Article
Biochemistry & Molecular Biology
Hui-Rong Bai, Jing Li, Li-Juan Lang, Yi Hao, Bei Jiang, Chao-Jiang Xiao
Summary: The phloridzin structure was confirmed as phloretin 6'-O-glucopyranoside by X-ray diffraction. The distribution changes of phloridzin in different phases of Malus rockii were quantified using HPLC. The concentration of phloridzin in leaves, twigs, and bark increased and then decreased, reaching the highest value in the fruitlet period. The highest concentration was found in leaves, ranging from 10.92% to 14.43%. Additionally, the decrease in phloridzin concentration in leaves during fruit ripening period was almost equivalent to the increase in phloretin concentration. This physiological phenomenon provides plant physiologists with a new perspective for the development and utilization of phloridzin.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Plant Sciences
Simon Miranda, Stefano Piazza, Floriana Nuzzo, Mingai Li, Jorge Lagreze, Axel Mithoefer, Alessandro Cestaro, Danuse Tarkowska, Richard Espley, Andrew Dare, Mickael Malnoy, Stefan Martens
Summary: The effects of targeting the key gene MdPGT1 involved in phloridzin biosynthesis in apple using conventional transgenesis and CRISPR/Cas9-mediated genome editing were simultaneously assessed. Knockdown lines showed impaired growth and leaf morphology, while genome-edited lines exhibited normal growth despite reduced phloridzin levels. Transcriptomic and metabolic analyses revealed regulated genes involved in phenylpropanoid and flavonoid pathways. Phytohormone profiling demonstrated differential modulation, with increased salicylic and jasmonic acid levels in dwarf lines and no correlation between auxin and ABA with growth phenotype.
Article
Multidisciplinary Sciences
Shalini Dixit, Shiv Vardan Singh, Shilpa Mohanty, Dnyaneshwar U. Bawankule, Anirban Pal, Karuna Shanker, M. M. Gupta, Tahmeena Khan, Nora Abdullah AlFaris, Jozaa Zaidan Altamimi, Tahany Saleh Aldayel
Summary: This study evaluated the neuroprotective, antioxidant, and antiplasmodial properties of polyphenols from Malus Sikkimensis. The results showed that phloretin displayed better antioxidant potential and significant antiplasmodial activity. Phloridzin and phloretin suppressed the release of pro-inflammatory cytokines in a dose-dependent manner and had potential anti-neuroinflammatory effects.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Plant Sciences
Ivana Sola, Danijela Poljuha, Maja Mikulic-Petkovsek, Dino Davosir, Marija Pinteric, Josipa Bilic, Robert Veberic, Metka Hudina, Gordana Rusak
Summary: The aim of this study was to evaluate the potential of young inflorescence tissues of Prunus, Malus, and Chaenomeles for application in the food industry and quality control. The study measured the contents of bioactive compounds and their antioxidant capacities, identified and quantified phenolic compounds, and evaluated the antidiabetic, anti-inflammatory, and cytotoxic properties. The results showed that the inflorescences of Prunus, Malus, and Chaenomeles could be used as functional food ingredients.
Article
Plant Sciences
Weitao Jiang, Ran Chen, Lei Zhao, Yanan Duan, Haiyan Wang, Zhubing Yan, Xiang Shen, Xuesen Chen, Chengmiao Yin, Zhiquan Mao
Summary: We isolated and identified a bacterium, Ochrobactrum haematophilum, from the rhizosphere soil of healthy replanted apple that produces IAA and degrades phloridzin. This bacterium can promote apple growth and degrade phenolic acids, providing a potential solution for the reduction of apple replant disease (ARD).
HORTICULTURAL PLANT JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jiahong Lv, Yi Feng, Lizhong Jiang, Guibin Zhang, Ting Wu, Xinzhong Zhang, Xuefeng Xu, Yi Wang, Zhenhai Han
Summary: In this study, a genome-wide comprehensive analysis of WOX genes in nine Rosaceae species was conducted, and their potential roles in Malus were investigated. The results revealed significant collinearity in Prunus. domestica among the Rosaceae species. The study also categorized the cis-elements in the WOX gene family into three categories and found that overexpression of MdWOX13-1 increased callus weight and enhanced ROS scavenging against drought stress by directly binding to the MdMnSOD promoter.
Article
Plant Sciences
Thaise Gabriele da Silva Brito, Ana Paula Sant'Anna da Silva, Rebeca Xavier da Cunha, Caique Silveira Martins da Fonseca, Tiago Ferreira da Silva Araujo, Janaina Karin de Lima Campos, Weber Melo Nascimento, Hallysson Douglas Andrade de Araujo, Joanda Paolla Raimundo e Silva, Josean Fechine Tavares, Bianka Santana dos Santos, Vera Lucia de Menezes Lima
Summary: Plinia cauliflora fruits are rich sources of secondary metabolites, mainly tannins and phenolic acids with high biological potential, which can effectively contribute to the approach of preventing and controlling chronic non-communicable diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
Lingli Li, Yang Ye, Mengran Zhao, Haodong Xin
Summary: The chloroplast genome of the Malus kansuensis, an important apple rootstock native to China, was sequenced and assembled. A total of 129 functional genes were predicted, including protein-coding genes, tRNA genes, and rRNA genes, showing consistency with traditional taxonomy.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Genetics & Heredity
Lingli Li, Xiting Gu, Jianwen Ma
Summary: The mitochondrial genome of Malus kansuensis was sequenced and assembled, revealing its close relationship with Malus domestica and Malus hupehensis. The genome is 385,436 bp long and contains 35 protein-coding genes, 21 tRNA genes, and 3 rRNA genes, with a bias towards (A + T) %.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Chemistry, Applied
Feiyu Yang, Jiaqiang Huang, Haiyan He, Xingrong Ju, Ying Ji, Feng Deng, Zhigao Wang, Rong He
Summary: This study separated and purified rapeseed peptides and identified Glu-Phe-Leu-Glu-Leu-Leu (EFLELL) peptides with good hypolipidaemic activity. The EFLELL peptide exerted a favorable hypolipidaemic effect by modulating the LDLR-PCSK9 signaling pathway.
Article
Plant Sciences
Marc Lahaye, Wafae Tabi, Lucie Le Bot, Mickael Delaire, Mathilde Orsel, Jose Antonio Campoy, Jose Quero Garcia, Sophie Le Gall
Summary: The composition of cell walls in apple and cherry fruits differs significantly during development, with varying pectin sugar composition and hemicellulose fine structure. While apples show changes in pectin domain proportions and HC sugars during fruit expansion, cherries display early peaks in HG content and continuous increase in RGI content. The different glucomannan contents released from cell walls may serve as early markers of apple mealiness and cherry skin-cracking susceptibility.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Microbiology
Silvia Parapini, Silvio Paone, Emanuela Erba, Loredana Cavicchini, Manoochehr Pourshaban, Francesco Celani, Alessandro Contini, Sarah D'Alessandro, Anna Olivieri
Summary: Malaria causes numerous cases and deaths annually, and the search for novel antimalarial drugs is essential. This study tested a series of Rac1 inhibitors and found that EHop-016 exhibited the most effective inhibitory activity against Plasmodium falciparum, without affecting red blood cell invasion but impacting parasite growth internally.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Plant Sciences
Aurita Butkeviciute, Jonas Viskelis, Mindaugas Liaudanskas, Pranas Viskelis, Valdimaras Janulis
Summary: The study found variations in antioxidant activity and composition of phenolic compounds in different apple cultivars stored under different controlled atmosphere conditions, highlighting the importance of determining optimal storage conditions for providing consumers with high-quality apples.
Article
Plant Sciences
Jiaying Yang, Yu Zhang, Lijuan Jiang, Caixia Li, Zhenxiao Sun, Yan Zhang, Tianfeng Lin, Yanyan Jiang, Bin Liu
Summary: This study investigated the hypolipidemic mechanism of Nelumbo nucifera alkaloids using a combination of UHPLC-LTQ-Orbitrap MSn, hypolipidemic activity evaluation, and transcriptome sequencing. The results indicated that the candidate genes involved in lipid metabolism were LDLR, LPL, and ANGPTL4, and they modulated the expression of key factors in bile secretion, glycerolipid metabolism, sphingolipid metabolism, and the PPAR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Scott Eagon, Jared T. Hammill, Kasey Fitzsimmons, Natalie Sienko, Brandon Nguyen, Jarvis Law, Aashrita Manjunath, Steven P. Wilkinson, Kara Thompson, Julia Elizabeth Glidden, Amy L. Rice, Mofolusho O. Falade, Joshua J. Kimball, Celine DiBernardo, R. Kiplin Guy
Summary: In the search for new anti-malarial drugs, this study reports the discovery of a derivative with potential efficacy against Plasmodium falciparum but without detectable toxicity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Organic
Yu Zhang, Han Yang, Xiang Dong, Chao-Jiang Xiao, Bei Jiang
Summary: A new cycloartane triterpenoid, along with known compounds, was isolated from the roots of Astragalus polycladus var. nigrescens. The structures of these compounds were determined through extensive spectroscopic analysis. This study provides valuable information on the chemical composition of Astragalus polycladus var. nigrescens.
LETTERS IN ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Ying Wang, Li-Juan Lang, Qi-Jie Zhu, Xiu-Rong Wu, Lei Shen, Bei Jiang, Chao-Jiang Xiao
Summary: Three new dibenzofurans and three known dibenzofurans were isolated from the twigs and leaves of Crataegus oresbia. Compound 3 exhibited stronger in vitro lipid-lowering activity than simvastatin.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Xiu-Rong Wu, Li-Juan Lang, Yi Shen, Xiang Dong, Chao-Jiang Xiao, Bei Jiang
Summary: In this study, several new benzophenone glycosides and flavonoid glycosides were isolated from the roots of Dobinea delavayi, and their structures were determined by comprehensive analysis. Additionally, the cytotoxicity and in vitro antimalarial activity of some compounds were evaluated.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiu-Rong Wu, Yi Shen, Hong-Mei Diao, Xiang Dong, Chao-Jiang Xiao, Bei Jiang
Summary: Eight undescribed sesquiterpenoids were isolated from the roots of Dobinea delavayi, including two eudesmane glycosides and five eudesmane aglycones. Some of these compounds were evaluated for their in vivo antimalarial activities, providing insights into the structure-activity relationship of eudesmane sesquiterpenoids.
Article
Chemistry, Medicinal
Hong -Mei Diao, Yi Hao, Jing Li, Hao-Wei Ling, Kai-Xuan Shi, Wei Zhang, Rong Liu, Xiu-Rong Wu, Chao-Jiang Xiao, Bei Jiang
Summary: Two new flavonoid glycosides (scutelikiosides A and B) and twenty-one known compounds were isolated from the roots of Scutellaria likiangensis Diels. Compound 17 showed significant antimalarial activity close to artemisinin, and compounds 6, 9-12, 14, 18, 19, and 22 exhibited moderate antimalarial activities. The study also provided a summary of the structure-activity relationship of the isolated flavonoids.
Article
Chemistry, Applied
Yi Hao, Xiao-Lei Luo, Min Wang, Rong Liu, Wei Zhang, Chao-Jiang Xiao, Bei Jiang
Summary: Two new farnesane sesquiterpenoid glycosides, rubusdelosides A and B (1 and 4), together with five known farnesane sesquiterpenoids (2, 3, and 5-7), and two known meroterpenoids (8 and 9), were isolated from water extract of the herbs of R. delavayi. Their structures were identified by the comprehensive analyses of physicochemical properties and spectroscopic data (NMR and HR-ESI-MS). Compounds 1-8 showed moderate in vivo anti-T. spiralis activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Agronomy
Xiu-Mei Chen, Wang Lu, Zi-Han Zhang, Pan-Pan Wang, Xiu-Juan Zhang, Chao-Jiang Xiao, Qiang Zhang, Jin-Ming Gao, Chun-Huan Li
Summary: By conducting bio-guided isolation of Caesalpinia pulcherrima, 11 novel cassane diterpenoids and 10 known sesquiterpenes were obtained. Capulchemin A exhibited remarkable antibacterial activity and significant control effect on kiwifruit canker. Some of these cassane diterpenoids also showed potential antifeedant activity against plant pests. Thus, capulchemin A could serve as a template for the development of new eco-friendly botanical bactericides.
PEST MANAGEMENT SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Ying Wang, Li Yang, Xin Liang, Wei Chen, Li-Tian Dong, Bei Jiang, Chao-Jiang Xiao
Summary: A new ursane triterpenoid caffeic acid ester, cratoresbate A, along with seven known ursane triterpenoids, was isolated from the twigs and leaves of Crataegus oresbia W. W. Sm. Cratoresbate A exhibited significant cytotoxicity against HepG2 cells with an IC50 value of 1.9 μmol L-1.
RUSSIAN CHEMICAL BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Hui-Rong Bai, Jing Li, Li-Juan Lang, Yi Hao, Bei Jiang, Chao-Jiang Xiao
Summary: The phloridzin structure was confirmed as phloretin 6'-O-glucopyranoside by X-ray diffraction. The distribution changes of phloridzin in different phases of Malus rockii were quantified using HPLC. The concentration of phloridzin in leaves, twigs, and bark increased and then decreased, reaching the highest value in the fruitlet period. The highest concentration was found in leaves, ranging from 10.92% to 14.43%. Additionally, the decrease in phloridzin concentration in leaves during fruit ripening period was almost equivalent to the increase in phloretin concentration. This physiological phenomenon provides plant physiologists with a new perspective for the development and utilization of phloridzin.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Plant Sciences
Zheng-rong Dou, F. A. Zhang, Guo-jun Zhou, Gao-fen Gong, Jia-jie Ding, Xu -hang Fan, Bei Jiang, Kai-ling Wang
Summary: Two fungal strains were isolated from the rhizosphere soil of Astragalus polycladus in Yunnan, China, and identified as a new fungal species of Varicosporellopsis based on morphology and phylogenetic analysis. Phylogenetic analysis revealed their relationship with other Varicosporellopsis species, and their unique morphological characteristics were described. This is the first report of Varicosporellopsis in China.
Article
Chemistry, Medicinal
Li Yang, Rong Liu, Li-Juan Lang, Yi Hao, Ying Wang, Bei Jiang, Chao-Jiang Xiao
Summary: A new dibenzofuran named 2-hydroxy-4,5-dimethoxydibenzofuran, along with seven known aromatic compounds, was isolated from the leaves and twigs of Malus rockii Rehder, Rosaceae. Their structures were identified through comprehensive analysis of spectroscopic and spectrometric data. 2-Hydroxy-4,5-dimethoxydibenzofuran and 2-hydroxy-4-methoxydibenzofuran exhibited significant in vitro lipid-lowering activities, while 5,7-dihydroxychromone showed weak activity.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)