Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

(2017) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation

(2017) Kristine L. Witt et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Three lessons for genetic toxicology from baseball analytics

(2017) Stephen D. Dertinger   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

International regulatory requirements for genotoxicity testing for pharmaceuticals used in human medicine, and their impurities and metabolites

(2017) Sheila M. Galloway   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9

(2016) Derek T. Bernacki et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

(2016) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

(2016) Carole L. Yauk et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Sesamol induces mitochondrial apoptosis pathway in HCT116 human colon cancer cells via pro-oxidant effect

(2016) Munthipha Khamphio et al.   LIFE SCIENCES

Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

(2016) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Complementarity of phosphorylated histones H2AX and H3 quantification in different cell lines for genotoxicity screening

(2015) Laure Khoury et al.   ARCHIVES OF TOXICOLOGY

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

(2015) Heng-Hong Li et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water

(2015) Clara H. Jeong et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay

(2015) Jennifer R. Cheung et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

(2014) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Micropatterned comet assay enables high throughput and sensitive DNA damage quantification

(2014) J. Ge et al.   MUTAGENESIS

A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors

(2014) P. Gollapudi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

(2014) Z. D. Nagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response

(2014) Teodora Nikolova et al.   TOXICOLOGICAL SCIENCES

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Effects of resveratrol on topoisomerase II-  activity: induction of micronuclei and inhibition of chromosome segregation in CHO-K1 cells

(2013) E. Basso et al.   MUTAGENESIS

Assessment of the in vitro γH2AX assay by High Content Screening as a novel genotoxicity test

(2013) Carolina Garcia-Canton et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death

(2012) J. T. Fox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents

(2012) Minerva Mercado-Feliciano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines

(2011) Kimiyo N. Yamamoto et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Resveratrol acts as a topoisomerase II poison in human glioma cells

(2011) Stefano Leone et al.   INTERNATIONAL JOURNAL OF CANCER

Genotoxicity screening via the γH2AX by flow assay

(2011) D.J. Smart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

(2011) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals

(2011) Giel Hendriks et al.   TOXICOLOGICAL SCIENCES

Computational Toxicology: Realizing the Promise of the Toxicity Testing 
in the 21st Century

(2010) Ivan Rusyn et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines

(2010) M. Audebert et al.   TOXICOLOGY LETTERS

Genotoxicity analysis of two hydroxyfuranones, byproducts of water disinfection, in human cells treated in vitro

(2009) Danae Liviac et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Improving dose selection and identification of aneugens in the in vitro chromosome aberration test by integration of flow cytometry-based methods

(2008) Paula A. Muehlbauer et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline

(2008) Althea Elliott et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY