Article
Respiratory System
Janette K. Burgess, Marnix R. Jonker, Marijn Berg, Nick T. H. ten Hacken, Kerstin B. Meyer, Maarten van den Berge, Martijn C. Nawijn, Irene H. Heijink
Summary: POSTN may serve as a biomarker for Type-2 mediated eosinophilic airway inflammation in asthma. IL-13 increases POSTN expression in bronchial epithelial cells and is higher in bronchial biopsies from asthma patients.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Critical Care Medicine
Ryan C. Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C. Altman, William A. Altemeier, Charles W. Frevert, Jason S. Debley, Adrian M. Piliponsky, Steven F. Ziegler, Sina A. Gharib, Teal S. Hallstrand
Summary: This study identified differentially expressed genes associated with exercise-induced bronchoconstriction in individuals with asthma using RNA-sequencing analysis. Experiments suggested that the interactions between airway epithelial cells, mast cells, and eosinophils are closely associated with indirect airway hyperresponsiveness and play a critical role in modulating airway inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Giuseppina Bertorelli, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta
Summary: AHR is a central pathophysiological feature of asthma, involving ASM with pro-inflammatory and immunomodulatory actions. mAbs target various inflammatory mediators to modulate ASM contractility, showing potential in treating severe asthma by preventing AHR.
Review
Pharmacology & Pharmacy
Mojdeh Matloubi, Latifa Koussih, Lianyu Shan, Chelsea Lukawy, Abdelilah S. Gounni
Summary: Asthma is a heterogeneous airway disease characterized by airway inflammation and remodeling, affecting more than 300 million people worldwide and posing a significant burden on society. Semaphorin3E, a critical molecule in lung pathophysiology, plays a role in both lung development and homeostasis. Recent studies have demonstrated that the Semaphorin3E-plexinD1 axis is implicated in asthma, impacting inflammatory and structural cells associated with airway inflammation, tissue remodeling, and airway hyperresponsiveness. This review highlights the potential role of the Semaphorin3E-plexinD1 axis as a therapeutic target in airway allergic diseases.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Jose M. Rodrigo-Munoz, Jose A. Canas, Beatriz Sastre, Marta Gil-Martinez, Raquel Garcia Latorre, Joaquin Sastre, Victoria del Pozo
Summary: miR-185-5p modulates the secretion of periostin by airway structural cells and smooth muscle contraction, which are related to asthma pathophysiology; decreased miR-185-5p expression and elevated periostin levels were observed in sputum cells from asthmatics, with an inverse correlation between POSTN and miR-185-5p.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment by blocking specific ion channels and downregulating inflammatory factors, mucins, and the MAPK/Akt signaling pathway in asthmatic mice, suggesting it as a promising therapeutic compound for asthma therapy.
MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jorge Reyes-Garcia, Abril Carbajal-Garcia, Luis M. Montano
Summary: Transient receptor potential (TRP) ion channels, particularly TRPV1, TRPV2, and TRPV4, play critical roles in the development of asthma. These channels contribute to environmental sensitization, airway inflammation, airway hyperresponsiveness, and remodeling, and may serve as novel therapeutic targets for asthma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Allergy
Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frossing, Alexander Silberbrandt, Morten Hostrup, Martin Thomassen, Caroline Sanden, Carl Magnus Clausson, Premkumar Siddhuraj, Daisy Bornesund, Juan Jose Nieto-Fontarigo, Lena Uller, Jonas Erjefalt, Celeste Porsbjerg
Summary: This study investigated the relationship between airway hyperresponsiveness and infiltrating mast cells, as well as the effectiveness of inhaled corticosteroid treatment. The results showed that inhaled corticosteroid treatment significantly improved airway hyperresponsiveness in both patients with high fractional exhaled nitric oxide (FENO) and patients with low FENO. However, there were differences in mast cell phenotypes and distribution between the two groups.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Cancan Zhang, Huisha Xu, Keilah G. Netto, Leon A. Sokulsky, Yiyan Miao, Zhongyuan Mo, Yan Meng, Yingying Du, Chengyong Wu, Liyou Han, Lirong Zhang, Chi Liu, Guojun Zhang, Fuguang Li, Ming Yang
Summary: In this study, the therapeutic potential of GGsTop, a γ-glutamyl transferase inhibitor, on acute asthma exacerbations was investigated using a murine model. The results showed that GGsTop significantly attenuated hallmark features of asthma exacerbation, including airway hyperresponsiveness, mucus hypersecretion, collagen deposition, and expression of inflammatory cytokines. Furthermore, GGsTop restored the level of glutathione and inhibited the activation of the LPS/NFκB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Amlan Chakraborty, Anita A. Pinar, Maggie Lam, Jane E. Bourke, Simon G. Royce, Cordelia Selomulya, Chrishan S. Samuel
Summary: This study conjugated relaxin to nanoparticles and delivered them intranasally to a preclinical rodent model of chronic allergic airways disease and collagen gel contraction from asthma patient-derived myofibroblasts, showing potential anti-remodeling and anti-inflammatory effects, which could be important for treating the central features of asthma.
Article
Physiology
Ryan C. Murphy, Ying Lai, James D. Nolin, Robier A. Aguillon Prada, Arindam Chakrabarti, Michael Novotny, Michael C. Seeds, William A. Altemeier, Michael H. Gelb, Robert Duncan Hite, Teal S. Hallstrand
Summary: Exercise challenge induces alterations in airway phospholipid structure and eicosanoid release in asthma, promoting bronchoconstriction, particularly in individuals with EIB who have higher basal levels of phospholipid turnover.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Respiratory System
Oliver Djurhuus Tupper, Charlotte Suppli Ulrik
Summary: This study aimed to explore long-term predictors of severe exacerbations and mortality in adults with well-characterised asthma. The results showed that increasing age, smoking history, decreased lung function, high blood eosinophils, prolonged symptom duration, and frequent use of reliever medication were predictors of asthma-related death and repeated severe exacerbations. Improving asthma control, including lung function and reducing the use of reliever medication, is crucial for enhancing the long-term outcome of asthma.
RESPIRATORY RESEARCH
(2021)
Review
Physiology
Dora (Jun Ping) Xiong, James G. Martin, Anne-Marie Lauzon
Summary: Asthma is a common chronic inflammatory disease of the airways that varies in its presentation and severity. Airway smooth muscle is the major contributor to airway narrowing and asthma symptoms. Various factors can contribute to the dysfunction of airway smooth muscle. Methodological limitations in studying the airways have hindered our understanding of asthma mechanisms.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Respiratory System
Eun Kyo Ha, Ju Hee Kim, Eun Lee, Myongsoon Sung, Hye Mi Jee, Hey Sung Baek, Youn Ho Shin, Na Hee Lee, Man Yong Han
Summary: The study found an association between low serum iron levels and airway dysfunction in children. Furthermore, a relationship was observed between low serum iron and high serum ferritin levels with reduced lung function as measured by oscillometry.
CLINICAL RESPIRATORY JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jae-Hyung Kim, Byung-Gook Kim, Yeong-Gwan Im
Summary: In this study, different muscle contraction patterns were observed in oromandibular dystonia (OMD) patients, with synchronous contractions of dystonic muscles frequently seen. Surface EMG can serve as an objective method for diagnosing oromandibular dystonia.
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2021)
Article
Allergy
Hey Sung Baek, Ha Young Won, Ju Hee Kim, Eun Kyo Ha, Hye Mi Jee, Youn Ho Shin, Mi-Ae Kim, Man Yong Han
Summary: Exposure to low molecular weight phthalates was significantly associated with airway dysfunction, and this effect was partially attributable to increased serum periostin levels.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Myongsoon Sung, Dong Keon Yon, Seung Won Lee, Ju Hee Kim, Hey Sung Baek, Hye Mi Jee, Youn Ho Shin, Man Yong Han
Summary: This study revealed that sensitization to pollen increases the risk of chronic cough in school-aged children, while exposure to smoking and mold is also associated with a higher likelihood of chronic cough.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jeong-Seung Kwon, Sang-Ho Han, Yeong-Gwan Im
Summary: This study investigated the surface electromyography (EMG) activity of the temporalis, masseter, digastric, and infrahyoid muscles during passive jaw opening in healthy adults. The results showed that passive jaw opening significantly reduces the EMG activity of the digastric and infrahyoid muscles, which could help reduce the load on these muscles.
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2022)
Article
Allergy
Ju Hee Kim, Eun Kyo Ha, Seung Won Lee, Hye Ryeong Cha, Hey-Sung Baek, Man Yong Han
Summary: This study found that low birth weight, high BMI during childhood, and the interaction between BMI during childhood and weight change during infancy are associated with an increased risk of childhood asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Allergy
Ju Hee Kim, Yoon Young Yi, Eun Kyo Ha, Hey Ryung Cha, Man Yong Han, Hey-Sung Baek
Summary: This study evaluated the association between atopic dermatitis (AD) and neurodevelopmental dysfunction in children and found that AD may be associated with an increased risk of neurodevelopmental dysfunction, particularly in the areas of gross and fine motor skills.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jae-Kwang Jung, Yeong-Gwan Im
Summary: This study aimed to evaluate the repeatability of surface EMG variables of myoelectric signals from the masseter and temporalis muscles using three different methods to induce maximum voluntary contraction (MVC) in healthy adults. The results showed that the surface EMG measurements according to the three MVC methods exhibited good to excellent reproducibility.
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Wenqi Fu, Yeong-Gwan Im, Byunggook Kim, Ok-Su Kim, Ying Yang, Jianan Song, Danyang Liu, Siyu Zhu, Jae-Seok Kang, Okjoon Kim
Summary: Photobiomodulation therapy can reduce the accumulation of unfolded and misfolded proteins in cells, which is beneficial for bone homeostasis and the treatment of bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Ji Eun Lim, Hye Min Kim, Ju Hee Kim, Hey Sung Baek, Man Yong Han
Summary: This study investigated the association between dyslipidemia and cholesterol levels in children and found that high cholesterol levels may be associated with the development of asthma in children.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Yeong-Gwan Im, Man-Yong Han, Hey-Sung Baek
Summary: This study investigated the relationship between serum 25-hydroxyvitamin D levels and temporomandibular disorders (TMDs) using large-scale health data. The results showed that deficient vitamin D levels were associated with an increased risk of TMDs, suggesting that vitamin D deficiency may be a potential risk factor for TMD development.
Article
Medicine, General & Internal
Ho-Jun Song, Yeong-Joon Park, Hie-Yong Jeong, Byung-Gook Kim, Jae-Hyung Kim, Yeong-Gwan Im
Summary: This study investigates the use of deep learning to detect abnormal regions on the dorsal tongue surface in patients and healthy adults. The deep learning model VGG16 was trained on 175 clinical photographic images, and point mapping segmentation was used for the segmentation of abnormal regions. The results show that the deep learning algorithm accurately identifies abnormal areas on the dorsal tongue surface, aiding in the diagnosis of specific diseases or conditions of the tongue mucosa.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Joo-Hyun Hong, Mi-Ra Kim, Bin-Na Lee, Won-Mann Oh, Kyung-San Min, Yeong-Gwan Im, Yun-Chan Hwang
Summary: The study revealed that bromelain has anti-inflammatory effects on lipopolysaccharide-induced human dental pulp cells by inhibiting the expression of inflammatory cytokines and regulating the NF-κB and MAPK pathways. Bromelain shows potential for use in regenerative endodontics, including vital pulp therapy.
MEDICINA-LITHUANIA
(2021)
Article
Allergy
Hyun Joo Lee, Jun Hong Park, Jae Min Kim, Ji Hye Kim, Hey-Sung Baek
Summary: A retrospective study analyzed data from 1,480 hospitalized children and found that the FilmArray method for respiratory viruses did not decrease hospital stay duration, but could quickly detect the prevalence of respiratory infections and assist in clinical treatment. It also reduced the time from admission to isolation by influenza infection in hospitalized children not initially diagnosed with influenza.
ALLERGY ASTHMA & RESPIRATORY DISEASE
(2021)
Article
Allergy
Se Hwan An, Hong Je Cho, Hey-Sung Baek, Myong Soon Sung, Jung Won Yoon, Sun Hee Choi, Youn Ho Sheen, Man Yong Han
ALLERGY ASTHMA & RESPIRATORY DISEASE
(2018)