Article
Biochemistry & Molecular Biology
Mehmet Berkoz, Ayhan Yigit, Miroslaw Krosniak
Summary: This study investigated the protective effects of myricetin (MYC) and fisetin (FST) against nephrotoxicity caused by exposure to lead acetate (LA). The results showed that MYC and FST could reduce lead accumulation in kidney tissues, improve antioxidant status, decrease oxidative stress and inflammatory response, and promote renal function recovery.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Applied
Xia Wang, Youpeng Sun, Peixuan Li, Zhikai Wu, Yichun Chen, Yiwu Fu, Hanpeng Wu, Yingrong Ye, Jingjing Wang, Zhengtao Yang, Ershun Zhou
Summary: This study demonstrates that myricetin has protective effects against acute liver failure induced by lipopolysaccharide/D-galactosamine. Myricetin can reduce pathological changes, improve liver function, alleviate oxidative stress and inflammation. These protective effects may be mediated by regulating the Nrf2 signaling pathway.
NATURAL PRODUCT RESEARCH
(2023)
Article
Immunology
Kexin Wang, Shouyang Gao, Junrong Wang, Fan Yu, Cong Ye
Summary: CA protects mice against LPS-induced endometritis by inhibiting ferroptosis through the Nrf2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Gamal A. Mohamed, Sabrin R. M. Ibrahim, Dina S. El-Agamy, Wael M. Elsaed, Alaa Sirwi, Hani Z. Asfour, Abdulrahman E. Koshak, Sameh S. Elhady
Summary: This study investigated the hepatoprotective effect of cucurbitacin E glucoside (CuE) against Con A-induced hepatitis. The results demonstrated that CuE could effectively attenuate liver damage, suppress oxidative stress, and inhibit inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yong Zhang, Zhen Han, Aimin Jiang, Di Wu, Shuangqiu Li, Ziyi Liu, Zhengkai Wei, Zhengtao Yang, Changming Guo
Summary: PTER, a stilbene compound with biological activities, shows protective effect against LPS-induced ALI by inhibiting inflammatory response and oxidative stress, suggesting its potential therapeutic application in ALI intervention.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Frank Cheau-Feng Lin, Shiuan-Shinn Lee, Yi-Ching Li, Yung-Chuan Ho, Wen-Ying Chen, Chun-Jung Chen, Min-Wei Lee, Kun-Lin Yeh, Stella Chin-Shaw Tsai, Yu-Hsiang Kuan
Summary: The study found that kirenol can alleviate LPS-induced lung injury by inhibiting the NF-kappa B proinflammatory pathway and promoting AMPK2/Nrf2-mediated HO-1 and antioxidant enzymes (AOE) activation.
Article
Biochemistry & Molecular Biology
Shan Hu, Beilei Liu, Manqi Yang, Shuai Mao, Hao Ju, Zheyu Liu, Min Huang, Gang Wu
Summary: A study found that carnosic acid (CA) can inhibit the oxidative damage, apoptosis, and pyroptosis induced by doxorubicin (DOX) in the heart, thereby protecting the heart. This study suggests that CA could be a potential therapeutic strategy in the prevention of DOX-associated cardiomyopathy.
Article
Biochemistry & Molecular Biology
Seong Hoon Kim, Hye-Won Yum, Seung Hyeon Kim, Wonki Kim, Su-Jung Kim, Chaekyun Kim, Kyeojin Kim, Young-Ger Suh, Young-Joon Surh
Summary: The study found that TauCl has protective effects against experimentally induced colon inflammation by reducing oxidative stress and inflammation through upregulation of Nrf2-dependent cytoprotective gene expression and blocking proinflammatory signaling mediated by NF-kappa B and STAT3.
Article
Integrative & Complementary Medicine
Qi Feng, Yang Yang, Yingjin Qiao, Yifeng Zheng, Xiaoyue Yu, Fengxun Liu, Hui Wang, Bin Zheng, Shaokang Pan, Kaidi Ren, Dongwei Liu, Zhangsuo Liu
Summary: Diabetic nephropathy (DN) is a major cause of end-stage renal disease. Ferroptosis, a form of cell death, plays a role in the development of DN. Quercetin (QCT), a natural flavonoid, has been reported to ameliorate DN. This study found that QCT inhibits ferroptosis of renal tubular epithelial cells by regulating the Nrf2/HO-1 signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Parasitology
Chengquan Han, Lizeng Guan, Lu Xu
Summary: T. gondii infection can cause liver injury, but the Chinese herbal extract luteoloside (Lut) has been found to have hepatoprotective effects by reducing inflammation and oxidative stress. Lut decreases inflammatory factors and oxidative products, while increasing antioxidant enzymes. It also inhibits inflammatory signaling pathways and enhances the antioxidant pathway.
PARASITOLOGY RESEARCH
(2023)
Article
Immunology
Chenchen Yuan, Xiaowu Dong, Songxin Xu, Qingtian Zhu, Xingmeng Xu, Junxian Zhang, Weijuan Gong, Yanbing Ding, Jiajia Pan, Guotao Lu, Weiwei Chen, Ting Xie, Baiqiang Li, Weiming Xiao
Summary: This study investigates the impact of AKBA on acute pancreatitis (AP) and its underlying mechanisms. The results demonstrate that AKBA exerts protective effects against AP by inhibiting oxidative stress and modulating the Nrf2/HO-1 pathway in macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Fangfang Li, Jingfeng Peng, Hui Feng, Yiming Yang, Jianbo Gao, Chunrui Liu, Jie Xu, Yanru Zhao, Siyu Pan, Yixiao Wang, Luhong Xu, Wenhao Qian, Jing Zong
Summary: This study reveals that KLF9 exacerbates cardiac dysfunction, inflammatory response, and oxidative stress in diabetic cardiomyopathy. KLF9 may be a potential therapeutic target for diabetic cardiomyopathy.
Article
Biochemistry & Molecular Biology
Chengxing Liu, Jin Zhou, Boyuan Wang, Yuqi Zheng, Shangwei Liu, Wenling Yang, Dazhu Li, Shaolin He, Jibin Lin
Summary: Bortezomib pretreatment mitigates myocardial ischemia reperfusion injury by inhibiting oxidative damage which is regulated by the Nrf2/HO-1 signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Plant Sciences
Ying Zhang, Zhaojun Li, Haijie Wu, Jing Wang, Sen Zhang
Summary: The study evaluates the renal protective effect of esculetin against the progression of lupus nephritis and finds that esculetin can significantly improve renal function and pathology. It exhibits antioxidant and anti-inflammatory properties and acts on LN through multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shaolin Tan, Yuangang Su, Linke Huang, Siyu Deng, Guohua Yan, Xue Yang, Runfeng Chen, Yansi Xian, Jiamin Liang, Qian Liu, Jianwen Cheng
Summary: Cor can inhibit osteoclastogenesis and bone resorption, reduce inflammator- induced bone defects, making it a potential therapeutic agent for osteoclast-mediated osteolytic diseases.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)