Article
Immunology
Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, Jan Dobes, Dieter Weichenhan, Marion Bahr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A. Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson
Summary: This study reveals the importance of FOXN1 in the development of thymic epithelial cells and hair follicle cells, and identifies key regulatory regions and transcription factors involved in its expression.
SCIENCE IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yongsheng Jia, Krithika N. Kodumudi, Ganesan Ramamoorthi, Amrita Basu, Colin Snyder, Doris Wiener, Shari Pilon-Thomas, Payal Grover, Hongtao Zhang, Mark Greene, Qianxing Mo, Zhongsheng Tong, Yong-Zi Chen, Ricardo L. B. Costa, Hyo Han, Catherine Lee, Hatem Soliman, Jose R. Conejo-Garcia, Gary Koski, Brian J. Czerniecki
Summary: The study reveals the impact of Th1 immune response on HER2 breast cancer, showing that IFN-gamma can regulate HER2 through the PDP pathway. Treatment with IFN-gamma or Th1-polarizing anti-HER2 vaccine can lead to decreased surface HER2 expression and induction of tumor senescence in HER2-resistant mammary carcinoma, demonstrating therapeutic potential through anti-tumor immunity.
Review
Biochemistry & Molecular Biology
Rahul Pandey, Marina Bakay, Hakon Hakonarson
Summary: CLEC16A is an important genetic risk factor for autoimmune disorders and Parkinson's disease, and it plays a critical role in various biological processes. Further functional studies are needed to fully understand the mechanisms involved, but mitophagy-inducing drugs may present an effective therapy for individuals with CLEC16A risk variants. This review discusses the emerging role of CLEC16A in health and disease and its potential applications in the clinic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Julie M. Mazet, Jagdish N. Mahale, Orion Tong, Robert A. Watson, Ana Victoria Lechuga-Vieco, Gabriela Pirgova, Vivian W. C. Lau, Moustafa Attar, Lada A. Koneva, Stephen N. Sansom, Benjamin P. Fairfax, Audrey Gerard
Summary: This study reveals that IFN-gamma directly acts on intra-tumoral CD8 T cells to restrict anti-tumor responses. The loss of sensitivity to IFN-gamma contributes to successful antitumor immunity. IFN-gamma inhibits the maintenance, clonal diversity, and proliferation of stem-like T cells, leading to decreased generation of T cells with intermediate expression of exhaustion markers.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Huaxing Huang, Jiafeng Liu, Mingsen Li, Huizhen Guo, Jin Zhu, Liqiong Zhu, Siqi Wu, Kunlun Mo, Ying Huang, Jieying Tan, Chaoqun Chen, Bofeng Wang, Yankun Yu, Li Wang, Yizhi Liu, Hong Ouyang
Summary: This study investigates the regulatory network involved in the acquisition of cell fate, focusing on the induction of surface epithelium from human embryonic stem cells. By analyzing changes in morphology-related genes and the remodeling of the cytoskeleton, the study identifies grainyhead-like 3 (GRHL3) as an initiation factor that drives the commitment to surface epithelium fate. Furthermore, the study uncovers a positive feedback loop between GRHL3 and bone morphogenetic protein 4 in regulating surface epithelium fate decisions.
Article
Oncology
In-Young Jung, Robert L. Bartoszek, Andrew J. Rech, Sierra M. Collins, Soon-Keat Ooi, Erik F. Williams, Caitlin R. Hopkins, Vivek Narayan, Naomi B. Haas, Noelle V. Frey, Elizabeth O. Hexner, Donald L. Siegel, Gabriela Plesa, David L. Porter, Adrian Cantu, John K. Everett, Sonia Guedan, Shelley L. Berger, Frederic D. Bushman, Friederike Herbst, Joseph A. Friederike
Summary: CAR T cell therapy has shown potential in treating hematologic cancers but is limited in solid tumors. Chronic stimulation of CAR T cells propagates inhibitory type I interferon signaling, hindering antitumor function. Knocking out the EGR2 transcriptional regulator improves CAR T cell efficacy and blocks interferon-induced dysfunction. The gene signature of EGR2 is a biomarker for CAR T cell failure and patient survival. Modulating CAR T cell-intrinsic resistance is crucial for improving therapy outcomes.
Article
Multidisciplinary Sciences
Simeon R. Mihaylov, Lydia M. Castelli, Ya-Hui Lin, Aytac Gul, Nikita Soni, Christopher Hastings, Helen R. Flynn, Oana Paun, Mark J. Dickman, Ambrosius P. Snijders, Robert Goldstone, Oliver Bandmann, Tatyana A. Shelkovnikova, Heather Mortiboys, Sila K. Ultanir, Guillaume M. Hautbergue
Summary: The RS domain of PGC-1α directly interacts with RNA and the nuclear RNA export receptor NXF1, and this RNA-binding activity is required for the nuclear export of mitochondrial-related mRNAs and mitochondrial homeostasis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Dilsad Herkiloglu, Sefik Gokce, Ozge Cevik
Summary: The present study reveals the association between IFN-gamma and IRF5 with missed abortion, showing that their protein levels and gene expression levels are significantly increased in cases of missed abortion. These findings suggest that IFN-gamma and IRF5 play an important role in placental invasion and pregnancy, and can be used as markers for endometrial implantation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Editorial Material
Multidisciplinary Sciences
Maggie P. Lauria Sneideman, Victoria H. Meller
Summary: A protein that upregulates gene expression of the X chromosome has been discovered in male mosquitoes, which is crucial for equalizing gene expression between sexes in organisms with X and Y chromosomes.
Article
Biochemistry & Molecular Biology
Yongsheng Huang, Qian Yang, Yueyuan Zheng, Lehang Lin, Xin Xu, Xiu-E Xu, Tiago C. Silva, Masaharu Hazawa, Li Peng, Haotian Cao, Yanbing Ding, Daning Lu, Benjamin P. Berman, Li-Yan Xu, En-Min Li, Dong Yin
Summary: The study identifies DLX5 as a significant SCC-promoting factor, showing a distinct bivalent reconfiguration of its promoter in normal tissues versus cancer, where it is co-regulated by SOX2 in ESCC. Silencing of DLX5 significantly inhibits SCC viability and collaborates with TP63 to regulate thousands of enhancers and promoters, activating cancer-promoting pathways.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Immunology
Qiang Li, Weicong Ren, Jinfeng Yuan, Haiping Guo, Yuanyuan Shang, Wei Wang, Junhua Pan, Mengqiu Gao, Yu Pang
Summary: This study compared the host immunological response to TB-specific antigens between active TB patients with positive and negative IGRA results. It found that the combination of IFN-γ and IL-4 performed well in identifying TB infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chau Yee Ng, Yen-Chuan Chiu, Yu-Pei Chan, Yu- Lin, Pei-Han Chung, Wen-Hung Chung, Cheng-Lung Ku
Summary: This study aims to evaluate the cytokine expression profiles in the skin and plasma and the utility of the biomarker panel in assessing disease activity, severity, and prognosis in patients with vitiligo. The results showed that IFN-gamma, CXCL9, CXCL10, and GzmB are highly expressed in vitiligo patients' lesion skin and plasma and may serve as biomarkers for the clinical activity, severity, and prognosis prediction in vitiligo patients. Among all, IFN-gamma exerts the highest predictive value in disease activity and treatment response, supporting the critical role of IFN-gamma in the pathogenesis of vitiligo.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Anthony S. Bonavia, Abigail Samuelsen, Zissis C. Chroneos, Eric Scott Halstead
Summary: We describe a rapid and precise assay for functional interrogation of the innate and adaptive immune system in healthy volunteers. The advantages of the ELLA microfluidic platform may represent a step forward in generating a point-of-care test with clinical utility for identifying deranged immune phenotypes in septic patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dinesh Kankanamge, Mithila Tennakoon, Ajith Karunarathne, N. Gautam
Summary: This review focuses on the current knowledge about the potential roles and mechanisms of the gamma subunits of heterotrimeric G proteins. Loss or dysregulation of specific gamma subunit types can result in different phenotypes and even cancers. Imaging studies have revealed that the membrane affinity of gamma subunits controls the sensitivity and adaptation of cells to external signals.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Biochemical Research Methods
Kaylin Cleo Januarie, Onyinyechi V. Uhuo, Emmanuel Iwuoha, Usisipho Feleni
Summary: Tuberculosis is a major infectious disease worldwide caused by Mycobacterium tuberculosis, with early diagnosis and treatment being crucial for control. However, current TB sensing techniques like ELISA and IGRAs have limitations in sensitivity and stage differentiation. Novel biosensor and microfluidic approaches show promise in improving interferon-gamma detection for TB diagnosis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Felicitas Bucher, Jungho Lee, Sanghee Shin, Minseok S. Kim, Yong-Seok Oh, Sanghoon Ha, Hongkai Zhang, Kyungmoo Yea
Article
Biochemistry & Molecular Biology
Felicitas Bucher, Mollie S. H. Friedlander, Edith Aguilar, Toshihide Kurihara, Tim U. Krohne, Yoshihiko Usui, Martin Friedlander
NEUROCHEMISTRY INTERNATIONAL
(2019)
Article
Ophthalmology
Hansjuergen Agostini, Zufar Mulyukov, Miltiadis Tsilimbaris, Pilar Calvo, Felicitas Bucher, David Gaucher, Etienne Pigeolet, Valeria Colafrancesco, Andreas Clemens
CURRENT EYE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Dokyung Jung, Felicitas Bucher, Suyeon Ryu, Jongwon Jeong, Beom Yong Lee, Youngtae Jeong, Minseok S. Kim, Yong-Seok Oh, Moon-Chang Baek, Jong Hyuk Yoon, Kyungmoo Yea
Article
Ophthalmology
Felicitas Bucher, Moritz Claudius Daniel, Daniel Boehringer, Clemens Lange, Thomas Reinhard, Hansjuergen Agostini, Stefan J. Lang
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2020)
Article
Pathology
Anja Schlecht, Stefaniya Boneva, Markus Gruber, Peipei Zhang, Ralf Horres, Felicitas Bucher, Claudia Auw-Haedrich, Lutz Hansen, Andreas Stahl, Ingo Hilgendorf, Hansjurgen Agostini, Peter Wieghofer, Gunther Schlunck, Julian Wolf, Clemens A. K. Lange
AMERICAN JOURNAL OF PATHOLOGY
(2020)
Article
Multidisciplinary Sciences
Sonya Neal, Della Syau, Anahita Nejatfard, Samantha Nadeau, Randolph Y. Hampton
Article
Multidisciplinary Sciences
Pingdewinde N. Sam, Elizabeth Calzada, Michelle Grace Acoba, Tian Zhao, Yasunori Watanabe, Anahita Nejatfard, Jonathan C. Trinidad, Timothy E. Shutt, Sonya E. Neal, Steven M. Claypool
Summary: The majority, if not all, functional Psd1 was found to be located in the mitochondrion, despite previous doubts. Mutant forms of Psd1 impairing a self-processing step can be dual-localized to the ER in a PE-limiting environment. This study suggests that severely impaired cellular PE metabolism triggers an ER-assisted adaptive response.
Article
Ophthalmology
Michael Reich, Sabine Jaegle, Elke Neumann-Haefelin, Jan-Helge Klingler, Charlotte Evers, Moritz Daniel, Felicitas Bucher, Franziska Ludwig, Simone Nuessle, Julia Kopp, Daniel Boehringer, Thomas Reinhard, Wolf A. Lagreze, Clemens Lange, Hansjuergen Agostini, Stefan J. Lang
Summary: This study found that the onset age and incidence of HR, CNSH, ccRCC, and PNEN in VHL patients are closely related to the type of genetic mutation, with patients with TV mutations showing higher incidence rates and earlier onset ages compared to those with AASD mutations, indicating a need for closer ophthalmological monitoring.
ACTA OPHTHALMOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Inseong Jung, Dokyung Jung, Zhao Zha, Jongwon Jeong, Soojeong Noh, Jiwon Shin, Jun-Kook Park, Kwang-Soo Kim, Youngtae Jeong, Jin Hur, Moon-Chang Baek, Sophia Diaz-Aguilar, Edith Aguilar, Martin Friedlander, Felicitas Bucher, Kyungmoo Yea
Summary: IFNG exhibits potent anti-angiogenic potential against VEGFa-induced angiogenesis by inhibiting proliferation, migration, and tube formation of HUVECs. Knockdown of STAT1 abolishes the inhibitory effect of IFNG on VEGFa-induced angiogenic processes. In a mouse model, IFNG shows strong anti-angiogenic efficacy without inducing functional side effects.
Article
Cell Biology
Anahita Nejatfard, Nicholas Wauer, Satarupa Bhaduri, Adam Conn, Saroj Gourkanti, Narinderbir Singh, Tiffany Kuo, Rachel Kandel, Rommie E. Amaro, Sonya E. Neal
Summary: A recent study identified a new protein, Dfm1, that plays a key role in retrotranslocation process, with conserved residues critical for this function. Additionally, it was found that Dfm1 possesses lipid thinning function to facilitate the removal of ER membrane substrates, a feature also conserved in its human homolog, Derlin-1.
Article
Ophthalmology
Anke Schmid, Felicitas Bucher, Erika Liczenczias, Sara Maslanka Figueroa, Bettina Mueller, Hansjuergen Agostini
Summary: This survey aimed to identify the factors and information that influence how patients with neovascular age-related macular degeneration (nAMD) handle their disease. A total of 5035 patients with nAMD in Germany were interviewed via an online survey. The results showed that most patients had sufficient understanding of the disease and were aware of the need for regular control and treatment. However, their knowledge about the risk factors for AMD, such as hereditary load and smoking, was limited.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Cell Biology
Dokyung Jung, Sanghee Shin, Sung-Min Kang, Inseong Jung, Suyeon Ryu, Soojeong Noh, Sung-Jin Choi, Jongwon Jeong, Beom Yong Lee, Kwang-Soo Kim, Christine Seulki Kim, Jong Hyuk Yoon, Chan-Hyeong Lee, Felicitas Bucher, Yong-Nyun Kim, Sin-Hyeog Im, Byoung-Joon Song, Kyungmoo Yea, Moon-Chang Baek
Summary: IL2-sEVs are potential cancer immunotherapeutic agents that regulate both immune and cancer cells by reprogramming miRNA levels, and improve anti-cancer efficacy by decreasing PD-L1 expression.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Ophthalmology
Michael Reich, Daniel Boehringer, Bertan Cakir, Felicitas Bucher, Moritz Daniel, Stefan Lang, Wolf Lagreze, Hansjuergen Agostini, Clemens Lange
OPHTHALMOLOGY AND THERAPY
(2019)
Article
Multidisciplinary Sciences
Moritz C. Daniel, Lisa Atzrodt, Felicitas Bucher, Katrin Wacker, Stefan Bohringer, Thomas Reinhard, Daniel Boehringer
SCIENTIFIC REPORTS
(2019)
