Synthesis of Antitumor Fluorinated Pyrimidine Nucleosides

Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

(2016) Long Ma et al.   RSC Advances

Synthesis and antitumor activity of capecitabine derivatives

(2015) Xuedong Jia et al.   CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

2′-Fluorination of Tricyclo-DNA Controls Furanose Conformation and Increases RNA Affinity

(2015) Alena Istrate et al.   ORGANIC LETTERS

Synthesis of the antitumoral nucleoside capecitabine through a chemo-enzymatic approach

(2015) Samuele Ciceri et al.   TETRAHEDRON LETTERS

Discovery of a Bacterial 5-Methylcytosine Deaminase

(2014) Daniel S. Hitchcock et al.   BIOCHEMISTRY

Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner

(2014) Kenzo Fujimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The synthesis of gemcitabine

(2014) Kylie Brown et al.   CARBOHYDRATE RESEARCH

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

(2014) David O’Hagan et al.   CHEMICAL REVIEWS

Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs

(2014) Cindy Serdjebi et al.   Expert Opinion on Drug Metabolism & Toxicology

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

(2014) Jason T. Weiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir

(2014) Manuel Peifer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An efficient biocatalytic system for floxuridine biosynthesis based on Lactobacillus animalis ATCC 35046 immobilized in Sr-alginate

(2014) Valeria A. Cappa et al.   PROCESS BIOCHEMISTRY

Stereochemical Preference of 2'-Deoxycytidine for Chiral Bis(diamido)-bridged Basket Resorcin[4]arenes

(2013) Ilaria D'Acquarica et al.   CHIRALITY

Synthesis and Cytostatic Evaluation of 4-N-Alkanoyl and 4-N-Alkyl Gemcitabine Analogues

(2013) Jesse Pulido et al.   JOURNAL OF MEDICINAL CHEMISTRY

A comparison between immobilized pyrimidine nucleoside phosphorylase from Bacillus subtilis and thymidine phosphorylase from Escherichia coli in the synthesis of 5-substituted pyrimidine 2′-deoxyribonucleosides

(2013) Immacolata Serra et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Gemcitabine–Coumarin–Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug

(2013) Sukhendu Maiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

One-pot approach to functional nucleosides possessing a fluorescent group using nucleobase-exchange reaction by thymidine phosphorylase

(2013) Akihiko Hatano et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Evidence produced in Japan: tegafur-based preparations for postoperative chemotherapy in breast cancer

(2013) Toru Watanabe   Breast Cancer

2′-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling

(2012) Katja Fauster et al.   ACS Chemical Biology

Synthesis and biological activity evaluation of cytidine-5′-deoxy-5-fluoro-N-[(alkoxy/aryloxy)] carbonyl-cyclic 2′,3′-carbonates

(2012) V. Jhansi Rani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and applications of fluorinated nucleoside analogues

(2012) Hanna Wójtowicz-Rajchel   JOURNAL OF FLUORINE CHEMISTRY

Biotransformation of halogenated 2′-deoxyribosides by immobilized lactic acid bacteria

(2012) Claudia N. Britos et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Rapid Continuous Synthesis of 5′-Deoxyribonucleosides in Flow via Brønsted Acid Catalyzed Glycosylation

(2012) Bo Shen et al.   ORGANIC LETTERS

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2′-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes

(2011) Johan Vande Voorde et al.   BIOCHEMICAL PHARMACOLOGY

Unprecedented gas-phase chiroselective logic gates

(2011) Bruno Botta et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recombinant lipase fromCandida rugosafor regioselective hydrolysis of peracetylated nucleosides. A comparison with commercial non-recombinant lipases

(2010) Teodora Bavaro et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Synthesis and in vitro cytotoxic activity on human anaplastic thyroid cancer cells of lipoamino acid conjugates of gemcitabine

(2010) Rosario Pignatello et al.   DRUG DEVELOPMENT RESEARCH

Synthesis and Crystal Structure of 2′-Se-Modified Guanosine Containing DNA

(2010) Jozef Salon et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Syntheses of Clofarabine and Gemcitabine From 2-Deoxyribonolactone

(2010) Yana Cen et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

An efficient large-scale synthesis of gemcitabine employing a crystalline 2,2-difluoro-α-ribofuranosyl bromide

(2010) Young-Kil Chang et al.   TETRAHEDRON

Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil

(2009) Zhongshan Zhang et al.   CARBOHYDRATE POLYMERS

An enzymatic route to 5-deoxy-5-[18F]fluoro-d-ribose, a [18F]-fluorinated sugar for PET imaging

(2009) Mayca Onega et al.   CHEMICAL COMMUNICATIONS

Evolving Approaches to Metastatic Breast Cancer Previously Treated with Anthracyclines and Taxanes

(2009) Conleth G. Murphy et al.   Clinical Breast Cancer

A Versatile Synthesis of 5′-Functionalized Nucleosides Through Regioselective Enzymatic Hydrolysis of Their Peracetylated Precursors

(2009) Teodora Bavaro et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

New [11C]Phosgene Based Synthesis of [11C]Pyrimidines for Positron Emission Tomography

(2009) Koh-ichi Seki et al.   HETEROCYCLES

Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles

(2009) Sarit S. Agasti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The dual role of thymidine phosphorylase in cancer development and chemotherapy

(2009) Annelies Bronckaers et al.   MEDICINAL RESEARCH REVIEWS

Recent advances in the synthesis of fluorinated nucleosides

(2009) Xiao-Long Qiu et al.   TETRAHEDRON

Fluorinase-Coupled Base Swaps: Synthesis of [18F]-5′-Deoxy-5′-fluorouridines

(2008) Margit Winkler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formulary Forum: Ixabepilone: A New Antimitotic for the Treatment of Metastatic Breast Cancer

(2008) Shriya Bhushan et al.   ANNALS OF PHARMACOTHERAPY

Design and synthesis of a β-lactamase activated 5-fluorouracil prodrug

(2008) Ryan M. Phelan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3-Aminoxypropionate-based linker system for cyclization activation in prodrug design

(2008) Yiyu Ge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Preclinical discovery of ixabepilone, a highly active antineoplastic agent

(2008) Francis Y. F. Lee et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

New Therapeutic Options for Chemotherapy-Resistant Metastatic Breast Cancer

(2008) Paolo Pronzato   DRUGS

A Model for Light-Triggered Porphyrin Anticancer Prodrugs Based on ano-Nitrobenzyl Photolabile Group

(2008) Weiying Lin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Vinorelbine in breast cancer

(2008) Jacques Bonneterre et al.   EXPERT OPINION ON PHARMACOTHERAPY

Fluorinated nucleosides: Synthesis and biological implication

(2008) Peng Liu et al.   JOURNAL OF FLUORINE CHEMISTRY

An Improved Preparation Process for Gemcitabine

(2008) Xiangrui Jiang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Chemoenzymatic preparation of nucleosides from furanoses

(2008) Marisa Taverna-Porro et al.   TETRAHEDRON LETTERS