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Multidisciplinary Sciences
Caroline Ritacco, Murat Cem Kose, Justine Courtois, Lorenzo Canti, Charline Beguin, Sophie Dubois, Benoit Vandenhove, Sophi Servais, Jo Caers, Yves Beguin, Gregory Ehx, Frederic Baron
Summary: Post-transplant administration of cyclophosphamide (PTCy) can attenuate xenogeneic graft-versus-host disease (xGVHD) by depleting proliferative T cells and highly xenoreactive T-cell clones, while not affecting graft-versus-leukemia effects.
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Pharmacology & Pharmacy
Xing Chang, Jingang Liu, Qian Yang, Yu Gao, Xiaofei Ding, Junjun Zhao, Yang Li, Zi Liu, Zengqiang Li, Yingliang Wu, Daiying Zuo
Summary: Metastasis and immunotherapy resistance are major challenges in aggressive breast cancer. This study found that HMGA1 regulates epithelial to mesenchymal transition (EMT) and immune checkpoint blockade (ICB) therapy response in aggressive BC. HMGA1 knockdown enhanced anti-tumor immunity and upregulated PD-L1 expression. The PD-L1/HMGA1/Wnt/β-catenin negative feedback loop was identified as a novel mechanism in aggressive BC. Targeting HMGA1 could potentially improve both anti-metastasis and immunotherapeutic responses.
BIOCHEMICAL PHARMACOLOGY
(2023)
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Hematology
Qingxiao Song, Xiaoning Wang, Xiwei Wu, Hanjun Qin, Yingfei Li, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng
Summary: The administration of tolerogenic anti-IL-2 monoclonal antibody early after allo-HCT can effectively reduce acute GVHD while preserving strong GVL activity, providing a novel approach for post-transplant complications management.
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Immunology
Ying Huang, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, Michael Choi, Charles Huang, Andrew N. Macintyre, Amanda Nichols, Fang Li, Chuan-Yuan Li, Nancie J. MacIver, Diana M. Cardona, Todd Brennan, Zhiguo Li, Nelson J. Chao, Jeffrey C. Rathmell, Benny J. Chen
Summary: The study demonstrates the critical role of glycolysis in inducing graft-versus-host disease (GVHD) and suggests that targeting glycolysis selectively prevents GVHD while preserving non-alloreactive T cells that protect against tumor growth. The findings provide important insights into the metabolic reprogramming of donor T cells and offer a potential therapeutic approach for improving the clinical outcome of transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
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Chemistry, Medicinal
Xiao-ling Zhang, Xiao-yan Zhang, Xiao-qun Ge, Ming-xuan Liu
Summary: The study found that HSP27 plays an important role in liver fibrosis, and reducing HSP27 expression can alleviate fibrosis. Mangiferin can inhibit liver fibrosis and reduce hepatocyte EMT.
PHYTOTHERAPY RESEARCH
(2022)
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Oncology
Camilla Bove, Silvia Arcangeli, Laura Falcone, Barbara Camisa, Rita El Khoury, Beatrice Greco, Anna De Lucia, Alice Bergamini, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci
Summary: This study investigated the role of CD4 and CD8 T cells in CD19 CAR-T cell responses and the development of cytokine release syndrome (CRS). CD4 CAR-T cells exhibited superior proliferation and activation potential compared to CD8 CAR-T cells. CD4 CAR-T cells were found to play a key role in the development of CRS, and CD4 CAR-T cells with embedded 4-1BB were associated with a safer profile. CD4 cells were crucial for maintaining long-term responses and the combination of CD4.BBz with CD8.28z CAR-T cells resulted in the lowest toxicity without compromising antitumor efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
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Hematology
Brian C. Betts, Joseph Pidala, Jongphil Kim, Asmita Mishra, Taiga Nishihori, Lia Perez, Jose Leonel Ochoa-Bayona, Farhad Khimani, Kelly Walton, Ryan Bookout, Michael Nieder, Divis K. Khaira, Marco Davila, Melissa Alsina, Teresa Field, Ernesto Ayala, Frederick L. Locke, Marcie Riches, Mohamed Kharfan-Dabaja, Hugo Fernandez, Claudio Anasetti
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Oncology
Martine Extermann, Christiaan Leeuwenburgh, Laila Samiian, Marina Sehovic, Jinze Xu, Christopher Cubitt, Paul B. Jacobsen, Marco Pahor, Stephen R. Grobmyer, Todd M. Manini
JOURNAL OF GERIATRIC ONCOLOGY
(2017)
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Oncology
Ozlen Saglam, Yin Xiong, Douglas C. Marchion, Carolina Strosberg, Robert M. Wenham, Joseph J. Johnson, Daryoush Saeed-Vafa, Christopher Cubitt, Ardeshir Hakam, Anthony M. Magliocco
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Multidisciplinary Sciences
Brian C. Betts, David Bastian, Supinya Iamsawat, Hung Nguyen, Jessica L. Heinrichs, Yongxia Wu, Anusara Daenthanasanmak, Anandharaman Veerapathran, Alison O'Mahony, Kelly Walton, Jordan Reff, Pedro Horna, Elizabeth M. Sagatys, Marie C. Lee, Jack Singer, Ying-Jun Chang, Chen Liu, Joseph Pidala, Claudio Anasetti, Xue-Zhong Yu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
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Immunology
Brian C. Betts, Frederick L. Locke, Elizabeth M. Sagatys, Joseph Pidala, Kelly Walton, Meghan Menges, Jordan Reff, Asim Saha, Julie Y. Djeu, John V. Kiluk, Marie C. Lee, Jongphil Kim, Chang Won Kang, Chih-Hang Anthony Tang, Jeremy Frieling, Conor C. Lynch, Alan List, Paulo C. Rodriguez, Bruce R. Blazar, Jose R. Conejo-Garcia, Juan R. Del Valle, Chih-Chi Andrew Hu, Claudio Anasetti
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Darcy Welch, Elliot Kahen, Brooke Fridley, Andrew S. Brohl, Christopher L. Cubitt, Damon R. Reed
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Oncology
Kendra Sweet, Rami Komrokji, Eric Padron, Christopher L. Cubitt, Joel G. Turner, Junmin Zhou, Alan F. List, David A. Sallman, Jana L. Dawson, Daniel M. Sullivan, Julio Chavez, Bijal D. Shah, Jeffrey E. Lancet
CLINICAL CANCER RESEARCH
(2020)
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Medicine, Research & Experimental
Bishwas Shrestha, Kelly Walton, Jordan Reff, Elizabeth M. Sagatys, Nhan Tu, Justin Boucher, Gongbo Li, Tayyebb Ghafoor, Martin Felices, Jeffrey S. Miller, Joseph Pidala, Bruce R. Blazar, Claudio Anasetti, Brian C. Betts, Marco L. Davila
JOURNAL OF CLINICAL INVESTIGATION
(2020)
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Medicine, Research & Experimental
Kelly Walton, Mario R. Fernandez, Elizabeth M. Sagatys, Jordan Reff, Jongphil Kim, Marie Catherine Lee, John Kiluk, Jane Yuet Ching Hui, David McKenna, Meghan Hupp, Colleen Forster, Michael A. Linden, Nicholas J. Lawrence, Harshani R. Lawrence, Joseph Pidala, Steven Z. Pavletic, Bruce R. Blazar, Said M. Sebti, John L. Cleveland, Claudio Anasetti, Brian C. Bett
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Oncology
Joel G. Turner, Yan Cui, Alexis A. Bauer, Jana L. Dawson, Juan A. Gomez, Jongphil Kim, Christopher L. Cubitt, Taiga Nishihori, William S. Dalton, Daniel M. Sullivan
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Oncology
Joseph Pidala, Kelly Walton, Hany Elmariah, Jongphil Kim, Asmita Mishra, Nelli Bejanyan, Taiga Nishihori, Farhad Khimani, Lia Perez, Rawan G. Faramand, Marco L. Davila, Michael L. Nieder, Elizabeth M. Sagatys, Shernan G. Holtan, Nicholas J. Lawrence, Harshani R. Lawrence, Bruce R. Blazar, Claudio Anasetti, Said M. Sebti, Brian C. Betts
Summary: The study aimed to evaluate the safety and efficacy of combining pacritinib and sirolimus in preventing GVHD after allogeneic hematopoietic cell transplantation. The results showed that the combination treatment significantly reduced the occurrence of GVHD, preserved donor CMV immunity, and allowed timely engraftment.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Corey Gallen, Christopher W. W. Dukes, Amy Aldrich, Lauren Macaisa, Qianxing Mo, Christopher L. L. Cubitt, Shari Pilon-Thomas, Anna R. R. Giuliano, Brian J. J. Czerniecki, Ricardo L. B. Costa
Summary: This study evaluated immune responses to SARS-CoV-2 in oncology workers over a long period of time. The results showed that both CD4(+) T-cell and immunoglobulin G responses increased significantly after vaccination, but could wane over time.
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Oncology
Ariosto Silva, Maria C. Silva, Praneeth Sudalagunta, Allison Distler, Timothy Jacobson, Aunshka Collins, Tuan Nguyen, Jinming Song, Dung-Tsa Chen, Lu Chen, Christopher Cubitt, Rachid Baz, Lia Perez, Dmitri Rebatchouk, William Dalton, James Greene, Robert Gatenby, Robert Gillies, Eduardo Sontag, Mark B. Meads, Kenneth H. Shain
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Oncology
David M. Woods, Rupal Ramakrishnan, Andressa S. Laino, Anders Berglund, Kelly Walton, Brian C. Betts, Jeffrey S. Weber
CLINICAL CANCER RESEARCH
(2018)