghao Zhang, Haonan Cui, Jiankang Wang, Yimeng Wang, Ying Tang, Wang Yang, Peng Zou, Xi Ling, Fei Han, Jinyi Liu, Qing Chen, Cuiqing Liu, Jia Cao, Lin Ao
Summary: This study investigates the effects of PM2.5 on Sertoli cells and explores the underlying mechanisms. Both in vivo and in vitro results demonstrate that PM2.5 reduces the number of Sertoli cells and inhibits cell proliferation, leading to cell dysfunction. Metabolomics and transcriptomics analyses reveal the activation of xenobiotic metabolism and disturbance of glutathione and purine metabolism after PM2.5 exposure. Further tests confirm the redox imbalance and DNA damage response induced by PM2.5. Moreover, PM2.5 induces ferroptosis through iron overload and lipid peroxidation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Xiaoling Liu, Chunyan Yao, Yan Tang, Xiaoyan Liu, Chenggang Duan, Chunmei Wang, Fei Han, Ying Xiang, Long Wu, Yafei Li, Ailing Ji, Tongjian Cai
Summary: Excessive exposure to manganese may lead to neuroinflammation, and it can inhibit the expression of p53 through DNA methylation, further inducing the expression of COX-2 in microglial cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Zhonghao Zhang, Jiankang Wang, Fuquan Shi, Yingqing Li, Peng Zou, Ying Tang, Chang Liu, Yimeng Wang, Xi Ling, Lei Sun, Cuiqing Liu, Yanshu Zhang, Fei Gao, Qing Chen, Lin Ao, Fei Han, Jinyi Liu, Jia Cao
Summary: This study establishes a real-time PM2.5 exposure model and reveals that PM2.5 exposure can lead to testicular dysfunction. Further investigation suggests that PM2.5 exposure can impact the methylation levels of testicular DNA, potentially resulting in decreased expression of key genes involved in spermatogenesis and synthesis of steroid hormones.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Oncology
Jianping Chen, Dandan Wang, Hongqiang Chen, Jin Gu, Xiao Jiang, Fei Han, Jia Cao, Wenbin Liu, Jinyi Liu
Summary: Our study reveals that TMEM196 functions as a novel suppressor of lung cancer metastasis through the Wnt/beta-catenin signaling pathway. TMEM196 mRNA and protein expression levels are significantly decreased in lung cancer tissues and cells. Low expression of TMEM196 is associated with poor prognosis in clinical patients. TMEM196 strongly inhibits tumor metastasis and progression in vitro and in vivo. Mechanistically, TMEM196 inhibits the Wnt signaling pathway and represses beta-catenin promoter transcription. Silencing TMEM196 results in upregulation of beta-catenin and downstream target genes MMP2 and MMP7. Inhibition of beta-catenin expression attenuates the antimetastatic effect of TMEM196 in lung cancer cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Yuehui Liang, Qinghong Jian, Ming-Gang Deng, Zongbi Yi, Chan Peng, Chunsheng Lu, Huan Yang, Jinyi Liu
Summary: This study evaluated lymph node ratio (LNR) as a predictor of postoperative radiotherapy (PORT) benefit in esophageal cancer patients. The results showed that LNR exceeding 0.23 was negatively associated with prognosis, and PORT was beneficial only in N1 stage with higher LNR.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Environmental Sciences
Jiankang Wang, Zhonghao Zhang, Fuquan Shi, Yingqing Li, Ying Tang, Chang Liu, Yimeng Wang, Jianping Chen, Xiao Jiang, Huan Yang, Lei Sun, Qing Chen, Lin Ao, Fei Han, Jinyi Liu, Jia Cao
Summary: This study investigates the underlying mechanisms of fine particulate matter (PM2.5) damage to the male reproductive system through in vivo and in vitro exposure models. The study observes significant pathological damage and abnormal mitochondria in spermatocytes in a real-time PM2.5 exposure animal model. It also finds significant alterations in key biomarkers of iron metabolism and ferroptosis in testis tissues, along with decreased cell viability in vitro. Additionally, the study identifies lipid metabolic genes (Acsl4 and Aloxe3) and the antioxidant gene Gpx4 as key target genes of ferroptosis caused by PM2.5 in spermatocytes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yingqing Li, Zhonghao Zhang, Jiankang Wang, Chang Liu, Yang Liu, Xiao Jiang, Qing Chen, Lin Ao, Jia Cao, Lei Sun, Fei Han, Jinyi Liu
Summary: Environmental hazards, such as noise and carbon monoxide (CO), are increasing concerns due to rapid industrialization. Existing studies mainly focus on the individual effects of noise and CO exposure, while the combined effects remain poorly understood. Our study aimed to examine the combined effects of noise and CO exposure on testicular function. We found that combined exposure to noise and CO was associated with a higher risk of testicular damage and male reproductive damage compared to exposure alone. Pterostilbene (PTE) showed potential as a treatment for injuries caused by combined exposure.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Chao-feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-yi Liu, Jia Cao
Summary: This study aimed to investigate the male reproductive toxicity of Benzo[b]fluoranthene (BbF) and its related mechanisms. The results showed that BbF induced apoptosis of Leydig cells through the Akt/p53 pathway, leading to testosterone decline and male reproductive damage. Furthermore, this study provided a valid approach by integrating computational toxicology and experimental methods in toxicity testing.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Chunsheng Lu, Yuehui Liang, Ya Cheng, Chan Peng, Yuanyuan Sun, Kangle Liu, Yingqing Li, Yixia Lou, Xiao Jiang, Aihua Zhang, Jinyi Liu, Jia Cao, Fei Han
Summary: This study found that microplastics have limited effects on male mice reproductive toxicity and the mechanisms involved are not clear yet. Microplastics at different doses can cause changes in the testes and epididymis of mice and induce apoptosis of spermatogenic cells. Transcriptome sequencing revealed that the p53 signaling pathway is involved in the apoptosis of spermatogenic cells induced by microplastics. Therefore, exposure to microplastics is an important risk factor for male mice reproductive health.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
