Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions

ESAT-6 Drives MMP-10 Gene Expression and Secretion in Tuberculosis

(2016) Sara Brilha et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo

(2016) Steven Levitte et al.   Cell Host & Microbe

Characterization of differential pore-forming activities of ESAT-6 proteins fromMycobacterium tuberculosisandMycobacterium smegmatis

(2016) Xiuli Peng et al.   FEBS LETTERS

Additive effect of recombinant Mycobacterium tuberculosis ESAT-6 protein and ESAT-6/CFP-10 fusion protein in adhesion of macrophages through fibronectin receptors

(2016) Mina Hemmati et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

EspC forms a filamentous structure in the cell envelope ofMycobacterium tuberculosisand impacts ESX-1 secretion

(2016) Ye Lou et al.   MOLECULAR MICROBIOLOGY

Discovery of the type VII ESX-1 secretion needle?

(2016) Louis S. Ates et al.   MOLECULAR MICROBIOLOGY

ESX secretion systems: mycobacterial evolution to counter host immunity

(2016) Matthias I. Gröschel et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism of ESAT-6 membrane interaction and its roles in pathogenesis of Mycobacterium tuberculosis

(2016) Xiuli Peng et al.   TOXICON

Mycobacterial escape from macrophage phagosomes to the cytoplasm represents an alternate adaptation mechanism

(2016) Shilpa V. Jamwal et al.   Scientific Reports

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Two distinct conformational states ofMycobacterium tuberculosisvirulent factor early secreted antigenic target 6 kDa are behind the discrepancy around its biological functions

(2015) Amira Refai et al.   FEBS Journal

Characterization ofMycobacterium tuberculosisEsxA Membrane Insertion

(2015) Yue Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication ofMycobacterium tuberculosisin macrophages

(2015) Alexander Speer et al.   MOLECULAR MICROBIOLOGY

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

(2015) Bappaditya Dey et al.   NATURE MEDICINE

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

(2015) Sara L. Lawrence et al.   Scientific Reports

Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

(2015) Fabien Le Chevalier et al.   Scientific Reports

Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis

(2014) C.J. Cambier et al.   CELL

Correlation of Phenotypic Profiles Using Targeted Proteomics Identifies Mycobacterial Esx-1 Substrates

(2014) Matthew M. Champion et al.   JOURNAL OF PROTEOME RESEARCH

Mycobacterium tuberculosis ESAT-6 is a leukocidin causing Ca2+ influx, necrosis and neutrophil extracellular trap formation

(2014) R J Francis et al.   Cell Death & Disease

Identification of a Key Residue for Oligomerisation and Pore-Formation of Clostridium perfringens NetB

(2014) Sérgio Fernandes da Costa et al.   Toxins

Measuring of Mycobacterium tuberculosis growth: a correlation of the optical measurements with colony forming units

(2013) Katia Peñuelas-Urquides et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

(2013) Kevin Takaki et al.   Nature Protocols

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

(2012) Diane Houben et al.   CELLULAR MICROBIOLOGY

Mycobacterium tuberculosisESAT-6 Exhibits a Unique Membrane-interacting Activity That Is Not Found in Its Ortholog from Non-pathogenicMycobacterium smegmatis

(2012) Joaquin De Leon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis

(2012) Stephen H.-F. Macdonald et al.   PLoS One

An In Vivo Platform for Rapid High-Throughput Antitubercular Drug Discovery

(2012) Kevin Takaki et al.   Cell Reports

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

Staphylococcus aureus Hemolysins, bi-component Leukocidins, and Cytolytic Peptides: A Redundant Arsenal of Membrane-Damaging Virulence Factors?

(2012) François Vandenesch et al.   Frontiers in Cellular and Infection Microbiology

Early Secreted Antigen ESAT-6 of Mycobacterium tuberculosis Promotes Protective T Helper 17 Cell Responses in a Toll-Like Receptor-2-dependent Manner

(2011) Samit Chatterjee et al.   PLoS Pathogens

Anti-Alpha-Hemolysin Monoclonal Antibodies Mediate Protection against Staphylococcus aureus Pneumonia

(2009) B. E. Ragle et al.   INFECTION AND IMMUNITY

ESAT-6 Inhibits Production of IFN-  by Mycobacterium tuberculosis-Responsive Human T Cells

(2009) X. Wang et al.   JOURNAL OF IMMUNOLOGY

Potential role for ESAT6 in dissemination ofM. tuberculosisvia human lung epithelial cells

(2009) Arvind G. Kinhikar et al.   MOLECULAR MICROBIOLOGY

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

(2008) J. Smith et al.   INFECTION AND IMMUNITY

Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

(2008) Wafa Frigui et al.   PLoS Pathogens