Synthesis, SAR and biological studies of sugar amino acid-based almiramide analogues: N-methylation leads the way

N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA

(2015) Thomas A. Hilimire et al.   ACS Chemical Biology

Enantiomeric Cyclic Peptides with Different Caco-2 Permeability Suggest Carrier-Mediated Transport

(2015) Udaya Kiran Marelli et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metadynamics Simulations Rationalise the Conformational Effects Induced byN-Methylation of RGD Cyclic Hexapeptides

(2015) Cristina Paissoni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Potential therapeutic targets and the role of technology in developing novel antileishmanial drugs

(2015) Rajalakshmi Rajasekaran et al.   DRUG DISCOVERY TODAY

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues

(2015) Andrew T. Bockus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of linear and cyclic opioid-based peptide analogs containing multipleN-methylated amino acid residues

(2015) Anna Adamska et al.   JOURNAL OF PEPTIDE SCIENCE

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Antileishmanial drug discovery: comprehensive review of the last 10 years

(2015) Jaiprakash N. Sangshetti et al.   RSC Advances

Synthesis, Structure–Activity Relationships, and Biological Studies of Chromenochalcones as Potential Antileishmanial Agents

(2014) Rahul Shivahare et al.   JOURNAL OF MEDICINAL CHEMISTRY

HBTU mediated 1-hydroxybenzotriazole (HOBt) conjugate addition: synthesis and stereochemical analysis of β-benzotriazole N-oxide substituted γ-amino acids and hybrid peptides

(2014) Sachitanand M. Mali et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A rapid entry to amino acid derived diverse 3,4-dihydropyrazines and dihydro[1,2,3]triazolo[1,5-a]pyrazines through 1,3-dipolar cycloaddition

(2014) Saurav Bera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A compendium of cyclic sugar amino acids and their carbocyclic and heterocyclic nitrogen analogues

(2013) Martijn Risseeuw et al.   AMINO ACIDS

A Synthetic Dolastatin 10 Analogue Suppresses Microtubule Dynamics, Inhibits Cell Proliferation, and Induces Apoptotic Cell Death

(2013) Praveen Kumar Gajula et al.   JOURNAL OF MEDICINAL CHEMISTRY

Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei

(2013) Laura M. Sanchez et al.   JOURNAL OF NATURAL PRODUCTS

Tetrahydrofuran amino acids of the past decade

(2013) Vitālijs Rjabovs et al.   TETRAHEDRON

N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Novel S-Adenosyl-l-Homocysteine Hydrolase Inhibitors through Homology-Model-Based Virtual Screening, Synthesis, and Biological Evaluation

(2012) Prashant Khare et al.   Journal of Chemical Information and Modeling

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified

(2012) Johannes G. Beck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Tubulin Colchicine Domain: a Molecular Modeling Perspective

(2011) Alberto Massarotti et al.   ChemMedChem

Solid-Phase Synthesis of NMe-IB-01212, a Highly N-Methylated Cyclic Peptide

(2011) Eleonora Marcucci et al.   ORGANIC LETTERS

Almiramides A−C: Discovery and Development of a New Class of Leishmaniasis Lead Compounds

(2010) Laura M. Sanchez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins

(2009) Rufine Akue-Gedu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure−Activity Relationship and Comparative Docking Studies for Cycloguanil Analogs as PfDHFR-TS Inhibitors

(2009) Prasanna Sivaprakasam et al.   Journal of Chemical Information and Modeling

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates againstTrypanosomaandLeishmania

(2009) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of cyclic peptide analogues of the 310 helical Pro138-Gly144 segment of human aquaporin-4 by olefin metathesis

(2009) Øyvind Jacobsen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Microtubules as antiparasitic drug targets

(2008) BJ Fennell et al.   Expert Opinion on Drug Discovery

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes

(2008) Manica Balasegaram et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE