Article
Engineering, Biomedical
Raymond M. Wang, Joshua M. Mesfin, Jervaughn Hunter, Paola Cattaneo, Nuno Guimaraes-Camboa, Rebecca L. Braden, Colin Luo, Ryan C. Hill, Monika Dzieciatkowska, Kirk C. Hansen, Sylvia Evans, Karen L. Christman
Summary: This study demonstrates that myocardial matrix hydrogel exhibits the ability to scavenge reactive oxygen species and protect cells from oxidative stress, as well as enhance cell proliferation. In in vivo experiments using a rat myocardial infarction model, animals treated with matrix injection showed increased thymidine analog uptake in cardiomyocytes, reduced oxidative damage, and improved preservation of tissue free thiol content compared to saline controls. Overall, this study provides evidence that the properties of the myocardial matrix material create a supportive microenvironment for cardiomyocytes undergoing DNA synthesis, potentially facilitating DNA repair or cell cycle activation.
ACTA BIOMATERIALIA
(2022)
Article
Endocrinology & Metabolism
Y. Li, J. Yang, Q. Feng, S-Q Li, Y. Lang, X-F Zhang, C. Ye
Summary: This study found that high cyclic tensile stress can reduce the viability of human chondrocytes, disrupt the extracellular matrix, and promote the generation of reactive oxygen species. The use of antioxidants and specific drugs can partially inhibit this damaging effect.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Review
Chemistry, Multidisciplinary
Konrad A. Szychowski, Bartosz Skora
Summary: ROS and EDPs play important roles in various physiological and pathological processes, and the relationship between them can vary greatly depending on the type of cells, tissue, or organism.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Kate Da Silva, Pradeep Kumar, Sandy F. van Vuuren, Viness Pillay, Yahya E. Choonara
Summary: Novel smart polymer hydrogel biomaterials with 3D printability and interpenetrating polymer networks have been developed for potential applications in traumatic brain injury treatment. These biomaterials have favorable chemical, mechanical, and morphological properties, showing promise in assisting neurological function restoration and neural tissue regeneration after TBI.
Article
Chemistry, Physical
Sajjad Naeimipour, Fatemeh Rasti Boroojeni, Robert Selegard, Daniel Aili
Summary: This study presents an enzyme-mediated thiol-based chemistry for the synthesis of carbohydrate-based hydrogels. The method allows for reversible cross-linking and tunable stiffness of the hydrogels by releasing protected thiols through enzymatic reactions. It also enables handling and encapsulation of cells under ambient conditions.
CHEMISTRY OF MATERIALS
(2022)
Review
Medicine, General & Internal
Lubing Cai, Luze Shi, Zhen Peng, Yaying Sun, Jiwu Chen
Summary: This review discusses the potential crosstalk between extracellular matrix (ECM) characteristics, mitochondrial homeostasis, and the pathogenesis of sarcopenia, a geriatric syndrome characterized by muscle mass, strength, and physical performance reduction. The interplay between ECM and mitochondria is evident, as ECM changes may mediate mitochondrial alterations via metabolism, ROS, SPARC pathway, and AMPK/PGC-1a signaling, leading to muscle degeneration. However, the precise effects of this crosstalk in skeletal muscle and aging are not yet fully understood.
ANNALS OF MEDICINE
(2023)
Article
Environmental Sciences
Chien-Liang Fang, Catherine Reena Paul, Cecilia Hsuan Day, Ruey-Lin Chang, Chia-Hua Kuo, Tsung-Jung Ho, Dennis Jine-Yuan Hsieh, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Summary: Poria cocos extract showed significant protective effects against H2O2-induced cell death, with a reduction in ROS accumulation. The extract suppressed the expression of metallomatrix proteinases, inflammatory markers, and skin aging markers while increasing TGF-beta 1 levels and antioxidant related proteins.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Sen Lin, Dahao Wang, Chang Xu, Peng Zhang, Kai Gao, Chang Liu, Xifan Mei
Summary: In this study, folic acid modified celastrol-loaded nanoparticles were developed, which can release RA symptoms and have validated anti-inflammatory effects. These nanoparticles modify the polarization of macrophages and significantly reduce inflammation levels in serum and joints.
MATERIALS & DESIGN
(2022)
Review
Medicine, General & Internal
Zhiyong Sun, Xiaozhou Zou, Meihua Bao, Zhongjie Huang, Yutao Lou, Yiwen Zhang, Ping Huang
Summary: Ferroptosis is a type of cell death that differs from autophagy or necrosis and is caused by an imbalance in lipid reactive oxygen species. Metabolic pathways and processes such as amino acid and lipid metabolism, iron handling, and mitochondrial respiration play a role in regulating sensitivity to ferroptosis. Organ fibrosis, characterized by excessive extracellular matrix deposition, can lead to organ dysfunction. This review explores the connection between ferroptosis and organ fibrosis, providing potential therapeutic approaches for fibrosis diseases.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Hanze Chen, Xinxin Xu, Qiwen Tang, Linhui Ni, Shuxia Cao, Yonggang Hao, Li Wang, Xingyue Hu
Summary: (+)-Borneol reduces ROS levels in activated neutrophils and inhibits NETosis induced by PMA stimulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sina Bader, Julia Wilmers, Teona Ontikatze, Violetta Ritter, Verena Jendrossek, Justine Rudner
Summary: Tumor hypoxia is a major driver of resistance to chemotherapy and radiotherapy. The pro-oxidative drug dihydroartemisinin (DHA) has shown to efficiently target both normoxic and hypoxic cancer cells. The mechanism behind DHA-mediated cytotoxicity in hypoxia is different from that in normoxia, with a complex interplay of apoptosis, autophagy, and cell death pathways.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hae Dong Jeong, Jin Hyung Kim, Go Eun Kwon, Seung-Taek Lee
Summary: Polyamine oxidase (PAOX) is an enzyme involved in the polyamine catabolism pathway and plays a crucial role in skin aging by generating hydrogen peroxide. Our study found that PAOX expression increased the secretion of MMP-1 and collagen degradation in fibroblast cultures, and this effect was mediated through the activation of specific signaling pathways and the increase in ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Renkai Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Wen Wang, Yiu-Wa Kwan, Emily Sze-Wan Wong, Yanbo Zhang, Jingjing Li, George Pak-Heng Leung
Summary: Despite various therapeutic approaches, developing novel and more effective methods for colorectal cancer treatment is crucial due to its high fatality rate. The recent study explored the anticancer effects of GAR E, a bioactive xanthone found in mangosteen, and identified the involvement of the ROS/JNK signaling pathway in its mechanism of action. The experiments demonstrated that GAR E inhibited colony formation and wound healing in cancer cells, triggered ROS production, induced mitochondrial dysfunction and apoptosis, and caused cell cycle arrest. In vivo experiments also confirmed the antitumor effect of GAR E in a xenograft mouse model. These findings suggest that GAR E could be a potential chemotherapeutic agent for colorectal cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Horticulture
Chen Li, Jiaqi Tao, Zhaoxia Wu
Summary: Mechanical damage during processing can accelerate the senescence and deterioration of fresh-cut red pitaya. In this study, a low-concentration and long-term gaseous ozone treatment was found to delay the decline in fruit quality, enhance the antioxidant activities, and regulate reactive oxygen species (ROS) metabolism of fresh-cut red pitaya fruit. The ozone treatment improved the activity of antioxidant enzymes, maintained the redox balance, and delayed senescence.
SCIENTIA HORTICULTURAE
(2023)
Article
Chemistry, Multidisciplinary
Yu-Ting Jiao, Yi-Ran Kang, Ming-Yong Wen, Hui-Qian Wu, Xin-Wei Zhang, Wei-Hua Huang
Summary: In this study, a dual-wire nanosensor was developed to measure intracellular GSH and ROS levels with high temporal resolution. The results revealed the rapid initiation and short-lived elimination process of the GSH system against ROS burst, with residual ROS still present in the cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)