Wobble uridine modifications–a reason to live, a reason to die?!

tRNA-targeting ribonucleases: molecular mechanisms and insights into their physiological roles

(2016) Tetsuhiro Ogawa   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Architecture of the yeast Elongator complex

(2016) Maria I Dauden et al.   EMBO REPORTS

Molecular architecture of the yeast Elongator complex reveals an unexpected asymmetric subunit arrangement

(2016) Dheva T Setiaputra et al.   EMBO REPORTS

Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification

(2016) Zhewang Lin et al.   Nature Chemical Biology

Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi

(2016) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An integrated, structure- and energy-based view of the genetic code

(2016) Henri Grosjean et al.   NUCLEIC ACIDS RESEARCH

tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast

(2016) Roland Klassen et al.   NUCLEIC ACIDS RESEARCH

Glutaredoxin GRXS17 Associates with the Cytosolic Iron-Sulfur Cluster Assembly Pathway

(2016) Sabrina Inigo et al.   PLANT PHYSIOLOGY

A [3Fe-4S] cluster is required for tRNA thiolation in archaea and eukaryotes

(2016) Yuchen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Independent suppression of ribosomal +1 frameshifts by different tRNA anticodon loop modifications

(2016) Roland Klassen et al.   RNA Biology

Design and synthesis of a minimal bacterial genome

(2016) C. A. Hutchison et al.   SCIENCE

Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi

(2016) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Many Faces of Elongator in Neurodevelopment and Disease

(2016) Marija Kojic et al.   Frontiers in Molecular Neuroscience

Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability

(2015) Viktoria Désirée Paul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

(2015) Danny D. Nedialkova et al.   CELL

Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes

(2015) Clement T. Y. Chan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis

(2015) Sophie Laguesse et al.   DEVELOPMENTAL CELL

Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification

(2015) Olga Kolaj-Robin et al.   FEBS Journal

Urmylation and tRNA thiolation functions of ubiquitin-like Uba4·Urm1 systems are conserved from yeast to man

(2015) André Jüdes et al.   FEBS LETTERS

Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

(2015) Homa Ghalei et al.   JOURNAL OF CELL BIOLOGY

tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae

(2015) Jadyn R. Damon et al.   MOLECULAR BIOLOGY OF THE CELL

Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures

(2015) Kshitiz Tyagi et al.   NUCLEIC ACIDS RESEARCH

Elongator-dependent modification of cytoplasmic tRNALysUUUis required for mitochondrial function under stress conditions

(2015) Marco Tigano et al.   NUCLEIC ACIDS RESEARCH

The role of wobble uridine modifications in +1 translational frameshifting in eukaryotes

(2015) Hasan Tükenmez et al.   NUCLEIC ACIDS RESEARCH

Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization

(2015) Aaron T. Larsen et al.   NUCLEIC ACIDS RESEARCH

Dimerization of elongator protein 1 is essential for Elongator complex assembly

(2015) Huisha Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2

(2015) Sebastian Glatt et al.   STRUCTURE

Meta-regulation of Arabidopsis Auxin Responses Depends on tRNA Maturation

(2015) Johannes Leitner et al.   Cell Reports

Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast

(2015) Wael Abdel-Fattah et al.   PLoS Genetics

Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation

(2015) Wenjun Deng et al.   PLoS Genetics

Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae

(2015) Roland Klassen et al.   PLoS One

Modify or die? - RNA modification defects in metazoans

(2015) L Peter Sarin et al.   RNA Biology

Modification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxes

(2015) M Eugenia Armengod et al.   RNA Biology

A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation

(2014) Peter C. Dedon et al.   CHEMICAL RESEARCH IN TOXICOLOGY

tRNA modifications regulate translation during cellular stress

(2014) Chen Gu et al.   FEBS LETTERS

Dph3 Is an Electron Donor for Dph1-Dph2 in the First Step of Eukaryotic Diphthamide Biosynthesis

(2014) Min Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of theSaccharomyces cerevisiaeElongator complex

(2014) Rachael Di Santo et al.   MOLECULAR MICROBIOLOGY

The diphthamide modification pathway fromSaccharomyces cerevisiae- revisited

(2014) Raffael Schaffrath et al.   MOLECULAR MICROBIOLOGY

Comparative Analysis of the Conserved Functions of Arabidopsis DRL1 and Yeast KTI12

(2014) Sang Eun Jun et al.   MOLECULES AND CELLS

Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism

(2014) Kiruthika Selvadurai et al.   Nature Chemical Biology

An evolutionary approach uncovers a diverse response of tRNA 2-thiolation to elevated temperatures in yeast

(2014) Fiona Alings et al.   RNA

Functional importance of Ψ38and Ψ39in distinct tRNAs, amplified for tRNAGln(UUG)by unexpected temperature sensitivity of the s2U modification in yeast

(2014) Lu Han et al.   RNA

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Predicting the Minimal Translation Apparatus: Lessons from the Reductive Evolution of Mollicutes

(2014) Henri Grosjean et al.   PLoS Genetics

Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation

(2013) Sunil Laxman et al.   CELL

Posttranscriptional RNA Modifications: Playing Metabolic Games in a Cell’s Chemical Legoland

(2013) Mark Helm et al.   CHEMISTRY & BIOLOGY

The biosynthesis and biological function of diphthamide

(2013) Xiaoyang Su et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structural insights into Elongator function

(2013) Sebastian Glatt et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding

(2013) V. A. N. Rezgui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA

(2013) Hirofumi Nakagawa et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Modification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs

(2013) Jorge Fernández-Vázquez et al.   PLoS Genetics

Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling

(2013) Boris Zinshteyn et al.   PLoS Genetics

Ubiquitin-Like Proteins

(2012) Annemarthe G. van der Veen et al.   Annual Review of Biochemistry

Anticodon nuclease encoding virus-like elements in yeast

(2012) Dhira Satwika et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A coordinated codon-dependent regulation of translation by Elongator

(2012) Fanelie Bauer et al.   CELL CYCLE

A new understanding of the decoding principle on the ribosome

(2012) Natalia Demeshkina et al.   NATURE

The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase

(2012) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications

(2012) Ashish Patil et al.   RNA Biology

A fungal anticodon nuclease ribotoxin exploits a secondary cleavage site to evade tRNA repair

(2012) B. Meineke et al.   RNA

Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop

(2012) M. P. Guy et al.   RNA

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

Translational Control of Cell Division by Elongator

(2012) Fanelie Bauer et al.   Cell Reports

Transfer RNA modifications: nature's combinatorial chemistry playground

(2012) Jane E. Jackman et al.   Wiley Interdisciplinary Reviews-RNA

Human tRNALys3UUU Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto–Enol Tautomerism

(2011) Franck A.P. Vendeix et al.   JOURNAL OF MOLECULAR BIOLOGY

Unexpected Accumulation of ncm5U and ncm5s2U in a trm9 Mutant Suggests an Additional Step in the Synthesis of mcm5U and mcm5s2U

(2011) Changchun Chen et al.   PLoS One

Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress: Fig. 1.

(2011) Matthew D. Petroski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier

(2011) Annemarthe G. Van der Veen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongator Complex Influences Telomeric Gene Silencing and DNA Damage Response by Its Role in Wobble Uridine tRNA Modification

(2011) Changchun Chen et al.   PLoS Genetics

Casein kinase 1: Complexity in the family

(2010) Jit Kong Cheong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Trm112p Is a 15-kDa Zinc Finger Protein Essential for the Activity of Two tRNA and One Protein Methyltransferases in Yeast

(2010) Marie-Hélène Mazauric et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rapamycin-sensitive Phosphoproteome Reveals That TOR Controls Protein Kinase A Toward Some But Not All Substrates

(2010) Alexandre Soulard et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanistic understanding of Pyrococcus horikoshiiDph2, a [4Fe–4S] enzyme required for diphthamidebiosynthesis

(2010) Xuling Zhu et al.   Molecular BioSystems

Elongator function in tRNA wobble uridine modification is conserved between yeast and plants

(2010) Constance Mehlgarten et al.   MOLECULAR MICROBIOLOGY

Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC

(2010) Birthe Meineke et al.   NUCLEIC ACIDS RESEARCH

PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae

(2010) C. Stark et al.   Database-The Journal of Biological Databases and Curation

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

Distinct Subsets of Sit4 Holophosphatases Are Required for Inhibition ofSaccharomyces cerevisiaeGrowth by Rapamycin and Zymocin

(2009) Daniel Jablonowski et al.   EUKARYOTIC CELL

Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4

(2009) Constance Mehlgarten et al.   MOLECULAR MICROBIOLOGY

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

(2009) Sebastian Leidel et al.   NATURE

Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions

(2009) Akiko Noma et al.   NUCLEIC ACIDS RESEARCH

Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis

(2009) Eugene G. Mueller et al.   PROTEIN SCIENCE

Defects in tRNA Modification Associated with Neurological and Developmental Dysfunctions in Caenorhabditis elegans Elongator Mutants

(2009) Changchun Chen et al.   PLoS Genetics

The Elongator Complex Interacts with PCNA and Modulates Transcriptional Silencing and Sensitivity to DNA Damage Agents

(2009) Qing Li et al.   PLoS Genetics

Molecular Mechanisms of the Cytotoxicity of ADP-Ribosylating Toxins

(2008) Qing Deng et al.   Annual Review of Microbiology

The Sulfurtransferase Activity of Uba4 Presents a Link between Ubiquitin-like Protein Conjugation and Activation of Sulfur Carrier Proteins†

(2008) Jennifer Schmitz et al.   BIOCHEMISTRY

Urm1 at the crossroad of modifications. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Patrick G A Pedrioli et al.   EMBO REPORTS

TheSaccharomyces cerevisiae60 S Ribosome Biogenesis Factor Tif6p Is Regulated by Hrr25p-mediated Phosphorylation

(2008) Partha Ray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding

(2008) Shinya Kurata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thio-modification of Yeast Cytosolic tRNA Requires a Ubiquitin-related System That Resembles Bacterial Sulfur Transfer Systems

(2008) Yumi Nakai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Mouse Ikbkap, a Subunit of Elongator, Leads to Transcriptional Deficits and Embryonic Lethality That Can Be Rescued by Human IKBKAP

(2008) Y.-T. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System

(2008) M. J. O. Johansson et al.   MOLECULAR AND CELLULAR BIOLOGY

RNA Repair: An Antidote to Cytotoxic Eukaryal RNA Damage

(2008) Jayakrishnan Nandakumar et al.   MOLECULAR CELL

A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11Dph3

(2008) Christian Br et al.   MOLECULAR MICROBIOLOGY

Yeast α-tubulin suppressor Ats1/Kti13 relates to the Elongator complex and interacts with Elongator partner protein Kti11

(2008) René Zabel et al.   MOLECULAR MICROBIOLOGY

The primary target of the killer toxin fromPichia acaciaeis tRNAGln

(2008) Roland Klassen et al.   MOLECULAR MICROBIOLOGY

PhosphoPep—a database of protein phosphorylation sites in model organisms

(2008) Bernd Bodenmiller et al.   NATURE BIOTECHNOLOGY

The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity

(2008) M. Dewez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

(2008) C. D. Schlieker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae

(2008) B. Huang et al.   RNA

Biochemical and Structural Characterization of a Novel Family of Cystathionine β-Synthase Domain Proteins Fused to a Zn Ribbon-Like Domain

(2007) Michael Proudfoot et al.   JOURNAL OF MOLECULAR BIOLOGY