Article
Biochemistry & Molecular Biology
Joseph W. Saelens, Mollie I. Sweeney, Gopinath Viswanathan, Ana Maria Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, Rachel M. Cronin, Erika J. Hughes, W. Jared Brewer, Jorn Coers, Matthew M. Champion, Patricia A. Champion, Craig B. Lowe, Clare M. Smith, Sunhee Lee, Jason E. Stout, David M. Tobin
Summary: The human pathogen Mycobacterium tuberculosis can cause lung disease and disseminate to other tissues. This study identified an outbreak of M. tuberculosis with high rates of extrapulmonary dissemination and bone disease. The causal strain carried a full-length ancestral version of the effector protein EsxM, which exacerbated dissemination through enhancement of macrophage motility and egress from granulomas, as well as alterations in macrophage actin dynamics. Reconstitution of ancestral EsxM in a modern attenuated strain altered the migratory mode of infected macrophages and promoted bone disease in a zebrafish model. The presence of a derived nonsense variant in EsxM in major M. tuberculosis lineages suggests a role for EsxM in regulating dissemination.
Article
Biochemistry & Molecular Biology
Sarah A. Clark, Lars E. Clark, Junhua Pan, Adrian Coscia, Lindsay G. A. McKay, Sundaresh Shankar, Rebecca Johnson, Vesna Brusic, Manish C. Choudhary, James Regan, Jonathan Z. Li, Anthony Griffiths, Jonathan Abraham
Summary: The study reveals that mutations occurring during the evolution of SARS-CoV-2 virus may lead to resistance against antibodies, posing challenges to long-term efficacy.
Article
Multidisciplinary Sciences
Aatir A. Tungekar, Lloyd W. Ruddock
Summary: With increased accessibility and tissue penetration, smaller antibody formats such as Fab and scFv have shown potential as effective and low-cost alternatives to full-length antibodies. Microbial hosts hold promise as production hosts for antibody fragments, but production limitations arise due to low target protein yields and protein folding complexity. This study reports an alternative antibody fragment format, FabH3, designed to overcome these limitations.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Udita Sanga, Hogeun Park, Courtney Hammond Wagner, Sameer H. Shah, Arika Ligmann-Zielinska
Summary: This study examines different decision-making theories in agricultural adaptation of farmers in India. Results show that utility maximization is more suitable for productivity-enhancing strategies, while self-satisficing and social norms are more closely related to the adoption of climate tolerant varieties.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Biology
Yuanyuan Feng, Xu Yang, Huining Ji, Zixin Deng, Shuangjun Lin, Jianting Zheng
Summary: Structural analysis of a Streptomyces viridochromogenes product template (PT) domain reveals molecular and functional similarities with known fungal PTs. The PT domain acts as an aldol cyclase to control the regiospecific aldol cyclization of reactive poly-beta-ketone intermediates. The bacterial PT closely resembles the dehydrase (DH) domains of modular type I polyketide synthases (PKSs) and represents an evolutionary intermediate between the two tailoring domains of type I PKSs.
COMMUNICATIONS BIOLOGY
(2022)
Article
Engineering, Chemical
Wenqi Zhou, Nuan Wen, Ziming Liu, Qi Wang, Han Tang, Jinwu Wang, Jinfeng Wang
Summary: A highly efficient deep-hole application method for liquid fertilizer based on alternate drilling was proposed in this study. The needle body is driven by a spur gear wheel system to puncture holes alternately with high speed and minimal soil disturbance. Field tests demonstrated that this method can achieve accurate fertilizer depth and hole spacing based on specific agronomic requirements.
Article
Pharmacology & Pharmacy
Kee Woong Kwon, Lee-Han Kim, Soon Myung Kang, Ju Mi Lee, Eunsol Choi, Jiyun Park, Jung Joo Hong, Sung Jae Shin
Summary: This study found that colchicine can enhance the anti-bacterial activity of macrophages against Mycobacterium tuberculosis (Mtb) through NLRP3-dependent IL-1 beta signaling and Cox-2-regulated PGE2 production. Oral administration of colchicine significantly reduces bacterial loads in the lungs and spleens in mice infected with Mtb.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xinlin Hu, Xiang Zhao, Meixing Wang, Pan Wu, Zhenghui Lu, Guimin Zhang
Summary: Rationally engineering the halophilicity of proteins is important for their efficient functioning in dehydrating conditions. This study identified that the surface charge distribution is a key structural feature determining the halophilicity of alpha-amylase Ha-Amy. By engineering local charge density on the protein surface, it is possible to tailor the protein's halophilicity. Importantly, this modification can be applied to non-catalytic domains, minimizing adverse effects on catalytic efficiency. These findings provide insights into protein salt-adaptation mechanisms and have practical applications in dehydrating conditions.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Immunology
Eleni Karakike, George N. Dalekos, Ioannis Koutsodimitropoulos, Maria Saridaki, Chryssa Pourzitaki, Georgios Papathanakos, Antigone Kotsaki, Stamatios Chalvatzis, Vasiliki Dimakopoulou, Nikolaos Vechlidis, Elisabeth Paramythiotou, Christina Avgoustou, Aikaterini Ioakeimidou, Elli Kouriannidi, Apostolos Komnos, Evangelia Neou, Nikoletta Rovina, Eleni Stefanatou, Haralampos Milionis, George Nikolaidis, Antonia Koutsoukou, Georgia Damoraki, George Dimopoulos, Vassileios Zoumpos, Jesper Eugen-Olsen, Karolina Akinosoglou, Nikolaos K. Gatselis, Vasilios Koulouras, Eleni Gkeka, Nikolaos Markou, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis
Summary: This study investigated the effect of personalized immunotherapy on critically ill COVID-19 patients. The results showed that anakinra had a favorable clinical improvement in patients with features of MALS. However, the tocilizumab treatment group had a higher incidence of secondary infections.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Pathology
Rohola Hosseini, Gerda E. M. Lamers, Erik Bos, Pancras C. W. Hogendoorn, Abraham J. Koster, Annemarie H. Meijer, Herman P. Spaink, Marcel J. M. Schaaf
Summary: The study used zebrafish larvae infected with Mycobacterium marinum as an animal model for tuberculosis. The results showed that Myd88 deficiency led to more compact granuloma structures and a reduced number of leukocytes. Additionally, the majority of bacteria in the Myd88 mutant were located extracellularly, while most bacteria in the wild type were intracellular.
Article
Computer Science, Artificial Intelligence
Kai Zhang, Qi Liu, Hao Qian, Biao Xiang, Qing Cui, Jun Zhou, Enhong Chen
Summary: This paper proposes a novel model called EATN for accurately classifying sentiment polarities towards aspects in multiple domains in sentiment analysis tasks. The model incorporates a Domain Adaptation Module (DAM) to learn common features and uses multiple-kernel selection method to reduce feature discrepancy among domains. Additionally, EATN includes an aspect-oriented multi-head attention mechanism to capture the direct associations between aspects and contextual sentiment words. Extensive experiments on six public datasets demonstrate the effectiveness and universality of the proposed method compared to current state-of-the-art methods.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Computer Science, Information Systems
Maiara Souza Coelho, Cesar A. Melo, Nelson L. S. da Fonseca
Summary: This study proposes and evaluates a video bitrate adaptation mechanism deployed in an overloaded channel of an access network, which improves the user experience in both live and on-demand modes.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Behavioral Sciences
Isidoro Riondato, Marco Gamba, Chia L. Tan, Kefeng Niu, Peter M. Narins, Yeqin Yang, Cristina Giacoma
Summary: The study found that low-pitched calls of the Guizhou snub-nosed monkey suffered less attenuation than high-pitched calls, with the monkeys emitting high-pitched calls from heights of 1.5 to 5.0 meters above the ground. This behavior, coupled with their vocal adaptations, may maximize transmission and efficacy in their natural habitat, supporting the Acoustic Adaptation Hypothesis.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kaiyun Yang, Mingtan Tang, Hao-Han Chang, Manju Kanamala, Alan James Davidson, Zimei Wu
Summary: Comparative study between non-pH-sensitive liposomes and mannosylated pH-sensitive liposomes for protein delivery to macrophages revealed that mannosylation enhanced cellular uptake and endosomal escape without affecting pH-responsiveness. GFP fluorescence acted as a probe for endosomal escape of liposomal cargo, showing efficient performance of mannosylated liposomes in facilitating intracellular delivery.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Biophysics
Ajay Goyal, Jitendra Prasad
Summary: This study aims to develop an in silico bone-adaptation model for woven bone at cellular and tissue levels. The model predicts woven bone growth based on ion diffusion and strain energy density. The results demonstrate that the model accurately predicts woven bone growth under different loading conditions, making it the first model to do so.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Review
Environmental Sciences
D. K. Gupta, D. Choudhary, A. Vishwakarma, M. Mudgal, A. K. Srivastava, A. Singh
Summary: The production of plastic in the world is a major environmental concern due to the limited recycling and the accumulation of waste, particularly microplastics, in the environment. This review focuses on the occurrence and effects of microplastics in the freshwater environment, highlighting the need for further research and understanding of their sources, distribution, characterization, and toxicological effects. It also suggests the development of a standard protocol for the identification of microplastics and proposes methods for their detection and prevention.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Komal Poonia, Pardeep Singh, Archana Singh, Sourbh Thakur, Quyet Van Le, Tansir Ahamad, Pankaj Raizada, Chuanyi Wang, Lan Huong Nguyen, Van-Huy Nguyen
Summary: This paper reviews the applications of photoelectrocatalysis in wastewater purification and energy recovery. The basics of photoelectrocatalysis, charge kinetics, photoelectrode selection and performance are discussed, along with modification strategies such as heterostructure formation and doping. The paper also presents applications of photoelectrocatalysis in hydrogen production, carbon dioxide reduction, energy production, and microbial fuel cells.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Dermatology
Rohit Gupta, Rachita Misri, Aayush Gupta, Manish Chowdhary, Archana Singh
Summary: There are pervasive transcriptional alterations in the fibroblasts of patients with non-segmental vitiligo. Downregulated genes are involved in keratinocyte-specific processes, while upregulated genes are associated with cell cycle regulation and cAMP metabolism. Experimental validation shows that melanocyte-deprived lesional fibroblasts have reduced proliferation potential.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Engineering, Environmental
Akanksha Chauhan, Anita Sudhaik, Pankaj Raizada, Aftab Aslam Parwaz Khan, Arachna Singh, Quyet Van Le, Van -Huy Nguyen, Tansir Ahamad, Sourbh Thakur, Pardeep Singh, Abdullah M. Asiri
Summary: The rapid growth of population and industries has caused major issues for environmental resources and energy. Environmental pollution is mainly caused by the discharge of hazardous pollutants into water, leading to a lack of access to clean water. Photocatalysis, particularly using Zinc selenide (ZnSe), has shown to be effective in improving the environment. This review focuses on the structural and optoelectronic properties of ZnSe and its applications in pollutant degradation and water purification, highlighting various strategies to enhance its photocatalytic activity.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Ecology
Dinesh Kumar Gupta, Amit Vishwakarma, Archana Singh
Summary: The outbreak of COVID-19 has led to a surge in the use of disposable face masks worldwide. These masks, made primarily of polypropylene and polyurethane, have become a potential source of microplastic pollutants in the environment. A study was conducted to evaluate the release of microplastic particles from N95 and surgical masks in water and the effect of temperature on this release.
REGIONAL STUDIES IN MARINE SCIENCE
(2023)
Review
Nanoscience & Nanotechnology
Anitao Sudhaik, Sonu, Vasudha Hasija, Rangabhashiyam Selvasembian, Tansir Ahamad, Arachana Singh, Aftab Aslam Parwaz Khan, Pankaj Raizada, Pardeep Singh
Summary: The top environmental problems in the contemporary era include energy shortage, waste resource recycling, and water pollution. Photocatalysis, g-C3N4 has gained attention due to its promising properties and excellent performance. Incorporating g-C3N4 with two or more semiconducting materials via heterojunction formation is an advantageous modification strategy. This review focuses on the photocatalytic applications of S-scheme-based g-C3N4 photocatalysts in pollutant degradation, H2 production, and CO2 reduction.
Article
Chemistry, Inorganic & Nuclear
Zakiullah Zaidi, Yesleen Gupta, Sorokhaibam Laxmi Gayatri, Archana Singh
Summary: This review article aims to examine the barriers to the increased use of liquid fuels in transportation, with a focus on desulfurization to reduce harmful emissions. The Environmental Protection Agency has enacted strict regulations to ensure compliance with sulfur standards. However, choosing the appropriate catalyst remains a challenge.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Palak Kamlesh, Palak Mehra, Deepika Tavar, Satya Prakash, Rajendra K. Sharma, Avanish Kumar Srivastava, Amit Paul, Archana Singh
Summary: Electrodeposition of iron oxide film was achieved without the need for controlled atmosphere by using a metal inorganic complex and non-aqueous electrolyte medium. The films deposited at higher temperatures showed improved water oxidation performance compared to those deposited at room temperature. This is the first report of electrodeposited crystalline iron-based film for alkaline oxygen evolution reaction application.
Article
Materials Science, Multidisciplinary
Deepika Tavar, R. K. Sharma, Mohammad Ashiq, Manish Mudgal, Archana Singh
Summary: Designing a low-cost electrocatalyst for oxygen evolution reaction is important. The study presents a CoMnOx catalyst anchored on reduced graphene oxide which shows high efficiency in water oxidation. The presence of rGO enhances the electrocatalytic performance and stability of the catalyst. The findings provide insights for the design of electrocatalysts in OER reaction.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Vishal Dutta, Anita Sudhaik, Tansir Sonu, Pankaj Raizada, Archana Singh, Tansir Ahamad, Sourbh Thakur, Quyet Van Le, Van-Huy Nguyen, Pardeep Singh
Summary: This study successfully reported the S-scheme-based hydrothermal synthesis of Ag-CuBi2O4/CNTs/Bi2S3 layered composites. The photocatalytic activity of nanocomposites with varying weight percent of Bi2S3 for the degradation of methyl orange (MO) and methylene blue (MB) dyes in the visible range was examined. Among the candidates, Ag-CuBi2O4/CNTs/Bi2S3 with a 10% loading of Bi2S3 showed the highest photocatalytic activity. The enhanced performance was attributed to the high surface area, reduced recombination rate of charge carriers, faster separation of photogenerated carriers, and high redox ability. The carbon nanotubes (CNTs) acted as a transfer bridge in the layered structure for electrons. The study provides an economical approach for obtaining a stable semiconductor-based photocatalytic system.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Materials Science, Multidisciplinary
Kusum Sharma, Abhinandan Kumar, Tansir Ahamad, Quyet Van Le, Pankaj Raizada, Archana Singh, Lan Huong Nguyen, Sourbh Thakur, Van-Huy Nguyen, Pardeep Singh
Summary: Vacancy engineering in metal sulfides has attracted significant attention due to its ability to modulate the optical and physiochemical properties of photocatalysts. This review article comprehensively highlights the role of S-vacancies in improving water-splitting activity and discusses various synthesis and characterization techniques for identifying vacancy defects.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Zakiullah Kamlesh, Zakiullah Zaidi, Manish Mudgal, Avanish Kumar Srivastava, Archana Singh
Summary: This study demonstrates a strategy for using electronic waste from nickel-metal hydride batteries as bifunctional electrocatalyst materials for the oxygen evolution reaction and hydrogen evolution reaction. The recycled steel-based electrodes show higher activity than commercial catalysts and have the potential for the development of economical and efficient electrodes from waste.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Satya Prakash, Deepika Kamlesh, Deepika Tavar, Sujoy Bandyopadhyay, Sandeep Singhai, Avanish Kumar Srivastava, Archana Singh
Summary: In this study, a novel water electrolysis catalyst in the form of a composite of pillared metal-organic framework (MOF) and graphene (G), denoted as Ni2Co(bdc)(2)D@G, was proposed. The electrochemical analysis showed that the Ni2Co(bdc)(2)D@G composite exhibited superior catalytic activity compared to Ni2Co(bdc)(2)D, with lower overpotential and higher current density. This improvement in performance was attributed to the synergistic effects between the MOF and graphene, the high surface area of the electrocatalyst, and the π-π interaction between the MOF and G.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Diksha Choudhary, Ankit Singh, Abhishek Giri, Harish Chandra Prasad, R. K. Sharma, Alka Mishra, Sandeep Singhai, Archana Singh
Summary: A new hybrid adsorbent, Ni(OH)2@hBN, has been developed for the removal of fluoride in groundwater. The adsorption capacity of this material is exceptionally high, surpassing that of common defluoridation adsorbents such as activated alumina and nickel oxide. The addition of functionalized boron nitride increased the surface area and provided hydroxyl group-containing sites for fluoride adsorption.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Vatika Soni, Pardeep Singh, Aftab Aslam Parwaz Khan, Arachana Singh, Ashok Kumar Nadda, Chaudhery Mustansar Hussain, Quyet Van Le, Stanislav Rizevsky, Van-Huy Nguyen, Pankaj Raizada
Summary: In recent years, photocatalysis has gained attention due to its potential applications in addressing energy and environmental challenges. The development of p-n heterojunctions in TiO2, ZnO, and other transition metal oxides is discussed as a solution to the difficulties in semiconductor photocatalysis. The benefits of constructing p-n junctions, including their impact on optical absorption and charge carrier separation, are highlighted.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
