Article
Endocrinology & Metabolism
Naser Owji, Fatemeh Moradi, Mohammad Reza Khalili, Hamidreza Jahanbani-Ardakani
Summary: This study found a reverse association between serum selenium levels and thyroid hormones in patients with Graves disease, with differences observed between the groups with and without orbitopathy. However, there were no significant differences in serum selenium levels between the GO and GD groups compared to the control group.
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
Soma Farag, Claire Feeney, Vickie Lee, Sonali Nagendran, Rajni Jain, Ahmad Aziz, Rashmi Akishar, Vassiliki Bravis, Karim Meeran
Summary: This study proposes a practical service evaluation model for multidisciplinary thyroid eye disease (MDTED) pathways, focusing on key performance indicators (KPIs) that can be implemented across most TED pathways. The study conducted a retrospective data collection from three MDTED clinics in London, providing valuable insights for units utilizing TEAMeD-5 and BOPSS audit criteria. Results showed that a significant percentage of patients had normal thyroid function at first clinic attendance and at discharge, highlighting the importance of early intervention and management in thyroid eye disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jun Jia, Jingjian Dong, Lin Deng
Summary: This network meta-analysis examined the comparative efficacy and safety of different intravenous glucocorticoid (GC) regimes for moderately severe Graves' orbitopathy (GO). The results indicated that weekly and monthly intravenous GC regimes were superior to oral GC regime in terms of response and clinical activity score change. Additionally, the weekly regime was associated with a decreased risk of adverse events compared to the oral and daily intravenous regimes. Further studies are needed to confirm these findings and compare the weekly and monthly regimes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Lilly H. H. Wagner, Elizabeth A. A. Bradley, Andrea A. A. Tooley, Yanhan Ren, Kharisa N. N. Rachmasari, Marius N. N. Stan
Summary: There is currently no universally accepted name for inflammatory disease of the eye and orbit associated with thyroid autoimmune disease. Variability in terminology impedes research and collaboration in this area. This study compares the frequency of different terms used in scientific literature and proposes standardized terminology based on data analysis. The results show changing trends in the use of specific terms over time.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Jaesung Lee, Sanghyuck Lee, Won Jun Lee, Nam Ju Moon, Jeong Kyu Lee
Summary: This study proposes a neural network-based method to evaluate the activity of thyroid-associated orbitopathy patients using orbital CT scans. The results show that the proposed neural network performs well in assessing the activity of TAO patients and outperforms other comparison models.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Jaesung Lee, Sanghyuck Lee, Won Jun Lee, Nam Ju Moon, Jeong Kyu Lee
Summary: This study proposes a neural network-based method for evaluating the activity of patients with thyroid-associated orbitopathy (TAO) using orbital computed tomography (CT). The neural network achieved high performance in distinguishing active and inactive TAO patients, outperforming the comparison models CSPDenseNet and ConvNeXt. Ablation studies identified the optimal number of active pipelines for the neural network. This study establishes a promising diagnostic tool for TAO activity.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Ming Hui Lee, Yip Han Chin, Cheng Han Ng, Kameswara Rishi Yeshayahu Nistala, Zachariah Gene Wing Ow, Gangadhara Sundar, Samantha Peiling Yang, Chin Meng Khoo
Summary: This study found that smoking is a significant risk factor for TED, and there is a significant association between male sex and the likelihood of smoking and TED. TED patients are older, and age and male sex are important risk factors for active TED patients compared to inactive TED patients.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
S. Khamisi, M. Lundqvist, P. Emadi, K. Almby, O. Ljunggren, F. A. Karlsson
Summary: The study found a potential association between serum thyroglobulin levels and the development of Graves' orbitopathy (GO) in patients with Graves' disease (GD), suggesting that evaluating thyroglobulin levels could help identify patients at increased risk of GO. Additionally, there was a tendency towards higher TRAb levels and lower TPOAb and TgAb levels in the GO group.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Joanna Rymuza, Katarzyna Pelewicz, Jerzy Przedlacki, Piotr Miskiewicz
Summary: IVMP pulse therapy has a negative effect on bone microarchitecture, leading to a decrease in TBS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Joanna Rymuza, Klaudia Gutowska, Dagmara Kurpios-Piec, Marta Struga, Piotr Miskiewicz
Summary: Intravenous methylprednisolone can decrease bone formation and resorption, but the effects are transient. The full course of therapy is associated with suppression of bone turnover.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Maryla Pelewicz, Joanna Rymuza, Katarzyna Pelewicz, Piotr Miskiewicz
Summary: The additional treatment with 12 pulses of ivMP can improve or stabilize the outcome of basic therapy in patients with DON.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ruiqi Ma, Lu Gan, Jie Guo, Zhiyu Peng, Jihong Wu, Andrew R. Harrison, Jiang Qian
Summary: This study reveals that Graves' orbitopathy (GO) orbital fibroblasts (OFs) exhibit stronger resistance to ferroptosis compared to control OFs. GO OFs undergo a glycolytic shift. Inhibition of glycolysis enhances ferroptosis sensitivity in GO OFs. Overexpression of IGF1R contributes to the glycolytic shift in GO OFs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Benjamin Billiet, Juan Manuel Chao de la Barca, Marc Ferre, Jeanne Muller, Anais Vautier, Sophie Assad, Odile Blanchet, Lydie Tessier, Celine Wetterwald, Justine Faure, Geoffrey Urbanski, Gilles Simard, Delphine Mirebeau-Prunier, Patrice Rodien, Philippe Gohier, Pascal Reynier
Summary: About half of patients with Graves' disease develop an orbitopathy related to an inflammatory expansion of the periorbital adipose tissue and muscles. This study used a targeted metabolomic approach to compare the metabolic composition of tears in patients with active versus inactive thyroid-associated orbitopathy. Several metabolites showed significant alterations in concentration between the two groups. The ratio putrescine/ornithine, representing the activity of ornithine decarboxylase, was significantly increased in patients with active versus inactive orbitopathy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Sita Virakul, Poorichaya Somparn, Trairak Pisitkun, Peter J. van der Spek, Virgil A. S. H. Dalm, Dion Paridaens, P. Martin van Hagen, Nattiya Hirankarn, Tanapat Palaga, Willem A. Dik
Summary: This study compared the proteome and global DNA methylation patterns of orbital fibroblasts isolated from active GO, inactive GO, and healthy controls. The results showed that orbital fibroblasts from active GO are involved in inflammation, cellular proliferation, hyaluronan synthesis, and adipogenesis, while fibroblasts from inactive GO are more focused on extracellular matrix remodeling. The findings suggest a potential therapeutic target in the effector function of orbital fibroblasts in Graves' ophthalmopathy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Ophthalmology
Hansol Jeon, Joo Yeon Lee, Yu Jeong Kim, Min Joung Lee
Summary: This study found a strong association between thyroid-stimulating immunoglobulin (TSI) levels and the activity of thyroid eye disease (TED). TSI could be a useful biomarker for identifying patients with active TED in clinical settings, even after adjusting for other clinical characteristics.
Article
Endocrinology & Metabolism
M. Leo, L. Bartalena, G. Rotondo Dottore, E. Piantanida, P. Premoli, I. Ionni, M. Di Cera, E. Masiello, L. Sassi, M. L. Tanda, F. Latrofa, P. Vitti, C. Marcocci, M. Marino
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2017)
Article
Endocrinology & Metabolism
S. Lisi, R. Botta, G. Rotondo Dottore, M. Leo, F. Latrofa, P. Vitti, M. Marino
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2016)
Article
Endocrinology & Metabolism
R. Botta, S. Lisi, G. Rotondo Dottore, P. Vitti, M. Marino
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2017)
Article
Endocrinology & Metabolism
G. Rotondo Dottore, I. Ionni, F. Menconi, G. Casini, S. Sellari-Franceschini, M. Nardi, P. Vitti, C. Marcocci, M. Marino
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
G. Rotondo Dottore, I. Ionni, F. Menconi, G. Casini, S. Sellari-Franceschini, M. Nardi, P. Vitti, C. Marcocci, M. Marino
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
M. Marino, G. Rotondo Dottore, I. Ionni, G. Lanzolla, E. Sabini, D. Ricci, A. Sframeli, B. Mazzi, F. Menconi, F. Latrofa, P. Vitti, C. Marcocci, L. Chiovato
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2019)
Letter
Endocrinology & Metabolism
I. Ionni, G. Rotondo Dottore, M. Marino
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
Giovanna Rotondo Dottore, Riccardo Chiarini, Maria De Gregorio, Marenza Leo, Giamberto Casini, Luca Cestari, Stefano Sellari-Franceschini, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marino