Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

Repurposing of Potent Drug Candidates for Multiparasite Targeting

(2017) Vitul Jain et al.   TRENDS IN PARASITOLOGY

Visceral leishmaniasis: Revisiting current treatments and approaches for future discoveries

(2016) Joo Hwan No   ACTA TROPICA

Antileishmanial Activity of Compounds Derived from the Medicines for Malaria Venture Open Access Box Against Intracellular Leishmania major Amastigotes

(2016) Mozna Khraiwesh et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Statin-induced chronic cholesterol depletion inhibits Leishmania donovani infection: Relevance of optimum host membrane cholesterol

(2016) G. Aditya Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Repurposing strategies for tropical disease drug discovery

(2016) Dana M. Klug et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase

(2016) Ana Marcu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The current treatment landscape: the need for antifungal stewardship programmes

(2016) Patricia Muñoz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure–Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis

(2016) Andrew M. Thompson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tamoxifen Induces Apoptosis of Leishmania major Promastigotes in Vitro

(2016) Masoud Doroodgar et al.   KOREAN JOURNAL OF PARASITOLOGY

Quercetin and Its Anti-Allergic Immune Response

(2016) Jiri Mlcek et al.   MOLECULES

Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice

(2016) Suraj P. Parihar et al.   Scientific Reports

Antileishmanial effect of mevastatin is due to interference with sterol metabolism

(2015) Neeradi Dinesh et al.   PARASITOLOGY RESEARCH

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB)

(2015) Rebuma Firdessa et al.   PLoS Neglected Tropical Diseases

Targeting Lysine Deacetylases (KDACs) in Parasites

(2015) Qi Wang et al.   PLoS Neglected Tropical Diseases

Histamine H1-receptor antagonists against Leishmania (L.) infantum: an in vitro and in vivo evaluation using phosphatidylserine-liposomes

(2014) Erika G. Pinto et al.   ACTA TROPICA

Dronedarone, an Amiodarone Analog with Improved Anti-Leishmania mexicana Efficacy

(2014) Gustavo Benaim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2-Acylamino-5-nitro-1,3-thiazoles: Preparation and in vitro bioevaluation against four neglected protozoan parasites

(2014) Carlos Nava-Zuazo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent progress in the study of the interactions of amphotericin B with cholesterol and ergosterol in lipid environments

(2014) Daniel Michał Kamiński   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Mianserin, an antidepressant kills Leishmania donovani by depleting ergosterol levels

(2014) Neeradi Dinesh et al.   EXPERIMENTAL PARASITOLOGY

An update on pharmacotherapy for leishmaniasis

(2014) Shyam Sundar et al.   EXPERT OPINION ON PHARMACOTHERAPY

Activity of anti-cancer protein kinase inhibitors against Leishmania spp.

(2014) L. Sanderson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis

(2014) Suman Gupta et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani

(2014) Sushma Singh et al.   PARASITOLOGY RESEARCH

Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

(2014) Stephen Patterson et al.   TRENDS IN PARASITOLOGY

Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery

(2014) Gautam Patel et al.   MedChemComm

Antileishmanial Activity of the Estrogen Receptor Modulator Raloxifene

(2014) Juliana Q. Reimão et al.   PLoS Neglected Tropical Diseases

Lethal action of the nitrothiazolyl-salicylamide derivative nitazoxanide via induction of oxidative stress in Leishmania (L.) infantum

(2013) Juliana Tonini Mesquita et al.   ACTA TROPICA

TheREnantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

(2013) Stephen Patterson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Natural product based leads to fight against leishmaniasis

(2013) Nisha Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Epidemiological surveillance of leishmaniasis in the European Union: operational and research challenges

(2013) L Gradoni   Eurosurveillance

Leishmanicidal activity of synthetic chalcones in Leishmania (Viannia) braziliensis

(2013) Tatiane F.P. de Mello et al.   EXPERIMENTAL PARASITOLOGY

Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole

(2013) Juliana Tonini Mesquita et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

In Vitro Activity of the Antifungal Azoles Itraconazole and Posaconazole against Leishmania amazonensis

(2013) Sara Teixeira de Macedo-Silva et al.   PLoS One

Imipramine Is an Orally Active Drug against Both Antimony Sensitive and Resistant Leishmania donovani Clinical Isolates in Experimental Infection

(2013) Sandip Mukherjee et al.   PLoS Neglected Tropical Diseases

Drug Repurposing: Far Beyond New Targets for Old Drugs

(2012) T. I. Oprea et al.   AAPS Journal

The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

(2012) T.J. Schmidt et al.   CURRENT MEDICINAL CHEMISTRY

The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase

(2012) Edson Roberto da Silva et al.   EXPERIMENTAL PARASITOLOGY

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

(2012) T. P. C. Dorlo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Abl and Arg Kinases Mediate Distinct Modes of Phagocytosis and Are Required for Maximal Leishmania Infection

(2012) D. M. Wetzel et al.   MOLECULAR AND CELLULAR BIOLOGY

Antileishmanial and Antitrypanosomal Activity of Triterpene Derivatives from Latex of Two Euphorbia Species

(2012) N. Mazoir et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Drug Repurposing and the Medicinal Chemist

(2012) Jeffrey Aubé   ACS Medicinal Chemistry Letters

Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease

(2012) Matthias Witschel et al.   PLoS Neglected Tropical Diseases

Pharmacokinetics of Oral Sitamaquine Taken with or without Food and Safety and Efficacy for Treatment of Visceral Leishmaniais: A Randomized Study in Bihar, India

(2011) Shyam Sundar et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Superior efficacy of oral fluconazole 400 mg daily versus oral fluconazole 200 mg daily in the treatment of cutaneous leishmania major infection: A randomized clinical trial

(2011) Maryam Emad et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Exploring Leishmania major Inositol Phosphorylceramide Synthase (LmjIPCS): Insights into the ceramide binding domain

(2011) John G. Mina et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

LeishVet guidelines for the practical management of canine leishmaniosis

(2011) Laia Solano-Gallego et al.   Parasites & Vectors

Kalanchoe pinnata inhibits mast cell activation and prevents allergic airway disease

(2011) E.A. Cruz et al.   PHYTOMEDICINE

The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

(2011) Rosario Diaz-Gonzalez et al.   PLoS Neglected Tropical Diseases

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

(2011) Geraldine De Muylder et al.   PLoS Neglected Tropical Diseases

Differential Effects of Paromomycin on Ribosomes ofLeishmania mexicanaand Mammalian Cells

(2010) Marisa M. Fernández et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure–activity relationship study

(2010) Juliana Q. Reimão et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase

(2010) John G. Mina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metabolism of two new benzodiazepine-type anti-leishmanial agents in rat hepatocytes and hepatic microsomes and their interaction with glutathione in macrophages

(2010) M. Dao Duong Thi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

In vitro and in vivo antileishmanial efficacy of nitazoxanide against Leishmania donovani

(2010) Ruiyan Zhang et al.   PARASITOLOGY RESEARCH

Antimony Toxicity

(2010) Shyam Sundar et al.   International Journal of Environmental Research and Public Health

Paromomycin for the Treatment of Visceral Leishmaniasis in Sudan: A Randomized, Open-Label, Dose-Finding Study

(2010) Ahmed M. Musa et al.   PLoS Neglected Tropical Diseases

Geographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: A Multicentre, Open-Label, Randomized Trial

(2010) Asrat Hailu et al.   PLoS Neglected Tropical Diseases

Amiodarone and Miltefosine Act Synergistically against Leishmania mexicana and Can Induce Parasitological Cure in a Murine Model of Cutaneous Leishmaniasis

(2009) X. Serrano-Martin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana

(2009) X. Serrano-Martin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group

(2009) Vishal Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

(2009) José C. Aponte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Leishmaniasis: Current Treatment and Prospects for New Drugs and Vaccines

(2009) Lukasz Kedzierski et al.   CURRENT MEDICINAL CHEMISTRY

Fighting Against Leishmaniasis: Search of Alkaloids as Future True Potential Anti-Leishmanial Agents

(2009) Bhuwan Mishra et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

(2008) R. Luise Krauth-Siegel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Relationship between Leishmaniasis and AIDS: the Second 10 Years

(2008) J. Alvar et al.   CLINICAL MICROBIOLOGY REVIEWS

Alkaloids: Future prospective to combat leishmaniasis

(2008) Bhuwan B. Mishra et al.   FITOTERAPIA

Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock

(2008) E.A. Cruz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY