Mangiferin prevents hepatocyte epithelial‐mesenchymal transition in liver fibrosis via targeting HSP27 ‐mediated JAK2 / STAT3 and TGF ‐β1/Smad pathway

Imbalance in mitochondrial dynamics induced by low PGC-1α expression contributes to hepatocyte EMT and liver fibrosis

(2020) Linzhong Zhang et al.   Cell Death & Disease

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

(2020) Ping An et al.   Nature Communications

Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy

(2020) Desong Kong et al.   Redox Biology

MicroRNA216b mediated downregulation of HSP27 / STAT3 / AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers

(2020) Jae Chul Lee et al.   PHYTOTHERAPY RESEARCH

Heat Shock Proteins and PD-1/PD-L1 as Potential Therapeutic Targets in Myeloproliferative Neoplasms

(2020) Steven De Almeida et al.   Cancers

Mangiferin and organ fibrosis: A mini review

(2020) Lijun Zhang et al.   BIOFACTORS

Pterostilbene prevents hepatocyte EMT in fructose-induced liver fibrosis through suppressing miR-34a/Sirt1/p53 and TGF-β1/Smads signaling

(2019) Lin Song et al.   BRITISH JOURNAL OF PHARMACOLOGY

Local unfolding of the HSP27 monomer regulates chaperone activity

(2019) T. Reid Alderson et al.   Nature Communications

TTC3 contributes to TGF-β1-induced epithelial−mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation

(2019) June-Hyung Kim et al.   Cell Death & Disease

The Hsp27-Mediated IkB α-NFkB Signaling Axis Promotes Radiation-Induced Lung Fibrosis

(2019) Jee-Youn Kim et al.   CLINICAL CANCER RESEARCH

Delineation of crosstalk between HSP27 and MMP-2/MMP-9: A synergistic therapeutic avenue for glioblastoma management

(2019) Y. Rajesh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner

(2019) Roma Kaul et al.   BRITISH JOURNAL OF CANCER

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Danshensu, a novel indoleamine 2,3-dioxygenase1 inhibitor, exerts anti-hepatic fibrosis effects via inhibition of JAK2-STAT3 signaling

(2019) Gang Cao et al.   PHYTOMEDICINE

Ginsenoside Rg1 ameliorates liver fibrosis via suppressing epithelial to mesenchymal transition and reactive oxygen species production in vitro and in vivo

(2018) Xiaoyu Wei et al.   BIOFACTORS

MicroRNA-29b-3p prevents Schistosoma japonicum -induced liver fibrosis by targeting COL1A1 and COL3A1

(2018) Ran Tao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

(2018) Margaux Sevin et al.   Nature Communications

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

(2018) Maurizio Parola et al.   MOLECULAR ASPECTS OF MEDICINE

Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling

(2018) Yan-zi Yang et al.   ACTA PHARMACOLOGICA SINICA

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multiverse nature of epithelial to mesenchymal transition

(2018) Pasquale Simeone et al.   SEMINARS IN CANCER BIOLOGY

Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1

(2017) Michelle Heirbaut et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions

(2017) Muhammad Ali et al.   PHYTOTHERAPY RESEARCH

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

(2017) Kun Zhang et al.   Nature Communications

Mangiferin modulation of metabolism and metabolic syndrome

(2016) Ekaterina Vladimirovna Fomenko et al.   BIOFACTORS

HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis

(2016) S.-H. Choi et al.   CANCER RESEARCH

Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Chen-wei Pan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HSP27 regulates TGF-β mediated lung fibroblast differentiation through the Smad3 and ERK pathways

(2016) Gang Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation

(2016) Shenglan Lin et al.   Oxidative Medicine and Cellular Longevity

Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling

(2016) Fang Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controversies over the Epithelial-to-Mesenchymal Transition in Liver Fibrosis

(2016) Kojiro Taura et al.   Journal of Clinical Medicine

Inhibition of Janus kinase-2 signalling pathway ameliorates portal hypertensive syndrome in partial portal hypertensive and liver cirrhosis rats

(2015) Dong Wang et al.   DIGESTIVE AND LIVER DISEASE

Hepatocytes in liver injury: Victim, bystander, or accomplice in progressive fibrosis?

(2015) Thomas Tu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Curcumin inhibits cobalt chloride-induced epithelial-to-mesenchymal transition associated with interference with TGF-β/Smad signaling in hepatocytes

(2015) Desong Kong et al.   LABORATORY INVESTIGATION

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis

(2014) Michaela Granzow et al.   HEPATOLOGY

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation

(2013) Guillaume Wettstein et al.   FASEB JOURNAL

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

(2013) Cliff Rowe et al.   HEPATOLOGY

Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells

(2013) Wei Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Up-Regulation of Tension-Related Proteins in Keloids

(2013) Edna Suarez et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Knock Down of Heat Shock Protein 27 (HspB1) Induces Degradation of Several Putative Client Proteins

(2012) Benjamin Gibert et al.   PLoS One

Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell-Mediated Tumor Killing and Memory Responses

(2011) G. M. Nagaraja et al.   Cancer Prevention Research

Mango Extracts and the Mango Component Mangiferin Promote Endothelial Cell Migration

(2010) Noor Huda Daud et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Colchicine reduces procollagen III and increases pseudocholinesterase in chronic liver disease

(2010) Sergio Muntoni   WORLD JOURNAL OF GASTROENTEROLOGY

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

(2009) Sergiy Kostenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways

(2008) Takashi Nitta et al.   HEPATOLOGY