Review
Genetics & Heredity
Jingyao Cui, Haoran Chen, Kaiwen Zhang, Xin Li
Summary: Wnt pathway plays a crucial role in cancer bone metastasis and targeted therapeutic strategies have shown promise. Current progress includes research on pharmacological Wnt modulators against breast cancer bone metastasis and exploration of emerging therapeutic strategies based on Wnt pathway-related targets, providing new ideas for the development of Wnt-based intervention strategies in the future.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Pharmacology & Pharmacy
Karmani Shah, Shivangi Panchal, Bhumika Patel
Summary: Porcupine, a member of the Wnt family, modulates cellular responses by palmitoylating Wnt proteins, showing potential in treating various cancers. While no Porcupine inhibitors have been commercialized yet, several molecules have progressed to Phase I clinical trials.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Pratibha Pandey, Fahad Khan, Min Choi, Sujeet Kumar Singh, Han Na Kang, Moon Nyeo Park, Seong-Gyu Ko, Sanjeev Kumar Sahu, Rupa Mazumder, Bonglee Kim
Summary: Natural products have been an unmatched source of anticancer medications in the current drug development period. They modify the cancer microenvironment and various signaling pathways, playing a significant role in cancer treatment. These substances are effective against multiple signaling pathways, particularly in cell death and embryonic developmental pathways. More research is needed to fully understand their function in cancer treatments and their potential as therapeutic agents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Adrian Matysek, Lina Sun, Sumudu Perera Kimmantudawage, Lei Feng, Andrea B. Maier
Summary: Dementia is a prevalent condition in the elderly population and current medication options have limited therapeutic benefits. This systematic review explores the potential of novel therapeutic compounds that target nutrient sensing pathways, specifically the sirtuin pathway, to prevent cognitive decline or improve cognition in aging, MCI, and dementia. The review finds that while animal studies show promising results, there is a lack of translation to human populations.
AGEING RESEARCH REVIEWS
(2023)
Review
Genetics & Heredity
Ankita Sharma, Rafeeq Mir, Sanjeev Galande
Summary: This review discusses the role of the Wnt/beta-catenin pathway in cell proliferation, differentiation, and migration, as well as its impact on embryonic development, tissue regeneration, and cancer. It highlights the influence of epigenetic factors on the pathway and the crosstalk with other signaling pathways, particularly the Hippo/YAP pathway. The review also emphasizes recent advances in developing potential therapeutic interventions targeting the epigenetic machinery for treating various cancers and regenerative therapies.
FRONTIERS IN GENETICS
(2021)
Review
Pharmacology & Pharmacy
Huy Nguyen, Sung-Jin Lee, Yang Li
Summary: Retinal ischemia is a major cause of visual impairment and blindness worldwide, often associated with various disorders. Diabetic retinopathy is a common cause, and its exact pathogenesis remains unclear, but vascular leakage plays a significant role in visual impairment. Current treatments have limitations, therefore there is a need for new therapies to address vessel regeneration and reperfusion in ischemic retinal areas. The Wnt signaling pathway in the retina could provide a novel disease modifying therapy.
Review
Biochemistry & Molecular Biology
Fernand Bteich, Mahshid Mohammadi, Terence Li, Muzaffer Ahmed Bhat, Amalia Sofianidi, Ning Wei, Chaoyuan Kuang
Summary: Colorectal cancer is a heterogeneous disease with various alterations at the cellular and molecular levels. KRAS mutations are found in up to 40% of CRCs and serve as both a prognostic and predictive biomarker. Targeting KRAS mutations in CRC is being explored through both indirect and direct strategies, with several KRAS allele-specific inhibitors in late-phase clinical trials and newer agents and targeting strategies undergoing preclinical and early-phase clinical testing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Review
Biochemistry & Molecular Biology
Mai Tanaka, Dietmar W. Siemann
Summary: Dysregulated signaling pathways in cancer cells and the tumor microenvironment, including the Axl and Gas6 pathways, have led to the development of therapeutic agents targeting the Gas6/Axl pathway. Promising results have been observed in both preclinical and clinical settings, indicating potential clinical efficacy of targeting Gas6 and Axl.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Mia C. Borlongan, Hongbin Wang
Summary: Tumorigenic cancer stem cells (CSCs) are a subset of cells within tumors that have distinct genetic and phenotypic profiles and signaling pathways compared to other tumor cells. Targeting the unique self-renewal and differentiation properties of CSCs could revolutionize cancer therapy. Understanding the signaling mechanisms of CSCs will improve our knowledge of cancer pathology and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Yan Yan, Yuanwang Qiu, Chantsalmaa Davgadorj, Chunfu Zheng
Summary: Numerous signaling pathway agonists or inhibitors have been found to reduce HBV replication, and some of them have been used in clinical trials. A combined strategy including antiviral therapy and immunomodulation is crucial for effective control of HBV infection. These findings assist in the design of novel agents to prevent HBV replication or carcinogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Sara A. Seifeldin, Khalid Alshaghdali, Samra Siddiqui, Mohamed Elfatih Abdelwadoud, Manish Vyas, Mohd Saeed, Avijit Mazumder, Amir Saeed
Summary: The Wnt pathway is crucial for human development and homeostasis. Dysregulation of this pathway has been linked to cancer. Wnt signaling plays a significant role in the development and metastasis of cancer, and targeting this pathway has become an important focus of cancer research. Flavonoids derived from plants have shown anticancer effects by influencing the Wnt pathway and other signaling pathways. This review comprehensively evaluates the impact of flavonoids on cancer development and metastasis through the Wnt pathway, providing evidence of their impact on molecular targets.
Review
Biochemistry & Molecular Biology
Fei Shao, Xiaonan Pang, Gyeong Hun Baeg
Summary: Breast cancer is the most common malignant tumor in women worldwide. Traditional treatments have side effects, but targeted therapies for breast cancer, focusing on the JAK/STAT signaling pathway, show promising potential. Inhibitors of JAK and STAT proteins have exhibited strong effects in inhibiting breast cancer and are being explored for clinical use.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Michal Caspi, Amnon Wittenstein, Michal Kazelnik, Yarden Shor-Nareznoy, Rina Rosin-Arbesfeld
Summary: The Wnt pathway plays a crucial role in regulating embryogenic developmental processes and tissue homeostasis via beta-catenin. Dysregulation of this pathway has been implicated in carcinogenesis, particularly in colorectal cancer. While the Wnt cascade is an attractive target for therapeutic intervention against CRC, its complexity and challenges need to be addressed for effective treatment.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Oncology
Yun Wang, Qian Liang, Kefeng Lei, Qingqing Zhu, Delong Zeng, Yuhong Liu, Yingsi Lu, Tingting Kang, Nannan Tang, Lifen Huang, Liping Ye, Di Tang, Chengming Zhu
Summary: MEX3A expression is significantly upregulated in breast cancer, related to tumor grade, and plays a critical role in promoting metastasis and maintaining stemness through the Wnt/beta-catenin pathway.