DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein–dynactin–cargo adaptor complexes

Review: Structure and mechanism of the dynein motor ATPase

(2016) Helgo Schmidt et al.   BIOPOLYMERS

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

Beyond spinal muscular atrophy with lower extremity dominance: cerebellar hypoplasia associated with a novel mutation inBICD2

(2016) C. Fiorillo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction

(2016) Mara A. Olenick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition

(2016) Vladislav Belyy et al.   NATURE CELL BIOLOGY

Recurrent de novo BICD2 mutation associated with arthrogryposis multiplex congenita and bilateral perisylvian polymicrogyria

(2016) Gianina Ravenscroft et al.   NEUROMUSCULAR DISORDERS

Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding

(2016) Casper C. Hoogenraad et al.   TRENDS IN CELL BIOLOGY

Application of targeted multi-gene panel testing for the diagnosis of inherited peripheral neuropathy provides a high diagnostic yield with unexpected phenotype-genotype variability

(2015) Thalia Antoniadi et al.   BMC Medical Genetics

Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells

(2015) Alexandre D. Baffet et al.   DEVELOPMENTAL CELL

Writing and Reading the Tubulin Code

(2015) Ian Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation screen reveals novel variants and expands the phenotypes associated with DYNC1H1

(2015) Alleene V. Strickland et al.   JOURNAL OF NEUROLOGY

Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy

(2015) M. Scoto et al.   NEUROLOGY

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Control of cytoplasmic dynein force production and processivity by its C-terminal domain

(2015) Matthew P. Nicholas et al.   Nature Communications

Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases

(2015) Joanna Lipka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy

(2014) Caroline A. Garrett et al.   BRAIN

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

Guidelines for investigating causality of sequence variants in human disease

(2014) D. G. MacArthur et al.   NATURE

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Mutations in BICD2 Cause Dominant Congenital Spinal Muscular Atrophy and Hereditary Spastic Paraplegia

(2013) Emily C. Oates et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular Defects in the Motor Adaptor BICD2 Cause Proximal Spinal Muscular Atrophy with Autosomal-Dominant Inheritance

(2013) Kristien Peeters et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in BICD2, which Encodes a Golgin and Important Motor Adaptor, Cause Congenital Autosomal-Dominant Spinal Muscular Atrophy

(2013) Kornelia Neveling et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dynein Recruitment to Nuclear Pores Activates Apical Nuclear Migration and Mitotic Entry in Brain Progenitor Cells

(2013) Daniel Jun-Kit Hu et al.   CELL

Novel DyneinDYNC1H1Neck and Motor Domain Mutations Link Distal Spinal Muscular Atrophy and Abnormal Cortical Development

(2013) Chiara Fiorillo et al.   HUMAN MUTATION

Crystal clear insights into how the dynein motor moves

(2013) A. P. Carter   JOURNAL OF CELL SCIENCE

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age

(2013) Judith Eschbach et al.   NEUROBIOLOGY OF DISEASE

Cytoplasmic dynein heavy chain: the servant of many masters

(2013) Giampietro Schiavo et al.   TRENDS IN NEUROSCIENCES

Cytoplasmic dynein

(2012) Victoria J. Allan   BIOCHEMICAL SOCIETY TRANSACTIONS

A mouse neurodegenerative dynein heavy chain mutation alters dynein motility and localization inNeurospora crassa

(2012) Senthilkumar Sivagurunathan et al.   Cytoskeleton

Identification of a Novel Site in the Tail of Dynein Heavy Chain Important for Dynein Functionin Vivo

(2012) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations inDYNC1H1cause severe intellectual disability with neuronal migration defects

(2012) Marjolein H Willemsen et al.   JOURNAL OF MEDICAL GENETICS

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

The 2.8 Å crystal structure of the dynein motor domain

(2012) Takahide Kon et al.   NATURE

A DYNC1H1 mutation causes a dominant spinal muscular atrophy with lower extremity predominance

(2012) Yoshinori Tsurusaki et al.   NEUROGENETICS

Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy

(2012) M. B. Harms et al.   NEUROLOGY

Reconstitution of the human cytoplasmic dynein complex

(2012) M. Trokter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Microtubule Binding and Release by Dynein

(2012) W. B. Redwine et al.   SCIENCE

Exome Sequencing Identifies a DYNC1H1 Mutation in a Large Pedigree with Dominant Axonal Charcot-Marie-Tooth Disease

(2011) Michael N. Weedon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Nucleotide-dependent behavior of single molecules of cytoplasmic dynein on microtubules in vitro

(2010) Michi Miura et al.   FEBS LETTERS

Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions

(2010) Wenhan Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

A cytoplasmic dynein tail mutation impairs motor processivity

(2010) Kassandra M. Ori-McKenney et al.   NATURE CELL BIOLOGY

A de novo paradigm for mental retardation

(2010) Lisenka E L M Vissers et al.   NATURE GENETICS

Dominant spinal muscular atrophy with lower extremity predominance: Linkage to 14q32

(2010) M. B. Harms et al.   NEUROLOGY

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

(2010) Daniël Splinter et al.   PLOS BIOLOGY

Dynein Light Intermediate Chain: An Essential Subunit That Contributes to Spindle Checkpoint Inactivation

(2008) Sarah Mische et al.   MOLECULAR BIOLOGY OF THE CELL