Review
Endocrinology & Metabolism
Mengyu Zhang, Wen Jiang, Ganghua Lu, Ru Wang, Zhongwei Lv, Dan Li
Summary: Hyperthyroidism is a condition characterized by excessive production of thyroid hormones, with Graves' disease being the most common cause. Disease models have been established, and novel treatments for Graves' disease and Graves' orbitopathy have been discovered. Potential therapeutic targets have also been identified in mouse models of Graves' orbitopathy. Human placental mesenchymal stem cells, fucoxanthin, and icariin may provide alternative therapies in addition to existing drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Filippo Biscarini, Giulia Masetti, Ilaria Muller, Hedda Luise Verhasselt, Danila Covelli, Giuseppe Colucci, Lei Zhang, Mohd Shazli Draman, Onyebuchi Okosieme, Pete Taylor, Chantal Daumerie, Maria-Cristina Burlacu, Michele Marino, Daniel George Ezra, Petros Perros, Sue Plummer, Anja Eckstein, Mario Salvi, Julian R. Marchesi, Marian Ludgate
Summary: This study compared the fecal microbiota in patients with hyperthyroidism caused by Graves disease (GD) and varying severity of Graves orbitopathy (GO) with healthy controls. The results showed an increase in Actinobacteria and a decrease in Bacteroidetes in GD/GO patients compared to controls. A higher Firmicutes to Bacteroidetes ratio was observed in GD/GO. Longitudinal analysis revealed a correlation between the presence of certain bacteria (Clostridiales) at diagnosis and the persistence of thyroid antibodies even after antithyroid drug treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
S. Ippolito, C. Cusini, P. Lasalvia, F. Gianfagna, G. Veronesi, D. Gallo, E. Masiello, P. Premoli, J. Sabatino, A. Mercuriali, A. Lai, E. Piantanida, M. L. Tanda, L. Bartalena
Summary: Recent studies suggest that the clinical phenotype of Graves' disease (GD) has become milder in terms of hyperthyroidism, goiter, and Graves' Orbitopathy at onset. Biochemical data showed lower levels of free thyroxine (FT4) and free triiodothyronine (FT3) in patients diagnosed after 2000 compared to those diagnosed before. Factors contributing to this change may include iodoprophylaxis, decrease in smoking rates, contraceptive pill and micronutrient use, as well as improved early diagnosis and management.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Beata Pyrzak, Malgorzata Ruminska, Ewelina Witkowska-Sedek, Anna Kucharska
Summary: Maternal Graves' disease can cause various thyroid dysfunctions in newborns, including hyperthyroidism and hypothyroidism. This study found that transient hyperthyroidism was the most common thyroid dysfunction in newborns with neonatal hyperthyroidism, but central hypothyroidism can also occur.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Daniela Gallo, Lorenzo Mortara, Giovanni Veronesi, Simona A. M. Cattaneo, Angelo Genoni, Matteo Gallazzi, Carlo Peruzzo, Paolo Lasalvia, Paola Moretto, Antonino Bruno, Alberto Passi, Andrea Pini, Andrea Nauti, Maria Antonietta Lavizzari, Michele Marino, Giulia Lanzolla, Maria Laura Tanda, Luigi Bartalena, Eliana Piantanida
Summary: This study explores whether the addition of selenium (Se) and vitamin D (VitD) to methimazole (MMI) treatment helps to more promptly control hyperthyroidism. Combination therapy can significantly reduce thyroid hormone levels and improve patients' quality of life during the early stages of treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Larisse Vieira Mendes Araruna, Daniela Camargo de Oliveira, Monica Corso Pereira, Arnaldo Moura Neto, Marcos Antonio Tambascia, Denise Engelbrecht Zantut-Wittmann
Summary: This study highlights the importance of cardiorespiratory reassessment in patients with Graves' disease even after long-term control of hyperthyroidism. Results indicate that about 30% of these patients still have pulmonary hypertension, which requires specific treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Martin Andersson, Soren Mattsson
Summary: Radioactive iodine is commonly used for the treatment of thyroid diseases, with EANM and ICRP developing pre-therapeutic procedures and biokinetic models. Combining the EANM method and ICRP model provides more accurate patient-specific dosimetry estimates and absorbed dose estimates including most organs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Naser Owji, Fatemeh Moradi, Mohammad Reza Khalili, Hamidreza Jahanbani-Ardakani
Summary: This study found a reverse association between serum selenium levels and thyroid hormones in patients with Graves disease, with differences observed between the groups with and without orbitopathy. However, there were no significant differences in serum selenium levels between the GO and GD groups compared to the control group.
ENDOCRINE PRACTICE
(2022)
Article
Biology
Dongxue Huo, Chaoping Cen, Haibo Chang, Qianying Ou, Shuaiming Jiang, Yonggui Pan, Kaining Chen, Jiachao Zhang
Summary: A 6-month study conducted by Huo et al in patients with Graves' Disease showed that the combination of probiotic Bifidobacterium longum with methimazole potentially improves thyroid function and regulates TRAb concentration through the gut-thyroid axis.
COMMUNICATIONS BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Stine Linding Andersen, Stig Andersen
Summary: Managing hyperthyroidism in pregnant women, especially those with Graves' disease, is crucial to prevent complications. The consequences of maternal hyperthyroidism on fetal growth and development are less understood compared to hypothyroidism. While experimental studies suggest potential adverse effects, human studies on developmental outcomes in children born to mothers with hyperthyroidism are inconclusive. More research is needed to understand the impact of hyperthyroidism and its treatment on pregnancy outcomes.
ENDOCRINE CONNECTIONS
(2021)
Review
Endocrinology & Metabolism
Giulia Lanzolla, Michele Marino, Claudio Marcocci
Summary: Selenium has been proposed as a therapy for Graves' hyperthyroidism and Graves' Orbitopathy, with studies showing potential benefits in patients with mild eye disease. Although the effectiveness of selenium in severe cases of Graves' Orbitopathy remains uncertain, its use is generally believed to be beneficial in clinical practice for patients with mild eye disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Ju-Wen Yang, Ling-Yuh Kao, Lan-Hsin Chuang, Ho-Min Chen
Summary: This is a case report of pediatric Graves' disease and ophthalmopathy in a 4-year-old child. The patient presented with hyperthyroidism and bilateral proptosis for 2 years. Long-term follow-up revealed improvement in the patient's condition and clinical manifestations of ophthalmopathy.
Article
Endocrinology & Metabolism
Nami Suzuki, Jaeduk Yoshimura Noh, Ran Yoshimura, Kentaro Mikura, Aya Kinoshita, Ai Suzuki, Takako Mitsumatsu, Ayako Hoshiyama, Miho Fukushita, Masako Matsumoto, Ai Yoshihara, Natsuko Watanabe, Kiminori Sugino, Koichi Ito
Summary: This study found that the severity of hyperthyroidism in GD was higher in males in their 20s and 30s, decreasing with age in both sexes. Females were more likely to achieve remission than males, and younger patients had a higher risk of recurrence, although recurrence was not related to sex.
Article
Endocrinology & Metabolism
Nanna Maria Uldall Torp, Niels Henrik Bruun, Peter Astrup Christensen, Aase Handberg, Stig Andersen, Stine Linding Andersen
Summary: This study established a pregnancy-specific cutoff for TRAb and found that TRAb-negative hyperthyroidism is predominant in early pregnancy and rarely develops into hyperthyroidism later on.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Verena Theiler-Schwetz, Thomas Benninger, Christian Trummer, Stefan Pilz, Markus Reichhartinger
Summary: This study developed a mathematical model for the dynamics of free thyroxine (FT4) during methimazole (MMI) treatment and validated it using patient data. They also developed a software application called DigiThy, which can be used as a practice tool for treating virtual patients or as a decision support system for MMI dosing recommendations. The efficacy of the MMI dosing recommendations from DigiThy was comparable to, or even superior to, that from clinical endocrinologists.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pathology
Silvia Uccella, Cristina Amaglio, Jean-Philippe Brouland, Eleonora Bianconi, Silvia Ippolito, Mahmoud Messerer, Nathalie Rouiller, Maria Laura Tanda, Fausto Sessa, Stefano La Rosa
Editorial Material
Endocrinology & Metabolism
M. L. Tanda, E. Piantanida, E. Masiello, C. Cusini, L. Bartalena
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2019)
Editorial Material
Endocrinology & Metabolism
M. L. Tanda, C. Cusini, A. Colombo, P. Premoli, S. Rosetti, A. Cromi, E. Piantanida, L. Bartalena
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2019)
Article
Endocrinology & Metabolism
P. Premoli, M. L. Tanda, E. Piantanida, G. Veronesi, D. Gallo, E. Masiello, S. Rosetti, C. Cusini, F. Boi, J. Bulla, R. Rodia, S. Mariotti, V. Capelli, M. Rotondi, F. Magri, L. Chiovato, R. Rocchi, M. C. Campopiano, R. Elisei, P. Vitti, F. Barbato, T. Pilli, M. G. Castagna, F. Pacini, L. Bartalena
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Letter
Nutrition & Dietetics
Antonella Olivieri, Sebastiano Ando, Marcello Bagnasco, Domenico Meringolo, Caterina Mian, Mariacarla Moleti, Efisio Puxeddu, Concetto Regalbuto, Augusto Taccaliti, Maria Laura Tanda, Massimo Tonacchera, Salvatore Ulisse
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Review
Endocrinology & Metabolism
D. Gallo, L. Mortara, M. B. Gariboldi, S. A. M. Cattaneo, S. Rosetti, L. Gentile, D. M. Noonan, P. Premoli, C. Cusini, M. L. Tanda, L. Bartalena, E. Piantanida
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Article
Endocrinology & Metabolism
S. Rosetti, M. L. Tanda, G. Veronesi, E. Masiello, P. Premoli, D. Gallo, C. Cusini, S. Donati, J. Sabatino, S. Ippolito, E. Piantanida, L. Bartalena
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Editorial Material
Endocrinology & Metabolism
M. L. Tanda, F. Trimarchi
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Clinical Neurology
Valentina Rebecchi, Daniela Gallo, Lucia Princiotta Cariddi, Eliana Piantanida, Payam Tabaee Damavandi, Federico Carimati, Marco Gallazzi, Alessandro Clemenzi, Paola Banfi, Elisa Candeloro, Maria Laura Tanda, Marco Mauri, Maurizio Versino
Summary: The study focuses on the relationship between vitamin D levels and pain chronification and extension in headache disorders. Findings suggest that vitamin D deficiency may be related to chronic headache due to its anti-inflammatory and tolerogenic properties, supporting the idea of a neuroinflammatory mechanism underlying migraine chronification.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
M. L. Tanda, S. Ippolito, D. Gallo, A. Baj, F. Novazzi, A. Genoni, M. Annoni, N. Mancini, N. Clementi, G. Finzi, E. Piantanida, P. Premoli, A. Lai, D. Dalla Gasperina, F. Maggi, S. Uccella
Summary: This study evaluated a patient suspected of subacute thyroiditis during the COVID-19 pandemic and detected SARS-CoV-2 in the cytologic sample. Histological and ultrastructural examinations confirmed the presence of viral particles in tumor cells. The coexistence of SARS-CoV-2 and thyroid sarcoma may have a synergistic effect, promoting viral persistence and tumor growth.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Endocrinology & Metabolism
Luigi Bartalena, Eliana Piantanida, Daniela Gallo, Silvia Ippolito, Maria Laura Tanda
Summary: Graves' disease is an autoimmune disorder caused by stimulatory TSHR antibodies. Treatment options include antithyroid drugs, radioactive iodine, and thyroidectomy. ATDs are the first-line treatment with a low recurrence rate, while RAI is safe but may progress eye disease.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Laura Croce, Luca Chiovato, Massimo Tonacchera, Elena Petrosino, Maria Laura Tanda, Mariacarla Moleti, Flavia Magri, Antonella Olivieri, Elizabeth N. Pearce, Mario Rotondi
Summary: The study aimed to review the available evidence from meta-analyses on iodine supplementation during pregnancy in areas with mild-moderate deficiency. The findings suggest a U-shaped correlation between iodine status and maternal and neonatal outcomes, but the results of intervention trials are inconclusive. More high-quality studies are needed to further clarify this issue.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Daniela Gallo, Denisa Baci, Natasa Kustrimovic, Nicola Lanzo, Bohdan Patera, Maria Laura Tanda, Eliana Piantanida, Lorenzo Mortara
Summary: Vitamin D plays a vital role in bone health and is involved in various cellular processes. It has been found to have clinical implications in immune surveillance against infections and autoimmune/inflammatory diseases. Recent research has focused on the role of innate immune cells and their interaction with vitamin D and acquired immune cells in the onset and regulation of certain autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Pawel Kubik, Daniela Gallo, Maria Laura Tanda, Jerzy Jankau, Raffaele Rauso, Wojciech Gruszczynski, Aleksandra Pawlowska, Pawel Chrapczynski, Maciej Malinowski, Dariusz Grzanka, Marta Smolinska, Paulina Antosik, Maria-Luiza Piesiakow, Bartlomiej Lukasik, Agnieszka Pawlowska-Kubik, Giorgio Stabile, Stefania Guida, Lukasz Kodlubanski, Tom Decates, Nicola Zerbinati
Summary: The study aimed to test the effect of Neauvia Stimulate on patients with Hashimoto's disease, which is a contraindication for hyaluronic acid fillers and calcium hydroxyapatite biostimulants. Histopathological analysis showed a significant reduction in inflammatory infiltration and T lymphocytes after the procedure, with no effect on antibody levels. Risk analysis confirmed the safety of using hyaluronic acid fillers cross-linked with polyethylene glycol in patients with Hashimoto's disease.
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)