期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2008, 期 5, 页码 793-796出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200700972
关键词
anticancer; prodrugs; porphyrinoids; light-triggered compounds; cytotoxicity
A model for light-triggered porphyrin anticancer prodrug 1 was designed and synthesized. Upon photolysis, prodrug 1 can efficiently liberate the anticancer drug tegafur. The MTT assay demonstrates that prodrug 1 is significantly less toxic than its parent drug tegafur, and I can release tegafur upon photoactivation in vitro. The light-triggered porphyrin anti-cancer prodrug technique developed herein may find useful applications in chemotherapy to minimize the side effects of anticancer drugs because of the tumor affinity property of porphyrin and the light-controllable anticancer drug dosing. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
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