Review
Plant Sciences
Rania Benjamaa, Abdelkarim Moujanni, Neha Kaushik, Eun Ha Choi, Abdel Khalid Essamadi, Nagendra Kumar Kaushik
Summary: The genus Euphorbia includes plants with toxic milky fluid or latex widely found in temperate and tropical zones. These plants have been used in traditional and complementary medicine for various health issues, and their medicinal properties are attributed to the presence of various compounds, with the focus on their latex. This review summarizes the current knowledge on the chemical composition and biological activities of latex from Euphorbia species, aiming to explore its medical applications and assess its ethnopharmacological potential.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Tomasz Czechowski, Edith Forestier, Sandesh H. Swamidatta, Alison D. Gilday, Amy Cording, Tony R. Larson, David Harvey, Yi Li, Zhesi He, Andrew J. King, Geoffrey D. Brown, Ian A. Graham
Summary: The majority of macro-and polycyclic Euphorbiaceae diterpenoids are derived from the common C20 precursor casbene, but the biosynthetic pathways for some of these diterpenoids are not yet clear. Using a metabolomics-guided transcriptomic approach, two casbene-derived diterpenoid gene clusters were discovered, with one gene identified as playing a crucial role in converting casbene to lathyrane diterpenoids.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Yan Yang, Xufei Chen, Fei Luan, Min Wang, Ze Wang, Jiuling Wang, Xirui He
Summary: Euphorbia helioscopia, known as Zeqi in China, is a widely distributed medicinal plant with a long history of traditional use. Modern pharmacological studies have shown its outstanding bioactivities, particularly in antiproliferative and multidrug resistance modulation, although more research is needed to fully explore its therapeutic potential.
Article
Plant Sciences
Xue-Xue Pu, Xiao-Qian Ran, Ying Yan, Qing-Yun Lu, Jin-Cun Li, Ying-Yao Li, Shi-Peng Guan, Ming-Ming Cao, Jie Liu, Xiao-Jiang Hao, Rong-Can Luo, Ying-Tong Di
Summary: Three new jatrophane diterpenoids, named euphpepluones P-R (1-3), were isolated from the whole plant Euphorbia peplus. Compounds 2 and 6 showed significant inhibition of autophagic flux, indicating potential bioactivity in this aspect.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Plant Sciences
Ying-Yao Li, Ying Yang, Mao Sun, Qing-Yun Lu, Xue-Xue Pu, Xiaoqian Ran, Dong-Mei Li, Jia-Jia Wan, Jian-Yi Huang, Shi-Peng Guan, Rongcan Luo, Yuan-Yuan Cheng, Ying-Tong Di, Xiao-Jiang Hao
Summary: Three new jatrophane polyesters (Euphopepluanones M-O 1-3) and eight known ones (4-11) were isolated from the leaves of Euphorbia peplus Linn. Their chemical structures were identified through extensive spectroscopic analysis and the absolute configuration of compound 1 was determined by X-ray crystallographic analysis. In addition, the anti-inflammatory effects of these compounds on lipopolysaccharide-induced RAW264.7 macrophages were evaluated in vitro. Among them, compounds 2 and 7 showed significant anti-inflammatory activity.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Plant Sciences
Miao-Miao Li, Yan-Ru Qi, Ya-Ping Feng, Wei Liu, Tao Yuan
Summary: Five new triterpenoids, named as euphatexols C-G (1-5), were isolated from the latex of Euphorbia resinifera. Their chemical structures were determined by extensive spectroscopic analysis. These compounds showed moderate anti-inflammatory activity, with IC50 values ranging from 22.30 to 48.04 µM.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Yan Min, Yan-Ni Chen, Dong-Mei Li, Qiu-Yan Mu, Zun-Ting Zhang, Xin Fang
Summary: A phytochemical investigation of the whole plant of Euphorbia peplus Linn. led to the isolation of a previously uncharacterized jatrophane type diterpenoid, euphopepluanone L (1), along with seven known compounds. The chemical structures of these compounds were established through extensive spectroscopic analysis, with several compounds being isolated from E. peplus for the first time. The chemotaxonomic significance of the isolates was also discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoqian Ran, Qing-Yun Lu, Ying-Yao Li, Xue-Xue Pu, Yarong Guo, Ming-Rui Yuan, Shi-Peng Guan, Mao Sun, Lijin Jiao, Yong-Gang Yao, Ying-Tong Di, Xiao-Jiang Hao, Rongcan Luo
Summary: A new ent-abietane diterpenoid, Euphejolkinolide A (1), was isolated from Euphorbia peplus L. and its structure and configurations were confirmed by spectroscopic analyses and single-crystal X-ray diffraction analysis. It was found that compound 1 could significantly induce lysosome biogenesis and promote autophagic flux, which is required for cellular homeostasis. The study also suggested that the carbony1 at C-7 in compound 1 might be a key active group. Overall, compound 1 shows potential for lysosome disorder therapy by inducing autophagy.
Article
Plant Sciences
Manisha Parashar, Sanjoy Kumar Dhar, Jaspreet Kaur, Arjun Chauhan, Jeewan Tamang, Gajendra Bahadur Singh, Asyakina Lyudmila, Kahkashan Perveen, Faheema Khan, Najat A. Bukhari, Gaurav Mudgal, Mayank Anand Gururani
Summary: In this study, two co-culturable bacterial endophytes, EP1-AS and EP1-BM, were isolated from the stem internodal segments of Euphorbia prostrata. These novel strains of Enterobacteriaceae, Lelliotia amnigena, showed significant plant growth promotion potential in wheat and tomato through seed-priming treatments. Field trials also demonstrated productive yields in wheat grain and tomato fruit harvests.
Article
Biochemistry & Molecular Biology
Shihong Luo, Chunshuai Huang, Juan Hua, Shuxi Jing, Linlin Teng, Ting Tang, Yan Liu, Shenghong Li
Summary: Plant latex, which is stored in laticiferous structures, is immediately exuded when plants are damaged. The primary function of plant latex is defense against natural enemies. Euphorbia jolkinii Boiss. is a perennial herbaceous plant that poses a significant threat to biodiversity and ecological integrity in northwest Yunnan, China. Various compounds, including a new isopentenyl disaccharide, were identified in the latex of E. jolkinii. Some compounds, such as meta-tyrosine and triterpenes, exhibited phytotoxic, antibacterial, and nematicidal activities, indicating their potential role as defensive substances.
JOURNAL OF CHEMICAL ECOLOGY
(2023)
Article
Agricultural Engineering
Meixiang Chen, Mei Tian, Fei Liu, Wanli Zhao, Jian Peng, Li Linwei, Min Yin, Yonghua Gu, Xu Feng, Yu Chen
Summary: Resource discovery for producing biologically active phytochemicals is crucial in the field of industrial crops. This study utilized UHPLC-MS to analyze the free ingenol content in 61 selected plant species from the Euphorbiaceae family, revealing varying levels of ingenol derivatives and identifying high-ingenol plant species. The research also confirmed the impact of greenhouse covering materials on the production of ingenol esters in Euphorbia plants.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Evolutionary Biology
Arielle R. Johnson, Yuanzheng Yue, Sarah B. Carey, Se Jin Park, Lars H. Kruse, Ashley Bao, Asher Pasha, Alex Harkess, Nicholas J. Provart, Gaurav D. Moghe, Margaret H. Frank
Summary: Euphorbia peplus is a small, fast-growing plant native to Eurasia and has become a weed in North America and Australia. It has medicinal value as a source for skin cancer drug ingenol mebutate and potential for latex production. The newly sequenced genome of E. peplus provides valuable genomic resources for research on latex production and ingenol mebutate biosynthesis in the Euphorbiaceae family.
GENOME BIOLOGY AND EVOLUTION
(2023)
Article
Biochemical Research Methods
Emadeldin M. Kamel, Noha A. Ahmed, Ashraf A. El-Bassuony, Omnia E. Hussein, Barakat Alrashdi, Sayed A. Ahmed, Al Mokhtar Lamsabhi, Hany H. Arab, Ayman M. Mahmoud
Summary: The study revealed the xanthine oxidase (XO) inhibitory activity of Euphorbia peplus phenolics, confirmed through in vitro, in vivo, and computational investigations. The isolated phenolics showed significant interactions with XO active site residues, forming hydrogen bonds. Molecular dynamics simulations demonstrated stability in the systems, with rigidity behavior observed at the drug binding site. The results suggest that these phenolics have potential as promising candidates for XO inhibitors.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Review
Biochemistry & Molecular Biology
Yang Xu, Peiyu Tang, Man Zhu, Yali Wang, Dejuan Sun, Hua Li, Lixia Chen
Summary: A large number of previously undescribed diterpenoids have been isolated from Euphorbia plants, showing various biological activities such as neuroprotection and antimalarial effects. These diterpenoids have been classified into 26 normal classes and 37 novel skeleton types based on their structure types.
Article
Chemistry, Multidisciplinary
Gordana B. Krstic, Ana Kostic, Milka B. Jadranin, Milica Pesic, Miroslav M. Novakovic, Ivana S. Aljancic, Vlatka V. Vajs
Summary: In this study, two new jatrophane diterpenes were isolated from the root of Euphorbia nicaeensis and their antitumor potential was evaluated on various cancer cell lines. The results showed that these compounds have different inhibition effects on cancer cell growth and also inhibit P-glycoprotein.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Yu Zhang, Han Yang, Xiang Dong, Chao-Jiang Xiao, Bei Jiang
Summary: A new cycloartane triterpenoid, along with known compounds, was isolated from the roots of Astragalus polycladus var. nigrescens. The structures of these compounds were determined through extensive spectroscopic analysis. This study provides valuable information on the chemical composition of Astragalus polycladus var. nigrescens.
LETTERS IN ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Ying Wang, Li-Juan Lang, Qi-Jie Zhu, Xiu-Rong Wu, Lei Shen, Bei Jiang, Chao-Jiang Xiao
Summary: Three new dibenzofurans and three known dibenzofurans were isolated from the twigs and leaves of Crataegus oresbia. Compound 3 exhibited stronger in vitro lipid-lowering activity than simvastatin.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Xiu-Rong Wu, Li-Juan Lang, Yi Shen, Xiang Dong, Chao-Jiang Xiao, Bei Jiang
Summary: In this study, several new benzophenone glycosides and flavonoid glycosides were isolated from the roots of Dobinea delavayi, and their structures were determined by comprehensive analysis. Additionally, the cytotoxicity and in vitro antimalarial activity of some compounds were evaluated.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiu-Rong Wu, Yi Shen, Hong-Mei Diao, Xiang Dong, Chao-Jiang Xiao, Bei Jiang
Summary: Eight undescribed sesquiterpenoids were isolated from the roots of Dobinea delavayi, including two eudesmane glycosides and five eudesmane aglycones. Some of these compounds were evaluated for their in vivo antimalarial activities, providing insights into the structure-activity relationship of eudesmane sesquiterpenoids.
Article
Plant Sciences
Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao
Summary: The study found that phloridzin highly accumulated in the Malus rockii Rehder plant, exhibiting significant hypolipidemic activity and moderate antimalarial and analgesic activities.
Article
Plant Sciences
Ya-Nan Chen, Han-Fu Liu, He Sun, Chao-Jiang Xiao, Bei Jiang, Lei Shen
Summary: The ethanolic extract of Bauhinia brachycarpa Benth (BBB) has been shown to have antinociceptive effects on neuropathic pain by inhibiting the inflammatory response and regulating the differentiation of microglia. The content of total flavonoids in BBB is related to its antinociceptive effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Yuehong Lu, Jing Ma, Qiuxian Yang, Zhengyang Zhang, Rina Wu, Chaojiang Xiao, Wang Li, Yuanli Li, Chunyan Gao
Summary: The physicochemical and emulsifying properties of pectin extracted from Ottelia acuminata inflorescence were investigated. The results showed that the pectin had low methylation and carried negative charges, with the charge density and molecular morphology changing significantly with pH variation. A formula for relating dynamic viscosity to temperature and concentration was established. Stable emulsions containing fifty percent oil fraction could be achieved at an OAIP concentration of 2.0 g/100 mL. However, emulsion layer separation was observed after 7 days for all emulsions at different pH values, Na+ and Ca2+ concentrations when the OAIP concentration was 1.0 g/100 mL.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Cell Biology
Jiqun Wang, Yunyuan Huang, Kaixuan Shi, Lingyuan Bao, Chaojiang Xiao, Tianyue Sun, Zhifan Mao, Jiali Feng, Zelan Hu, Zhenghan Guo, Jing Li, Bei Jiang, Wenwen Liu, Jian Li
Summary: The development of safe and effective therapeutic interventions to delay aging and reduce the risk of aging-related diseases is of great importance. Chinese herbal medicine, with its multiple components and targets, has shown potential in treating aging and complex diseases. This study found that Nicandra physalodes extract (HL0285) exhibited lifespan extension activity in Caenorhabditis elegans (C. elegans), improved healthspan, enhanced stress resistance, and delayed the progression of neurodegenerative diseases. HL0285 also ameliorated senescence in human lung fibroblasts and reversed liver function damage in aging mice induced by doxorubicin. The longevity effect of HL0285 in C. elegans was dependent on specific signaling pathways. Overall, HL0285 has demonstrated antiaging effects and should be further explored as a potential antiaging agent.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Qi-Jie Zhu, Li-Juan Lang, Ying Wang, De-Quan Zhang, Bei Jiang, Chao-Jiang Xiao
Summary: This study investigated the chemical constituents of wild Crataegus scabrifolia fruits and their lipid-lowering activities. Ten triterpenoids were isolated and identified, with some of them exhibiting significant lipid-lowering activities. The results suggest that these triterpenoids may have potential as lipid-lowering agents.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Hong -Mei Diao, Yi Hao, Jing Li, Hao-Wei Ling, Kai-Xuan Shi, Wei Zhang, Rong Liu, Xiu-Rong Wu, Chao-Jiang Xiao, Bei Jiang
Summary: Two new flavonoid glycosides (scutelikiosides A and B) and twenty-one known compounds were isolated from the roots of Scutellaria likiangensis Diels. Compound 17 showed significant antimalarial activity close to artemisinin, and compounds 6, 9-12, 14, 18, 19, and 22 exhibited moderate antimalarial activities. The study also provided a summary of the structure-activity relationship of the isolated flavonoids.
Article
Chemistry, Applied
Yi Hao, Xiao-Lei Luo, Min Wang, Rong Liu, Wei Zhang, Chao-Jiang Xiao, Bei Jiang
Summary: Two new farnesane sesquiterpenoid glycosides, rubusdelosides A and B (1 and 4), together with five known farnesane sesquiterpenoids (2, 3, and 5-7), and two known meroterpenoids (8 and 9), were isolated from water extract of the herbs of R. delavayi. Their structures were identified by the comprehensive analyses of physicochemical properties and spectroscopic data (NMR and HR-ESI-MS). Compounds 1-8 showed moderate in vivo anti-T. spiralis activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Agronomy
Xiu-Mei Chen, Wang Lu, Zi-Han Zhang, Pan-Pan Wang, Xiu-Juan Zhang, Chao-Jiang Xiao, Qiang Zhang, Jin-Ming Gao, Chun-Huan Li
Summary: By conducting bio-guided isolation of Caesalpinia pulcherrima, 11 novel cassane diterpenoids and 10 known sesquiterpenes were obtained. Capulchemin A exhibited remarkable antibacterial activity and significant control effect on kiwifruit canker. Some of these cassane diterpenoids also showed potential antifeedant activity against plant pests. Thus, capulchemin A could serve as a template for the development of new eco-friendly botanical bactericides.
PEST MANAGEMENT SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Ying Wang, Li Yang, Xin Liang, Wei Chen, Li-Tian Dong, Bei Jiang, Chao-Jiang Xiao
Summary: A new ursane triterpenoid caffeic acid ester, cratoresbate A, along with seven known ursane triterpenoids, was isolated from the twigs and leaves of Crataegus oresbia W. W. Sm. Cratoresbate A exhibited significant cytotoxicity against HepG2 cells with an IC50 value of 1.9 μmol L-1.
RUSSIAN CHEMICAL BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Hui-Rong Bai, Jing Li, Li-Juan Lang, Yi Hao, Bei Jiang, Chao-Jiang Xiao
Summary: The phloridzin structure was confirmed as phloretin 6'-O-glucopyranoside by X-ray diffraction. The distribution changes of phloridzin in different phases of Malus rockii were quantified using HPLC. The concentration of phloridzin in leaves, twigs, and bark increased and then decreased, reaching the highest value in the fruitlet period. The highest concentration was found in leaves, ranging from 10.92% to 14.43%. Additionally, the decrease in phloridzin concentration in leaves during fruit ripening period was almost equivalent to the increase in phloretin concentration. This physiological phenomenon provides plant physiologists with a new perspective for the development and utilization of phloridzin.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Chemistry, Medicinal
Li Yang, Rong Liu, Li-Juan Lang, Yi Hao, Ying Wang, Bei Jiang, Chao-Jiang Xiao
Summary: A new dibenzofuran named 2-hydroxy-4,5-dimethoxydibenzofuran, along with seven known aromatic compounds, was isolated from the leaves and twigs of Malus rockii Rehder, Rosaceae. Their structures were identified through comprehensive analysis of spectroscopic and spectrometric data. 2-Hydroxy-4,5-dimethoxydibenzofuran and 2-hydroxy-4-methoxydibenzofuran exhibited significant in vitro lipid-lowering activities, while 5,7-dihydroxychromone showed weak activity.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.
