Article
Veterinary Sciences
Leticia Lima de Almeida, Renata Azevedo de Abreu, Maira Morales Brito, Thayna Pantoja Gardes, Renato Bueno Flores, Roberto Rodrigues da Rosa Filho, Camila Infantosi Vannucchi
Summary: This study found that puppies born by c-section had lower oxygen saturation at birth and 1 hour, as well as higher protein oxidation compared to those born by vaginal delivery. Vaginally delivered puppies had higher TBARS levels, while c-section puppies had higher GPx activity. Additionally, SOD decreased in c-section puppies within 72 hours. Overall, c-section may result in puppies being less exposed to the negative consequences of oxidative stress.
Article
Respiratory System
Gozde Gurdeniz, Madeleine Ernst, Daniela Rago, Min Kim, Julie Courraud, Jakob Stokholm, Klaus Bonnelykke, Anders Bjorkbom, Urvish Trivedi, Soren J. Sorensen, Susanne Brix, David Hougaard, Morten Rasmussen, Arieh S. Cohen, Hans Bisgaard, Bo Chawes
Summary: Cesarean section is related to newborn metabolomic profiles, gut microbiome data, and cord blood immunology, indicating an increased risk of childhood asthma.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Pediatrics
Antonio Poerio, Silvia Galletti, Michelangelo Baldazzi, Silvia Martini, Alessandra Rollo, Sofia Spinedi, Francesco Raimondi, Maurizio Zompatori, Luigi Corvaglia, Arianna Aceti
Summary: The study evaluated the reliability of lung ultrasound in predicting the need for admission to the NICU in infants born by caesarean section. The results showed that the 3P-LUS examination performed 30 minutes after birth is a reliable tool to identify those term and late preterm infants born by CS who will require NICU admission.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Hoang Thi Nam Giang, Do Thi Thuy Duy, Le Tho Minh Hieu, Nguyen Lam Vuong, Nguyen Thi Tu Ngoc, Mai Thi Phuong, Nguyen Tien Huy
Summary: This study investigated the rate and associated factors of caesarean deliveries in urban areas of Vietnam. The findings revealed a high overall caesarean section rate, with significantly higher rates in private hospitals compared to public hospitals. Factors associated with a higher rate of caesarean section included increasing age, pre-pregnancy body mass index, gestational weight gain, and infant's birth weight; being a first-time mother; living in urban areas; and giving birth in private hospitals. These findings highlight the urgent need for comprehensive investigations into the reasons for caesarean deliveries in Vietnam.
Article
Multidisciplinary Sciences
Charlotta Larsson, Elin Djuvfelt, Anna Lindam, Katarina Tunon, Par Nordin
Summary: Caesarean section is associated with an increased risk for complications such as bowel obstruction, incisional hernia, and abdominal pain. Factors such as smoking, obesity, and multiple previous caesarean deliveries significantly contribute to these risks. Preventing smoking and obesity in fertile women remains crucial for reducing complications post-cesarean section.
Article
Infectious Diseases
Thor Haahr, Tine Dalsgaard Clausen, Jonathan Thorsen, Morten A. Rasmussen, Martin S. Mortensen, Jenni Lehtimaki, Shiraz A. Shah, Mathis H. Hjelmso, Klaus Bonnelykke, Bo L. Chawes, Gisle Vestergaard, Bo Jacobsson, Per-Goran Larsson, Susanne Brix, Soren J. Sorensen, Hans Bisgaard, Jakob Stokholm
Summary: The study found that changes in vaginal microbiota during pregnancy correlated with bacterial vaginosis status and vaginal community state type. A novel vaginal dysbiosis score was developed and found to be significantly associated with an increased risk of emergency cesarean section.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Oncology
Ritika Sharma, Martin G. Frasch, Camila Zelgert, Peter Zimmermann, Bibiana Fabre, Rory Wilson, Melanie Waldenberger, James W. MacDonald, Theo K. Bammler, Silvia M. Lobmaier, Marta C. Antonelli
Summary: Maternal stress before, during and after pregnancy has significant effects on the neurocognitive development of infants. This study aimed to find noninvasive epigenetic biomarkers of prenatal stress (PS) in newborns' saliva. Through DNA methylation analysis, significant associations were found between specific pregnancy worries and cortisol levels, and certain genes involved in secretion, transportation, signaling pathways, and neuronal signaling were identified. Early assessment of these noninvasive biomarkers can help detect at-risk babies and allocate resources for early intervention programs effectively.
CLINICAL EPIGENETICS
(2022)
Article
Pediatrics
I. M. Davies, K. J. Crossley, E. V. Mcgillick, I. Nitsos, K. Rodgers, A. Thiel, V. A. Zahra, A. B. te Pas, S. B. Hooper
Summary: The study investigates the breathing patterns of newborn lambs and finds that there is significant heterogeneity in respiratory patterns during the immediate newborn period, which also change with time. This study provides insight into respiratory behaviors that may indicate respiratory distress in full-term newborn infants.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Sarah Nazzari, Serena Grumi, Giacomo Biasucci, Lidia Decembrino, Elisa Fazzi, Roberta Giacchero, Maria Luisa Magnani, Renata Nacinovich, Barbara Scelsa, Arsenio Spinillo, Elena Capelli, Elisa Roberti, Livio Provenzi, MOM-COPE Study Grp
Summary: This study suggests that prenatal maternal stress during the COVID-19 pandemic might have increased the risk of an altered socio-cognitive development in infants as assessed through an observational paradigm at 12 months. Special preventive attention should be devoted to infants born during the pandemic.
Article
Public, Environmental & Occupational Health
Yunhui Tang, Jing Gao, Liping Sun, Yifei Gao, Fang Guo, Qi Chen
Summary: The study found that pregnant women who attended a prenatal education class had a significantly higher rate of attempting vaginal delivery and a lower rate of caesarean section, especially on maternal request. Therefore, attendance of prenatal education courses plays a crucial role in influencing the mode of delivery and reducing unnecessary caesarean sections.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Obstetrics & Gynecology
Grace E. Boyd, Jade Lodge, Christopher J. Flatley, Sailesh Kumar
Summary: The study found that caesarean delivery is more beneficial for periviable breech infants, especially those over 24 weeks gestation, in improving perinatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Pediatrics
Vivek Bhat, Shiv Sajan Saini, Naresh Sachdeva, Rama Walia, Venkataseshan Sundaram, Sourabh Dutta
Summary: The prevalence of adrenal insufficiency at the onset of neonatal septic shock was estimated, and the results showed that the incidence rate was 27% in this study.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Neora Alterman, Jennifer J. Kurinczuk, Maria A. Quigley
Summary: This study found that infants born by planned caesarean section have a slightly higher risk of severe lower respiratory tract infections during infancy compared to those born vaginally. Infants born by any type of caesarean section may also have a small increased risk of severe upper respiratory tract infections. Further research is needed to confirm these findings.
Review
Nutrition & Dietetics
Eliska Pivrncova, Iva Kotaskova, Vojtech Thon
Summary: C-section and intrapartum antibiotic exposure affect the infant's gut microbiota by reducing the abundance of Bacteroidetes. Exclusive breastfeeding helps to restore Actinobacteria and Bifidobacteria.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Serife Ozlem Genc, Huseyin Erdal
Summary: By comparing newborns from cesarean section and vaginal delivery, it was found that the vaginal delivery group had higher total antioxidant status, lower oxidative stress index, and lower total oxidant status. The levels of native and total thiol were higher, while disulfide levels were lower in the vaginal delivery group. These results indicate that disulfide formation leads to decreased antioxidant capacity in women undergoing cesarean section.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Svetlana Encica, Adrian Molnar, Simona Manole, Teodora Filan, Simona Oprita, Eugen Bursasiu, Romana Vulturar, Laura Damian
Summary: Thoracic aortic aneurysms can lead to fatal dissection if not detected, requiring close follow-up and strict hypertension control. Genetic testing revealed a variant in the PRKG1 gene related to blood pressure regulation, suggesting possible genetic links. Peripheral signs such as hypertension and scoliosis may indicate connective tissue diseases, serving as diagnostic clues.
Article
Health Care Sciences & Services
Simona Manole, Roxana Pintican, George Popa, Raluca Rancea, Alexandra Dadarlat-Pop, Romana Vulturar, Emanuel Palade
Summary: Arrhythmogenic right ventricular dysplasia (ARVD) is a rare genetic condition that can lead to sudden death, affecting the myocardium and causing electrical conduction issues, resulting in arrhythmias and abnormal myocardial movements. Diagnosis can be challenging, but cardiac MRI plays an increasingly important role in accurately depicting myocardial abnormalities and guiding patient management.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Romana Vulturar, Adina Chis, Sebastian Pintilie, Ilinca Maria Farcas, Alina Botezatu, Cristian Cezar Login, Adela-Viviana Sitar-Taut, Olga Hilda Orasan, Adina Stan, Cecilia Lazea, Camelia Al-Khzouz, Monica Mager, Mihaela Adela Vintan, Simona Manole, Laura Damian
Summary: Glut1 deficiency syndrome is a disease caused by mutations in the SLC2A1 gene, resulting in impaired glucose transport across the blood-brain barrier. The syndrome presents with age-specific symptoms including metabolic epileptic encephalopathy, movement disorders, and developmental delay. Diagnosis is confirmed through glucose testing and genetic analysis.
Article
Biochemistry & Molecular Biology
Cecilia Bacali, Romana Vulturar, Smaranda Buduru, Angela Cozma, Adriana Fodor, Adina Chis, Ondine Lucaciu, Laura Damian, Mirela Liliana Moldovan
Summary: The oral microbiome, a biofilm made up of numerous microorganisms, plays a crucial role in the overall health of the human body. It is heavily influenced by various factors and is associated with a range of systemic disorders. The analysis of the oral microbiome can potentially be used in personalized medicine for prevention, diagnosis, and treatment.
Review
Psychology, Clinical
Andrei C. Miu, Aurora Szentagotai-Tatar, Robert Balazsi, Diana Nechita, Ioana Bunea, Seth D. Pollak
Summary: Childhood adversity is closely related to the occurrence of psychopathology, and emotion regulation is one potential psychological mechanism. This meta-analysis found that emotion regulation difficulties, habitual rumination, and suppression were positively associated with childhood adversity and psychopathology. In contrast, habitual reappraisal use showed negative relations. These emotion regulation measures mediated the relationship between childhood adversity and psychopathology, while distraction was not related to either.
CLINICAL PSYCHOLOGY REVIEW
(2022)
Article
Psychology, Multidisciplinary
Lia-Ecaterina Oltean, Andrei C. Miu, Radu Soflau, Aurora Szentagotai-Tatar
Summary: The outcomes of gratitude interventions vary across studies and the underlying mechanisms and effect modifiers are not well-understood. This study investigated the effectiveness of a gratitude intervention in reducing depressive symptoms and negative affect, and increasing positive affect. The study also explored changes in reward processing and the role of childhood adversity and trait gratitude as moderators. The findings showed that the intervention effectively reduced depressive symptoms and negative affect, but had no effect on positive affect. The severity of childhood adversity and trait gratitude moderated the effectiveness of the intervention. These results suggest that gratitude interventions may not be suitable for everyone and should be tailored for individuals with a history of severe childhood adversity.
JOURNAL OF HAPPINESS STUDIES
(2022)
Review
Biochemistry & Molecular Biology
Laura Damian, Cristian Cezar Login, Carolina Solomon, Cristina Belizna, Svetlana Encica, Laura Urian, Ciprian Jurcut, Bogdan Stancu, Romana Vulturar
Summary: Inclusion body myositis is a late-onset inflammatory myopathy that is not commonly associated with cancer, but recent studies have shown a significant association with large granular lymphocyte leukemia. The pathogenesis of IBM involves CD8+ cytotoxic T cells and interferon gamma. Additionally, there are shared molecular mechanisms between IBM and cancer, such as mitochondrial dysfunction, autophagy, and cell cycle dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Endocrinology & Metabolism
Laura Otilia Damian, Diana Miclea, Romana Vulturar, Alexandra Craciun
Summary: The coexistence of osteogenesis imperfecta and inflammatory arthritis is rarely reported, but there may be complex pathogenic links between the two. Structural abnormalities and repeated trauma in osteogenesis imperfecta can activate innate immunity and trigger arthritis, increasing the need for therapeutic targets.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Cecilia Lazea, Laura Damian, Romana Vulturar, Calin Lazar
Summary: This study describes a group of Romanian children with PFAPA syndrome. The clinical and laboratory features of these patients were similar to those described in the literature. Younger patients had more frequent febrile attacks, and showed a favorable response to corticosteroid treatment.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Humanities, Multidisciplinary
Simina Pitur, Andrei C. Miu
Summary: This study aimed to examine the impact of reading experience and individual differences on emotions evoked by poetry, as well as the moderating and mediating roles of empathy, imagery, and proneness to fantasize in this relationship. The results showed that participants with greater reading experience, higher levels of auditory imagery control, and a higher level of proneness to fantasize experienced more intense emotions while reading poetry. Furthermore, the experiences of empathy, visual imagery, and auditory imagery for words during the reading session mediated the effects of reading experience on emotion intensity.
PSYCHOLOGY OF AESTHETICS CREATIVITY AND THE ARTS
(2022)
Review
Pharmacology & Pharmacy
Amal Dagni, Simona Codruta Heghes, Ramona Suharoschi, Oana Lelia Pop, Adriana Fodor, Romana Vulturar, Angela Cozma, Oufaa Aniq Filali, Dan Cristian Vodnar, Abdelaziz Soukri, Bouchra El Khalfi
Summary: The genus Dysphania, belonging to the Amaranthaceae family, is a widely available plant known for its numerous health benefits. It includes more than 47 species, with five species being extensively studied. D. ambrosioides has been used for thousands of years as a remedy for various ailments. Recent investigations have focused on the essential oils of Dysphania, which have shown antibacterial, antioxidant, and antiviral properties due to specific components such as terpenoids. However, some compounds in Dysphania have also demonstrated toxicological effects. This study aimed to provide data on the chemical composition and pharmacological activities of Dysphania essential oils.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Simona Manole, Raluca Rancea, Romana Vulturar, Siao-Pin Simon, Adrian Molnar, Laura Damian
Summary: Hughes-Stovin syndrome is a rare disease characterized by thrombophlebitis and multiple pulmonary and/or bronchial aneurysms. The exact etiology and pathogenesis of HSS are still not fully understood. It is believed that vascular inflammation plays a key role in the development of HSS, leading to pulmonary thrombosis. It is possible that Hughes-Stovin syndrome shares common pathways with Behcet syndrome and other vascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Psychology, Clinical
Stefania Crisan, Maria Stoia, Elena Predescu, Andrei C. Miu, Aurora Szentagotai-Tatar
Summary: This meta-analysis examined the associations between adverse childhood events (ACEs) and cluster C personality disorders. The results showed consistent associations between ACEs and all cluster C personality disorders. The associations weakened with age.
CLINICAL PSYCHOLOGY & PSYCHOTHERAPY
(2023)
Article
Biodiversity Conservation
Amal Dagni, Ramona Suharoschi, Simona-Codruta Heghes, Rodica Varban, Oana Lelia Pop, Romana Vulturar, Adriana Fodor, Angela Cozma, Abdelaziz Soukri, Bouchra El Khalfi
Summary: Plants in Morocco have long been recognized as a cultural heritage and medicinal remedy for various ailments. This study collected and documented the knowledge of herbalists in Casablanca regarding the use of plants in traditional medicine to treat fevers. The findings revealed 22 different species of medicinal plants used for this purpose, with Dysphania ambrosioides L. and Citrus x limon (L.) Osbeck being the most frequently recommended.
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)
