Article
Multidisciplinary Sciences
Abby Basya Finkelstein, Heloise Leblanc, Rebecca H. Cole, Troy Gallerani, Anahita Vieira, Yosif Zaki, Steve Ramirez
Summary: This study found that stressful social experiences enhance the recall of previous fear memories in male mice, whereas social buffering of distress from conspecifics blocks this enhancement. The reactivation of cells in the dentate gyrus during the social experiences was shown to be functional components of engrams, and stimulation of these cells can drive fear-related behaviors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Behavioral Sciences
Marise B. Parent, Suzanne Higgs, Lucy G. Cheke, Scott E. Kanoski
Summary: The review highlights a bidirectional relationship between memory and eating in both humans and rodents. In humans, amnesia is linked to impaired processing of hunger cues and disrupted meal-related memory, while obesity is associated with hippocampal disturbances. Evidence from rodent studies suggests that hippocampal neural activity and endocrine/neuropeptide systems play roles in controlling meal-related memory and energy status cues. Furthermore, consumption of hypercaloric diets and obesity can disrupt these processes, leading to a potential vicious cycle contributing to diet-induced obesity.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
History & Philosophy Of Science
Jonathan Najenson
Summary: This paper evaluates the implications of applying optogenetic tools to the localization of the engram, discussing challenges to vehicle and content localization, as well as the silent engram hypothesis. Overall, the author argues that conceptions of engram localization need to be revised to align with optogenetic studies.
Review
Neurosciences
Kaori Takehara-Nishiuchi
Summary: Psychological theories suggest that the hippocampus forms associations among events rapidly and stabilizes them through interactions with the neocortex. Recent advances have allowed for a deeper understanding of the genetic, physiological, and structural mechanisms underlying systems memory consolidation.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anna Sancho-Balsells, Sara Borras-Pernas, Veronica Brito, Jordi Alberch, Jean-Antoine Girault, Albert Giralt
Summary: Chronic stress can lead to neurological disorders, such as major depression, and affects the hippocampus, leading to functional changes. The transcription factor Egr1 plays a role in hippocampal function but its involvement in stress-induced effects is not well understood. This study used mice and found that stress protocols induced activation or deactivation of hippocampal CA1 neural ensembles, along with dendritic spine pathology, in an Egr1-dependent manner. Manipulating superficial pyramidal neurons in the hippocampus resulted in the amelioration of depressive-like behaviors and cognitive impairments caused by chronic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Daniela J. Palombo, Dominoe Jones, Caroline Strang, Mieke Verfaellie
Summary: The hippocampus is crucial for episodic memory and imagination. A study examined whether amnesia is more severe when the memory content requires scene construction. The results showed that amnesic patients were equally impaired in recalling words with high and low scene imagery, suggesting that the role of the hippocampus extends to content that doesn't demand scene construction.
Review
Behavioral Sciences
Omid Miry, Jie Li, Lu Chen
Summary: This review summarizes theories and experimental evidence on hippocampal memory engram formation and function, discussing the latest advances in the field and highlighting the mechanisms of engram allocation. Unanswered questions for future investigations are identified to achieve a more comprehensive understanding of memory formation and retrieval.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Marco Sparaco, Rosario Pascarella, Carmine Franco Muccio, Marialuisa Zedde
Summary: Transient global amnesia (TGA) is a sudden onset memory disorder characterized by a temporary loss of memory for up to 24 hours, without any other neurological deficits. The diagnosis can be confirmed using Magnetic Resonance Imaging (MRI), although its practical utility in managing patients is still being debated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Marco Sparaco, Rosario Pascarella, Carmine Franco Muccio, Marialuisa Zedde
Summary: Transient global amnesia (TGA) is a clinical syndrome characterized by a temporary memory disorder with unknown etiology. Current research focuses on the vascular, epileptic, and migraine-related mechanisms, as well as the vulnerability of CA1 neurons in the hippocampus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
History & Philosophy Of Science
Peter Langland-Hassan
Summary: This paper discusses criticisms of the causal theory of memory and proposes a revised causal theory through considering the phenomenon of forgetting through repetition. The revised theory suggests that individual memory traces are shaped by multiple past experiences.
Article
Neurosciences
Jessica Leake, Raphael Zinn, Laura H. Corbit, Michael S. Fanselow, Bryce Vissel
Summary: Memories formed under inadequate learning time display maladaptive properties, with differences in neuronal activation impacting memory specificity. Larger memory engrams support better neuronal and behavioral discrimination, showing the influence of previous learning and present experience on behavior.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Bethany E. Frost, Sean K. Martin, Matheus Cafalchio, Md Nurul Islam, John P. Aggleton, Shane M. O'Mara
Summary: Lesions affecting the anterior thalamic nuclei may be responsible for diencephalic amnesia, similar to how hippocampal lesions cause temporal lobe amnesia. The core element of diencephalic amnesia seems to be the loss of information in hippocampal output regions following anterior thalamic pathology, possibly due to the direct connections between the two areas.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Mieke Verfaellie, Renee Hunsberger, Margaret M. Keane
Summary: Studies on amnesic patients with medial temporal lobe (MTL) lesions have shown inconsistent results in moral decision-making, with personal framing not affecting the participants' moral judgments. Patients with MTL damage were less willing to endorse utilitarian options and rated actions as more emotionally intense compared to controls, suggesting the necessity of episodic processes in evaluating action-outcome contingencies.
Review
Psychology, Experimental
Hans J. Markowitsch, Angelica Staniloiu
Summary: Autobiographical-episodic memory is the most complex of the five long-term memory systems. It develops late and is vulnerable to brain damage and psychiatric disorders. It is characterized by fragility and distortion, and is influenced by both brain structures and the social environment.
WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
(2023)
Article
Multidisciplinary Sciences
Akiko Wagatsuma, Teruhiro Okuyama, Chen Sun, Lillian M. Smith, Kuniya Abe, Susumu Tonegawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Takashi Kitamura, Sachie K. Ogawa, Dheeraj S. Roy, Teruhiro Okuyama, Mark D. Morrissey, Lillian M. Smith, Roger L. Redondo, Susumu Tonegawa
Review
Multidisciplinary Sciences
Sheena A. Josselyn, Susumu Tonegawa
Article
Neurosciences
Chen Sun, Wannan Yang, Jared Martin, Susumu Tonegawa
NATURE NEUROSCIENCE
(2020)
Correction
Neurosciences
Chen Sun, Wannan Yang, Jared Martin, Susumu Tonegawa
Summary: A correction to this paper has been published, please see the link for details.
NATURE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Christopher J. MacDonald, Susumu Tonegawa
Summary: The study demonstrates that spatial and temporal coding in dCA1 is largely segregated with respect to the dCA2-dCA1 circuit, suggesting that CA2 plays a critical role in representing the flow of time in memory within the hippocampal network.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Multidisciplinary Sciences
Christopher J. MacDonald, Susumu Tonegawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Daigo Takeuchi, Dheeraj Roy, Shruti Muralidhar, Takashi Kawai, Andrea Bari, Chanel Lovett, Heather A. Sullivan, Ian R. Wickersham, Susumu Tonegawa
Summary: The anterior cingulate cortex plays a critical role in allowing animals to update their behavior in response to environmental changes. This study demonstrates that the pathway from the cingulate to secondary motor cortex is necessary for updating motor rules following behavioral errors.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Andrea Bari, Sangyu Xu, Michele Pignatelli, Daigo Takeuchi, Jiesi Feng, Yulong Li, Susumu Tonegawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)