Article
Reproductive Biology
Rui Feng, Samson O. Adeniran, Fushuo Huang, Yulong Li, Mingjun Ma, Peng Zheng, Guixue Zhang
Summary: The study demonstrates that melatonin can alleviate LPS-induced inflammation and TJs injury in newborn calf Sertoli cells through modulating the TLR4/MyD88/NF-kappa B signaling pathway.
Article
Plant Sciences
Yuxin Dai, Qiulu Lu, Peiyi Li, Junyu Zhu, Jiaxin Jiang, Tong Zhao, Yue Hu, Kang Ding, Min Zhao
Summary: This study aimed to investigate the mechanism of Xianglian Pill (XLP) in treating ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). The results showed that XLP treated UC by regulating the TLR4/MyD88/NF-kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Haiyang Lu, Xiaoqiang Xu, Di Fu, Yubei Gu, Rong Fan, Hongmei Yi, Xiangyi He, Chaofu Wang, Binshen Ouyang, Ping Zhao, Li Wang, Pengpeng Xu, Shu Cheng, Zhifeng Wang, Duowu Zou, Lizhong Han, Weili Zhao
Summary: This study explores the role of gut microbiota in lymphoma progression. The researchers found a distinct microbiota profile of intestinal lymphoma, with decreased symbiotic microbes, particularly Eubacterium rectale. Transfer of E. rectale-deficit microbiota to mice caused inflammation and TNF production, while E. rectale treatment reduced TNF levels and the incidence of lymphoma in mice. The researchers also found that lipopolysaccharide from the resident microbiota of lymphoma patients and mice synergizes with TNF signaling, reinforcing the NF-kappa B pathway, and enhancing intestinal B cell survival and proliferation.
CELL HOST & MICROBE
(2022)
Article
Biochemistry & Molecular Biology
Shaimaa Hussein, Gellan Alaa Mohamed Kamel
Summary: This study found that PIO can protect against cisplatin-induced testicular toxicity in rats by inhibiting the TLR4/MyD88/NF-κB signal pathway.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Immunology
Cuicui Yang, Shili Gong, Xiaoping Chen, Mingyang Wang, Li Zhang, Lan Zhang, Chaoying Hu
Summary: The study found that AGC can suppress neuronal loss, reduce neurological deficits, inhibit pro-inflammatory cytokine release, and increase anti-inflammatory cytokines. AGC supports microglia transition from M1 to M2 and inhibits NF-rB p65 phosphorylation through the TLR4/Myd88 signaling pathway, showing potential for clinical use in reducing inflammation and aiding in recovery after stroke.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Xiaoying Zhang, Wenjuan Liu, Shuanglin Zhang, Jinyu Wang, Xihan Yang, Ruixuan Wang, Tingxu Yan, Bo Wu, Yiyang Du, Ying Jia
Summary: This study first reported the chemical profile of Wei-Tong-Xin (WTX) and revealed that WTX inhibited the occurrence of gastric antral inflammation and improved functional dyspepsia (FD) symptoms induced by chemotherapy drug cisplatin (CIS) by remodeling the gut microbiota structure and adjusting the levels of metabolites.
Article
Dentistry, Oral Surgery & Medicine
Yiyun Yue, Xinchan Liu, Yan Li, Boyuan Xia, Weixian Yu
Summary: This study aimed to clarify the immune mechanism of hepatic injury induced by periodontitis using a rat model. The results showed higher levels of inflammatory response and bone retraction in the periodontitis group, along with elevated levels of immune markers. The study concluded that the TLR4/MyD88/NF-kappa B pathway may play a role in periodontitis-induced liver inflammation in rats.
Article
Immunology
Xiangbing Mao, Rui Sun, Qingxiang Wang, Daiwen Chen, Bing Yu, Jun He, Jie Yu, Junqiu Luo, Yuheng Luo, Hui Yan, Jianping Wang, Huifen Wang, Quyuan Wang
Summary: This study investigated whether l-isoleucine administration could alleviate dextran sulfate sodium (DSS)-induced colitis in rats. The results showed that l-isoleucine supplementation improved inflammation, restored cell function, reduced disease activity index and mitigated colonic damage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Longxiang Huang, Yuanjing Li, Zhe Cheng, Zi Lv, Suxin Luo, Yong Xia
Summary: Increased expression of PCSK9 during sepsis activates the TLR4/MyD88/NF-κB and NLRP3 pathways, inducing inflammation, vascular endothelial dysfunction, and decreased survival rates. Inhibition of PCSK9 may be a potential clinical therapeutic target to improve vascular endothelial function in sepsis.
Article
Biochemistry & Molecular Biology
Xinnan Gu, Mengjuan Wei, Feifei Hu, Hao Ouyang, Zhenlin Huang, Bin Lu, Lili Ji
Summary: In this study, it was found that chlorogenic acid (CGA) effectively improved non-alcoholic steatohepatitis (NASH) by inhibiting hepatic inflammation. CGA alleviated liver oxidative injury by activating nuclear factor erythroid 2-related factor 2 (Nrf2) and reduced liver steatosis by up-regulating peroxisome proliferator-activated receptor-alpha (PPAR alpha). Furthermore, CGA blocked the LPS-TLR4-MyD88 signaling pathway and attenuated hepatic inflammation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Haizhu Xing, Shubo Zhang, Min You, Ming Yan, Jie Zhang, Jiayi Chen, Yang Chen, Xiaoli Liu, Jing Zhu
Summary: In this study, the neuroprotective effects and mechanisms of thymoquinone (TQ) in paclitaxel-induced peripheral neuropathy (PIPN) were investigated. The results demonstrated that TQ significantly alleviated pain behavior, modulated pathological changes, and reduced inflammatory factors induced by PIPN. Further experiments revealed that TQ exerts neuroprotective effects by regulating the TLR4/MyD88 and its downstream NF-kappa B and MAPKs inflammatory pathways. Molecular docking and cellular thermal shift assay confirmed the interaction between TQ and TLR4.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Hidayat Ullah Khan, Khurram Aamir, Patricia Regina Jusuf, Gautam Sethi, Sreenivas Patro Sisinthy, Reena Ghildyal, Aditya Arya
Summary: In this study, lauric acid was used to investigate its anti-inflammatory role in LPS-induced liver inflammation in rats. The results showed that lauric acid treatment could reduce pro-inflammatory cytokine levels, alleviate liver inflammation, and downregulate TLR4/NF-kappa B mediating proteins in liver tissues.
Article
Nutrition & Dietetics
Zijie Rong, Yuliang Huang, Honghua Cai, Min Chen, Hao Wang, Guihua Liu, Zhiwen Zhang, Jiawen Wu
Summary: The study demonstrated an imbalance in gut microbiota in SCI mice, with increased pro-inflammatory factors and decreased anti-inflammatory factors, elevated apoptosis rates, and activation of the TLR4/MyD88 signaling pathway. Fecal transplantation exacerbated inflammation and worsened SCI in the experimental mice.
FRONTIERS IN NUTRITION
(2021)
Article
Cell Biology
Tian Yu, Feng Xiaojuan, Liu Jinxi, Miao Xinyan, Xu Jie, Tian Yuexin, Liu Qingjuan, Zhang Wei, Gu Cunyang, Huang Jie, Wu Lunbi, Zhao Hang, Liu Shuxia, Guo Huifang
Summary: The study revealed that HRGEC injury and SDC-1 shedding contribute to increased permeability and proteinuria formation in lupus nephritis. Inhibiting extracellular HMGB1 and/or downstream TLR4/MyD88/NF-kappa B/p65 signaling pathway also improved GEC monolayer permeability, reduced glycocalyx shedding, enhanced intercellular tight junctions and cytoskeletal arrangement, and decreased NO level and VCAM-1 expression, indicating the potential therapeutic target for lupus nephritis treatment.
MEDIATORS OF INFLAMMATION
(2021)
Article
Pharmacology & Pharmacy
Xin Zhao, Jinfan Tian, Yue Liu, Zhishuai Ye, Mingyue Xu, Rongchong Huang, Xiantao Song
Summary: This study investigates the role of toll-like receptor 4-myeloid differentiation factor 88 (TLR4-Myd88) dependent caveolin-1 (Cav-1) expression modulation in coronary artery spasm (CAS) and explores the underlying pathogenic mechanisms. The findings suggest that Cav-1, upregulated by TLR4-Myd88, serves as an important modulator of CAS microenvironment establishment in vivo and in vitro, making it a potential pharmacologic target for the treatment of vasospasm via reduced endothelial cell inflammation.
VASCULAR PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jian An, Ye Du, Xiaohong Li, Qingbo Bao, Yanqing Guo, Yang Song, Yongping Jia
Summary: The study demonstrates that early application of sacubitril-valsartan has a protective effect on rats with acute myocardial infarction. The sacubitril-valsartan group showed a reduction in left ventricular volume and collagen fiber range, as well as an increase in ejection fraction compared to the valsartan group.
Article
Cardiac & Cardiovascular Systems
Neel M. Butala, Yang Song, Changyu Shen, David J. Cohen, Robert W. Yeh
Summary: Intensive monitoring in TAVR trials resulted in more monitoring action items, but did not significantly affect trial outcomes. Tailored limited monitoring strategies can be implemented without influencing the integrity of TAVR trial outcomes.
AMERICAN HEART JOURNAL
(2022)
Article
Peripheral Vascular Disease
Manish Saxena, Roland E. Schmieder, Ajay J. Kirtane, Felix Mahfoud, Joost Daemen, Jan Basile, Philipp Lurz, Philippe Gosse, Kintur Sanghvi, Naomi D. L. Fisher, Lars C. Rump, Atul Pathak, Peter J. Blankestijn, Anthony Mathur, Yale Wang, Michael A. Weber, Andrew S. P. Sharp, Michael J. Bloch, Neil C. Barman, Lisa Claude, Yang Song, Michel Azizi, Melvin D. Lobo
Summary: This post-hoc analysis of the RADIANCE-HTN SOLO study found that predictors of response to renal denervation (RDN) included higher baseline daytime ambulatory diastolic blood pressure and use of antihypertensive medications, with orthostatic hypertension potentially predicting response. Obese females also appeared to have a better response to RDN in an interaction model.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Naomi D. L. Fisher, Ajay J. Kirtane, Joost Daemen, Florian Rader, Melvin D. Lobo, Manish Saxena, Josephine Abraham, Roland E. Schmieder, Andrew S. P. Sharp, Philippe Gosse, Lisa Claude, Yang Song, Michel Azizi
Summary: This study investigated the association between plasma renin and aldosterone concentrations and the blood pressure response to renal denervation. The results showed that renal denervation reduced daytime ambulatory systolic blood pressure, but renin and aldosterone concentrations did not predict the blood pressure response to renal denervation.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Jiefan Gao, Li Wang, Lei Bu, Yangyang Song, Xiao Huang, Jing Zhao
Summary: This research investigates the impact of 1,25VitD3 on the regulatory T cells/Th17 axis and the expressions and concentrations of related cytokines in women with URSA. The results suggest that 1,25VitD3 plays a role in modulating immune responses by strengthening Tregs function and inhibiting inflammatory responses of Th17 cells, which may be beneficial for successful pregnancy outcomes.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nino Mihatov, Eric A. Secemsky, Dean J. Kereiakes, P. Gabriel Steg, Donald E. Cutlip, Ajay J. Kirtane, Roxana Mehran, Bokai Zhao, Yang Song, C. Michael Gibson, Robert W. Yeh
Summary: In a low-bleeding risk population, stratifying patients based on predicted ischemic risk and the DAPT score best discerned benefit versus harm of extended DAPT duration on ischemic events, bleeding events, and NACE.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2022)
Letter
Critical Care Medicine
Anica C. Law, Wei Tian, Yang Song, Jennifer P. Stevens, Allan J. Walkey
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Environmental Sciences
Huihui Cao, Xiaona Li, Changsheng Qu, Meng Gao, Hu Cheng, Ni Ni, Shi Yao, Yongrong Bian, Chenggang Gu, Xin Jiang, Yang Song
Summary: This study determined the residual concentrations and bioaccessibility of PAHs in soils from two industrial sites. The results showed heavy PAH contamination, with high molecular weight PAHs accounting for a significant portion. The bioaccessibility of certain PAH compounds decreased with increasing ring number. Soil properties such as dissolved organic matter, total organic carbon, total potassium, and total manganese concentrations had significant effects on the bioaccessibility of PAHs.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Environmental Sciences
Bingwei Yang, Zhishuai Ye, Yawen Wang, Hongzhou Guo, Hans-Joachim Lehmler, Rongchong Huang, Erqun Song, Yang Song
Summary: This study found that environmental pollutant exposure may contribute to atherosclerosis and identified early biomarkers associated with this condition. Experimental evidence confirmed the role of these biomarkers in atherogenesis.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Haidong Li, Xiaoqi Tao, Erqun Song, Yang Song
Summary: Iron oxide nanoparticles (IONPs) are an important component of airborne particulate matter and may have adverse effects on respiratory health. This study found that IONPs interact with pulmonary surfactant, leading to reduced cellular uptake and increased cytotoxicity. Mechanistic studies showed that IONPs react with intracellular hydrogen peroxide, generating hydroxyl radicals and causing oxidative stress, lipid accumulation, and inflammation.
Article
Cardiac & Cardiovascular Systems
Anna K. Krawisz, Sahana Natesan, Rishi K. Wadhera, Siyan Chen, Yang Song, Robert W. Yeh, Michael R. Jaff, Jay Giri, Howard Julien, Eric A. Secemsky
Summary: Black adults in the United States have a higher incidence of peripheral artery disease and limb amputations compared to White adults. Racial differences exist in the incidence and outcomes of peripheral endovascular intervention (PVI). Black adults who undergo PVI are younger, more likely to be female, and have a higher burden of comorbidities. They are also more likely to undergo PVI for chronic limb-threatening ischemia. The association between Black race and adverse outcomes is driven by a higher burden of comorbidities. Early identification and aggressive management of risk factors and comorbidities are important in reducing racial disparities in peripheral artery disease and adverse events after PVI.
Article
Cardiac & Cardiovascular Systems
Ashley N. Kyalwazi, Emefah C. Loccoh, LaPrincess C. Brewer, Elizabeth O. Ofili, Jiaman Xu, Yang Song, Karen E. Joynt Maddoxe, Robert W. Yeh, Rishi K. Wadhera
Summary: Over the past 20 years, cardiovascular mortality rates have declined significantly for Black and White adults in the United States, but disparities still exist, especially in terms of geographic determinants of health and residential racial segregation.
Letter
Cardiac & Cardiovascular Systems
Eric A. Secemsky, Yang Song, Marc Schermerhorn, Robert W. Yeh
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Environmental Sciences
Jia Gu, Wei Zhang, Sai Xu, Yang Song, Jun Ma
Summary: This study systematically investigates the role of hydrogen sulfide (H2S) in the transformation of tetrachloro-p-benzoquinone (TCBQ) under UV irradiation. The findings show that the first triplet state of TCBQ can react with bisulfide anion (HS-) to form primary dechlorination product (HS-TriCBQ). The addition of nucleophiles (OH- or HS-) to the hydroxyl or thiol group is the most efficient pathway for dechlorination, and electron transfer from HS- can generate hydrosulfide radical for the dechlorination of TCBQ.
Article
Spectroscopy
Tian Peng, Xiao Xue-song, Su Gui-tian, Duan Han-feng, Jin Yao-dong, Song Yang-yang, Huang Tao, Zhang Hang
Summary: Ionic liquids have unique properties that make them attractive in the chemical industry and related fields. However, their classification as green solvents requires further study on their toxicity, degradation, and environmental impact. Therefore, the development of detection methods for ionic liquids in different solvents is of great importance.
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2022)
