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Therapeutic opportunities based on caspase modulation

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

期刊

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

卷 82, 期 -, 页码 150-157

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

DOI: 10.1016/j.semcdb.2017.12.008

关键词

Apoptosis; Cell death; Cancer; Caspases

类别

Cell Biology Developmental Biology

资金

Deutsche Forschungsgemeinschaft
BMBF
Deutsche Krebshilfe
LOEWE Ub-Net

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Protocol

Reagent

摘要

Caspases are a family of proteolytic enzymes that play a critical role in the regulation of programmed cell death via apoptosis. Activation of caspases is frequently impaired in human cancers, contributing to cancer formation, progression and therapy resistance. A better understanding of the molecular mechanisms regulating caspase activation in cancer cells is therefore highly important. Thus, targeted modulation of caspase activation and apoptosis represents a promising approach for the development of new therapeutic options to elucidate cancer cell death. (C) 2017 Elsevier Ltd. All rights reserved.

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Camonis, Nadine Camougrand, Michelangelo Campanella, Edward M. Campbell, Francois-Xavier Campbell-Valois, Silvia Campello, Ilaria Campesi, Juliane C. Campos, Olivier Camuzard, Jorge Cancino, Danilo Candido de Almeida, Laura Canesi, Isabella Caniggia, Barbara Canonico, Carles Canti, Bin Cao, Michele Caraglia, Beatriz Carames, Evie H. Carchman, Elena Cardenal-Munoz, Cesar Cardenas, Luis Cardenas, Sandra M. Cardoso, Jennifer S. Carew, Georges F. Carle, Gillian Carleton, Silvia Carloni, Didac Carmona-Gutierrez, Leticia A. Carneiro, Oliana Carnevali, Julian M. Carosi, Serena Carra, Alice Carrier, Lucie Carrier, Bernadette Carroll, A. Brent Carter, Andreia Neves Carvalho, Magali Casanova, Caty Casas, Josefina Casas, Chiara Cassioli, Eliseo F. Castillo, Karen Castillo, Sonia Castillo-Lluva, Francesca Castoldi, Marco Castori, Ariel F. Castro, Margarida Castro-Caldas, Javier Castro-Hernandez, Susana Castro-Obregon, Sergio D. Catz, Claudia Cavadas, Federica Cavaliere, Gabriella Cavallini, Maria Cavinato, Maria L. Cayuela, Paula Cebollada Rica, Valentina Cecarini, Francesco Cecconi, Marzanna Cechowska-Pasko, Simone Cenci, Victoria Ceperuelo-Mallafre, Joao J. Cerqueira, Janete M. Cerutti, Davide Cervia, Vildan Bozok Cetintas, Silvia Cetrullo, Han-Jung Chae, Andrei S. Chagin, Chee-Yin Chai, Gopal Chakrabarti, Oishee Chakrabarti, Tapas Chakraborty, Trinad Chakraborty, Mounia Chami, Georgios Chamilos, David W. Chan, Edmond Y. W. Chan, Edward D. Chan, H. Y. Edwin Chan, Helen H. Chan, Hung Chan, Matthew T. Chan, Yau Sang Chan, Partha K. Chandra, Chih-Peng Chang, Chunmei Chang, Hao-Chun Chang, Kai Chang, Jie Chao, Tracey Chapman, Nicolas Charlet-Berguerand, Samrat Chatterjee, Shail K. Chaube, Anu Chaudhary, Santosh Chauhan, Edward Chaum, Frederic Checler, Michael E. Cheetham, ChangShi Chen, Guang-Chao Chen, Jian-Fu Chen, Liam L. Chen, Leilei Chen, Lin Chen, Mingliang Chen, MuKuan Chen, Ning Chen, Quan Chen, Ruey-Hwa Chen, Shi Chen, Wei Chen, Weiqiang Chen, XinMing Chen, Xiong-Wen Chen, Xu Chen, Yan Chen, Ye-Guang Chen, Yingyu Chen, Yongqiang Chen, YuJen Chen, Yue-Qin Chen, Zhefan Stephen Chen, Zhi Chen, Zhi-Hua Chen, Zhijian J. Chen, Zhixiang Chen, Hanhua Cheng, Jun Cheng, Shi-Yuan Cheng, Wei Cheng, Xiaodong Cheng, Xiu-Tang Cheng, Yiyun Cheng, Zhiyong Cheng, Zhong Chen, Heesun Cheong, Jit Kong Cheong, Boris Chernyak, Sara Cherry, Chi Fai Randy Cheung, Chun Hei Antonio Cheung, King-Ho Cheung, Eric Chevet, Richard J. Chi, Alan Kwok Shing Chiang, Ferdinando Chiaradonna, Roberto Chiarelli, Mario Chiariello, Nathalia Chica, Susanna Chiocca, Mario Chiong, Shih-Hwa Chiou, Abhilash Chiramel, Valerio Chiurchiu, Dong-Hyung Cho, Seong-Kyu Choe, Augustine M. K. Choi, Mary E. Choi, Kamalika Roy Choudhury, Norman S. Chow, Charleen T. Chu, Jason P. Chua, John Jia En Chua, Hyewon Chung, Kin Pan Chung, Seockhoon Chung, So-Hyang Chung, Yuen-Li Chung, Valentina Cianfanelli, Iwona A. Ciechomska, Mariana Cifuentes, Laura Cinque, Sebahattin Cirak, Mara Cirone, Michael J. Clague, Robert Clarke, Emilio Clementi, Eliana M. Coccia, Patrice Codogno, Ehud Cohen, Mickael M. Cohen, Tania Colasanti, Fiorella Colasuonno, Robert A. Colbert, Anna Colell, Nuria S. Coll, Mark O. Collins, Maria Colombo, Daniel A. Colon-Ramos, Lydie Combaret, Sergio Comincini, Marcia R. Cominetti, Antonella Consiglio, Andrea Conte, Fabrizio Conti, Viorica Raluca Contu, Mark R. Cookson, Kevin M. Coombs, Isabelle Coppens, Maria Tiziana Corasaniti, Dale P. Corkery, Nils Cordes, Katia Cortese, Maria do Carmo Costa, Sarah Costantino, Paola Costelli, Ana Coto-Montes, Peter J. Crack, Jose L. Crespo, Alfredo Criollo, Valeria Crippa, Riccardo Cristofani, Tamas Csizmadia, Antonio Cuadrado, Bing Cui, Jun Cui, Yixian Cui, Yong Cui, Emmanuel Culetto, Andrea C. Cumino, Andrey Cybulsky, Mark J. Czaja, Stanislaw J. Czuczwar, Stefania D'Adamo, Marcello D'Amelio, Daniela D'Arcangelo, Andrew C. D'Lugos, Gabriella D'Orazi, James A. da Silva, Hormos Salimi Dafsari, Ruben K. Dagda, Yasin Dagdas, Maria Daglia, Xiaoxia Dai, Yun Dai, Yuyuan Dai, Jessica Dal Col, Paul Dalhaimer, Luisa Dalla Valle, Tobias Dallenga, Guillaume Dalmasso, Markus Damme, Ilaria Dando, Nico P. Dantuma, April L. Darling, Hiranmoy Das, Srinivasan Dasarathy, Santosh K. Dasari, Srikanta Dash, Oliver Daumke, Adrian N. Dauphinee, Jeffrey S. Davies, Valeria A. Davila, Roger J. Davis, Tanja Davis, Sharadha Dayalan Naidu, Francesca De Amicis, Karolien De Bosscher, Francesca De Felice, Lucia De Franceschi, Chiara De Leonibus, Mayara G. de Mattos Barbosa, Guido R. Y. De Meyer, Angelo De Milito, Cosimo De Nunzio, Clara De Palma, Mauro De Santi, Claudio De Virgilio, Daniela De Zio, Jayanta Debnath, Brian J. DeBosch, JeanPaul Decuypere, Mark A. Deehan, Gianluca Deflorian, James DeGregori, Benjamin Dehay, Gabriel Del Rio, Joe R. Delaney, Lea M. D. Delbridge, Elizabeth Delorme-Axford, M. Victoria Delpino, Francesca Demarchi, Vilma Dembitz, Nicholas D. Demers, Hongbin Deng, Zhiqiang Deng, Joern Dengjel, Paul Dent, Donna Denton, Melvin L. DePamphilis, Channing J. Der, Vojo Deretic, Albert Descoteaux, Laura Devis, Sushil Devkota, Olivier Devuyst, Grant Dewson, Mahendiran Dharmasivam, Rohan Dhiman, Diego di Bernardo, Manlio Di Cristina, Fabio Di Domenico, Pietro Di Fazio, Alessio Di Fonzo, Giovanni Di Guardo, Gianni M. Di Guglielmo, Luca Di Leo, Chiara Di Malta, Alessia Di Nardo, Martina Di Rienzo, Federica Di Sano, George Diallinas, Jiajie Diao, Guillermo Diaz-Araya, Ines Diaz-Laviada, Jared M. Dickinson, Marc Diederich, Melanie Dieude, Ivan Dikic, Shiping Ding, Wen-Xing Ding, Luciana Dini, Miroslav Dinic, Albena T. Dinkova-Kostova, Marc S. Dionne, Jorg H. W. Distler, Abhinav Diwan, Ian M. C. Dixon, Mojgan Djavaheri-Mergny, Ina Dobrinski, Oxana Dobrovinskaya, Radek Dobrowolski, Renwick C. J. Dobson, Serap Dokmeci Emre, Massimo Donadelli, Bo Dong, Xiaonan Dong, Zhiwu Dong, Gerald W. Dorn Ii, Volker Dotsch, Huan Dou, Juan Dou, Moataz Dowaidar, Sami Dridi, Liat Drucker, Ailian Du, Caigan Du, Guangwei Du, Hai-Ning Du, Li-Lin Du, Andre du Toit, Shao-Bin Duan, Xiaoqiong Duan, Sonia P. Duarte, Anna Dubrovska, Elaine A. Dunlop, Nicolas Dupont, Raul Duran, Bilikere S. Dwarakanath, Sergey A. Dyshlovoy, Darius Ebrahimi-Fakhari, Leopold Eckhart, Charles L. Edelstein, Thomas Efferth, Eftekhar Eftekharpour, Ludwig Eichinger, Nabil Eid, Tobias Eisenberg, N. Tony Eissa, Sanaa Eissa, Miriam Ejarque, Abdeljabar El Andaloussi, Nazira El-Hage, Shahenda El-Naggar, Anna Maria Eleuteri, Eman S. El-Shafey, Mohamed Elgendy, Aristides G. Eliopoulos, Maria M. Elizalde, Philip M. Elks, Hans-Peter Elsasser, Eslam S. Elsherbiny, Brooke M. Emerling, N. C. Tolga Emre, Christina H. Eng, Nikolai Engedal, Anna-Mart Engelbrecht, Agnete S. T. Engelsen, Jorrit M. Enserink, Ricardo Escalante, Audrey Esclatine, Mafalda Escobar-Henriques, Eeva-Liisa Eskelinen, Lucile Espert, Makandjou-Ola Eusebio, Gemma Fabrias, Cinzia Fabrizi, Antonio Facchiano, Francesco Facchiano, Bengt Fadeel, Claudio Fader, Alex C. Faesen, W. Douglas Fairlie, Alberto Falco, Bjorn H. Falkenburger, Daping Fan, Jie Fan, Yanbo Fan, Evandro F. Fang, Yanshan Fang, Yognqi Fang, Manolis Fanto, Tamar Farfel-Becker, Mathias Faure, Gholamreza Fazeli, Anthony O. Fedele, Arthur M. Feldman, Du Feng, Jiachun Feng, Lifeng Feng, Yibin Feng, Yuchen Feng, Wei Feng, Thais Fenz Araujo, Thomas A. Ferguson, Jose C. Fernandez-Checa, Sonia FernandezVeledo, Alisdair R. Fernie, Anthony W. Ferrante, Alessandra Ferraresi, Merari F. Ferrari, Julio C. B. Ferreira, Susan Ferro-Novick, Antonio Figueras, Riccardo Filadi, Nicoletta Filigheddu, Eduardo FilippiChiela, Giuseppe Filomeni, Gian Maria Fimia, Vittorio Fineschi, Francesca Finetti, Steven Finkbeiner, Edward A. Fisher, Paul B. Fisher, Flavio Flamigni, Steven J. Fliesler, Trude H. Flo, Ida Florance, Oliver Florey, Tullio Florio, Erika Fodor, Carlo Follo, Edward A. Fon, Antonella Forlino, Francesco Fornai, Paola Fortini, Anna Fracassi, Alessandro Fraldi, Brunella Franco, Rodrigo Franco, Flavia Franconi, Lisa B. Frankel, Scott L. Friedman, Leopold F. Frohlich, Gema Fruhbeck, Jose M. Fuentes, Yukio Fujiki, Naonobu Fujita, Yuuki Fujiwara, Mitsunori Fukuda, Simone Fulda, Luc Furic, Norihiko Furuya, Carmela Fusco, Michaela U. Gack, Lidia Gaffke, Sehamuddin Galadari, Alessia Galasso, Maria F. Galindo, Sachith Gallolu Kankanamalage, Lorenzo Galluzzi, Vincent Galy, Noor Gammoh, Boyi Gan, Ian G. Ganley, Feng Gao, Hui Gao, Minghui Gao, Ping Gao, Shou-Jiang Gao, Wentao Gao, Xiaobo Gao, Ana Garcera, Maria Noe Garcia, Veronica E. Garcia, Francisco Garcia-Del Portillo, Vega Garcia-Escudero, Aracely GarciaGarcia, Marina Garcia-Macia, Diana Garcia-Moreno, Carmen Garcia-Ruiz, Patricia Garcia-Sanz, Abhishek D. Garg, Ricardo Gargini, Tina Garofalo, Robert F. Garry, Nils C. Gassen, Damian Gatica, Liang Ge, Wanzhong Ge, Ruth Geiss-Friedlander, Cecilia Gelfi, Pascal Genschik, Ian E. Gentle, Valeria Gerbino, Christoph Gerhardt, Kyla Germain, Marc Germain, David A. Gewirtz, Elham Ghasemipour Afshar, Saeid Ghavami, Alessandra Ghigo, Manosij Ghosh, Georgios Giamas, Claudia Giampietri, Alexandra Giatromanolaki, Gary E. Gibson, Spencer B. Gibson, Vanessa Ginet, Edward Giniger, Carlotta Giorgi, Henrique Girao, Stephen E. Girardin, Mridhula Giridharan, Sandy Giuliano, Cecilia Giulivi, Sylvie Giuriato, Julien Giustiniani, Alexander Gluschko, Veit Goder, Alexander Goginashvili, Jakub Golab, David C. Goldstone, Anna Golebiewska, Luciana R. Gomes, Rodrigo Gomez, Ruben Gomez-Sanchez, Maria Catalina Gomez-Puerto, Raquel Gomez-Sintes, Qingqiu Gong, Felix M. Goni, Javier Gonzalez-Gallego, Tomas Gonzalez-Hernandez, Rosa A. Gonzalez-Polo, Jose A. Gonzalez-Reyes, Patricia Gonzalez-Rodriguez, Ing Swie Goping, Marina S. Gorbatyuk, Nikolai Gorbunov, Roxana M. Gorojod, Sharon M. Gorski, Sandro Goruppi, Cecilia Gotor, Roberta A. Gottlieb, Illana Gozes, Devrim Gozuacik, Martin Graef, Markus H. Graler, Veronica Granatiero, Daniel Grasso, Joshua P. Gray, Douglas R. Green, Alexander Greenhough, Stephen L. Gregory, Edward F. Griffin, Mark W. Grinstaff, Frederic Gros, Charles Grose, Angelina S. Gross, Florian Gruber, Paolo Grumati, Tilman Grune, Xueyan Gu, Jun-Lin Guan, Carlos M. Guardia, Kishore Guda, Flora Guerra, Consuelo Guerri, Prasun Guha, Carlos Guillen, Shashi Gujar, Anna Gukovskaya, Ilya Gukovsky, Jan Gunst, Andreas Gunther, Anyonya R. Guntur, Chuanyong Guo, Chun Guo, Hongqing Guo, Lian-Wang Guo, Ming Guo, Pawan Gupta, Alvaro F. Fernandez, Shashi Kumar Gupta, Swapnil Gupta, Veer Bala Gupta, Vivek Gupta, Asa B. Gustafsson, David D. Gutterman, H. B. Ranjitha, Annakaisa Haapasalo, James E. Haber, Shinji Hadano, Anders J. Hafren, Mansour Haidar, Belinda S. Hall, Gunnel Hallden, Anne Hamacher-Brady, Andrea Hamann, Maho Hamasaki, Weidong Han, Malene Hansen, Phyllis Hanson, Zijian Hao, Masaru Harada, Ljubica Harhaji-Trajkovic, Nirmala Hariharan, Nigil Haroon, James Harris, Takafumi Hasegawa, Noor Hasima Nagoor, Jeffrey A. Haspel, Volker Haucke, Wayne D. Hawkins, Bruce A. Hay, Cole M. Haynes, Soren B. Hayrabedyan, Thomas S. Hays, Congcong He, Qin He, RongRong He, You-Wen He, Yu-Ying He, Yasser Heakal, Alexander M. Heberle, J. Fielding Hejtmancik, Gudmundur Vignir Helgason, Vanessa Henkel, Marc Herb, Alexander Hergovich, Anna Herman-Antosiewicz, Agustin Hernandez, Carlos Hernandez, Sergio Hernandez-Diaz, Virginia Hernandez-Gea, Amaury Herpin, Judit Herreros, Javier H. Hervas, Daniel Hesselson, Claudio Hetz, Volker T. Heussler, Yujiro Higuchi, Sabine Hilfiker, Joseph A. Hill, William S. Hlavacek, Emmanuel A. Ho, Idy H. T. Ho, Philip Wing-Lok Ho, ShuLeong Ho, Wan Yun Ho, G. Aaron Hobbs, Mark Hochstrasser, Peter H. M. Hoet, Daniel Hofius, Paul Hofman, Annika Hohn, Carina Holmberg, Jose R. Hombrebueno, Chang-Won Hong, Yi-Ren Hong, Lora Hooper, Thorsten Hoppe, Rastislav Horos, Yujin Hoshida, I-Lun Hsin, Hsin-Yun Hsu, Bing Hu, Dong Hu, Li-Fang Hu, Ming Chang Hu, Ronggui Hu, Wei Hu, Yu-Chen Hu, Zhuo-Wei Hu, Fang Hua, Jinlian Hua, Yingqi Hua, Chongmin Huan, Canhua Huang, Chuanshu Huang, Chuanxin Huang, Chunling Huang, Haishan Huang, Kun Huang, Michael L. H. Huang, Rui Huang, Shan Huang, Tianzhi Huang, Xing Huang, Yuxiang Jack Huang, Tobias B. Huber, Virginie Hubert, Christian A. Hubner, Stephanie M. Hughes, William E. Hughes, Magali Humbert, Gerhard Hummer, James H. Hurley, Sabah Hussain, Salik Hussain, Patrick J. Hussey, Martina Hutabarat, Hui-Yun Hwang, Seungmin Hwang, Antonio Ieni, Fumiyo Ikeda, Yusuke Imagawa, Yuzuru Imai, Carol Imbriano, Masaya Imoto, Denise M. Inman, Ken Inoki, Juan Iovanna, Renato Iozzo, Giuseppe Ippolito, Javier E. Irazoqui, Pablo Iribarren, Mohd Ishaq, Makoto Ishikawa, Nestor Ishimwe, Ciro Isidoro, Nahed Ismail, Shohreh Issazadeh-Navikas, Eisuke Itakura, Daisuke Ito, Davor Ivankovic, Saska Ivanova, Anand Krishnan Iyer, Jose M. Izquierdo, Masanori Izumi, Marja Jaattela, Majid Sakhi Jabir, William T. Jackson, Nadia Jacobo-Herrera, Anne-Claire Jacomin, Elise Jacquin, Pooja Jadiya, Hartmut Jaeschke, Chinnaswamy Jagannath, Arjen J. Jakobi, Johan Jakobsson, Bassam Janji, Pidder JansenDurr, Patric J. Jansson, Jonathan Jantsch, Slawomir Januszewski, Alagie Jassey, Steve Jean, Helene JeltschDavid, Pavla Jendelova, Andreas Jenny, Thomas E. Jensen, Niels Jessen, Jenna L. Jewell, Jing Ji, Lijun Jia, Rui Jia, Liwen Jiang, Qing Jiang, Richeng Jiang, Teng Jiang, Xuejun Jiang, Yu Jiang, Maria Jimenez-Sanchez, Eun-Jung Jin, Fengyan Jin, Hongchuan Jin, Li Jin, Luqi Jin, Meiyan Jin, Si Jin, Eun-Kyeong Jo, Carine Joffre, Terje Johansen, Gail V. W. Johnson, Simon A. Johnston, Eija Jokitalo, Mohit Kumar Jolly, Leo A. B. Joosten, Joaquin Jordan, Bertrand Joseph, Dianwen Ju, Jeong-Sun Ju, Jingfang Ju, Esmeralda Juarez, Delphine Judith, Gabor Juhasz, Youngsoo Jun, Chang Hwa Jung, SungChul Jung, Yong Keun Jung, Heinz Jungbluth, Johannes Jungverdorben, Steffen Just, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Daniel Kaganovich, Alon Kahana, Renate Kain, Shinjo Kajimura, Maria Kalamvoki, Manjula Kalia, Danuta S. Kalinowski, Nina Kaludercic, Ioanna Kalvari, Joanna Kaminska, Vitaliy O. Kaminskyy, Hiromitsu Kanamori, Keizo Kanasaki, Chanhee Kang, Rui Kang, Sang Sun Kang, Senthilvelrajan Kaniyappan, Tomotake Kanki, Thirumala-Devi Kanneganti, Anumantha G. Kanthasamy, Arthi Kanthasamy, Marc Kantorow, Orsolya Kapuy, Michalis Karamouzis, Md Razaul Karim, Parimal Karmakar, Rajesh G. Katare, Masaru Kato, Stefan H. E. Kaufmann, Anu Kauppinen, Gur P. Kaushal, Susmita Kaushik, Kiyoshi Kawasaki, Kemal Kazan, Po-Yuan Ke, Damien J. Keating, Ursula Keber, John H. Kehrl, Kate E. Keller, Christian W. Keller, Jongsook Kim Kemper, Candia M. Kenific, Oliver Kepp, Stephanie Kermorgant, Andreas Kern, Robin Ketteler, Tom G. Keulers, Boris Khalfin, Hany Khalil, Bilon Khambu, Shahid Y. Khan, Vinoth Kumar Megraj Khandelwal, Rekha Khandia, Widuri Kho, Noopur Khobrekar, Sataree Khuansuwan, Mukhran Khundadze, Samuel A. Killackey, Dasol Kim, Deok Ryong Kim, Do-Hyung Kim, Dong-Eun Kim, Eun Young Kim, Eun-Kyoung Kim, HakRim Kim, Hee-Sik Kim, Hyung-Ryong Kim, Jeong Hun Kim, Jin Kyung Kim, Jin-Hoi Kim, Joungmok Kim, Ju Hwan Kim, Keun Il Kim, Peter K. Kim, Seong-Jun Kim, Scot R. Kimball, Adi Kimchi, Alec C. Kimmelman, Tomonori Kimura, Matthew A. King, Kerri J. Kinghorn, Conan G. Kinsey, Vladimir Kirkin, Lorrie A. Kirshenbaum, Sergey L. Kiselev, Shuji Kishi, Katsuhiko Kitamoto, Yasushi Kitaoka, Kaio Kitazato, Richard N. Kitsis, Josef T. Kittler, Ole Kjaerulff, Peter S. Klein, Thomas Klopstock, Jochen Klucken, Helene Knovelsrud, Roland L. Knorr, Ben C. B. Ko, Fred Ko, JiunnLiang Ko, Hotaka Kobayashi, Satoru Kobayashi, Ina Koch, Jan C. Koch, Ulrich Koenig, Donat Kogel, Young Ho Koh, Masato Koike, Sepp D. Kohlwein, Nur M. Kocaturk, Masaaki Komatsu, Jeannette Konig, Toru Kono, Benjamin T. Kopp, Tamas Korcsmaros, Gozde Korkmaz, Viktor Korolchuk, Monica Suarez Korsnes, Ali Koskela, Janaiah Kota, Yaichiro Kotake, Monica L. Kotler, Yanjun Kou, Michael Koukourakis, Evangelos Koustas, Attila L. Kovacs, Tibor Kovacs, Daisuke Koya, Tomohiro Kozako, Claudine Kraft, Dimitri Krainc, Helmut Kramer, Anna D. Krasnodembskaya, Carole Kretz-Remy, Guido Kroemer, Nicholas T. Ktistakis, Kazuyuki Kuchitsu, Sabine Kuenen, Lars Kuerschner, Thomas Kukar, Ajay Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Sharad Kumar, Shinji Kume, Caroline Kumsta, Chanakya N. Kundu, Mondira Kundu, Ajaikumar B. Kunnumakkara, Lukasz Kurgan, Tatiana G. Kutateladze, Ozlem Kutlu, SeongAe Kwak, Ho Jeong Kwon, Taeg Kyu Kwon, Yong Tae Kwon, Irene Kyrmizi, Albert La Spada, Patrick Labonte, Sylvain Ladoire, Ilaria Laface, Frank Lafont, Diane C. Lagace, Vikramjit Lahiri, Zhibing Lai, Angela S. Laird, Aparna Lakkaraju, Trond Lamark, Sheng-Hui Lan, Ane Landajuela, Darius J. R. Lane, Jon D. Lane, Charles H. Lang, Carsten Lange, Rupert Langer, Pierre Lapaquette, Jocelyn Laporte, Nicholas F. LaRusso, Isabel Lastres-Becker, Wilson Chun Yu Lau, Gordon W. Laurie, Sergio Lavandero, Betty Yuen Kwan Law, Helen Ka-wai Law, Rob Layfield, Weidong Le, Herve Le Stunff, Alexandre Y. Leary, Jean-Jacques Lebrun, Lionel Y. W. Leck, Jean-Philippe Leduc-Gaudet, Changwook Lee, Chung-Pei Lee, Da-Hye Lee, Edward B. Lee, Erinna F. Lee, Gyun Min Lee, He-Jin Lee, Heung Kyu Lee, Jae Man Lee, Jason S. Lee, Jin-A Lee, Joo-Yong Lee, Jun Hee Lee, Michael Lee, Min Goo Lee, Min Jae Lee, Myung-Shik Lee, Sang Yoon Lee, Seung-Jae Lee, Stella Y. Lee, Sung Bae Lee, Won Hee Lee, Ying-Ray Lee, Yong-ho Lee, Youngil Lee, Christophe Lefebvre, Renaud Legouis, Yu L. Lei, Yuchen Lei, Sergey Leikin, Gerd Leitinger, Leticia Lemus, Shuilong Leng, Olivia Lenoir, Guido Lenz, Heinz Josef Lenz, Paola Lenzi, Yolanda Leon, Andreia M. Leopoldino, Christoph Leschczyk, Stina Leskela, Elisabeth Letellier, Chi-Ting Leung, Po Sing Leung, Jeremy S. Leventhal, Beth Levine, Patrick A. Lewis, Klaus Ley, Bin Li, Da-Qiang Li, Jianming Li, Jing Li, Jiong Li, Ke Li, Liwu Li, Mei Li, Min Li, Min Li, Ming Li, Mingchuan Li, Pin-Lan Li, MingQing Li, Qing Li, Sheng Li, Tiangang Li, Wei Li, Wenming Li, Xue Li, Yi-Ping Li, Yuan Li, Zhiqiang Li, Zhiyong Li, Zhiyuan Li, Jiqin Lian, Chengyu Liang, Qiangrong Liang, Weicheng Liang, Yongheng Liang, YongTian Liang, Guanghong Liao, Lujian Liao, Mingzhi Liao, Yung-Feng Liao, Mariangela Librizzi, Pearl P. Y. Lie, Mary A. Lilly, Hyunjung J. Lim, Thania R. R. Lima, Federica Limana, Chao Lin, Chih-Wen Lin, Dar-Shong Lin, Fu-Cheng Lin, Jiandie D. Lin, Kurt M. Lin, Kwang-Huei Lin, Liang-Tzung Lin, Pei-Hui Lin, Qiong Lin, Shaofeng Lin, Su-Ju Lin, Wenyu Lin, Xueying Lin, Yao-Xin Lin, Yee-Shin Lin, Rafael Linden, Paula Lindner, Shuo-Chien Ling, Paul Lingor, Amelia K. Linnemann, YihCherng Liou, Marta M. Lipinski, Saska Lipovsek, Vitor A. Lira, Natalia Lisiak, Paloma B. Liton, Chao Liu, Ching-Hsuan Liu, Chun-Feng Liu, Cui Hua Liu, Fang Liu, Hao Liu, Hsiao-Sheng Liu, Hua-feng Liu, Huifang Liu, Jia Liu, Jing Liu, Julia Liu, Leyuan Liu, Longhua Liu, Meilian Liu, Qin Liu, Wei Liu, Wende Liu, Xiao-Hong Liu, Xiaodong Liu, Xingguo Liu, Xu Liu, Xuedong Liu, Yanfen Liu, Yang Liu, Yang Liu, Yueyang Liu, Yule Liu, J. Andrew Livingston, Gerard Lizard, Jose M. Lizcano, Senka Ljubojevic-Holzer, Matilde E. LLeonart, David Llobet-Navas, Alicia Llorente, Chih Hung Lo, Damian Lobato-Marquez, Qi Long, Yun Chau Long, Ben Loos, Julia A. Loos, Manuela G. Lopez, Guillermo Lopez-Domenech, Jose Antonio Lopez-Guerrero, Ana T. Lopez-Jimenez, Israel Lopez-Valero, Magdalena J. Lorenowicz, Mar Lorente, Peter Lorincz, Laura Lossi, Sophie Lotersztajn, Penny E. Lovat, Jonathan F. Lovell, Alenka Lovy, Guang Lu, Haocheng Lu, Jia-Hong Lu, Jin-Jian Lu, Mengji Lu, Shuyan Lu, Alessandro Luciani, John M. Lucocq, Paula Ludovico, Micah A. Luftig, Morten Luhr, Diego Luis-Ravelo, Julian J. Lum, Liany Luna-Dulcey, Anders H. Lund, Viktor K. Lund, Jan D. Lunemann, Patrick Luningschror, Honglin Luo, Rongcan Luo, Shouqing Luo, Zhi Luo, Claudio Luparello, Bernhard Luscher, Luan Luu, Alex Lyakhovich, Konstantin G. Lyamzaev, Alf Hakon Lystad, Lyubomyr Lytvynchuk, Alvin C. Ma, Changle Ma, Mengxiao Ma, Ning-Fang Ma, Quan-Hong Ma, Xinliang Ma, Yueyun Ma, Zhenyi Ma, Ormond A. MacDougald, Fernando Macian, Gustavo C. MacIntosh, Jeffrey P. MacKeigan, Kay F. Macleod, Sandra Maday, Frank Madeo, Muniswamy Madesh, Tobias Madl, Julio Madrigal-Matute, Akiko Maeda, Yasuhiro Maejima, Marta Magarinos, Poornima Mahavadi, Emiliano Maiani, Kenneth Maiese, Panchanan Maiti, Maria Chiara Maiuri, Barbara Majello, Michael B. Major, Elena Makareeva, Fayaz Malik, Karthik Mallilankaraman, Walter Malorni, Alina Maloyan, Najiba Mammadova, Gene Chi Wai Man, Federico Manai, Joseph D. Mancias, Eva-Maria Mandelkow, Michael A. Mandell, Angelo A. Manfredi, Masoud H. Manjili, Ravi Manjithaya, Patricio Manque, Bella B. Manshian, Raquel Manzano, Claudia Manzoni, Kai Mao, Cinzia Marchese, Sandrine Marchetti, Anna Maria Marconi, Fabrizio Marcucci, Stefania Mardente, Olga A. Mareninova, Marta Margeta, Muriel Mari, Sara Marinelli, Oliviero Marinelli, Guillermo Marino, Sofia Mariotto, Richard S. Marshall, Mark R. Marten, Sascha Martens, Alexandre P. J. Martin, Katie R. Martin, Sara Martin, Shaun Martin, Adrian Martin-Segura, Miguel A. Martin-Acebes, Inmaculada Martin-Burriel, Marcos Martin-Rincon, Paloma Martin-Sanz, Jose A. Martina, Wim Martinet, Aitor Martinez, Ana Martinez, Jennifer Martinez, Moises Martinez Velazquez, Nuria Martinez-Lopez, Marta Martinez-Vicente, Daniel O. Martins, Ulo Lange, Oscar Lopez-Perez, Joilson O. Martins, Waleska K. Martins, Tania Martins-Marques, Emanuele Marzetti, Shashank Masaldan, Celine Masclaux-Daubresse, Douglas G. Mashek, Valentina Massa, Lourdes Massieu, Glenn R. Masson, Laura Masuelli, Anatoliy Masyuk, Tetyana Masyuk, Paola Matarrese, Ander Matheu, Satoaki Matoba, Sachiko Matsuzaki, Pamela Mattar, Alessandro Matte, Domenico Mattoscio, Jose L. Mauriz, Mario Mauthe, Caroline Mauvezin, Emanual Maverakis, Paola Maycotte, Johanna Mayer, Gianluigi Mazzoccoli, Cristina Mazzoni, Joseph R. Mazzulli, Nami McCarty, Christine McDonald, Mitchell R. McGill, Sharon L. McKenna, BethAnn McLaughlin, Fionn McLoughlin, Mark A. McNiven, Thomas G. McWilliams, Fatima Mechta-Grigoriou, Tania Catarina Medeiros, Diego L. Medina, Lynn A. Megeney, Klara Megyeri, Maryam Mehrpour, Jawahar L. Mehta, Alfred J. Meijer, Annemarie H. Meijer, Jakob Mejlvang, Alicia Melendez, Annette Melk, Gonen Memisoglu, Alexandrina F. Mendes, Delong Meng, Fei Meng, Tian Meng, Rubem Menna-Barreto, Manoj B. Menon, Carol Mercer, Anne E. Mercier, Jean-Louis Mergny, Adalberto Merighi, Seth D. Merkley, Giuseppe Merla, Volker Meske, Ana Cecilia Mestre, Shree Padma Metur, Christian Meyer, Hemmo Meyer, Wenyi Mi, Jeanne Mialet-Perez, Junying Miao, Lucia Micale, Yasuo Miki, Enrico Milan, Dana L. Miller, Samuel Miller, Silke Miller, Steven W. Millward, Ira Milosevic, Elena A. Minina, Hamed Mirzaei, Hamid Reza Mirzaei, Mehdi Mirzaei, Amit Mishra, Nandita Mishra, Paras Kumar Mishra, Maja Misirkic Marjanovic, Roberta Misasi, Amit Misra, Gabriella Misso, Claire Mitchell, Geraldine Mitou, Tetsuji Miura, Shigeki Miyamoto, Makoto Miyazaki, Mitsunori Miyazaki, Taiga Miyazaki, Keisuke Miyazawa, Noboru Mizushima, Trine H. Mogensen, Baharia Mograbi, Reza Mohammadinejad, Yasir Mohamud, Abhishek Mohanty, Sipra Mohapatra, Torsten Mohlmann, Asif Mohmmed, Anna Moles, Kelle H. Moley, Maurizio Molinari, Vincenzo Mollace, Andreas Buch Muller, Bertrand Mollereau, Faustino Mollinedo, Costanza Montagna, Mervyn J. Monteiro, Andrea Montella, L. Ruth Montes, Barbara Montico, Vinod K. Mony, Giacomo Monzio Compagnoni, Michael N. Moore, Mohammad A. Moosavi, Ana L. Mora, Marina Mora, David Morales-Alamo, Rosario Moratalla, Paula Moreira, Elena Morelli, Sandra Moreno, Daniel Moreno-Blas, Viviana Moresi, Benjamin Morga, Alwena H. Morgan, Fabrice Morin, Hideaki Morishita, Orson L. Moritz, Mariko Moriyama, Yuji Moriyasu, Manuela Morleo, Eugenia Morselli, Jose F. Moruno-Manchon, Jorge Moscat, Serge Mostowy, Elisa Motori, Andrea Felinto Moura, Naima Moustaid-Moussa, Maria Mrakovcic, Gabriel MucinoHernandez, Anupam Mukherjee, Subhadip Mukhopadhyay, Jean M. Mulcahy Levy, Victoriano Mulero, Sylviane Muller, Christian Munch, Ashok Munjal, Pura Munoz-Canoves, Teresa Munoz-Galdeano, Christian Munz, Tomokazu Murakawa, Claudia Muratori, Brona M. Murphy, J. Patrick Murphy, Aditya Murthy, Timo T. Myohanen, Indira U. Mysorekar, Jennifer Mytych, Seyed Mohammad Nabavi, Massimo Nabissi, Peter Nagy, Jihoon Nah, Aimable Nahimana, Ichiro Nakagawa, Ken Nakamura, Hitoshi Nakatogawa, Shyam S. Nandi, Meera Nanjundan, Monica Nanni, Gennaro Napolitano, Roberta Nardacci, Masashi Narita, Melissa Nassif, Ilana Nathan, Manabu Natsumeda, Ryno J. Naude, Christin Naumann, Olaia Naveiras, Fatemeh Navid, Steffan T. Nawrocki, Taras Y. Nazarko, Francesca Nazio, Florentina Negoita, Thomas Neill, Amanda L. Neisch, Luca M. Neri, Mihai G. Netea, Patrick Neubert, Thomas P. Neufeld, Dietbert Neumann, Albert Neutzner, Phillip T. Newton, Paul A. Ney, Ioannis P. Nezis, Charlene C. W. Ng, Tzi Bun Ng, Hang T. T. Nguyen, Long T. Nguyen, Hong-Min Ni, Cliona Ni Cheallaigh, Zhenhong Ni, M. Celeste Nicolao, Francesco Nicoli, Manuel Nieto-Diaz, Per Nilsson, Shunbin Ning, Rituraj Niranjan, Hiroshi Nishimune, Mireia Niso-Santano, Ralph A. Nixon, Annalisa Nobili, Clevio Nobrega, Takeshi Noda, Uxia Nogueira-Recalde, Trevor M. Nolan, Ivan Nombela, Ivana Novak, Beatriz Novoa, Takashi Nozawa, Nobuyuki Nukina, Carmen Nussbaum-Krammer, Jesper Nylandsted, ,

Summary: The guidelines presented in this article aim to assist researchers in selecting and interpreting methods to examine autophagy, as well as to help reviewers provide constructive critiques of reports focused on these processes. It emphasizes that no single assay is perfect for every situation, and multiple techniques may be needed to properly monitor autophagy in different experimental settings. The article also highlights the importance of targeting multiple autophagy-related genes in genetic approaches to block autophagy effectively.

AUTOPHAGY (2021)

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Review Cell Biology

Composition and function of stress granules and P-bodies in plants

Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz

Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Calvin cycle and guard cell metabolism impact stomatal function

P. Lemonnier, T. Lawson

Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Perspectives on improving crop Rubisco by directed evolution

Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney

Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Natural variation in metabolism of the Calvin-Benson cycle

Vittoria Clapero, Stephanie Arrivault, Mark Stitt

Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Emerging functions of thrombospondin-1 in immunity

Sukhbir Kaur, David D. Roberts

Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Molecular evolution of the Thrombospondin superfamily

Richard P. Tucker, Josephine C. Adams

Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Thrombospondins in the tumor microenvironment

James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler

Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis

Hana Fakim, Christine Vande Velde

Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Developmental heterogeneity of vascular cells: Insights into cellular plasticity in atherosclerosis?

Alexander Lin, Yogambha Ramaswamy, Ashish Misra

Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

The Calvin Benson cycle in bacteria: New insights from systems biology

Elton P. Hudson

Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Mechanisms controlling metabolite concentrations of the Calvin

Xin-Guang Zhu, Haim Treves, Honglong Zhao

Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

The antagonistic relationship between apoptosis and polyploidy in development and cancer

Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi

Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

The mechanisms and roles of mitochondrial dynamics in C. elegans

Daniel Campbell, Steven Zuryn

Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Vagal pathways for systemic regulation of glucose metabolism

Diba Borgmann, Henning Fenselau

Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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Review Cell Biology

Molecular cell types as functional units of the efferent vagus nerve

Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell

Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024)

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