Article
Cell Biology
Shunpan Shu, Mingsheng Jiang, Xue Deng, Wenkai Yue, Xu Cao, Kai Zhang, Zeqing Wang, Hao He, Jihong Cui, Qiangqiang Wang, Kun Qu, Yanshan Fang
Summary: In this study, the downregulation of the Drosophila gene CG32529/GLAD in adult flies led to shortened lifespan and age-dependent brain degeneration. The regulation mainly affected the surface glia and cortex glia, disrupting the blood-brain barrier and glial meshwork. The upregulation of immune-related genes was found to be the most significant transcriptional change in response to RNAi-GLAD.
Article
Food Science & Technology
Hui Shi, Xuqiao Hu, Hang Zheng, Chunlei Li, Lianli Sun, Zhongyi Guo, Weijuan Huang, Rongmin Yu, Liyan Song, Jianhua Zhu
Summary: Two novel antioxidant peptides, D2-G1S-1 and G2-G1S-2, identified from Arca subcrenata exhibited potent antioxidant activities, extending the mean lifespan of Caenorhabditis elegans and improving age-associated physiological functions. These peptides could potentially be developed as cosmetics additives.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Multidisciplinary Sciences
Aranzazu Arias-Rojas, Dagmar Frahm, Robert Hurwitz, Volker Brinkmann, Igor Iatsenko
Summary: This study reveals that commensal-encoded resilience mechanisms, including resistance to antimicrobial peptides (AMPs), are necessary to maintain the stable association between host and microbiota during inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
YeongHo Kim, Gyuhyeong Goh, Young Ho Kim
Summary: Research found that Drosophila melanogaster exhibited higher survival rates when exposed to environmental chemicals compared to D. suzukii. AMPs expressed in D. melanogaster were also more abundant, particularly in the gut and fat body. AMPs regulated by the IMD pathway play a crucial role in the chemical tolerance of D. melanogaster, enabling these flies to adapt to their habitats through physiological responses.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Cell Biology
Nan Xin, Jenni Durieux, Chunxia Yang, Suzanne Wolff, Hyun-Eui Kim, Andrew Dillin
Summary: The mitochondrial unfolded protein response (UPRmt) maintains mitochondrial proteostasis by regulating the transcription factor ATFS-1. After UPRmt activation, ATFS-1 enters the nucleus to regulate UPRmt genes. The study found that despite reduced mitochondrial membrane potential, mitochondrial import increases during UPRmt activation, and an intact import machinery is essential for UPRmt-mediated lifespan extension.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Entomology
Minli Dai, Jin Yang, Xinyi Liu, Haoyi Gu, Fanchi Li, Bing Li, Jing Wei
Summary: This study revealed the changes in gene expression in the fat body of the silkworm parasitized by dipteran tachinid parasitoids through transcriptome analysis. It was found that the parasitoids perturb the host's basal metabolism, induce the host's immune response, and lead to incomplete larval-pupal ecdysis of the host.
Article
Biochemistry & Molecular Biology
Xiaohan Zhang, Hao Wang, Ying Han, Ya Pei, Yatu Guo, Steve W. Cui
Summary: Purple sweet potatoes extract (PSPE) can extend lifespan, enhance antioxidant capacity, maintain intestinal homeostasis, improve intestinal barrier function and prevent aging-related complications in fruit flies through various mechanisms.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Yan Zhang, Ada W. C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G. E. Marsh, Robert Busch, Derek C. Macallan, Becca Asquith
Summary: Inhibitory killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses and affect T cell lifespan. The iKIR-ligand genotype is significantly associated with CD8+ T cell lifespan, with individuals having 4 iKIR-ligand gene pairs having double the lifespan compared to individuals with 2 gene pairs. The iKIR-ligand genotype also alters the immune aging phenotype of CD8+ and CD4+ T cells.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Qianqian Wang, Junhui Zhang, Jiachen Zhuang, Fei Shen, Minjie Zhao, Juan Du, Peng Yu, Hao Zhong, Fengqin Feng
Summary: This study found that supplementation with soft-shelled turtle peptides could prolong the lifespan and healthspan of fruit flies. It improved antioxidant, starvation, and heat stress abilities, and achieved anti-aging effects by enhancing autophagy and reducing oxidative stress through the downregulation of the target of rapamycin signaling pathway.
Article
Food Science & Technology
Andrea Torreggiani, Marzia Beccaccioli, Michela Verni, Valentina Cecchetti, Andrea Minisci, Massimo Reverberi, Erica Pontonio, Carlo Giuseppe Rizzello
Summary: The extract obtained from Trametes versicolor has shown strong antifungal activity, which can extend the shelf-life of baked goods. Sour bread made with the Trametes extract and sourdough has a longer mold-free shelf-life and less impact on the leavening performance, texture, and sensory features of bread.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biophysics
Emanuelle D. Freitas, Rogerio A. Rataglioli, Josephine Oshodi, Marisa M. Beppu
Summary: The coronavirus pandemic has highlighted the importance of bioactive materials in mitigating viral infections. Bioinspired antimicrobial peptides (AMPs) have emerged as suitable building blocks for antimicrobial coatings due to their versatile design and environmentally friendly features. This review discusses the advances and opportunities in using AMPs to create virucidal coatings, including the fundamental characteristics of peptide structure, advances in coating medical devices, and the role of different materials in designing antiviral coatings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Editorial Material
Genetics & Heredity
Kristopher Burkewitz
Summary: Transcriptional elongation rates affect transcript quality and alternative splicing during aging in animals. Recent research suggests that interventions that slow elongation rates can delay senescence and promote longevity.
TRENDS IN GENETICS
(2023)
Article
Cell Biology
Kira Allmeroth, Matias D. Hartman, Martin Purrio, Andrea Mesaros, Martin S. Denzel
Summary: This study found that glucosamine supplementation had no significant effects on weight, metabolism, and tolerance in mice, but positively affected memory in male mice. Genetic activation of the HBP pathway did not result in any changes in behavior, memory, or survival.
Article
Biochemistry & Molecular Biology
Jonathan D. Dorigatti, Kevin M. Thyne, Brett C. Ginsburg, Adam B. Salmon
Summary: Activation of AMP activated protein kinase (AMPK) signaling has been shown to extend lifespan and improve healthspan across multiple species. However, supplementing fruit flies with beta-guanidinopropionic acid (GPA) did not extend lifespan and may actually have detrimental effects on stress resistance and lifespan, highlighting the importance of replication studies in the field of aging.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Nutrition & Dietetics
Haitao Zhou, Shanshan Ding, Chuanxin Sun, Jiahui Fu, Dong Yang, Xie Wang, Chih-chen Wang, Lei Wang
Summary: This study found that the water extract of Lycium barbarum berry can extend the lifespan of Caenorhabditis elegans, with a more prominent effect in worms with shorter lifespans. The lifespan extension effect is dependent on the deacetylase sir-2.1 and can rescue the deficiency of heat shock transcription factor-1 (hsf-1). Furthermore, Lycium barbarum berry extract can also extend lifespan and alleviate toxic protein aggregation in neurodegenerative worms with hsf-1 deficiency.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Tetsushi Mori, Jackson K. B. Cahn, Micheal C. Wilson, Roy A. Meoded, Vincent Wiebach, Ana Flavia Canovas Martinez, Eric J. N. Helfrich, Andreas Albersmeier, Daniel Wibberg, Steven Datwyler, Ray Keren, Adi Lavy, Christian Rueckert, Micha Ilan, Joern Kalinowski, Shigeki Matsunaga, Haruko Takeyama, Joern Piel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Michihiro Ito, Kotaro Watanabe, Toru Maruyama, Tetsushi Mori, Kentaro Niwa, Seinen Chow, Haruko Takeyama
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Medicinal
Toshiyuki Shibata, Reona Fujii, Yoshihiko Nishioka, Hideo Miyake, Tetsushi Mori, Reiji Tanaka
NATURAL PRODUCT COMMUNICATIONS
(2019)
Article
Microbiology
Yukino Mizutani, Shunpei Iehata, Tetsushi Mori, Ryota Oh, Satoshi Fukuzaki, Reiji Tanaka
Article
Microbiology
Daichi Toyohara, Yasuhito Yokoi, Go Inoue, Takahiro Muraoka, Tetsushi Mori
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Maho Kashitani, Taiki Okabe, Hikaru Oyama, Kaede Noguchi, Haruka Yamazaki, Rei Suo, Tetsushi Mori, Haruo Sugita, Shiro Itoi
MARINE BIOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Yukino Mizutani, Tetsushi Mori, Taeko Miyazaki, Satoshi Fukuzaki, Reiji Tanaka
Article
Biochemistry & Molecular Biology
Yuzuki Tanaka, Yoshihiro Murase, Toshiyuki Shibata, Reiji Tanaka, Tetsushi Mori, Hideo Miyake
Summary: In this study, recombinant enzymes were prepared and immobilized to efficiently convert alginate into DEH. The immobilized enzymes showed high activity even after repeated use, resulting in a relatively high DEH yield.
Article
Microbiology
Abdullah Adham Zulmajdi, Tatsuru Okazaki, Tetsushi Mori
Summary: This article introduces a strain Kangiella sp. TOML190 from the surface of a crustacean, and genetic background analysis reveals its unique features possibly related to symbiotic adaptation to its host.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Biotechnology & Applied Microbiology
Hikaru Oyama, Masaaki Ito, Rei Suo, Naoko Goto-Inoue, Mizuki Morisasa, Tsukasa Mori, Haruo Sugita, Tetsushi Mori, Ryota Nakahigashi, Masaatsu Adachi, Toshio Nishikawa, Shiro Itoi
Summary: In the toxic flatworm Planocera multitentaculata, the localization of tetrodotoxin (TTX) and its analogues varies during different stages of maturity, with 5,6,11-trideoxyTTX being abundant during spawning and 11-norTTX-6(S)-ol consistently localized in the pharyngeal tissue.
MARINE BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yasuhito Yokoi, Yugo Kawabuchi, Abdullah Adham Zulmajdi, Reiji Tanaka, Toshiyuki Shibata, Takahiro Muraoka, Tetsushi Mori
Summary: The use of CPP-PNA conjugates helps elucidate the function of unknown proteins in native bacteria, providing a simple and efficient alternative for the lack of screening methods.
Article
Nanoscience & Nanotechnology
Go Inoue, Daichi Toyohara, Tetsushi Mori, Takahiro Muraoka
Summary: The study found that elongating the main chain and shortening the side chain can enhance the permeation efficiency of cationic short peptides through bacterial cell membranes. Among the investigated BCPPs, the 2,3-diaminopropionic acid nonamer showed the highest permeation efficiency into bacterial cells of diverse strains, enabling the transport of oligo peptide nucleic acids and subsequent growth inhibition.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Medicinal
Shingo Sugiura, Ryosuke Taniguchi, Yoshihiko Nishioka, Ryota Iwase, Reiji Tanaka, Hideo Miyake, Tetsushi Mori, Mitsuyoshi Ueda, Toshiyuki Shibata
NATURAL PRODUCT COMMUNICATIONS
(2018)
Article
Chemistry, Medicinal
Shingo Sugiura, Yuya Midami, Ryosuke Taniguchi, Reiji Tanaka, Hideo Miyake, Tetsushi Mori, Mitsuyoshi Ueda, Toshiyuki Shibata
NATURAL PRODUCT COMMUNICATIONS
(2017)
Meeting Abstract
Chemistry, Medicinal
Franziska Hemmerling, Masato Kogawa, Masahito Hosokawa, Masahiro Ando, Tetsushi Mori, Hanna Maciejewska-Rodrigues, Jackson K. B. Cahn, Haruko Takeyama, Jorn Piel