Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling

R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification

(2016) Yasuhiko Takegami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Abnormal expression of key genes and proteins in the canonical Wnt/β-catenin pathway of articular cartilage in a rat model of exercise-induced osteoarthritis

(2016) SHEN-SHEN LIU et al.   Molecular Medicine Reports

Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice

(2016) Wafa Bouaziz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular hydrogen suppresses activated Wnt/β-catenin signaling

(2016) Yingni Lin et al.   Scientific Reports

LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation

(2014) Nobuyuki Asai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Verapamil Protects against Cartilage Degradation in Osteoarthritis by Inhibiting Wnt/β-Catenin Signaling

(2014) Akira Takamatsu et al.   PLoS One

Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

(2013) Masaki Matsushita et al.   PLoS One

A Wnt/β-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes

(2012) Bin Ma et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Role of S100A12 in the pathogenesis of osteoarthritis

(2012) Motoshige Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WNT Signaling and Cartilage: Of Mice and Men

(2012) Bin Ma et al.   CALCIFIED TISSUE INTERNATIONAL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Cartilage development and degeneration: a Wnt Wnt situation

(2012) Katherine Ann Staines et al.   CELL BIOCHEMISTRY AND FUNCTION

Antidepressants and the relief of osteoarthritic pain - Findings from a study examining adjunctive duloxetine

(2012) L. Citrome et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

ATDC5: An excellent in vitro model cell line for skeletal development

(2012) Yongchang Yao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Growth Hormone Improves Growth Retardation Induced by Rapamycin without Blocking Its Antiproliferative and Antiangiogenic Effects on Rat Growth Plate

(2012) Óscar Álvarez-García et al.   PLoS One

Bone morphogenetic protein-2-induced Wnt/beta-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

(2012) Ioanna Papathanasiou et al.   ARTHRITIS RESEARCH & THERAPY

Alternative Wnt Pathways and Receptors

(2012) R. van Amerongen   Cold Spring Harbor Perspectives in Biology

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis

(2011) Eiji Kozawa et al.   ARTHRITIS AND RHEUMATISM

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

(2011) Giovanna Nalesso et al.   JOURNAL OF CELL BIOLOGY

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors

(2010) Sandra Sacre et al.   ARTHRITIS AND RHEUMATISM

To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

(2010) Arjen B. Blom et al.   CURRENT DRUG TARGETS

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat

(2010) N. Gerwin et al.   OSTEOARTHRITIS AND CARTILAGE

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

WNT signaling in osteoarthritis and osteoporosis: What is the biological significance for the clinician?

(2009) Liesbet Lodewyckx et al.   Current Rheumatology Reports

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

Alternative Wnt Signaling Is Initiated by Distinct Receptors

(2008) R. van Amerongen et al.   Science Signaling