Article
Biochemistry & Molecular Biology
Samayitree Das, Sharon D'Souza, Bhavya Gorimanipalli, Rohit Shetty, Arkasubhra Ghosh, Vrushali Deshpande
Summary: Infection mediated ocular surface stress responses are important early defense mechanisms in response to host cell damage. Understanding the etiology and pathogenesis of ocular infections is crucial for early diagnosis and effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Ken Fukuda, Tomoka Mizobuchi, Isana Nakajima, Tatsuma Kishimoto, Yusaku Miura, Yoshinori Taniguchi
Summary: Relapsing polychondritis (RPC) is a rare systemic immune-mediated disease characterized by recurrent inflammation of cartilaginous and proteoglycan-rich tissues. Ocular tissues are also targets of inflammation in RPC, affecting approximately half of the patients. Physicians should be vigilant of RPC when encountering patients with recurrent ocular inflammation and various systemic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Sarah Atta, Chandrashan Perera, Shannon Nayyar, Regis P. Kowalski, Vishal Jhanji
Summary: Ocular infections caused by Serratia marcescens are associated with risk factors such as contact lens use, corneal disease, and history of ocular surgery. Poor outcomes were linked to older age, infiltrate size, presence of hypopyon, worse initial visual acuity, longer time to epithelial defect closure, and history of glaucoma.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Biotechnology & Applied Microbiology
Aditya Josyula, Revaz Omiadze, Kunal Parikh, Pranjali Kanvinde, Matthew B. Appell, Pratikkumar Patel, Hiwa Saeed, Yogesh Sutar, Nicole Anders, Ping He, Peter J. McDonnell, Justin Hanes, Abhijit A. Date, Laura M. Ensign
Summary: This study describes an ion-pairing approach to creating MOX-PAM NS for the treatment of ocular infections, significantly increasing ocular drug absorption and demonstrating good prophylactic and treatment efficacy in a rat model.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Ophthalmology
Jay J. Meyer
Summary: This study evaluated the rates of HSV-1 and HSV-2 in ocular specimens and found that HSV-2 is a rare cause of ocular infection but may cause severe vision-threatening disease.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Microbiology
Roger A. A. Astley, Md Huzzatul Mursalin, Phillip S. S. Coburn, Erin T. T. Livingston, James W. W. Nightengale, Eddy Bagaruka, Jonathan J. J. Hunt, Michelle C. C. Callegan
Summary: Ocular infections can lead to permanent visual impairment or blindness, causing a loss of quality of life. Bacteria are the main cause of these infections. This survey of bacterial isolates from the eye reveals a wide range of species, from common to rare and unique bacteria. Staphylococci are the most commonly isolated bacteria, while pseudomonads are the most common Gram-negative bacteria, except in the vitreous where Serratia is the most common. Empiric treatments are generally effective for most infections caused by these bacteria.
Article
Chemistry, Multidisciplinary
Hui Shi, Jianhong Zhou, Yuan Wang, Yutuo Zhu, Deqing Lin, Lei Lei, Serhii Vakal, Jiaqing Wang, Xingyi Li
Summary: This study presents a minimally invasive delivery system for treating fungal keratitis using a dissolving microneedle patch based on Poly(D,L-lactide) and hyaluronic acid. The microneedle patch shows excellent properties and can penetrate the cornea with no ocular irritation. In a rabbit model, the microneedle patch medication exhibits superior therapeutic effects compared to eye drops and is comparable to intrastromal injection, offering a cost-effective treatment solution.
Review
Microbiology
Allison H. Shannon, Sara A. Adelman, Erin A. Hisey, Sanskruti S. Potnis, Vanessa Rozo, Madeline W. Yung, Jennifer Y. Li, Christopher J. Murphy, Sara M. Thomasy, Brian C. Leonard
Summary: Microbial keratitis is a common eye condition that causes pain and visual impairment worldwide. Current treatment with antimicrobial drugs is often limited due to high rates of pathogen resistance. Recent studies suggest that antimicrobial peptides (AMPs) found on the ocular surface could be potential therapeutic agents for microbial keratitis.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Ophthalmology
Upeka Nanayakkara, Muhammad A. Khan, Dilnoor K. Hargun, Shobini Sivagnanam, Chameen Samarawickrama
Summary: Streptococcus is a diverse bacterial genus that is part of the ocular surface microbiome and is implicated in various eye infections, such as conjunctivitis, keratitis, endophthalmitis, dacryocystitis, and orbital cellulitis, which can lead to decreased visual acuity and surgical intervention.
SURVEY OF OPHTHALMOLOGY
(2023)
Review
Microbiology
Takanori Aoki, Koji Kitazawa, Hideto Deguchi, Chie Sotozono
Summary: Corynebacterium species, commonly found in the healthy conjunctiva of adults, have been reported as potentially pathogenic in recent years. Patients with poor immunity or corneal damage are at a higher risk for Corynebacterium-related ocular infections. These species are resistant to quinolones on the ocular surface but remain susceptible to third-generation cephems.
Article
Microbiology
Eric C. Ledbetter, Chloe B. Spertus, Diego G. Diel, Edward J. Dubovi
Summary: In this study, no evidence of subclinical ocular CaHV-1 shedding was detected in mature dogs with experimentally induced latent CaHV-1 infection, suggesting that frequent and thorough monitoring may be necessary to detect brief shedding episodes that may occur.
VETERINARY MICROBIOLOGY
(2021)
Article
Infectious Diseases
Madeeha Afzal, Ajay Kumar Vijay, Fiona Stapleton, Mark D. P. Willcox
Summary: Staphylococcus aureus isolates exhibited varying levels of resistance to antibiotics and disinfecting solutions, with microbial keratitis strains commonly showing resistance to multiple drugs. Strains from Australia were generally more susceptible to antibiotics compared to those from the USA, highlighting regional differences in resistance patterns.
Article
Infectious Diseases
Yu-Qiang Zhang, Ting-Ting Xu, Fu-Yan Wang, Shuang Wang, Jun Cheng
Summary: This study reports the first case of primary M. Haemophilus infection in the cornea of a healthy adult. The pathogen was detected through high-throughput sequencing and treated with penetrating keratoplasty and antimicrobial therapy. The study highlights the importance of diagnosing and treating M. Haemophilus keratitis among clinicians.
BMC INFECTIOUS DISEASES
(2023)
Article
Ophthalmology
Farhad Hafezi, Emilio de Almeida Torres-Netto, Leonard Kollros, Nan-Ji Lu, Nikki Hafezi, Cosimo Mazzotta, M. Enes Aydemir, Mark Hillen
Summary: This study compared the complication rates of epithelium-off corneal cross-linking (epi-off CXL) performed in an office-based setting with those performed in an operating room. The results showed that there was no increased risk of complications associated with office-based epi-off CXL compared to operating room settings.
Article
Infectious Diseases
Eric G. Romanowski, Shilpi Gupta, Androulla Pericleous, Daniel E. Kadouri, Robert M. Q. Shanks
Summary: Predatory bacteria can eliminate Gram-negative pathogens on the ocular surface, but do not significantly affect the ability of the ocular surface to clear these pathogens.
Letter
Ophthalmology
Dalia G. Said, Andrew R. Ross, Marco Messina, Imran Mohammed, Harminder S. Dua
Letter
Ophthalmology
Imran Mohammed, Andrew Ross, John O. Britton, Dalia G. Said, Harminder S. Dua
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Pathology
Delu Song, Yoshiyasu Ueda, Rupak Bhuyan, Imran Mohammed, Takashi Miwa, Damodar Gullipali, Hangsoo Kim, Lin Zhou, Ying Song, Hannah Schultz, Albert Bargoud, Joshua L. Dunaief, Wen-Chao Song
AMERICAN JOURNAL OF PATHOLOGY
(2019)
Review
Ophthalmology
Mouhamed A. Al-Aqaba, Virinder K. Dhillon, Imran Mohammed, Dalia G. Said, Harminder S. Dua
PROGRESS IN RETINAL AND EYE RESEARCH
(2019)
Article
Ophthalmology
Mouhamed Ali Al-Aqaba, Fady S. Anis, Imran Mohammed, Anjali Dias Samarawickrama Yapa, Winfried M. Amoaku, Harminder Singh Singh Dua
Summary: This study utilized in vivo confocal microscopy to describe the features of human limbal nerve corpuscles and their correlation with histological features. The study found a strong correlation between in vivo and histological results, indicating the potential use of IVCM in studying LNCs in normal and disease conditions.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Microbiology
Imran Mohammed, Dalia G. Said, Mario Nubile, Leonardo Mastropasqua, Harminder S. Dua
FRONTIERS IN MICROBIOLOGY
(2019)
Review
Immunology
Darren Shu Jeng Ting, Roger W. Beuerman, Harminder S. Dua, Rajamani Lakshminarayanan, Imran Mohammed
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Ophthalmology
Imran Mohammed, Bina Kulkarni, Lana A. Faraj, Ali Abbas, Harminder S. Dua, Anthony J. King
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Imran Mohammed, Debasmita Mohanty, Dalia G. Said, Manas Ranjan Barik, Mamatha M. Reddy, Ahmed Alsaadi, Sujata Das, Harminder Singh Dua, Ruchi Mittal
Summary: AMP expression is a consistent feature of FK, with HBD-1 and -2 being most consistently expressed while LL-37 is the least, indicating a certain specificity of AMP expression related to FK. These results will aid in identifying HBD sequence templates for designing FK-specific peptides for potential therapeutic use.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Rashmi Deshmukh, Darren Shu Jeng Ting, Ahmad Elsahn, Imran Mohammed, Dalia G. Said, Harminder Singh Dua
Summary: Ikervis is a useful topical treatment for managing ocular surface inflammatory diseases in real-world settings, but preparations with improved tolerability are needed to benefit a larger number of patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Darren Shu Jeng Ting, Eunice Tze Leng Goh, Venkatesh Mayandi, Joanna M. F. Busoy, Thet Tun Aung, Mercy Halleluyah Periayah, Mario Nubile, Leonardo Mastropasqua, Dalia G. Said, Hla M. Htoon, Veluchamy Amutha Barathi, Roger W. Beuerman, Rajamani Lakshminarayanan, Imran Mohammed, Harminder S. Dua
Summary: The study successfully developed a novel antimicrobial therapy based on human-derived hybrid host defense peptides (HyHDPs) through combination of functional amino acids in parent peptides. The second-generation peptide CaD23 demonstrated good efficacy against various bacteria and minimal cytotoxicity to human cells. Pre-clinical murine studies showed that CaD23 was effective against Gram-positive bacteria without promoting antimicrobial resistance.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Darren Shu Jeng Ting, Jianguo Li, Chandra S. Verma, Eunice T. L. Goh, Mario Nubile, Leonardo Mastropasqua, Dalia G. Said, Roger W. Beuerman, Rajamani Lakshminarayanan, Imran Mohammed, Harminder S. Dua
Summary: CaD23 is a novel synthetic HDP with strong antimicrobial efficacy, especially in combination with antibiotics. Its rapid antimicrobial action is mainly attributed to its membrane-permeabilising mechanism, and MD simulations are useful for elucidating its mechanism of action and guiding design optimization.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Infectious Diseases
Waqas Ali, Ahmad Elsahn, Darren S. J. Ting, Harminder S. Dua, Imran Mohammed
Summary: One of the major challenges in the medical community today is the increasing antimicrobial resistance (AMR) coupled with the reduction in available antimicrobial treatments. The overuse of antibiotics has led to a significant rise in AMR, with estimates suggesting over 10 million lives could be lost by 2050. Host Defence Peptides (HDPs) have shown promise as an alternative to traditional antibiotics, demonstrating efficacy against currently resistant microbial variants. In light of the global COVID-19 pandemic, the potential use of HDPs as a therapeutic option and preventive measure against the spread of the SARS-CoV-2 variant has been examined.
Review
Medicine, General & Internal
Darren Shu Jeng Ting, Imran Mohammed, Rajamani Lakshminarayanan, Roger W. Beuerman, Harminder S. Dua
Summary: Vision is considered the most important sense in humans, and the ocular surface plays a crucial role in defending the eye against environmental stress and pathogens. Host defense peptides (HDPs) are innate immune molecules that have antimicrobial and other biological functions. This review provides an updated overview of HDPs at the ocular surface, their involvement in ocular diseases/conditions, current developments in HDP-based treatments for ocular diseases and infections, and the future potential of HDP-based clinical pharmacotherapy for ocular diseases.
FRONTIERS IN MEDICINE
(2022)
Meeting Abstract
Ophthalmology
Darren Ting, Dalia Said, Mario Nubile, Leonardo Mastropasqua, Veluchamy Barathi, Roger Beuerman, Rajamani Lakshminarayanan, Imran Mohammed, Harminder Dua
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)