Editorial Material
Nutrition & Dietetics
G. Varesco, S. K. Hunter, V. Rozand
Summary: As individuals age, there is a wide range of variability in motor function among older adults, partly due to their differences in habitual physical activity. Quantifying and considering participants' physical activity levels in aging studies can help distinguish changes in motor function associated with biological aging from those induced by inactivity.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Review
Cardiac & Cardiovascular Systems
Ryan Mao Heng Lim, Angela S. S. Koh
Summary: Metabolomics profiling is a valuable tool in investigating the mechanisms underlying how physical activity influences cardiovascular aging, shedding light on the progression of cardiovascular disease. This review highlights the importance of metabolic pathways connecting physical activity with cardiovascular aging.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Geriatrics & Gerontology
Megan Hetherington-Rauth, Joao P. Magalhaes, Pedro B. Judice, Ignacio Ara, Gil B. Rosa, Ines R. Correia, Asier Manas, Luis B. Sardinha
Summary: The study found that higher sedentary time (ST) was associated with lower composite physical function (CPF) score, while higher moderate-to-vigorous physical activity (MVPA) was associated with better CPF score. Breaks in sedentary time (BST) were not related to physical independence after accounting for MVPA and ST. MVPA was found to moderate the relationship between ST and physical independence.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Eva Serna, Cristina Cespedes, Jose Vina
Summary: The aryl hydrocarbon receptor, in addition to its role in xenobiotic detoxification, also plays a significant role in physiological functions and the aging process. Modulation of the signaling pathway of this receptor could be an interesting therapeutic target for aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Jordan Granet, Eva Peyrusque, Fabien Ruiz, Fanny Buckinx, Lilia Ben Abdelkader, Thien Thanh Dang-Vu, Marie-Jose Sirois, Jean-Philippe Gouin, Benjamin Pageaux, Mylene Aubertin-Leheudre
Summary: Background Periods of prolonged lockdown increase the risk of physical inactivity, which can contribute to physical decline among older adults. Online technology could be an innovative solution to promote physical activity (PA) habits in this context. The goal of this study was to examine and compare the acceptability, feasibility, and potential benefits of 2 modalities of web-based PA interventions in older adults during the coronavirus disease 2019 lockdown. Results showed that web-based PA interventions are feasible, acceptable, and beneficial for improving functional capacities and physical performance during periods of lockdown. However, the interactive web and live modalities appear to be more effective for promoting some of these outcomes than recorded and individual modalities.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Pedro G. S. Braga, Fatima R. Freitas, Andre L. L. Bachi, Gislene R. Amirato, Roberta V. Baroni, Maria Janieire N. N. Alves, Rodolfo P. Vieira, Mauro W. Vaisberg, Marlene N. Aldin, Roberto Kalil Filho, Antonio M. Figueiredo Neto, Nagila R. T. Damasceno, Thauany M. Tavoni, Raul C. Maranhao, Zhen Chen
Summary: This study investigated the effects of regular physical activity on two important functions of HDL, namely cholesterol reception and antioxidant capacity. The results showed that active individuals had higher HDL-C levels, better cholesterol transfer, and more HDL subfractions compared to inactive individuals. Age did not have a significant effect on these functions.
Article
Public, Environmental & Occupational Health
Yujie Liu, Xiao Hou, Zhengyan Tang, Hanyue Zhang, Jingmin Liu
Summary: Physical activity, especially leisure and work-related activities, has a positive impact on reducing cognitive reaction time in older adults. Maintaining a moderate level of physical activity is recommended to delay the decline in cognitive function.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Zachary S. Clayton, Rachel A. Gioscia-Ryan, Jamie N. Justice, Kara L. Lubieniecki, David A. Hutton, Matthew J. Rossman, Melanie C. Zigler, Douglas R. Seals
Summary: This study found that consuming a Western diet accelerates declines in physical function compared to a healthy diet in mice, and that voluntary exercise can attenuate the decline in physical function, especially for mice consuming a Western diet.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Nutrition & Dietetics
Marc Sim, Lauren C. Blekkenhorst, Nicola P. Bondonno, Simone Radavelli-Bagatini, Peter Peeling, Catherine P. Bondonno, Dianna J. Magliano, Jonathan E. Shaw, Richard Woodman, Kevin Murray, Joshua R. Lewis, Robin M. Daly, Jonathan M. Hodgson
Summary: The study found that higher habitual dietary nitrate intake, predominantly from vegetables, is associated with stronger lower-limb muscle strength and better physical function. Physical activity level does not influence the relationship between nitrate intake and muscle function.
JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Eeva Aartolahti, Johanna Eronen, Timo Tormakangas, Taina Rantanen, Mirja Hirvensalo, Lotta Palmberg, Heidi Skantz, Anne Viljanen, Erja Portegijs, Susanne Iwarsson, Merja Rantakokko
Summary: This study found that older adults with moderate to high levels of physical activity are more willing to increase their activity when the perceived opportunities for activity are suboptimal, while those with low levels of physical activity are less likely to increase activity for this reason. Therefore, improving equity in physical activity for the elderly requires providing support and opportunities at every level of physical activity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Geriatrics & Gerontology
Razak M. Gyasi, Yvonne Dodzi Ami Adjakloe, Lawrencia Pokua Siaw, Peter Bai James, Padmore Adusei Amoah, Kabila Abass, Samuel Adu-Gyamfi, David R. Phillips
Summary: This large and representative study found that pain among older adults can result in impaired physical function, but this relationship can be modified by physical activity participation. The study highlights the importance of physical activity in managing pain and improving functional ability in aging adults.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Geriatrics & Gerontology
Lucas Melo Neves, Raphael Ritti-Dias, Valeria Juday, Raquel Marquesini, Aline Mendes Gerage, Gilberto Candido Laurentino, Renato Hoffmann Nunes, Brendon Stubbs, Carlos Ugrinowitsch
Summary: Brain atrophy, a decrease in brain volume, is associated with cognitive health in older adults. Insufficient moderate and vigorous physical activity (MVPA) has been linked to lower brain volume. This study found that meeting weekly MVPA recommendations helps preserve the volume of over 30 brain areas and structures in older adults. Additionally, cardiorespiratory fitness is an important predictor of brain volume preservation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Vivian Castillo de Lima, Luz Albany Arcila Castano, Ricardo Aurelio Carvalho Sampaio, Priscila Yukari Sewo Sampaio, Camila Vieira Ligo Teixeira, Marco Carlos Uchida
Summary: Agility training is essential for improving neuromuscular performance and balance in older adults. This study examined the physical and cognitive effects of an agility ladder training program on healthy older adults. The results showed that only the group that received cognitive training alongside agility training showed improvements in cognitive function, while the group that only performed agility training saw improvements in physical performance.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Catherine O'Brien, Roee Holtzer
Summary: Background: Physical reserve (PR) refers to one's ability to maintain physical functioning despite age, illness, or injury. This study quantified PR using a residual measurement approach and predicted fall-risk. Results showed that higher PR was associated with reduced odds of reporting falls and incident falls among older adults.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Clinical Neurology
Susana Lopez-Ortiz, Simone Lista, Pedro L. Valenzuela, Jose Pinto-Fraga, Ricardo Carmona, Filippo Caraci, Giuseppe Caruso, Nicola Toschi, Enzo Emanuele, Audrey Gabelle, Robert Nistico, Francesco Garaci, Alejandro Lucia, Alejandro Santos-Lozano
Summary: The study summarizes the relationship between physical activity and the development of Alzheimer's disease, as well as the impact of exercise on patients with Alzheimer's disease. The findings suggest that physical activity can lower the risk of Alzheimer's disease and exercise has positive effects on cognitive function, physical performance, and functional independence.
JOURNAL OF NEUROLOGY
(2023)
Article
Critical Care Medicine
Zudin A. Puthucheary, Rahul Phadke, Jaikitry Rawal, Mark J. W. McPhail, Paul S. Sidhu, Anthea Rowlerson, John Moxham, Stephen Harridge, Nicholas Hart, Hugh E. Montgomery
CRITICAL CARE MEDICINE
(2015)
Editorial Material
Sport Sciences
S. D. R. Harridge
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2015)
Article
Multidisciplinary Sciences
Chibeza C. Agley, Anthea M. Rowlerson, Cristiana P. Velloso, Norman L. Lazarus, Stephen D. R. Harridge
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Article
Critical Care Medicine
Angela S. McNelly, Jai Rawal, Dinesh Shrikrishna, Nicholas S. Hopkinson, John Moxham, Stephen D. Harridge, Nicholas Hart, Hugh E. Montgomery, Zudin A. Puthucheary
CRITICAL CARE MEDICINE
(2016)
Article
Biology
Louise A. Moyle, Eric Blanc, Oihane Jaka, Johanna Prueller, Christopher R. S. Banerji, Francesco Saverio Tedesco, Stephen D. R. Harridge, Robert D. Knight, Peter S. Zammit
Review
Neurosciences
Norman R. Lazarus, Janet M. Lord, Stephen D. R. Harridge
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Sport Sciences
Tessa E. Morris-Paterson, Stephen A. Stimpson, Ram R. Miller, Matthew E. Barton, Michael S. Leonard, Owen Carmichael, Ken A. van Someren, Stephen D. R. Harridge
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2020)
Review
Physiology
Michaeljohn Kalakoutis, Irene Di Giulio, Abdel Douiri, Julien Ochala, Stephen D. R. Harridge, Roger C. Woledge
Summary: Chemically skinned fibres are used to study human muscle contractile function and specific force (SF) is an important parameter. Variability in SF across studies is due to methodological differences, with solution composition likely being a key factor influencing the values. Despite this variability, consistency in SF values is observed in fibres containing specific myosin heavy chain isoforms.
Editorial Material
Sport Sciences
Stephen D. R. Harridge
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Review
Sport Sciences
Jamie Pethick, Matthew J. D. Taylor, Stephen D. R. Harridge
Summary: During voluntary muscle contractions, force output exhibits fluctuations in both magnitude and complexity. Older adults demonstrate greater magnitude and lower complexity in force fluctuations, indicating decreased steadiness and adaptability of force output. Age-associated loss-of-force control is correlated with decreased performance in daily activities and may be more important for functional capacity than age-associated decreases in maximal strength. Acute physical activity interventions have shown promise in reversing the loss-of-force control in older individuals, but the long-term effects are still unknown.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Editorial Material
Sport Sciences
Stephen D. R. Harridge
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Cell Biology
Michaeljohn Kalakoutis, Ross D. D. Pollock, Norman R. R. Lazarus, R. Andrew Atkinson, Marc George, Onur Berber, Roger C. C. Woledge, Julien Ochala, Stephen D. R. Harridge
Summary: The specific force (SF) of human aging in single muscle fibers is inconsistent in different studies, which may result from variations in the health status/physical activity levels and methodological differences. This study compared SF in fibers from older hip fracture patients, healthy master cyclists, and healthy nontrained young adults using two different activating solutions. The results showed that the activating solution significantly affected the force and revealed a difference in sensitivity in muscle fibers of hip fracture patients.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Pediatrics
C. Alvarez, R. Ramirez-Campillo, J. Cano-Montoya, R. Ramirez-Velez, S. D. R. Harridge, A. M. Alonso-Martinez, M. Izquierdo
Letter
Critical Care Medicine
Zudin A. Puthucheary, Angela S. McNelly, Jai Rawal, Bronwen Connolly, Paul S. Sidhu, Anthea Rowlerson, John Moxham, Stephen D. Harridge, Nicholas Hart, Hugh E. Montgomery
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
