Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

(2016) Pamela A. Haile et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for the Non-catalytic Functions of Protein Kinases

(2016) Jennifer E. Kung et al.   STRUCTURE

How Do Protein Kinases Take a Selfie (Autophosphorylate)?

(2016) Jonah Beenstock et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity

(2015) Adam K. Charnley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

(2015) Peter Canning et al.   CHEMISTRY & BIOLOGY

The emerging role of native mass spectrometry in characterizing the structure and dynamics of macromolecular complexes

(2015) Elisabetta Boeri Erba et al.   PROTEIN SCIENCE

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

(2015) Ueli Nachbur et al.   Nature Communications

The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling

(2014) Aaron T. Irving et al.   Cell Host & Microbe

In VivoInhibition of RIPK2 Kinase Alleviates Inflammatory Disease

(2014) Justine T. Tigno-Aranjuez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRAK4 Dimerization and trans -Autophosphorylation Are Induced by Myddosome Assembly

(2014) Ryan Ferrao et al.   MOLECULAR CELL

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation

(2014) Neroshan Thevakumaran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

(2014) Adelajda Zorba et al.   eLife

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

(2013) Jiancheng Hu et al.   CELL

Receptor-Interacting Protein 2 Gene Silencing Attenuates Allergic Airway Inflammation

(2013) F. Y. Goh et al.   JOURNAL OF IMMUNOLOGY

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

(2013) Philip A. Harris et al.   ACS Medicinal Chemistry Letters

Structural Insights into RIP3-Mediated Necroptotic Signaling

(2013) Tian Xie et al.   Cell Reports

Massign: An Assignment Strategy for Maximizing Information from the Mass Spectra of Heterogeneous Protein Assemblies

(2012) Nina Morgner et al.   ANALYTICAL CHEMISTRY

A Dual Role for Receptor-interacting Protein Kinase 2 (RIP2) Kinase Activity in Nucleotide-binding Oligomerization Domain 2 (NOD2)-dependent Autophagy

(2012) Craig R. Homer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

(2012) Catherine Leimkuhler Grimes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands

(2011) Joao G. Magalhaes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR2 and RIP2 Pathways Mediate Autophagy ofListeria monocytogenesvia Extracellular Signal-regulated Kinase (ERK) Activation

(2011) Paras K. Anand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Glu–Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase Fold

(2011) Jie Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase

(2011) Jue Wang et al.   STRUCTURE

The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation

(2011) Michael H. Shaw et al.   TRENDS IN IMMUNOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses

(2010) J. T. Tigno-Aranjuez et al.   GENES & DEVELOPMENT

Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding

(2010) Apratim Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis

(2009) Ikuo Okafuji et al.   ARTHRITIS AND RHEUMATISM

Defining the conserved internal architecture of a protein kinase

(2009) Alexandr P. Kornev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Kinase Activity of Rip2 Determines Its Stability and Consequently Nod1- and Nod2-mediated Immune Responses

(2009) Chiara Nembrini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ID23-2 structural biology microfocus beamline at the ESRF

(2009) David Flot et al.   JOURNAL OF SYNCHROTRON RADIATION

Large-scale Proteomics Analysis of the Human Kinome

(2009) Felix S. Oppermann et al.   MOLECULAR & CELLULAR PROTEOMICS

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

(2008) G. Y. Chen et al.   CANCER RESEARCH