期刊
PEDIATRIC PULMONOLOGY
卷 52, 期 11, 页码 1384-1404出版社
WILEY
DOI: 10.1002/ppul.23782
关键词
infant; infection; microbiome; RNA; ribosomal; 16S
资金
- Australian Government Research Training Program
- Australian Cystic Fibrosis Research Trust Postgraduate Studentship
- Royal Children's Hospital Foundation
- Royal Children's Hospital Cystic Fibrosis Research Trust
- Thoracic Society of Australia and New Zealand Vertex Cystic Fibrosis Paediatric Clinical Fellowship
Infection plays a critical role in the pathogenesis of cystic fibrosis (CF) lung disease. Over the past two decades, the application of molecular and extended culture-based techniques to microbial analysis has changed our understanding of the lungs in both health and disease. CF lung disease is a polymicrobial disorder, with obligate and facultative anaerobes recovered alongside traditional pathogens in varying proportions, with some differences observed to correlate with disease stage. While healthy lungs are not sterile, differences between the lower airway microbiota of individuals with CF and disease-controls are already apparent in childhood. Understanding the evolution of the CF airway microbiota, and its relationship with clinical treatments and outcome at each disease stage, will improve our understanding of the pathogenesis of CF lung disease and potentially inform clinical management. This review summarizes current knowledge of the early development of the respiratory microbiota in healthy children and then discusses what is known about the airway microbiota in individuals with CF, including how it evolves over time and where future research priorities lie.
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