let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery

Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells

(2016) X Sun et al.   CANCER GENE THERAPY

Subtype-specific micro-RNA expression signatures in breast cancer progression

(2016) Vilde D. Haakensen et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review)

(2016) ROBERTO GAMBARI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth

(2016) Boyko S. Atanassov et al.   MOLECULAR CELL

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

(2016) Julia Beermann et al.   PHYSIOLOGICAL REVIEWS

Histone Modifications and Cancer

(2016) James E. Audia et al.   Cold Spring Harbor Perspectives in Biology

USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B

(2016) Xianjiang Lan et al.   Cell Reports

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

(2016) Ohad Tarcic et al.   Cell Reports

MicroRNA let-7b suppresses human gastric cancer malignancy by targeting ING1

(2015) X Han et al.   CANCER GENE THERAPY

Combinatorial Action of MicroRNAslet-7and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation

(2015) Carlos Stahlhut et al.   CELL CYCLE

Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma

(2015) Zijing Wang et al.   HUMAN PATHOLOGY

USP22 promotes tumor progression and induces epithelial–mesenchymal transition in lung adenocarcinoma

(2015) Jing Hu et al.   LUNG CANCER

Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer

(2015) Tianzhen Wang et al.   Molecular Cancer

miRWalk2.0: a comprehensive atlas of microRNA-target interactions

(2015) Harsh Dweep et al.   NATURE METHODS

Loss of H2Bub1 Expression is Linked to Poor Prognosis in Nodal Negative Colorectal Cancers

(2015) Nathaniel Melling et al.   PATHOLOGY & ONCOLOGY RESEARCH

Outside the coding genome, mammalian microRNAs confer structural and functional complexity

(2015) Virginie Olive et al.   Science Signaling

Comprehensive Catalog of Currently Documented Histone Modifications

(2015) Yingming Zhao et al.   Cold Spring Harbor Perspectives in Biology

High USP22 expression indicates poor prognosis in hepatocellular carcinoma

(2015) Bo Tang et al.   Oncotarget

microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer

(2015) Dong-liang Chen et al.   Oncotarget

Biogenesis and regulation of the let-7 miRNAs and their functional implications

(2015) Hosuk Lee et al.   Protein & Cell

Outside the coding genome, mammalian microRNAs confer structural and functional complexity

(2015) Virginie Olive et al.   Science Signaling

Cancer metastases: challenges and opportunities

(2015) Xiangming Guan   Acta Pharmaceutica Sinica B

Writing and reading H2B monoubiquitylation

(2014) Gilad Fuchs et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Therapeutic Potential of MicroRNA Let-7: Tumor Suppression or Impeding Normal Stemness

(2014) Shao-Chih Chiu et al.   CELL TRANSPLANTATION

Histone H2B monoubiquitination: roles to play in human malignancy

(2014) Alexander J Cole et al.   ENDOCRINE-RELATED CANCER

Ubiquitin-specific Peptidase 42 (USP42) Functions to Deubiquitylate Histones and Regulate Transcriptional Activity

(2014) Andreas K. Hock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of microRNA-26a is associated with metastatic potential and the poor prognosis of osteosarcoma patients

(2014) QI-CHUN SONG et al.   ONCOLOGY REPORTS

MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3

(2013) Bingtian Zhao et al.   CANCER LETTERS

A new genome-driven integrated classification of breast cancer and its implications

(2013) Sarah-Jane Dawson et al.   EMBO JOURNAL

Let-7c inhibits A549 cell proliferation through oncogenic TRIB2 related factors

(2013) Ping-Yu Wang et al.   FEBS LETTERS

Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation

(2013) J. Hausser et al.   GENOME RESEARCH

Prognostic significance of let-7b expression in breast cancer and correlation to its target gene of BSG expression

(2013) Lin Ma et al.   MEDICAL ONCOLOGY

Let-7c Governs the Acquisition of Chemo- or Radioresistance and Epithelial-to-Mesenchymal Transition Phenotypes in Docetaxel-Resistant Lung Adenocarcinoma

(2013) Shi-Yun Cui et al.   MOLECULAR CANCER RESEARCH

The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

(2013) Xiaowen Hu et al.   MOLECULAR CANCER RESEARCH

The shaping and functional consequences of the microRNA landscape in breast cancer

(2013) Heidi Dvinge et al.   NATURE

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

(2013) E. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased histone H2B monoubiquitination in malignant gastric carcinoma

(2013) Zi-Jing Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Functional microRNA targets in protein coding sequences

(2012) Martin Reczko et al.   BIOINFORMATICS

Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

(2012) S. B. Chernikova et al.   CANCER RESEARCH

miRNA-34b Inhibits Prostate Cancer through Demethylation, Active Chromatin Modifications, and AKT Pathways

(2012) S. Majid et al.   CLINICAL CANCER RESEARCH

The enigmatic role of H2Bub1 in cancer

(2012) Steven A. Johnsen   FEBS LETTERS

The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells

(2012) Oleksandra Karpiuk et al.   MOLECULAR CELL

RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

(2012) Gilad Fuchs et al.   MOLECULAR CELL

A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20

(2012) Michael Blank et al.   NATURE MEDICINE

Coupling of Glucose Deprivation with Impaired Histone H2B Monoubiquitination in Tumors

(2012) Yasuyo Urasaki et al.   PLoS One

let-7b and miR-126 Are Down-Regulated in Tumor Tissue and Correlate with Microvessel Density and Survival Outcomes in Non–Small–Cell Lung Cancer

(2012) Edin Jusufović et al.   PLoS One

High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer

(2011) M. P. H. M. Jansen et al.   BREAST CANCER RESEARCH AND TREATMENT

Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B

(2011) T. Prenzel et al.   CANCER RESEARCH

The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair

(2011) Vijayalakshmi Kari et al.   CELL CYCLE

Down-regulation ofBRCA1expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers

(2011) Amandine I. Garcia et al.   EMBO Molecular Medicine

miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes

(2011) Harsh Dweep et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer

(2011) Youxue Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

(2011) G. Lang et al.   MOLECULAR AND CELLULAR BIOLOGY

MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma

(2011) Zuping Zhang et al.   Molecular Cancer

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

RNF20 Inhibits TFIIS-Facilitated Transcriptional Elongation to Suppress Pro-oncogenic Gene Expression

(2011) Efrat Shema et al.   MOLECULAR CELL

WAC, a Functional Partner of RNF20/40, Regulates Histone H2B Ubiquitination and Gene Transcription

(2011) Feng Zhang et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia

(2011) Ying Zhang et al.   PLoS One

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling

(2011) Ashish Lal et al.   PLoS Genetics

Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer

(2010) Yingchun Zhao et al.   BREAST CANCER RESEARCH AND TREATMENT

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

The role of deubiquitinating enzymes in chromatin regulation

(2010) Boyko S. Atanassov et al.   FEBS LETTERS

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

(2010) Patryk Moskwa et al.   MOLECULAR CELL

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability

(2009) M. B. Chandrasekharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

(2008) S. Sander et al.   BLOOD

MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN

(2008) H. Yang et al.   CANCER RESEARCH

MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth

(2008) Julia Schultz et al.   CELL RESEARCH

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

(2008) E. Shema et al.   GENES & DEVELOPMENT

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

(2008) Xiao-Yong Zhang et al.   MOLECULAR CELL

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

(2008) Yue Zhao et al.   MOLECULAR CELL

Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells

(2008) Neri Minsky et al.   NATURE CELL BIOLOGY

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

(2008) T. D. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA