Diastereoselective [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2HCHN2: syntheses of CF2H-containing spirooxindoles

Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

(2017) Katharina J. Hock et al.   GREEN CHEMISTRY

Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

(2017) Angelo Aguilar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium

(2017) Zhang Feng et al.   Nature Chemistry

Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes

(2017) James R. Bour et al.   ORGANOMETALLICS

Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides

(2017) Changhui Lu et al.   Chemical Science

Metal-Catalyzed Direct Difluoromethylation Reactions

(2017) Jian Rong et al.   Asian Journal of Organic Chemistry

The Evolution of Pd0/PdII-Catalyzed Aromatic Fluorination

(2016) Aaron C. Sather et al.   ACCOUNTS OF CHEMICAL RESEARCH

Controlled Fluoroalkylation Reactions by Visible-Light Photoredox Catalysis

(2016) Tanmay Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fine Design of Photoredox Systems for Catalytic Fluoromethylation of Carbon–Carbon Multiple Bonds

(2016) Takashi Koike et al.   ACCOUNTS OF CHEMICAL RESEARCH

Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

(2016) Jian Rong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

(2016) Xiaoyu Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents

(2016) Bin Yu et al.   Anti-Cancer Agents in Medicinal Chemistry

Visible-light-mediated radical oxydifluoromethylation of olefinic amides for the synthesis of CF2H-containing heterocycles

(2016) Weijun Fu et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with 3-alkenyl-5-arylfuran-2(3H)-ones

(2016) Zhen-Hua Wang et al.   CHEMICAL COMMUNICATIONS

The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations

(2016) Chuanfa Ni et al.   CHEMICAL SOCIETY REVIEWS

Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach

(2016) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of CF2H-Substituted Pyrazolines by [3+2] Cycloaddition between CF2HCHN2and Electron-Deficient Alkenes

(2016) Jue Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

(2016) Long Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorination methods in drug discovery

(2016) Damian E. Yerien et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent

(2016) Hiroki Serizawa et al.   ORGANIC LETTERS

Palladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent

(2016) Kohsuke Aikawa et al.   ORGANIC LETTERS

Pd-Catalyzed Transfer of Difluorocarbene

(2016) Xiao-Yun Deng et al.   ORGANIC LETTERS

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

(2016) Shengzheng Wang et al.   ORGANIC LETTERS

Enantioselective Synthesis of Dihydrospiro[indoline-3,4′-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction

(2016) Nandarapu Kumarswamyreddy et al.   ORGANIC LETTERS

Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters

(2016) S. M. Banik et al.   SCIENCE

Origin of Stereoselectivity in Cooperative Asymmetric Catalysis Involving N-Heterocyclic Carbenes and Lewis Acids toward the Synthesis of Spirooxindole Lactone

(2016) Yernaidu Reddi et al.   ACS Catalysis

Therapeutic Potential of Spirooxindoles as Antiviral Agents

(2016) Na Ye et al.   ACS Infectious Diseases

α-Regioselective [3 + 2] annulations with Morita–Baylis–Hillman carbonates of isatins and 2-nitro-1,3-enynes

(2016) Guang-Yao Ran et al.   Organic Chemistry Frontiers

Advances in Transition-Metal-Mediated Di-and Monofluoroalkylations

(2015) Chuanfa Ni et al.   ACTA CHIMICA SINICA

Recent Advances of α-Isothiocyanato Compounds in the Catalytic Asymmetric Reaction

(2015) Wen-Yong Han et al.   ADVANCED SYNTHESIS & CATALYSIS

In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes

(2015) Pavel K. Mykhailiuk   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Difluoromethylation Reaction

(2015) Yang Lu et al.   CURRENT ORGANIC CHEMISTRY

Organocatalytic Asymmetric Michael/Cyclization Cascade Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with α,β-Unsaturated Acyl Phosphonates for the Construction of Spirocyclic Oxindole-γ-lactones/lactams

(2015) Lin Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate

(2015) Zhang Feng et al.   ORGANIC LETTERS

Zn-Catalyzed Diastereo- and Enantioselective Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles: Stereocontrolled Syntheses of Polycyclic Spirooxindoles

(2015) Jian-Qiang Zhao et al.   ORGANIC LETTERS

Organocatalytic Enantioselective 1,3-Dipolar Cycloadditions between Seyferth–Gilbert Reagent and Isatylidene Malononitriles: Synthesis of Chiral Spiro-phosphonylpyrazoline-oxindoles

(2015) Taiping Du et al.   ORGANIC LETTERS

Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles

(2015) Jian-Qiang Zhao et al.   ORGANIC LETTERS

An overview of reductive trifluoromethylation reactions using electrophilic ‘+CF3’ reagents

(2015) Shi-Meng Wang et al.   TETRAHEDRON

Oxidative Trifluoromethylation and Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane as a Nucleophilic CF3 Source

(2014) Lingling Chu et al.   ACCOUNTS OF CHEMICAL RESEARCH

β-Functionalization of Carboxylic Anhydrides with β-Alkyl Substituents through Carbene Organocatalysis

(2014) Zhichao Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

Recent progress in transition-metal-catalyzed trifluoromethylation of olefins using electrophilic CF3 reagents

(2014) Takashi Koike et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthesis of CF3-Containing 3,3′-Cyclopropyl Spirooxindoles by Sequential [3 + 2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2-Trifluorodiazoethane

(2014) Tian-Ren Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Lewis Acid Catalyzed Unprecedented [3 + 2] Cycloaddition Yields 3,3′-Pyrrolidinyldispirooxindoles Containing Four Contiguous Chiral Stereocenters with Two Contiguous Quaternary Spirostereocenters

(2014) Koorathota Suman et al.   ORGANIC LETTERS

Visible-Light-Mediated Fluoroalkylation of Isocyanides with Ethyl Bromofluoroacetates: Unified Synthesis of Mono- and Difluoromethylated Phenanthridine Derivatives

(2014) Xiaoyang Sun et al.   ORGANIC LETTERS

Visible Light-Mediated C–H Difluoromethylation of Electron-Rich Heteroarenes

(2014) Yi-Ming Su et al.   ORGANIC LETTERS

Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides

(2014) Yang Gu et al.   Nature Communications

Metal and carbene organocatalytic relay activation of alkynes for stereoselective reactions

(2014) Kayambu Namitharan et al.   Nature Communications

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

(2014) Xue-Liang Jiang et al.   Organic Chemistry Frontiers

Catalytic fluorination of unactivated C(sp3)–H bonds

(2014) Jun-An Ma et al.   Organic Chemistry Frontiers

Bicyclization of Diazomethanes: A Synthetic Strategy for Fused Pyrazoles

(2013) He Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles

(2013) Liang Hong et al.   ADVANCED SYNTHESIS & CATALYSIS

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preparation of pharmaceutical important fluorinated 1-arylethanols using isolated enzymes

(2013) Bård Helge Hoff et al.   BIOORGANIC CHEMISTRY

Development of Synthetic Transformations by Control of Acid-Catalyzed Reactions of Diazocarbonyl Compounds

(2013) Takuya Hashimoto et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane

(2012) G. K. Surya Prakash et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategies for the enantioselective synthesis of spirooxindoles

(2012) Nicolas R. Ball-Jones et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Noncovalent Organocatalysis: A Powerful Tool for the Nucleophilic Epoxidation of α-Ylideneoxindoles

(2011) Chiara Palumbo et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Fluorine in health care: Organofluorine containing blockbuster drugs

(2010) David O’Hagan   JOURNAL OF FLUORINE CHEMISTRY

Catalytic enantioselective 1,3-dipolar cycloadditions of alkyl diazoacetates with α,β-disubstituted acroleins

(2009) Lizhu Gao et al.   CHEMICAL COMMUNICATIONS

Recent development of reactions with α-diazocarbonyl compounds as nucleophiles

(2009) Yan Zhang et al.   CHEMICAL COMMUNICATIONS

Synthesis of Celecoxib Analogues Possessing aN-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity

(2009) Morshed A. Chowdhury et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient method for the synthesis of functionalized pyrazoles by catalyst-free one-pot tandem reaction of nitroalkenes with ethyl diazoacetate

(2009) Jian-Wu Xie et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART