Review
Chemistry, Multidisciplinary
Yawen Yao, Xintong Meng, Cheng Li, Katrien V. Bernaerts, Kai Zhang
Summary: Carbohydrates are considered as an ideal candidate for chirality study due to their unique chemical structures, abundance, and sustainability. Efforts have been made to design and synthesize diverse carbohydrate derivatives and self-assemble them into various supermolecular morphologies. However, there is still insufficient understanding of how carbohydrate structures and self-assembly approaches affect the final morphologies and properties for future demands.
Article
Chemistry, Multidisciplinary
Shuang Chen, Zenghui Li, Chunhui Zhang, Xia Wu, Wenjie Wang, Qingjun Huang, Weiyu Chen, Junfeng Shi, Dan Yuan
Summary: As an important noncovalent interaction, cation-p interaction plays a crucial role in various biological and chemical applications. In this study, peptide amphiphiles were designed with cation-p interaction pairs, which could self-assemble into supramolecular hydrogels under physiological conditions. The influence of cation-p interaction on peptide folding propensity, morphology, and rigidity of the hydrogel was thoroughly investigated. The results showed that cation-p interaction can serve as a major driving force for peptide folding, resulting in the formation of fibril-rich hydrogels. Additionally, the designed peptides showed high efficacy in cytosolic protein delivery. This work provides a novel strategy to generate supramolecular biomaterials using cation-p interactions for the first time.
Article
Biochemistry & Molecular Biology
Zhen Guo, Yongshun Song, Yujiao Wang, Tingyuan Tan, Yuwen Ji, Guangxu Zhang, Jun Hu, Yi Zhang
Summary: The study investigated the chiral characteristics of supramolecular microstructures formed by two chiral peptides composed of either L- or D-amino acids. It was found that the peptides self-assembled into either right- or left-handed helical nanofibrils individually, but formed achiral nanowire-like structures when co-assembled in varying concentration ratios. Molecular dynamics simulations showed a preference for self-assembly into handed nanofibrils, but a higher probability for co-assembly when presented together. This sheds light on the molecular mechanisms of the macrochirality of peptide supramolecular microstructures.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Tengyan Xu, Huihui Ren, Yu Fang, Kun Liang, Hongyue Zhang, Dingwei Li, Yitong Chen, Bowen Zhu, Huaimin Wang
Summary: This study presents the first example of a peptidic hydrogel gated bio-FET by surface assisted self-assembly for label-free and real-time monitoring of glucose. The boric acid-containing peptide forms a hydrogel layer on the surface of In2O3, which interacts with glucose reversibly and influences the semiconductor's conductivity. The results demonstrate the superiority of hydrogel gated bio-FET for real-time monitoring of glucose in complex environments and its potential as a wearable device. This work illustrates a simple and fundamental strategy for integrating peptidic hydrogel with bio-FET for the real-time detection of analytes.
APPLIED MATERIALS TODAY
(2023)
Article
Chemistry, Multidisciplinary
Hongfang Li, Cuijuan Xing, Weitao Huo, Jun Zhao, Yongchao Hao, Zhangji Hu
Summary: By synthesizing a porphyrin covalently modified peptide, a hydrogel with enhanced mechanical strength and improved efficiency in photoelectric conversion was successfully constructed.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Agricultural Engineering
Hao Meng, Yijie Zhao, Shuo Wang, Yonggui Wang, Zefang Xiao, Haigang Wang, Daxin Liang, Yanjun Xie
Summary: This study focused on the formation of lignin-based petaloid nanoflakes (LPNFs) through the crystallization of lignin stearoyl esters (LSEs) and their application to transform hydrophilic substrates into superhydrophobic surfaces. The synthesis of LPNFs with tunable structures offers a new strategy for the derivation and value-added utilization of lignin.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Vijay Kumar Pal, Sangita Roy
Summary: Noncovalent interactions among short peptides and proteins lead to their self-assembly into supramolecular packaging, providing the basis of life. These assemblies are sensitive to environmental conditions and can be used to develop stimuli-responsive biomaterials. Here, the cooperative effect of divalent metal ions in promoting hydrogelation in collagen-inspired self-assembling peptide is reported for the first time, showing potential for advanced biomaterial development.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Polymer Science
Raliat O. Abioye, Caleb Acquah, Pei Chun Queenie Hsu, Nico Huttmann, Xiaohong Sun, Chibuike C. Udenigwe
Summary: Egg white protein hydrolysate generated with pepsin was found to contain peptides with self-assembly and hydrogelation properties. The study identified several aggregation-prone peptides, including NIFYCPIAIM which formed beta-sheet structures with heterogeneous particle size distribution, and MMYQIGLF and VYSFSLASRL which formed densely packed fibrils. These findings provide valuable insights into the influence of peptide sequence on hydrogelation and self-assembly, and the potential of food peptides in biomaterial applications.
Article
Chemistry, Multidisciplinary
Martin Calvelo, Charlotte Lynch, Juan R. Granja, Mark S. P. Sansom, Rebeca Garcia-Fandino
Summary: The study investigated the behavior of two self-assembling peptide motifs through MD simulations, demonstrating the impact of water molecules in nanopores on channel properties. Different water models exhibit varying dynamic behavior in self-assembled cyclic peptide nanotubes, influencing water diffusion and ion flux through the channels.
Article
Biochemistry & Molecular Biology
Maria Cristina Cringoli, Silvia Marchesan
Summary: Cysteine redox chemistry is used in nature for protein assembly and has inspired the design of self-assembling peptides. This review focuses on recent advancements in using Cys thiol-disulfide redox chemistry to modulate hydrogelation of various peptide classes.
Article
Biochemistry & Molecular Biology
Anne George, Narayanaswamy Jayaraman
Summary: This study investigates ethylene glycol-tethered anthracenemethyl glucosides, which can self-assemble into chiral structures in aqueous solution, with morphology controlled by the linker length.
CARBOHYDRATE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rie Wakabayashi, Ayato Higuchi, Hiroki Obayashi, Masahiro Goto, Noriho Kamiya
Summary: This study investigated the self-assembly and enzymatic post-modification of short aromatic peptide amphiphiles, showing that these molecules can form fibrous structures and their assembly is influenced by solution pH. Moreover, enzymatic reactions showed different rates at varying pH, indicating pH dependency in the enzyme-catalyzed post-modification process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Polymer Science
Shuangyang Li, Qixuan Yu, Hongpeng Li, Meiqi Chen, Ye Jin, Da Liu
Summary: Regenerative medicine is an increasingly popular research topic, focusing on the regeneration of skin, bone, and nerves. The development of a new drug is urgently needed due to the vulnerability and weak self-repair ability of these tissues. Self-assembled peptide hydrogel, a scaffolding material similar to the cytoplasmic matrix, has shown great potential in promoting cell adhesion, migration, proliferation, and division. However, more research is needed to understand the specific mechanisms of self-assembled peptide hydrogels in tissue regeneration.
Article
Chemistry, Multidisciplinary
Muhetaerjiang Mamuti, Rui Zheng, Hong-Wei An, Hao Wang
Summary: The emergence of nanomedicine has significantly improved the pharmacokinetics of conventional therapeutic agents. However, biological barriers and changes in stability and surface properties during transportation hinder its clinical translation. Therefore, a strategy of in vivo self-assembly has been proposed to overcome these challenges and enhance targeted accumulation towards disease sites.
Article
Chemistry, Multidisciplinary
Guillermo Moreno-Alcantar, Alessandro Aliprandi, Remi Rouquette, Luca Pesce, Klaus Wurst, Claudio Perego, Peter Bruggeller, Giovanni M. Pavan, Luisa De Cola
Summary: Self-assembly relies on the ability of smaller entities to arrange into organized systems, with the design of the media playing a crucial role. The media determines the self-assembly pathway and can control the wrapping process of supramolecular homo-aggregates by a different crystal lattice component. This reverse coating process is controlled by the media composition and could lead to the construction of hierarchical supramolecular structures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Normazida Rozi, Mohd Hazani Mat Zaid, Nurfaizah Abu Tahrim, Masato Ikeda, Sharina Abu Hanifah
Summary: The impact of estrogenic endocrine-disrupting chemicals (eEDCs) exposure is unpredictable. The incomplete removal of estrogenic eEDCs from wastewater treatment plants has raised concerns about water re-use. Therefore, accurate analysis of effluent from wastewater treatment plants is crucial for the preliminary assessment of eEDCs detection and identification of their presence in the environment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Taku Ohtomi, Sayuri L. Higashi, Daisuke Mori, Aya Shibata, Yoshiaki Kitamura, Masato Ikeda
Summary: By adjusting the position of the side chain phenyl group, the dimensions and morphology of self-assembled nanostructures of dipeptide hydrazides can be changed, highlighting the significance of systematic investigations in exploring functional soft nanomaterials.
Article
Biochemistry & Molecular Biology
Naoki Tsutsumi, Akitaka Ito, Azumi Ishigamori, Masato Ikeda, Masayuki Izumi, Rika Ochi
Summary: In this study, a novel bola-amphiphilic glycosylated lipopeptide-type supramolecular hydrogelator is presented, exhibiting reversible thermochromism and gel-sol transition. The investigation focused on the effects of different numbers of F residues on gelation ability and morphology of self-assembled nanostructures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Nanami Shirakami, Sayuri L. Higashi, Yugo Kawaki, Yoshiaki Kitamura, Aya Shibata, Masato Ikeda
Summary: In this study, a reduction-responsive oligonucleotide was constructed by post-modifying an oligonucleotide with a diazo compound bearing a 4-nitrobenzyl group. The introduction of the 4-nitrobenzyl group and the subsequent reduction-triggered recovery of the original oligonucleotide were confirmed using HPLC and mass spectrometry. The protocol for preparing this reduction-responsive oligonucleotide is simple and it holds promise for various applications in the fields of chemical and synthetic biology.
Article
Chemistry, Multidisciplinary
Nanami Shirakami, Yugo Kawaki, Sayuri L. Higashi, Aya Shibata, Yoshiaki Kitamura, Sharina Abu Hanifah, Lim Lee Wah, Masato Ikeda
Summary: Oxidation-responsive oligonucleotides can exhibit controlled functions by sensing dysregulated oxidation conditions in living systems. The postmodification approach described here involves introducing a 4-boronobenzyl group to a phosphate group at the 5'-terminal of an ON using the reactivity of diazo compounds.
Article
Chemistry, Multidisciplinary
Yuki Shintani, Taku Ohtomi, Aya Shibata, Yoshiaki Kitamura, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Masato Ikeda
Summary: In this study, we demonstrated the construction of thermally stable supramolecular hydrogels through thermolysin-assisted biocatalysis, as well as the post-assembly modification of these structures using fluorescence imaging.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Sayuri L. Higashi, Yuki Shintani, Masato Ikeda
Summary: Artificially synthesized stimuli-responsive biomolecules are attractive molecular tools for monitoring and modulating biological systems. This Concept article reviews the molecular design of reduction-responsive biomolecules, such as peptides, nucleic acids, and saccharides, produced by introducing nitroaryl groups into them, with a special emphasis on simple 4-nitrobenzene-based motifs.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Sayuri L. Higashi, Ayaka Isogami, Junko Takahashi, Aya Shibata, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Shunsuke Sawada, Shinya Tsukiji, Kazunori Matsuura, Masato Ikeda
Summary: In this study, a new reduction-cleavable spacer (RCS) based on a nitrobenzene scaffold was designed and synthesized for constructing reduction-responsive oligonucleotides using standard phosphoramidite chemistry. Furthermore, it was demonstrated that the introduction of the RCS in the middle of an oligonucleotide (30 nt) allowed for the construction of a self-assembled microsphere capable of exhibiting a reduction-responsive disassembly.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Editorial Material
Polymer Science
Takeshi Serizawa, Masato Ikeda, Keiji Tanaka
Review
Polymer Science
Aya Shibata, Sayuri L. Higashi, Masato Ikeda
Summary: In this review, the application of nucleic acid-based fluorescent sensors in exploring intracellular phenomena is discussed. Different types of sensing systems and their characteristics are introduced, with a focus on recent examples of signal amplification systems for detecting small amounts of target analytes under isothermal conditions.
Article
Chemistry, Multidisciplinary
Shintaro Sugiura, Yuki Shintani, Daisuke Mori, Sayuri L. Higashi, Aya Shibata, Yoshiaki Kitamura, Shin-ichiro Kawano, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Masato Ikeda
Summary: The artificial construction of multicomponent supramolecular materials has attracted attention due to their orthogonally assembled architectures. In this study, we combined peptide-based self-assembled fibrous nanostructures with globular DNA nanoflowers to develop unique hybrid materials. Fluorescence imaging was used to dissect the orthogonally constructed architectures. By utilizing the distinct functions of peptides and DNA, these materials show promising opportunities for bioapplications as a soft matrix.
Article
Chemistry, Multidisciplinary
Naoki Tsutsumi, Akitaka Ito, Yosuke Niko, Yui Bando, Kiyonori Takahashi, Masato Ikeda, Kaori Yoneyama, Takayoshi Nakamura, Masayuki Izumi, Rika Ochi
Summary: In this study, we developed glycolipid-type amphiphiles with aggregation-induced emission (AIE) features and found that the design of molecular packing plays a crucial role in controlling the AIE properties.
Article
Chemistry, Analytical
Normazida Rozi, Sharina Abu Hanifah, Nurul Huda Abd Karim, Lee Yook Heng, Sayuri L. L. Higashi, Masato Ikeda
Summary: This study successfully developed an electrochemical biosensor for rapid detection of E2 in water samples. The biosensor uses split DNA aptamers and differential pulse voltammetry to detect E2 even at low concentrations, with good selectivity and repeatability.
Article
Polymer Science
Ayaka Isogami, Sayuri L. Higashi, Bioru Okumura, Aya Shibata, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Shinya Tsukiji, Kazunori Matsuura, Masato Ikeda
Summary: The article describes the construction of a hierarchical supramolecular structure composed of reduction-responsive DNA microspheres and semi-artificial glycopeptide-based micro-asters, which are obtained through the (self-)assembly of oligonucleotides and a semi-artificial glycopeptide in a single thermal annealing process under aqueous conditions in the presence of Mg2+.
Article
Chemistry, Multidisciplinary
Sayuri L. Higashi, Masato Ikeda
Summary: Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials developed based on modular molecular design. Glucosamine-based derivatives were found to be the only molecules capable of forming hydrogels, compared to galactosamine-based molecules.
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
