期刊
POLYMER CHEMISTRY
卷 8, 期 13, 页码 1999-2004出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7py00270j
关键词
-
资金
- Ministry of Education, Youth and Sports [LH14079, LO1507]
- Czech Science Foundation [16-02870S, 15-13853S, 17-09998S]
- National Science Foundation through the University of Minnesota MRSEC, Award [DMR-1420013]
A new reactive oxygen species (ROS)-sensitive, self-immolative biodegradable polyoxalate prodrug based on the anticancer chemotherapeutic hormone analog diethylstilbestrol was synthesized via one-pot step-growth polymerization. The nanoparticles prepared from this prodrug undergo self-immolative degradation releasing the chemotherapeutic drug in ROS-rich environments, e.g., in cancer cells. This new ROS self-immolative polyprodrug backbone eliminates the need for a linker between polymer chain and drug, resulting in a more specific drug release and minimized toxic side effects to non-ROS-producing cells as proven by in vitro experiments. The strategy enables re-utilization of a successful chemotherapeutic agent that has been clinically under-utilized due to dose-related side effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据