Correction
Neurosciences
Chen Sun, Wannan Yang, Jared Martin, Susumu Tonegawa
Summary: A correction to this paper has been published, please see the link for details.
NATURE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Babak Shahbaba, Lingge Li, Forest Agostinelli, Mansi Saraf, Keiland W. Cooper, Derenik Haghverdian, Gabriel A. Elias, Pierre Baldi, Norbert J. Fortin
Summary: The hippocampus plays a critical role in the temporal organization of experiences, encoding and predicting the sequential order of nonspatial event sequences.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Nitzan Geva, Daniel Deitch, Alon Rubin, Yaniv Ziv
Summary: Hippocampal activity is critical for spatial memory, but the coding of hippocampal neurons gradually changes over time, a phenomenon known as representational drift. The passage of time and the amount of experience are two factors that affect memory, but their specific influence on hippocampal representational drift is still unclear.
Article
Biology
Asako Noguchi, Kotaro Yamashiro, Nobuyoshi Matsumoto, Yuji Ikegaya
Summary: A deep neural network model can predict theta oscillations in the mouse hippocampal CA1 area based on membrane potentials of as few as three pyramidal cells. Theta oscillations are characteristic local field potentials (LFPs) in the hippocampus that occur during spatial navigation, exploratory sniffing, and rapid eye movement sleep. This study found a weak but significant correlation between the temporal evolution of theta oscillations in membrane potentials and LFP theta oscillations, and a deep neural network was able to predict LFP waveforms based on the membrane potentials of three neurons.
COMMUNICATIONS BIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Xinzhu Yu
Summary: A recent study suggests the existence of glial place cells in the hippocampus, as hippocampal astrocytes were found to encode complementary spatial information in addition to the location-specific activity of place cells.
Article
Biochemistry & Molecular Biology
Su-Min Lee, Jae-Min Seol, Inah Lee
Summary: The subiculum, located at the interface of the hippocampus and the rest of the brain, plays an important role in hippocampal-dependent memory tasks. However, its exact functions are still largely unknown. In this study, researchers used spiking phases in relation to theta rhythm to divide the broad firing fields of subicular neurons into multiple subfields. They found that subicular cells integrate multiple task-related factors using theta rhythm to associate environmental context with action.
Article
Neurosciences
Huanqiu Zhang, P. Dylan Rich, Albert K. K. Lee, Tatyana O. O. Sharpee
Summary: Neurons in the rat hippocampus represent space using a non-linear hyperbolic geometry, which provides greater positional information compared to a linear scale. The size of the representation matches the predicted number of neurons, and expands dynamically proportional to the logarithm of exploration time. These findings demonstrate how neural circuits achieve efficient representations using dynamic hyperbolic geometry.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Angelo Forli, Michael M. Yartsev
Summary: This article examines hippocampal activity in groups of bats engaged in collective spatial behavior and finds that many hippocampal neurons are tuned to key features of group dynamics. Social responses are anatomically distributed and robustly represented at the population level.
Review
Neurosciences
Dheeraj S. Roy, Ying Zhang, Michael M. Halassa, Guoping Feng
Summary: Recent studies using advanced expression profiling have revealed gene expression gradients within and across thalamic nuclei, redefining functional units of the thalamus. Thalamic subnetworks, defined by the intersection of genetics, connectivity, and computation, provide a more appropriate level of functional description.
NATURE NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Asokan Devarajan, Ke Wang, Kassandra Shannon, Yujuan Su, Jamie Verheyden, Xin Sun, Marmar Vaseghi
Summary: Significant cardiorespiratory coordination is required for maintaining physiological function, and the sensory neuronal cross-talk between the heart and the lungs is mediated by sensory neural pathways in the autonomic ganglia. The presence of cardiorespiratory neurons in the vagal ganglia suggests a pre-existing neuronal substrate for cardiorespiratory neurotransmission, which may play an important role in cardiopulmonary diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
J. Terreros-Roncal, E. P. Moreno-Jimenez, M. Flor-Garcia, C. B. Rodriguez-Moreno, M. F. Trinchero, F. Cafini, A. Rabano, M. Llorens-Martin
Summary: Disrupted hippocampal performance is a major factor contributing to psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. Adult hippocampal neurogenesis (AHN) plays a crucial role in several neurodegenerative diseases, with abnormalities found in adult-born dentate granule cells. Aging and diseases alter the neurogenic niche, reduce microglial phagocytic capacity, trigger astrogliosis, and change the microvasculature of the dentate gyrus, leading to enhanced vulnerability of AHN to neurodegeneration.
Article
Multidisciplinary Sciences
Adi Doron, Alon Rubin, Aviya Benmelech-Chovav, Netai Benaim, Tom Carmi, Ron Refaeli, Nechama Novick, Tirzah Kreisel, Yaniv Ziv, Inbal Goshen
Summary: This study used two-photon microscopy to investigate the real-time calcium activity of astrocytes in the hippocampus of awake mice. The researchers found that astrocytes exhibit persistent ramping activity towards the reward location in a familiar environment, but not in a new one. Shifting the reward location within a familiar environment also resulted in diminished ramping. After additional training, the ramping activity was re-established.
Article
Cell Biology
Barnabas Kocsis, Sergio Martinez-Bellver, Richard Fiath, Andor Domonkos, Katalin Sviatko, Daniel Schlingloff, Peter Bartho, Tamas F. Freund, Istvan Ulbert, Szabolcs Kali, Viktor Varga, Balazs Hangya
Summary: Episodic learning and memory retrieval are dependent on the GABAergic network of the medial septum, which achieves theta synchrony through synchronization of pacemakers and glutamatergic neurons. These findings provide experimental and theoretical support for a frequency-synchronization mechanism for pacing hippocampal theta.
Article
Neurosciences
Karen Safaryan, Mayank R. Mehta
Summary: Hippocampal theta rhythm plays a vital role in neuroplasticity, learning, and memory, with variations across species. Running in virtual reality greatly amplifies theta rhythmicity and can even lead to the emergence of a novel rhythm, indicating that multisensory experience influences hippocampal rhythms. Virtual reality can be utilized to enhance or regulate brain rhythms and influence neural dynamics, connections, and plasticity.
NATURE NEUROSCIENCE
(2021)
Article
Biology
Shogo Soma, Shinya Ohara, Satoshi Nonomura, Naofumi Suematsu, Junichi Yoshida, Eva Pastalkova, Yutaka Sakai, Ken-Ichiro Tsutsui, Yoshikazu Isomura
Summary: Electrophysiological recordings in rats show that the hippocampal CA1 region represents learning-related action and reward events faster than the lateral entorhinal cortex. The timing of representation of action and reward events differs between the two regions. Additionally, ramping activity towards spontaneous action is correlated with waiting time in both regions, suggesting the involvement of the entorhinal-hippocampal circuits in optimizing behaviors.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Takashi Kitamura, Chen Sun, Jared Martin, Lacey J. Kitch, Mark J. Schnitzer, Susumu Tonegawa
Article
Multidisciplinary Sciences
Akiko Wagatsuma, Teruhiro Okuyama, Chen Sun, Lillian M. Smith, Kuniya Abe, Susumu Tonegawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Dheeraj S. Roy, Shruti Muralidhar, Lillian M. Smith, Susumu Tonegawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Takashi Kitamura, Sachie K. Ogawa, Dheeraj S. Roy, Teruhiro Okuyama, Mark D. Morrissey, Lillian M. Smith, Roger L. Redondo, Susumu Tonegawa
Review
Multidisciplinary Sciences
Sheena A. Josselyn, Susumu Tonegawa
Correction
Neurosciences
Chen Sun, Wannan Yang, Jared Martin, Susumu Tonegawa
Summary: A correction to this paper has been published, please see the link for details.
NATURE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Christopher J. MacDonald, Susumu Tonegawa
Summary: The study demonstrates that spatial and temporal coding in dCA1 is largely segregated with respect to the dCA2-dCA1 circuit, suggesting that CA2 plays a critical role in representing the flow of time in memory within the hippocampal network.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Multidisciplinary Sciences
Christopher J. MacDonald, Susumu Tonegawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Daigo Takeuchi, Dheeraj Roy, Shruti Muralidhar, Takashi Kawai, Andrea Bari, Chanel Lovett, Heather A. Sullivan, Ian R. Wickersham, Susumu Tonegawa
Summary: The anterior cingulate cortex plays a critical role in allowing animals to update their behavior in response to environmental changes. This study demonstrates that the pathway from the cingulate to secondary motor cortex is necessary for updating motor rules following behavioral errors.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Andrea Bari, Sangyu Xu, Michele Pignatelli, Daigo Takeuchi, Jiesi Feng, Yulong Li, Susumu Tonegawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Dheeraj S. Roy, Takashi Kitamura, Teruhiro Okuyama, Sachie K. Ogawa, Chen Sun, Yuichi Obata, Atsushi Yoshiki, Susumu Tonegawa