The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

Short-term oral exposure to low doses of nano-sized TiO 2 and potential modulatory effects on intestinal cells

(2017) Maria Grazia Ammendolia et al.   FOOD AND CHEMICAL TOXICOLOGY

Fecal biomarkers in inflammatory bowel disease

(2017) Robert N Lopez et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Multiwalled Carbon Nanotubules Induce Pathological Changes in the Digestive Organs of Mice

(2016) A. G. Masyutin et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Structural and Functional Analysis of the Small Intestine in Rats After Six-Month-Long Exposure to Multiwalled Carbon Nanotubes

(2016) N. N. Belyaeva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Occupational Risk Assessment of Engineered Nanomaterials: Limits, Challenges and Opportunities

(2016) Veruscka Leso et al.   Current Nanoscience

Micro- and nanoparticulates for DNA vaccine delivery

(2016) Eric Farris et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

(2016) Pedro A Ruiz et al.   GUT

Contribution of ionic silver to genotoxic potential of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by the cytokinesis-block micronucleus assay

(2016) Saura C. Sahu et al.   JOURNAL OF APPLIED TOXICOLOGY

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biomarkers of susceptibility: State of the art and implications for occupational exposure to engineered nanomaterials

(2016) Ivo Iavicoli et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

New frontiers in nanotoxicology: Gut microbiota/microbiome-mediated effects of engineered nanomaterials

(2016) Antonio Pietroiusti et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Tuning the inflammatory response to silver nanoparticles via quercetin in Caco-2 (co-)cultures as model of the human intestinal mucosa

(2016) Alina Martirosyan et al.   TOXICOLOGY LETTERS

Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium

(2016) Katherine M. Williams et al.   JOURNAL OF NANOBIOTECHNOLOGY

Protein corona-induced modification of silver nanoparticle aggregation in simulated gastric fluid

(2016) Andrew P. Ault et al.   Environmental Science-Nano

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition

(2015) Simon Sebastian Raesch et al.   ACS Nano

Nutrition and the science of disease prevention: a systems approach to support metabolic health

(2015) Brian J. Bennett et al.   Annals of the New York Academy of Sciences

Impact of food components during in vitro digestion of silver nanoparticles on cellular uptake and cytotoxicity in intestinal cells

(2015) Dajana Lichtenstein et al.   BIOLOGICAL CHEMISTRY

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

Preparation of UV-protective kefiran/nano-ZnO nanocomposites: Physical and mechanical properties

(2015) Iman Shahabi-Ghahfarrokhi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Detection and Characterization of SiO2 and TiO2 Nanostructures in Dietary Supplements

(2015) Jin-Hee Lim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biological effect of food additive titanium dioxide nanoparticles on intestine: anin vitrostudy

(2015) Zheng-Mei Song et al.   JOURNAL OF APPLIED TOXICOLOGY

Proteomic responses of human intestinal Caco-2 cells exposed to silver nanoparticles and ionic silver

(2015) Axel Oberemm et al.   JOURNAL OF APPLIED TOXICOLOGY

Identification of Nanoscale Ingredients in Commercial Food Products and their Induction of Mitochondrially Mediated Cytotoxic Effects on Human Mesenchymal Stem Cells

(2015) Jegan Athinarayanan et al.   JOURNAL OF FOOD SCIENCE

Rapid Kinetics of Size and pH-Dependent Dissolution and Aggregation of Silver Nanoparticles in Simulated Gastric Fluid

(2015) Jessica L. Axson et al.   Journal of Physical Chemistry C

Toxicity of Zinc Oxide Nanoparticles in Rats Treated by Two Different Routes: Single Intravenous Injection and Single Oral Administration

(2015) Jonghye Choi et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering

(2015) S. Balog et al.   Nanoscale

Repeated dose (28-day) administration of silver nanoparticles of varied size and coating does not significantly alter the indigenous murine gut microbiome

(2015) Laura A. Wilding et al.   Nanotoxicology

Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model

(2015) Ingrid L. Bergin et al.   Nanotoxicology

An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells

(2015) Jonathan J. Powell et al.   Nature Nanotechnology

In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

(2015) Dingsheng Li et al.   Particle and Fibre Toxicology

Effects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium

(2015) Anastasia Georgantzopoulou et al.   Particle and Fibre Toxicology

Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers

(2015) Laetitia C. Pele et al.   Particle and Fibre Toxicology

Dietary silver nanoparticles can disturb the gut microbiota in mice

(2015) Sybille van den Brule et al.   Particle and Fibre Toxicology

How meaningful are risk determinations in the absence of a complete dataset? Making the case for publishing standardized test guideline and ‘no effect’ studies for evaluating the safety of nanoparticulates versus spurious ‘high effect’ results from single investigative studies

(2015) David B Warheit et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells

(2015) Hanqing Chen et al.   Small

Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells

(2015) Andrea Zijno et al.   TOXICOLOGY IN VITRO

Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles

(2015) Kate Jones et al.   TOXICOLOGY LETTERS

Insights into the Cellular Response Triggered by Silver Nanoparticles Using Quantitative Proteomics

(2014) Thiago Verano-Braga et al.   ACS Nano

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: Oral route

(2014) Adeline Tarantini et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health

(2014) Emily B. Hollister et al.   GASTROENTEROLOGY

Synergistic Effects of Zinc Oxide Nanoparticles and Fatty Acids on Toxicity to Caco-2 Cells

(2014) Yi Cao et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

ACS Select on Nanotechnology in Food and Agriculture: A Perspective on Implications and Applications

(2014) Hongda Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by fluorescent microscopy of cytochalasin B-blocked micronucleus formation

(2014) Saura C. Sahu et al.   JOURNAL OF APPLIED TOXICOLOGY

Biomarkers of nanomaterial exposure and effect: current status

(2014) Ivo Iavicoli et al.   JOURNAL OF NANOPARTICLE RESEARCH

In vitro cytotoxicity of silver nanoparticles and zinc oxide nanoparticles to human epithelial colorectal adenocarcinoma (Caco-2) cells

(2014) Yijuan Song et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats

(2014) Katherine Williams et al.   Nanotoxicology

An integrated approach for the in vitro dosimetry of engineered nanomaterials

(2014) Joel M Cohen et al.   Particle and Fibre Toxicology

Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

(2014) Emilie Brun et al.   Particle and Fibre Toxicology

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation

(2014) Hedwig M Braakhuis et al.   Particle and Fibre Toxicology

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

(2014) Rona Miethling-Graff et al.   TOXICOLOGY IN VITRO

Uptake of different crystal structures of TiO2 nanoparticles by Caco-2 intestinal cells

(2014) Constantinos Gitrowski et al.   TOXICOLOGY LETTERS

Engineered Nanomaterials in Food: Implications for Food Safety and Consumer Health

(2014) Alina Martirosyan et al.   International Journal of Environmental Research and Public Health

Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles

(2014) Cindy Gunawan et al.   Journal of Materials Chemistry B

Physicochemical properties and in vitro intestinal permeability properties and intestinal cell toxicity of silica particles, performed in simulated gastrointestinal fluids

(2013) Kumiko Sakai-Kato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Linking the gut microbiota to human health

(2013) Virginia Robles Alonso et al.   BRITISH JOURNAL OF NUTRITION

Toxicity of commercially available engineered nanoparticles to Caco-2 and SW480 human intestinal epithelial cells

(2013) Talia E. Abbott Chalew et al.   CELL BIOLOGY AND TOXICOLOGY

The dynamics of gut-associated microbial communities during inflammation

(2013) Sebastian E Winter et al.   EMBO REPORTS

Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions

(2013) Seung Hyeok Seok et al.   JOURNAL OF APPLIED TOXICOLOGY

Spectroscopic studies of conformational changes of β-lactoglobulin adsorbed on gold nanoparticle surfaces

(2013) Thunnalin Winuprasith et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Analytically monitored digestion of silver nanoparticles and their toxicity on human intestinal cells

(2013) Linda Böhmert et al.   Nanotoxicology

In vitrotoxicity assessment of silver nanoparticles in the presence of phenolic compounds – preventive agents against the harmful effect?

(2013) Alina Martirosyan et al.   Nanotoxicology

Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns

(2013) Susan C. Tilton et al.   Nanotoxicology

Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen

(2013) Roberta Tassinari et al.   Nanotoxicology

Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration

(2013) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Changes in silver nanoparticles exposed to human synthetic stomach fluid: Effects of particle size and surface chemistry

(2013) Samuel K. Mwilu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Mechanistic study on the biological effects of silver and gold nanoparticles in Caco-2 cells – Induction of the Nrf2/HO-1 pathway by high concentrations of silver nanoparticles

(2013) Sasitorn Aueviriyavit et al.   TOXICOLOGY LETTERS

Cytotoxicity of peptide-coated silver nanoparticles on the human intestinal cell line Caco-2

(2012) Linda Böhmert et al.   ARCHIVES OF TOXICOLOGY

Effects of Titanium Dioxide Nanoparticles on Small Intestinal Mucosa in Rats

(2012) G. E. Onishchenko et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Toxicity of ZnO nanoparticles in healthy adult mice

(2012) Mohammad Esmaeillou et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Nanoparticles: a review of particle toxicology following inhalation exposure

(2012) Shahnaz Bakand et al.   INHALATION TOXICOLOGY

Comparative study of ZnO and TiO2nanoparticles: physicochemical characterisation and toxicological effects on human colon carcinoma cells

(2012) Isabella De Angelis et al.   Nanotoxicology

Behaviour of silver nanoparticles and silver ions in anin vitrohuman gastrointestinal digestion model

(2012) Agata P. Walczak et al.   Nanotoxicology

Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells

(2012) Kirsten Gerloff et al.   Nanotoxicology

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Oral exposure to polystyrene nanoparticles affects iron absorption

(2012) Gretchen J. Mahler et al.   Nature Nanotechnology

Intestinal toxicity evaluation of TiO2 degraded surface-treated nanoparticles: a combined physico-chemical and toxicogenomics approach in caco-2 cells

(2012) Matthieu Fisichella et al.   Particle and Fibre Toxicology

Alterations in physical state of silver nanoparticles exposed to synthetic human stomach fluid

(2012) Kim R. Rogers et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles

(2012) Yun Wang et al.   Small

Interactions of Engineered Nanoparticles with Organs Protected by Internal Biological Barriers

(2012) Antonio Pietroiusti et al.   Small

Titanium dioxide induced inflammation in the small intestine

(2012) Carolina Maciel Nogueira   WORLD JOURNAL OF GASTROENTEROLOGY

Characterization of Translocation of Silver Nanoparticles and Effects on Whole-Genome Gene Expression Using an In Vitro Intestinal Epithelium Coculture Model

(2011) Hans Bouwmeester et al.   ACS Nano

Subacute oral toxicity investigation of nanoparticulate and ionic silver in rats

(2011) Niels Hadrup et al.   ARCHIVES OF TOXICOLOGY

Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles

(2011) Birgit K. Gaiser et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles

(2011) Suxing Gui et al.   JOURNAL OF HAZARDOUS MATERIALS

CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-  and IL-6 and Promote Cigarette Smoke-Induced Emphysema

(2011) Z. Xiong et al.   JOURNAL OF IMMUNOLOGY

Responses of human cells to ZnO nanoparticles: a gene transcription study

(2011) Philip J. Moos et al.   Metallomics

Investigation of genotoxic and cytotoxic effects of micro- and nanosized titanium dioxide in six organs of mice in vivo

(2011) Lyudmila P. Sycheva et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

(2011) Ching-Hao Li et al.   Nanotoxicology

Prevalence and characteristics of functional dyspepsia among workers exposed to cement dust

(2011) Luca Coppeta et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Models for oral uptake of nanoparticles in consumer products

(2011) Eleonore Fröhlich et al.   TOXICOLOGY

Nanosilver Particle Effects on Drug Metabolism In Vitro

(2010) J. G. Lamb et al.   DRUG METABOLISM AND DISPOSITION

Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles

(2010) Eun-Jung Park et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract

(2010) Jonathan J. Powell et al.   JOURNAL OF AUTOIMMUNITY

Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles

(2010) Yaling Cui et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A Three-Dimensional Coculture of Enterocytes, Monocytes and Dendritic Cells To Model Inflamed Intestinal Mucosa in Vitro

(2010) Fransisca Leonard et al.   MOLECULAR PHARMACEUTICS

NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration

(2010) Qian Bu et al.   NANOTECHNOLOGY

Subchronic oral toxicity of silver nanoparticles

(2010) Yong Soon Kim et al.   Particle and Fibre Toxicology

Deposition and biokinetics of inhaled nanoparticles

(2010) Marianne Geiser et al.   Particle and Fibre Toxicology

Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells

(2010) Barbara De Berardis et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Colony Forming Efficiency and microscopy analysis of multi-wall carbon nanotubes cell interaction

(2010) Jessica Ponti et al.   TOXICOLOGY LETTERS

Histochemical study of intestinal mucins after administration of silver nanoparticles in Sprague–Dawley rats

(2009) Gil Nam Jeong et al.   ARCHIVES OF TOXICOLOGY

Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice

(2009) Yanmei Duan et al.   BIOMATERIALS

Toxicity and cellular responses of intestinal cells exposed to titanium dioxide

(2009) Brian A. Koeneman et al.   CELL BIOLOGY AND TOXICOLOGY

Aerophagia: Excessive Air Swallowing Demonstrated by Esophageal Impedance Monitoring

(2009) Gerrit J.M. Hemmink et al.   Clinical Gastroenterology and Hepatology

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth factors: possible roles for clinical management of the short bowel syndrome

(2009) Mark E. McMellen et al.   Seminars in Pediatric Surgery

Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects

(2009) Alaaldin M. Alkilany et al.   Small

Cytotoxicity of carboxylic acid functionalized single wall carbon nanotubes on the human intestinal cell line Caco-2

(2009) Angeles Jos et al.   TOXICOLOGY IN VITRO

Silver nanoparticles as a potential antimicrobial additive for weaned pigs

(2008) M. Fondevila et al.   ANIMAL FEED SCIENCE AND TECHNOLOGY

Comparison of acute responses of mice livers to short-term exposure to nano-sized or micro-sized silver particles

(2008) Kyungeun Cha et al.   BIOTECHNOLOGY LETTERS

Twenty-Eight-Day Oral Toxicity, Genotoxicity, and Gender-Related Tissue Distribution of Silver Nanoparticles in Sprague-Dawley Rats

(2008) Yong Soon Kim et al.   INHALATION TOXICOLOGY

Effect of Micro/Nano Silica Particle Feeding for Mice

(2008) Soo Jeong So et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

In vitrocytotoxicity of functionalized single walled carbon nanotubes for targeted gene delivery applications

(2008) Arun Kulamarva et al.   Nanotoxicology

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicity of CdSe Nanoparticles in Caco-2 Cell Cultures

(2008) Lin Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY